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INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges.

Jungersen G, Piedrahita J.

ILAR J. 2018 Dec 31;59(3):209-210. doi: 10.1093/ilar/ilz014.


Editorial: "Humanized" Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials.

Schachtschneider KM, Jungersen G, Schook LB, Shanmuganayagam D.

Front Oncol. 2019 Aug 27;9:793. doi: 10.3389/fonc.2019.00793. eCollection 2019. No abstract available.


The Effect of Inactivated Mycobacterium Paratuberculosis Vaccine on the Response to a Heterologous Bacterial Challenge in Pigs.

Jensen KJ, Hansen MS, Heegaard PMH, Benn CS, Jungersen G.

Front Immunol. 2019 Jul 5;10:1557. doi: 10.3389/fimmu.2019.01557. eCollection 2019.


Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.

Thakur A, Mikkelsen H, Jungersen G.

J Immunol Res. 2019 Apr 14;2019:1356540. doi: 10.1155/2019/1356540. eCollection 2019. Review.


Genital Infiltrations of CD4+ and CD8+ T Lymphocytes, IgA+ and IgG+ Plasma Cells and Intra-Mucosal Lymphoid Follicles Associate With Protection Against Genital Chlamydia trachomatis Infection in Minipigs Intramuscularly Immunized With UV-Inactivated Bacteria Adjuvanted With CAF01.

Erneholm K, Lorenzen E, Bøje S, Olsen AW, Jungersen G, Jensen HE, Cassidy JP, Andersen P, Agerholm JS, Follmann F.

Front Microbiol. 2019 Feb 8;10:197. doi: 10.3389/fmicb.2019.00197. eCollection 2019.


Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research.

Overgaard NH, Fan TM, Schachtschneider KM, Principe DR, Schook LB, Jungersen G.

ILAR J. 2018 Dec 31;59(3):247-262. doi: 10.1093/ilar/ily014.


Animal Models for Influenza A Virus Infection Incorporating the Involvement of Innate Host Defenses: Enhanced Translational Value of the Porcine Model.

Starbæk SMR, Brogaard L, Dawson HD, Smith AD, Heegaard PMH, Larsen LE, Jungersen G, Skovgaard K.

ILAR J. 2018 Dec 31;59(3):323-337. doi: 10.1093/ilar/ily009.


Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves.

Thakur A, Andrea A, Mikkelsen H, Woodworth JS, Andersen P, Jungersen G, Aagaard C.

PLoS One. 2018 Jul 31;13(7):e0201253. doi: 10.1371/journal.pone.0201253. eCollection 2018.


Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.

Overgaard NH, Principe DR, Schachtschneider KM, Jakobsen JT, Rund LA, Grippo PJ, Schook LB, Jungersen G.

Front Immunol. 2018 Jun 7;9:1301. doi: 10.3389/fimmu.2018.01301. eCollection 2018.


Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE.

Nat Immunol. 2018 Apr;19(4):386-396. doi: 10.1038/s41590-018-0068-4. Epub 2018 Mar 19.


Contribution of the swine model in the study of human sexually transmitted infections.

Käser T, Renois F, Wilson HL, Cnudde T, Gerdts V, Dillon JR, Jungersen G, Agerholm JS, Meurens F.

Infect Genet Evol. 2018 Dec;66:346-360. doi: 10.1016/j.meegid.2017.11.022. Epub 2017 Nov 23. Review.


Low antigen dose formulated in CAF09 adjuvant Favours a cytotoxic T-cell response following intraperitoneal immunization in Göttingen minipigs.

Overgaard NH, Frøsig TM, Jakobsen JT, Buus S, Andersen MH, Jungersen G.

Vaccine. 2017 Oct 9;35(42):5629-5636. doi: 10.1016/j.vaccine.2017.08.057. Epub 2017 Sep 5.


The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform.

Schachtschneider KM, Schwind RM, Newson J, Kinachtchouk N, Rizko M, Mendoza-Elias N, Grippo P, Principe DR, Park A, Overgaard NH, Jungersen G, Garcia KD, Maker AV, Rund LA, Ozer H, Gaba RC, Schook LB.

Front Oncol. 2017 Aug 23;7:190. doi: 10.3389/fonc.2017.00190. eCollection 2017. Review.


Prediction and in vitro verification of potential CTL epitopes conserved among PRRSV-2 strains.

Welner S, Nielsen M, Rasmussen M, Buus S, Jungersen G, Larsen LE.

