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Items: 17


The role of mitochondrial oxidative stress in the metabolic alterations in diet-induced obesity in rats.

Marín-Royo G, Rodríguez C, Le Pape A, Jurado-López R, Luaces M, Antequera A, Martínez-González J, Souza-Neto FV, Nieto ML, Martínez-Martínez E, Cachofeiro V.

FASEB J. 2019 Nov;33(11):12060-12072. doi: 10.1096/fj.201900347RR. Epub 2019 Aug 1.


The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction.

Marín-Royo G, Ortega-Hernández A, Martínez-Martínez E, Jurado-López R, Luaces M, Islas F, Gómez-Garre D, Delgado-Valero B, Lagunas E, Ramchandani B, García-Bouza M, Nieto ML, Cachofeiro V.

Sci Rep. 2019 Jan 24;9(1):444. doi: 10.1038/s41598-018-36914-y.


Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity.

Marín-Royo G, Gallardo I, Martínez-Martínez E, Gutiérrez B, Jurado-López R, López-Andrés N, Gutiérrez-Tenorio J, Rial E, Bartolomé MAV, Nieto ML, Cachofeiro V.

Dis Model Mech. 2018 Feb 5;11(2). pii: dmm032086. doi: 10.1242/dmm.032086.


The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity.

Gutiérrez-Tenorio J, Marín-Royo G, Martínez-Martínez E, Martín R, Miana M, López-Andrés N, Jurado-López R, Gallardo I, Luaces M, San Román JA, González-Amor M, Salaices M, Nieto ML, Cachofeiro V.

Sci Rep. 2017 Dec 1;7(1):16802. doi: 10.1038/s41598-017-17103-9.


The impact of obesity in the cardiac lipidome and its consequences in the cardiac damage observed in obese rats.

Marín-Royo G, Martínez-Martínez E, Gutiérrez B, Jurado-López R, Gallardo I, Montero O, Bartolomé MV, San Román JA, Salaices M, Nieto ML, Cachofeiro V.

Clin Investig Arterioscler. 2018 Jan - Feb;30(1):10-20. doi: 10.1016/j.arteri.2017.07.004. Epub 2017 Aug 30. English, Spanish.


Galectin-3 inhibition prevents adipose tissue remodelling in obesity.

Martínez-Martínez E, Calvier L, Rossignol P, Rousseau E, Fernández-Celis A, Jurado-López R, Laville M, Cachofeiro V, López-Andrés N.

Int J Obes (Lond). 2016 Jun;40(6):1034-8. doi: 10.1038/ijo.2016.19. Epub 2016 Feb 8.


The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

Martínez-Martínez E, Rodríguez C, Galán M, Miana M, Jurado-López R, Bartolomé MV, Luaces M, Islas F, Martínez-González J, López-Andrés N, Cachofeiro V.

J Mol Cell Cardiol. 2016 Mar;92:96-104. doi: 10.1016/j.yjmcc.2016.01.012. Epub 2016 Jan 15.


Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity.

Martínez-Martínez E, López-Ándres N, Jurado-López R, Rousseau E, Bartolomé MV, Fernández-Celis A, Rossignol P, Islas F, Antequera A, Prieto S, Luaces M, Cachofeiro V.

Hypertension. 2015 Nov;66(5):961-9. doi: 10.1161/HYPERTENSIONAHA.115.06032. Epub 2015 Sep 8.


Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertension.

Martínez-Martínez E, Calvier L, Fernández-Celis A, Rousseau E, Jurado-López R, Rossoni LV, Jaisser F, Zannad F, Rossignol P, Cachofeiro V, López-Andrés N.

Hypertension. 2015 Oct;66(4):767-75. doi: 10.1161/HYPERTENSIONAHA.115.05876. Epub 2015 Aug 3.


The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats.

Miana M, Galán M, Martínez-Martínez E, Varona S, Jurado-López R, Bausa-Miranda B, Antequera A, Luaces M, Martínez-González J, Rodríguez C, Cachofeiro V.

Dis Model Mech. 2015 Jun;8(6):543-51. doi: 10.1242/dmm.020107. Epub 2015 Apr 7.


Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation.

Martínez-Martínez E, Cachofeiro V, Rousseau E, Álvarez V, Calvier L, Fernández-Celis A, Leroy C, Miana M, Jurado-López R, Briones AM, Jaisser F, Zannad F, Rossignol P, López-Andrés N.

Mol Cell Endocrinol. 2015 Aug 15;411:20-7. doi: 10.1016/j.mce.2015.04.007. Epub 2015 Apr 17.


Leptin, a mediator of cardiac damage associated with obesity.

Martínez-Martínez E, Jurado-López R, Cervantes-Escalera P, Cachofeiro V, Miana M.

Horm Mol Biol Clin Investig. 2014 Apr;18(1):3-14. doi: 10.1515/hmbci-2013-0060. Review.


Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity.

Martínez-Martínez E, Jurado-López R, Valero-Muñoz M, Bartolomé MV, Ballesteros S, Luaces M, Briones AM, López-Andrés N, Miana M, Cachofeiro V.

J Hypertens. 2014 May;32(5):1104-14; discussion 1114. doi: 10.1097/HJH.0000000000000149.


The potential role of leptin in the vascular remodeling associated with obesity.

Martínez-Martínez E, Miana M, Jurado-López R, Bartolomé MV, Souza Neto FV, Salaices M, López-Andrés N, Cachofeiro V.

Int J Obes (Lond). 2014 Dec;38(12):1565-72. doi: 10.1038/ijo.2014.37. Epub 2014 Mar 3.


A role for soluble ST2 in vascular remodeling associated with obesity in rats.

Martínez-Martínez E, Miana M, Jurado-López R, Rousseau E, Rossignol P, Zannad F, Cachofeiro V, López-Andrés N.

PLoS One. 2013 Nov 12;8(11):e79176. doi: 10.1371/journal.pone.0079176. eCollection 2013.


DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

Martín R, Miana M, Jurado-López R, Martínez-Martínez E, Gómez-Hurtado N, Delgado C, Bartolomé MV, San Román JA, Cordova C, Lahera V, Nieto ML, Cachofeiro V.

PLoS One. 2012;7(7):e41545. doi: 10.1371/journal.pone.0041545. Epub 2012 Jul 23.


The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study.

Alvarez G, Visitación Bartolomé M, Miana M, Jurado-López R, Martín R, Zuluaga P, Martinez-Martinez E, Nieto ML, Alvarez-Sala LA, Millán J, Lahera V, Cachofeiro V.

J Vasc Res. 2012;49(2):111-22. doi: 10.1159/000332332. Epub 2012 Jan 13.

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