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Items: 38


In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo.

Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J.

mSphere. 2019 Jul 31;4(4). pii: e00254-19. doi: 10.1128/mSphere.00254-19.


Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae.

Novotny LA, Brockman KL, Mokrzan EM, Jurcisek JA, Bakaletz LO.

J Pediatr Infect Dis. 2019 Feb;14(2):69-77. doi: 10.1055/s-0038-1660818. Epub 2018 Jul 6.


Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery.

Rood KM, Buhimschi IA, Jurcisek JA, Summerfield TL, Zhao G, Ackerman WE, Wang W, Rumpf RW, Thung SF, Bakaletz LO, Buhimschi CS.

Sci Rep. 2018 Jun 8;8(1):8756. doi: 10.1038/s41598-018-27134-5.


Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae.

Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO.

MBio. 2017 Dec 19;8(6). pii: e01466-17. doi: 10.1128/mBio.01466-17.


Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

Jurcisek JA, Brockman KL, Novotny LA, Goodman SD, Bakaletz LO.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6632-E6641. doi: 10.1073/pnas.1705508114. Epub 2017 Jul 10.


Identification of biofilms in post-tympanostomy tube otorrhea.

Idicula WK, Jurcisek JA, Cass ND, Ali S, Goodman SD, Elmaraghy CA, Jatana KR, Bakaletz LO.

Laryngoscope. 2016 Aug;126(8):1946-51. doi: 10.1002/lary.25826. Epub 2016 Jan 4.


Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo.

Novotny LA, Jurcisek JA, Goodman SD, Bakaletz LO.

EBioMedicine. 2016 Aug;10:33-44. doi: 10.1016/j.ebiom.2016.06.022. Epub 2016 Jun 16.


ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.

Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz LO.

J Infect Dis. 2016 Sep 1;214(5):817-24. doi: 10.1093/infdis/jiw243. Epub 2016 Jun 10.


A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP.

Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.


Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.

Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP.

J Infect Dis. 2015 Aug 15;212(4):645-53. doi: 10.1093/infdis/jiv103. Epub 2015 Feb 23.


Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media.

Novotny LA, Jurcisek JA, Ward MO Jr, Jordan ZB, Goodman SD, Bakaletz LO.

Mol Microbiol. 2015 Apr;96(2):276-92. doi: 10.1111/mmi.12934. Epub 2015 Feb 15.


Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

Cho C, Chande A, Gakhar L, Bakaletz LO, Jurcisek JA, Ketterer M, Shao J, Gotoh K, Foster E, Hunt J, O'Brien E, Apicella MA.

Infect Immun. 2015 Mar;83(3):950-7. doi: 10.1128/IAI.02601-14. Epub 2014 Dec 29.


Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms.

Brockson ME, Novotny LA, Mokrzan EM, Malhotra S, Jurcisek JA, Akbar R, Devaraj A, Goodman SD, Bakaletz LO.

Mol Microbiol. 2014 Sep;93(6):1246-58. doi: 10.1111/mmi.12735. Epub 2014 Aug 19.


Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.

Das S, Rosas LE, Jurcisek JA, Novotny LA, Green KB, Bakaletz LO.

Laryngoscope. 2014 Mar;124(3):608-15. doi: 10.1002/lary.24333. Epub 2013 Oct 2.


Antibodies directed against integration host factor mediate biofilm clearance from Nasopore.

Brandstetter KA, Jurcisek JA, Goodman SD, Bakaletz LO, Das S.

Laryngoscope. 2013 Nov;123(11):2626-32. doi: 10.1002/lary.24183. Epub 2013 May 13.


Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis.

Gustave JE, Jurcisek JA, McCoy KS, Goodman SD, Bakaletz LO.

J Cyst Fibros. 2013 Jul;12(4):384-9. doi: 10.1016/j.jcf.2012.10.011. Epub 2012 Nov 17.


Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.

Brockson ME, Novotny LA, Jurcisek JA, McGillivary G, Bowers MR, Bakaletz LO.

PLoS One. 2012;7(6):e40088. doi: 10.1371/journal.pone.0040088. Epub 2012 Jun 29.


Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins.

Goodman SD, Obergfell KP, Jurcisek JA, Novotny LA, Downey JS, Ayala EA, Tjokro N, Li B, Justice SS, Bakaletz LO.

Mucosal Immunol. 2011 Nov;4(6):625-37. doi: 10.1038/mi.2011.27. Epub 2011 Jun 29.


In vitro biofilm formation in an 8-well chamber slide.

Jurcisek JA, Dickson AC, Bruggeman ME, Bakaletz LO.

J Vis Exp. 2011 Jan 20;(47). pii: 2481. doi: 10.3791/2481.


Mapping the anatomy of respiratory syncytial virus infection of the upper airways in chinchillas (Chinchilla lanigera).

Grieves JL, Jurcisek JA, Quist B, Durbin RK, Peeples ME, Durbin JE, Bakaletz LO.

Comp Med. 2010 Jun;60(3):225-32.


Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae.

McGillivary G, Mason KM, Jurcisek JA, Peeples ME, Bakaletz LO.

Cell Microbiol. 2009 Sep;11(9):1399-408. doi: 10.1111/j.1462-5822.2009.01339.x. Epub 2009 Jun 2.


The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant.

Morton DJ, Seale TW, Bakaletz LO, Jurcisek JA, Smith A, VanWagoner TM, Whitby PW, Stull TL.

Int J Med Microbiol. 2009 Nov;299(7):479-88. doi: 10.1016/j.ijmm.2009.03.004. Epub 2009 May 17.


Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation.

Luke NR, Jurcisek JA, Bakaletz LO, Campagnari AA.

Infect Immun. 2007 Dec;75(12):5559-64. Epub 2007 Oct 1.


The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.

Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS Jr, Bakaletz LO.

Mol Microbiol. 2007 Sep;65(5):1288-99. Epub 2007 Jul 23.


Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.

Jurcisek J, Greiner L, Watanabe H, Zaleski A, Apicella MA, Bakaletz LO.

Infect Immun. 2005 Jun;73(6):3210-8.


Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus.

Gitiban N, Jurcisek JA, Harris RH, Mertz SE, Durbin RK, Bakaletz LO, Durbin JE.

J Virol. 2005 May;79(10):6035-42.


Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae.

Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R, Munson RS Jr.

Infect Immun. 2005 Mar;73(3):1635-43.


Anatomy of the nasal cavity in the chinchilla.

Jurcisek JA, Durbin JE, Kusewitt DF, Bakaletz LO.

Cells Tissues Organs. 2003;174(3):136-52.


A method to monitor DNA transfer during transfection.

Johnson AL, Jurcisek JA, Trask OJ Jr, Au JL.

AAPS PharmSci. 1999;1(2):E6.


Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae.

Novotny LA, Jurcisek JA, Pichichero ME, Bakaletz LO.

Infect Immun. 2000 Apr;68(4):2119-28.


Aberrant crypts: putative preneoplastic foci in human colonic mucosa.

Pretlow TP, Barrow BJ, Ashton WS, O'Riordan MA, Pretlow TG, Jurcisek JA, Stellato TA.

Cancer Res. 1991 Mar 1;51(5):1564-7.


Colonic aberrant crypts in azoxymethane-treated F344 rats have decreased hexosaminidase activity.

Pretlow TP, O'Riordan MA, Kolman MF, Jurcisek JA.

Am J Pathol. 1990 Jan;136(1):13-6.

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