Immunogenetics. 2017 Oct;69(10):689-702. doi: 10.1007/s00251-017-1004-8. Epub 2017 Jun 7.


Identification of cross-reacting T-cell epitopes in structural and non-structural proteins of swine and pandemic H1N1 influenza A virus strains in pigs.

Baratelli M, Pedersen LE, Trebbien R, Larsen LE, Jungersen G, Blanco E, Nielsen J, Montoya M.

J Gen Virol. 2017 May;98(5):895-899. doi: 10.1099/jgv.0.000748. Epub 2017 May 30.


Intrauterine inoculation of minipigs with Chlamydia trachomatis during diestrus establishes a longer lasting infection compared to vaginal inoculation during estrus.

Lorenzen E, Follmann F, Secher JO, Goericke-Pesch S, Hansen MS, Zakariassen H, Olsen AW, Andersen P, Jungersen G, Agerholm JS.

Microbes Infect. 2017 Jun;19(6):334-342. doi: 10.1016/j.micinf.2017.01.008. Epub 2017 Feb 9.


Improved Culture Medium (TiKa) for Mycobacterium avium Subspecies Paratuberculosis (MAP) Matches qPCR Sensitivity and Reveals Significant Proportions of Non-viable MAP in Lymphoid Tissue of Vaccinated MAP Challenged Animals.

Bull TJ, Munshi T, Mikkelsen H, Hartmann SB, Sørensen MR, Garcia JS, Lopez-Perez PM, Hofmann S, Hilpert K, Jungersen G.

Front Microbiol. 2017 Jan 4;7:2112. doi: 10.3389/fmicb.2016.02112. eCollection 2016.


Transfer of maternal immunity to piglets is involved in early protection against Mycoplasma hyosynoviae infection.

Lauritsen KT, Hagedorn-Olsen T, Jungersen G, Riber U, Stryhn H, Friis NF, Lind P, Kristensen B.

Vet Immunol Immunopathol. 2017 Jan;183:22-30. doi: 10.1016/j.vetimm.2016.12.002. Epub 2016 Dec 5.


Expanding specificity of class I restricted CD8+ T cells for viral epitopes following multiple inoculations of swine with a human adenovirus vectored foot-and-mouth disease virus (FMDV) vaccine.

Pedersen LE, Patch JR, Kenney M, Glabman RA, Nielsen M, Jungersen G, Buus S, Golde WT.

Vet Immunol Immunopathol. 2016 Nov 15;181:59-67. doi: 10.1016/j.vetimm.2016.07.012. Epub 2016 Jul 27.


Investigating the Role of Surface Materials and Three Dimensional Architecture on In Vitro Differentiation of Porcine Monocyte-Derived Dendritic Cells.

Hartmann SB, Mohanty S, Skovgaard K, Brogaard L, Flagstad FB, Emnéus J, Wolff A, Summerfield A, Jungersen G.

PLoS One. 2016 Jun 30;11(6):e0158503. doi: 10.1371/journal.pone.0158503. eCollection 2016.


Revisiting the IFN-γ release assay: Whole blood or PBMC cultures? - And other factors of influence.

Hartmann SB, Emnéus J, Wolff A, Jungersen G.

J Immunol Methods. 2016 Jul;434:24-31. doi: 10.1016/j.jim.2016.04.003. Epub 2016 Apr 9.


Characterization of cytological changes, IgA, IgG and IL-8 levels and pH value in the vagina of prepubertal and sexually mature Ellegaard Göttingen minipigs during an estrous cycle.

Lorenzen E, Agerholm JS, Grossi AB, Bojesen AM, Skytte C, Erneholm K, Follmann F, Jungersen G.

Dev Comp Immunol. 2016 Jun;59:57-62. doi: 10.1016/j.dci.2016.01.006. Epub 2016 Jan 20.


Intramuscular Priming and Intranasal Boosting Induce Strong Genital Immunity Through Secretory IgA in Minipigs Infected with Chlamydia trachomatis.

Lorenzen E, Follmann F, Bøje S, Erneholm K, Olsen AW, Agerholm JS, Jungersen G, Andersen P.

Front Immunol. 2015 Dec 16;6:628. doi: 10.3389/fimmu.2015.00628. eCollection 2015.


A combined prediction strategy increases identification of peptides bound with high affinity and stability to porcine MHC class I molecules SLA-1*04:01, SLA-2*04:01, and SLA-3*04:01.

