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Items: 49


Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens.

Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED.

Nat Microbiol. 2020 Jan;5(1):93-101. doi: 10.1038/s41564-019-0595-2. Epub 2019 Oct 28.


Modifying a covarying protein-DNA interaction changes substrate preference of a site-specific endonuclease.

Laforet M, McMurrough TA, Vu M, Brown CM, Zhang K, Junop MS, Gloor GB, Edgell DR.

Nucleic Acids Res. 2019 Nov 18;47(20):10830-10841. doi: 10.1093/nar/gkz866.


NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB.

Popović V, Morrison E, Rosanally AZ, Balachandran N, Senson AW, Szabla R, Junop MS, Berti PJ.

Biochemistry. 2019 Oct 15;58(41):4236-4245. doi: 10.1021/acs.biochem.9b00654. Epub 2019 Oct 4.


Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage.

Mok MCY, Campalans A, Pillon MC, Guarné A, Radicella JP, Junop MS.

Sci Rep. 2019 Feb 28;9(1):3095. doi: 10.1038/s41598-019-39543-1.


Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases.

McMurrough TA, Brown CM, Zhang K, Hausner G, Junop MS, Gloor GB, Edgell DR.

Nucleic Acids Res. 2018 Dec 14;46(22):11990-12007. doi: 10.1093/nar/gky976.


Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink.

Buzon B, Grainger R, Huang S, Rzadki C, Junop MS.

Nucleic Acids Res. 2018 Sep 28;46(17):9057-9066. doi: 10.1093/nar/gky759.


Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function.

Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL.

Sci Rep. 2018 Feb 8;8(1):2600. doi: 10.1038/s41598-018-20925-w.


Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.

Balachandran N, Heimhalt M, Liuni P, To F, Wilson DJ, Junop MS, Berti PJ.

Biochemistry. 2016 Dec 6;55(48):6617-6629. Epub 2016 Nov 17.


Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.

Lee SK, Shanmughapriya S, Mok MCY, Dong Z, Tomar D, Carvalho E, Rajan S, Junop MS, Madesh M, Stathopulos PB.

Cell Chem Biol. 2016 Sep 22;23(9):1157-1169. doi: 10.1016/j.chembiol.2016.07.012. Epub 2016 Aug 25.


The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions.

Buensuceso RN, Nguyen Y, Zhang K, Daniel-Ivad M, Sugiman-Marangos SN, Fleetwood AD, Zhulin IB, Junop MS, Howell PL, Burrows LL.

J Bacteriol. 2016 Jul 28;198(16):2263-74. doi: 10.1128/JB.00322-16. Print 2016 Aug 15.


Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB.

Sugiman-Marangos SN, Weiss YM, Junop MS.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4308-13. doi: 10.1073/pnas.1520847113. Epub 2016 Apr 4.


Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE.

Nguyen Y, Harvey H, Sugiman-Marangos S, Bell SD, Buensuceso RN, Junop MS, Burrows LL.

J Biol Chem. 2015 Oct 30;290(44):26856-65. doi: 10.1074/jbc.M115.683334. Epub 2015 Sep 10.


Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin.

Nguyen Y, Sugiman-Marangos S, Harvey H, Bell SD, Charlton CL, Junop MS, Burrows LL.

J Biol Chem. 2015 Jan 2;290(1):601-11. doi: 10.1074/jbc.M114.616904. Epub 2014 Nov 11.


Evaluation of the calmodulin-SOX9 interaction by "magnetic fishing" coupled to mass spectrometry.

McFadden MJ, Hryciw T, Brown A, Junop MS, Brennan JD.

Chembiochem. 2014 Nov 3;15(16):2411-9. doi: 10.1002/cbic.201402414. Epub 2014 Sep 18.


Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo.

Allison SE, Tuinema BR, Everson ES, Sugiman-Marangos S, Zhang K, Junop MS, Coombes BK.

J Biol Chem. 2014 Aug 22;289(34):23734-44. doi: 10.1074/jbc.M114.578476. Epub 2014 Jul 17.


Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.

Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K.

Mol Cell Biol. 2014 Jun;34(12):2162-75. doi: 10.1128/MCB.01554-13. Epub 2014 Mar 31.


Exploring intermolecular interactions of a substrate binding protein using a riboswitch-based sensor.

Fowler CC, Sugiman-Marangos S, Junop MS, Brown ED, Li Y.

Chem Biol. 2013 Dec 19;20(12):1502-12. doi: 10.1016/j.chembiol.2013.10.014. Epub 2013 Nov 27.


Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states.

Sugiman-Marangos SN, Peel JK, Weiss YM, Ghirlando R, Junop MS.

Nucleic Acids Res. 2013 Nov;41(21):9934-44. doi: 10.1093/nar/gkt759. Epub 2013 Aug 23.


Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair.

McFadden MJ, Lee WK, Brennan JD, Junop MS.

Proteins. 2014 Feb;82(2):187-94. doi: 10.1002/prot.24349. Epub 2013 Sep 20.


The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.

Boyle AJ, Roddick LA, Bhakta V, Lambourne MD, Junop MS, Liaw PC, Weitz JI, Sheffield WP.

BMC Biochem. 2013 Mar 7;14:6. doi: 10.1186/1471-2091-14-6.


Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence.

Desroy N, Denis A, Oliveira C, Atamanyuk D, Briet S, Faivre F, LeFralliec G, Bonvin Y, Oxoby M, Escaich S, Floquet S, Drocourt E, Vongsouthi V, Durant L, Moreau F, Verhey TB, Lee TW, Junop MS, Gerusz V.

J Med Chem. 2013 Feb 28;56(4):1418-30. doi: 10.1021/jm301499r. Epub 2013 Feb 14.


Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.

Lee TW, Verhey TB, Antiperovitch PA, Atamanyuk D, Desroy N, Oliveira C, Denis A, Gerusz V, Drocourt E, Loutet SA, Hamad MA, Stanetty C, Andres SN, Sugiman-Marangos S, Kosma P, Valvano MA, Moreau F, Junop MS.

J Med Chem. 2013 Feb 28;56(4):1405-17. doi: 10.1021/jm301483h. Epub 2013 Jan 22.


Structure of an asymmetric ternary protein complex provides insight for membrane interaction.

Dempsey BR, Rezvanpour A, Lee TW, Barber KR, Junop MS, Shaw GS.

Structure. 2012 Oct 10;20(10):1737-45. doi: 10.1016/j.str.2012.08.004. Epub 2012 Aug 30.


Structural characterization of a novel Chlamydia pneumoniae type III secretion-associated protein, Cpn0803.

Stone CB, Sugiman-Marangos S, Bulir DC, Clayden RC, Leighton TL, Slootstra JW, Junop MS, Mahony JB.

PLoS One. 2012;7(1):e30220. doi: 10.1371/journal.pone.0030220. Epub 2012 Jan 17.


Crystallization and preliminary X-ray diffraction analysis of the human XRCC4-XLF complex.

Andres SN, Junop MS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1399-402. doi: 10.1107/S1744309111033549. Epub 2011 Oct 27.


Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions.

Jackson SG, Al-Saigh S, Schultz C, Junop MS.

BMC Struct Biol. 2011 Feb 10;11:11. doi: 10.1186/1472-6807-11-11.


Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-protein interactions.

McFadden MJ, Junop MS, Brennan JD.

Anal Chem. 2010 Dec 1;82(23):9850-7. doi: 10.1021/ac102164d. Epub 2010 Nov 10.


Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host.

Cooper CA, Zhang K, Andres SN, Fang Y, Kaniuk NA, Hannemann M, Brumell JH, Foster LJ, Junop MS, Coombes BK.

PLoS Pathog. 2010 Feb 5;6(2):e1000751. doi: 10.1371/journal.ppat.1000751.


The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins.

Sugiman-Marangos S, Junop MS.

Nucleic Acids Res. 2010 Jun;38(10):3432-40. doi: 10.1093/nar/gkq036. Epub 2010 Feb 2.


Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.

Taylor PL, Sugiman-Marangos S, Zhang K, Valvano MA, Wright GD, Junop MS.

Biochemistry. 2010 Feb 9;49(5):1033-41. doi: 10.1021/bi901780j.


Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions .

Jackson SG, Zhang F, Chindemi P, Junop MS, Berti PJ.

Biochemistry. 2009 Dec 15;48(49):11715-23. doi: 10.1021/bi901524q.


Structural and phylogenetic analysis of a conserved actinobacteria-specific protein (ASP1; SCO1997) from Streptomyces coelicolor.

Gao B, Sugiman-Marangos S, Junop MS, Gupta RS.

BMC Struct Biol. 2009 Jun 10;9:40. doi: 10.1186/1472-6807-9-40.


Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.

Wu PY, Frit P, Meesala S, Dauvillier S, Modesti M, Andres SN, Huang Y, Sekiguchi J, Calsou P, Salles B, Junop MS.

Mol Cell Biol. 2009 Jun;29(11):3163-72. doi: 10.1128/MCB.01895-08. Epub 2009 Mar 30.


Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA.

Willems AR, Tahlan K, Taguchi T, Zhang K, Lee ZZ, Ichinose K, Junop MS, Nodwell JR.

J Mol Biol. 2008 Mar 7;376(5):1377-87. doi: 10.1016/j.jmb.2007.12.061. Epub 2008 Jan 4.


Crystal structure of human XLF: a twist in nonhomologous DNA end-joining.

Andres SN, Modesti M, Tsai CJ, Chu G, Junop MS.

Mol Cell. 2007 Dec 28;28(6):1093-101.


Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.

Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS.

J Biol Chem. 2008 Feb 1;283(5):2835-45. Epub 2007 Dec 3.


Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.

Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD.

J Med Chem. 2007 Feb 22;50(4):755-64.


A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region.

Summerfield RL, Daigle DM, Mayer S, Mallik D, Hughes DW, Jackson SG, Sulek M, Organ MG, Brown ED, Junop MS.

J Med Chem. 2006 Nov 30;49(24):6977-86.


Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms.

Jackson SG, Zhang Y, Bao X, Zhang K, Summerfield R, Haslam RJ, Junop MS.

Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):324-30. Epub 2006 Feb 22.


Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

Modesti M, Junop MS, Ghirlando R, van de Rakt M, Gellert M, Yang W, Kanaar R.

J Mol Biol. 2003 Nov 21;334(2):215-28.


DNA mismatch repair: from structure to mechanism.

Yang W, Junop MS, Ban C, Obmolova G, Hsieh P.

Cold Spring Harb Symp Quant Biol. 2000;65:225-32. Review. No abstract available.


In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination.

Junop MS, Yang W, Funchain P, Clendenin W, Miller JH.

DNA Repair (Amst). 2003 Apr 2;2(4):387-405.


Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.

Junop MS, Obmolova G, Rausch K, Hsieh P, Yang W.

Mol Cell. 2001 Jan;7(1):1-12.


Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.

Junop MS, Modesti M, Guarné A, Ghirlando R, Gellert M, Yang W.

EMBO J. 2000 Nov 15;19(22):5962-70.


Intragenic suppression of integration-defective IS10 transposase mutants.

Junop MS, Hockman D, Haniford DB.

Genetics. 1994 Jun;137(2):343-52.

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