Pedersen LE, Rasmussen M, Harndahl M, Nielsen M, Buus S, Jungersen G.

Immunogenetics. 2016 Feb;68(2):157-65. doi: 10.1007/s00251-015-0883-9. Epub 2015 Nov 14.


Novel Adjuvants and Immunomodulators for Veterinary Vaccines.

Heegaard PM, Fang Y, Jungersen G.

Methods Mol Biol. 2016;1349:63-82. doi: 10.1007/978-1-4939-3008-1_5.


Establishing the pig as a large animal model for vaccine development against human cancer.

Overgaard NH, Frøsig TM, Welner S, Rasmussen M, Ilsøe M, Sørensen MR, Andersen MH, Buus S, Jungersen G.

Front Genet. 2015 Sep 15;6:286. doi: 10.3389/fgene.2015.00286. eCollection 2015.


Repeated examination of natural sapovirus infections in pig litters raised under experimental conditions.

Lauritsen KT, Hansen MS, Johnsen CK, Jungersen G, Böttiger B.

Acta Vet Scand. 2015 Sep 26;57:60. doi: 10.1186/s13028-015-0146-7.


A multi-subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN-γ⁺ CMI responses protects against a genital infection in minipigs.

Bøje S, Olsen AW, Erneholm K, Agerholm JS, Jungersen G, Andersen P, Follmann F.

Immunol Cell Biol. 2016 Feb;94(2):185-95. doi: 10.1038/icb.2015.79. Epub 2015 Aug 13.


Immune gene expression in the spleen of chickens experimentally infected with Ascaridia galli.

Dalgaard TS, Skovgaard K, Norup LR, Pleidrup J, Permin A, Schou TW, Vadekær DF, Jungersen G, Juul-Madsen HR.

Vet Immunol Immunopathol. 2015 Mar 15;164(1-2):79-86. doi: 10.1016/j.vetimm.2015.01.003. Epub 2015 Jan 14.


Cytokine gene expression profiles in chicken spleen and intestinal tissues during Ascaridia galli infection.

Pleidrup JA, Norup LR, Dalgaard TS, Kaiser P, Permin A, Schou TW, Vadekær DF, Jungersen G, Sørensen P, Juul-Madsen HR.

Vet Parasitol. 2014 Dec 15;206(3-4):317-21.


Swine Leukocyte Antigen (SLA) class I allele typing of Danish swine herds and identification of commonly occurring haplotypes using sequence specific low and high resolution primers.

Pedersen LE, Jungersen G, Sorensen MR, Ho CS, Vadekær DF.

Vet Immunol Immunopathol. 2014 Dec 15;162(3-4):108-16. doi: 10.1016/j.vetimm.2014.10.007. Epub 2014 Oct 23.


Vaccination of pigs with attenuated Lawsonia intracellularis induced acute phase protein responses and primed cell-mediated immunity without reduction in bacterial shedding after challenge.

Riber U, Heegaard PM, Cordes H, Ståhl M, Jensen TK, Jungersen G.

Vaccine. 2015 Jan 1;33(1):156-62. doi: 10.1016/j.vaccine.2014.10.084. Epub 2014 Nov 11.


Identification of swine influenza virus epitopes and analysis of multiple specificities expressed by cytotoxic T cell subsets.

Pedersen LE, Breum SØ, Riber U, Larsen LE, Jungersen G.

Virol J. 2014 Sep 6;11:163. doi: 10.1186/1743-422X-11-163.


Ascaridia galli infection influences the development of both humoral and cell-mediated immunity after Newcastle Disease vaccination in chickens.

Pleidrup J, Dalgaard TS, Norup LR, Permin A, Schou TW, Skovgaard K, Vadekær DF, Jungersen G, Sørensen P, Juul-Madsen HR.

Vaccine. 2014 Jan 9;32(3):383-92. doi: 10.1016/j.vaccine.2013.11.034. Epub 2013 Nov 21.


No protection in chickens immunized by the oral or intra-muscular immunization route with Ascaridia galli soluble antigen.

Andersen JP, Norup LR, Dalgaard TS, Rothwell L, Kaiser P, Permin A, Schou TW, Fink DR, Jungersen G, Sørensen P, Juul-Madsen HR.

Avian Pathol. 2013;42(3):276-82. doi: 10.1080/03079457.2013.783199.


Characterisation of an ELISA detecting immunoglobulin G to Mycobacterium avium subsp. paratuberculosis in bovine colostrum.

Zervens LM, Nielsen SS, Jungersen G.

Vet J. 2013 Sep;197(3):889-91. doi: 10.1016/j.tvjl.2013.03.018. Epub 2013 Apr 20.


Cell-mediated and humoral immune responses after immunization of calves with a recombinant multiantigenic Mycobacterium avium subsp. paratuberculosis subunit vaccine at different ages.

Thakur A, Aagaard C, Stockmarr A, Andersen P, Jungersen G.

Clin Vaccine Immunol. 2013 Apr;20(4):551-8. doi: 10.1128/CVI.05574-11. Epub 2013 Feb 6.


Identification of peptides from foot-and-mouth disease virus structural proteins bound by class I swine leukocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401.

Pedersen LE, Harndahl M, Nielsen M, Patch JR, Jungersen G, Buus S, Golde WT.

Anim Genet. 2013 Jun;44(3):251-8. doi: 10.1111/j.1365-2052.2012.02400.x. Epub 2012 Sep 18.


Comparison of parasite-specific immunoglobulin levels in two chicken lines during sustained infection with Ascaridia galli.

Norup LR, Dalgaard TS, Pleidrup J, Permin A, Schou TW, Jungersen G, Fink DR, Juul-Madsen HR.

Vet Parasitol. 2013 Jan 16;191(1-2):187-90. doi: 10.1016/j.vetpar.2012.07.031. Epub 2012 Aug 7.


Immune markers and correlates of protection for vaccine induced immune responses.

Thakur A, Pedersen LE, Jungersen G.

Vaccine. 2012 Jul 13;30(33):4907-20. doi: 10.1016/j.vaccine.2012.05.049. Epub 2012 May 30. Review.


Correlation of antigen-specific IFN-γ responses of fresh blood samples from Mycobacterium avium subsp. paratuberculosis infected heifers with responses of day-old samples co-cultured with IL-12 or anti-IL-10 antibodies.

Mikkelsen H, Aagaard C, Nielsen SS, Jungersen G.

Vet Immunol Immunopathol. 2012 Jun 15;147(1-2):69-76. doi: 10.1016/j.vetimm.2012.04.002. Epub 2012 Apr 17.


Cell-mediated and humoral immune responses in pigs following primary and challenge-exposure to Lawsonia intracellularis.

Cordes H, Riber U, Jensen TK, Jungersen G.

Vet Res. 2012 Feb 8;43:9. doi: 10.1186/1297-9716-43-9.


Characterization of the long-term immune response to vaccination against Mycobacterium avium subsp. paratuberculosis in Danish dairy cows.

Thomsen VT, Nielsen SS, Thakur A, Jungersen G.

Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):316-22. doi: 10.1016/j.vetimm.2011.11.021. Epub 2011 Dec 3.


Novel antigens for detection of cell mediated immune responses to Mycobacterium avium subsp. paratuberculosis infection in cattle.

Mikkelsen H, Aagaard C, Nielsen SS, Jungersen G.

Vet Immunol Immunopathol. 2011 Sep 15;143(1-2):46-54. doi: 10.1016/j.vetimm.2011.06.022. Epub 2011 Jun 13. Erratum in: Vet Immunol Immunopathol. 2012 May 15;146(3-4):296-8.


Use of the johnin PPD interferon-gamma assay in control of bovine paratuberculosis.

Jungersen G, Mikkelsen H, Grell SN.

Vet Immunol Immunopathol. 2012 Jul 15;148(1-2):48-54. doi: 10.1016/j.vetimm.2011.05.010. Epub 2011 May 7.


Review of Mycobacterium avium subsp. paratuberculosis antigen candidates with diagnostic potential.

Mikkelsen H, Aagaard C, Nielsen SS, Jungersen G.

Vet Microbiol. 2011 Aug 26;152(1-2):1-20. doi: 10.1016/j.vetmic.2011.03.006. Epub 2011 Mar 16. Review.


Induction of foot-and-mouth disease virus-specific cytotoxic T cell killing by vaccination.

Patch JR, Pedersen LE, Toka FN, Moraes M, Grubman MJ, Nielsen M, Jungersen G, Buus S, Golde WT.

Clin Vaccine Immunol. 2011 Feb;18(2):280-8. doi: 10.1128/CVI.00417-10. Epub 2010 Dec 22.

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