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Items: 1 to 50 of 93

1.

Adenosine 5'-Monophosphate Protects From Hypoxia By Lowering Mitochondrial Metabolism and Oxygen Demand.

Kondo Y, Sueyoshi K, Zhang J, Bao Y, Li X, Fakhari M, Slubowski CJ, Bahrami S, Ledderose C, Junger WG.

Shock. 2019 Aug 27. doi: 10.1097/SHK.0000000000001440. [Epub ahead of print]

PMID:
31460871
2.

Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense.

Kondo Y, Ledderose C, Slubowski CJ, Fakhari M, Sumi Y, Sueyoshi K, Bezler AK, Aytan D, Arbab M, Junger WG.

J Leukoc Biol. 2019 Aug 8. doi: 10.1002/JLB.4HI0319-109R. [Epub ahead of print]

PMID:
31392789
3.

Purinergic P2Y2 receptors modulate endothelial sprouting.

Mühleder S, Fuchs C, Basílio J, Szwarc D, Pill K, Labuda K, Slezak P, Siehs C, Pröll J, Priglinger E, Hoffmann C, Junger WG, Redl H, Holnthoner W.

Cell Mol Life Sci. 2019 Jul 5. doi: 10.1007/s00018-019-03213-2. [Epub ahead of print]

PMID:
31278420
4.

Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation.

Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG.

Purinergic Signal. 2019 Jun;15(2):127-137. doi: 10.1007/s11302-019-09653-6. Epub 2019 Mar 27.

5.

Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors.

Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG.

J Biol Chem. 2019 Apr 19;294(16):6283-6293. doi: 10.1074/jbc.RA118.007188. Epub 2019 Feb 20.

PMID:
30787105
6.

Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1β Production, and the Host Immune Response to Infection.

Lee AH, Ledderose C, Li X, Slubowski CJ, Sueyoshi K, Staudenmaier L, Bao Y, Zhang J, Junger WG.

Crit Care Med. 2018 Dec;46(12):e1183-e1189. doi: 10.1097/CCM.0000000000003446.

PMID:
30247270
7.

Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality.

Sumi Y, Ledderose C, Li L, Inoue Y, Okamoto K, Kondo Y, Sueyoshi K, Junger WG, Tanaka H.

Shock. 2019 Jun;51(6):698-705. doi: 10.1097/SHK.0000000000001227.

PMID:
30052576
8.

Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration.

Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG.

J Clin Invest. 2018 Aug 1;128(8):3583-3594. doi: 10.1172/JCI120972. Epub 2018 Jul 23.

9.

Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate.

Qi B, Yu T, Wang C, Wang T, Yao J, Zhang X, Deng P, Xia Y, Junger WG, Sun D.

J Exp Clin Cancer Res. 2016 Oct 3;35(1):161.

10.

Adenosine arrests breast cancer cell motility by A3 receptor stimulation.

Ledderose C, Hefti MM, Chen Y, Bao Y, Seier T, Li L, Woehrle T, Zhang J, Junger WG.

Purinergic Signal. 2016 Dec;12(4):673-685. Epub 2016 Aug 30.

11.

Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis.

Li X, Kondo Y, Bao Y, Staudenmaier L, Lee A, Zhang J, Ledderose C, Junger WG.

Crit Care Med. 2017 Jan;45(1):e97-e104.

12.

Purinergic Signaling and the Immune Response in Sepsis: A Review.

Ledderose C, Bao Y, Kondo Y, Fakhari M, Slubowski C, Zhang J, Junger WG.

Clin Ther. 2016 May;38(5):1054-65. doi: 10.1016/j.clinthera.2016.04.002. Epub 2016 May 5. Review.

13.

Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling?

Ledderose C, Woehrle T, Ledderose S, Strasser K, Seist R, Bao Y, Zhang J, Junger WG.

Purinergic Signal. 2016 Sep;12(3):439-51. doi: 10.1007/s11302-016-9510-y. Epub 2016 Mar 28.

14.

NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine.

Bai A, Moss A, Rothweiler S, Serena Longhi M, Wu Y, Junger WG, Robson SC.

Nat Commun. 2015 Nov 9;6:8819. doi: 10.1038/ncomms9819.

15.

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN.

PLoS Pathog. 2015 Oct 20;11(10):e1005177. doi: 10.1371/journal.ppat.1005177. eCollection 2015 Oct.

16.

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis.

Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG.

J Cell Biol. 2015 Sep 28;210(7):1153-64. doi: 10.1083/jcb.201503066.

17.

Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.

Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG.

J Infect Dis. 2016 Feb 1;213(3):456-64. doi: 10.1093/infdis/jiv373. Epub 2015 Jul 6.

18.

Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases.

Chen Y, Bao Y, Zhang J, Woehrle T, Sumi Y, Ledderose S, Li X, Ledderose C, Junger WG.

Shock. 2015 Sep;44(3):221-7. doi: 10.1097/SHK.0000000000000402.

19.

Novel method for real-time monitoring of ATP release reveals multiple phases of autocrine purinergic signalling during immune cell activation.

Ledderose C, Bao Y, Zhang J, Junger WG.

Acta Physiol (Oxf). 2015 Feb;213(2):334-45. doi: 10.1111/apha.12435. Epub 2014 Dec 29.

20.

Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation.

Weihs AM, Fuchs C, Teuschl AH, Hartinger J, Slezak P, Mittermayr R, Redl H, Junger WG, Sitte HH, Rünzler D.

J Biol Chem. 2014 Sep 26;289(39):27090-104. doi: 10.1074/jbc.M114.580936. Epub 2014 Aug 12.

21.

Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling.

Bao Y, Ledderose C, Seier T, Graf AF, Brix B, Chong E, Junger WG.

J Biol Chem. 2014 Sep 26;289(39):26794-803. doi: 10.1074/jbc.M114.572495. Epub 2014 Aug 7.

22.

Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling.

Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG.

J Biol Chem. 2014 Sep 12;289(37):25936-45. doi: 10.1074/jbc.M114.575308. Epub 2014 Jul 28.

23.

Plasma ATP is required for neutrophil activation in a mouse sepsis model.

Sumi Y, Woehrle T, Chen Y, Bao Y, Li X, Yao Y, Inoue Y, Tanaka H, Junger WG.

Shock. 2014 Aug;42(2):142-7. doi: 10.1097/SHK.0000000000000180.

24.

Abandon the mouse research ship? Not just yet!

Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH.

Shock. 2014 Jun;41(6):463-75. doi: 10.1097/SHK.0000000000000153.

25.

Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury.

Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Baker AJ, Shek PN, Hoyt DB, Bulger EM.

Shock. 2013 Nov;40(5):366-74. doi: 10.1097/SHK.0000000000000038.

26.

Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils.

Bao Y, Chen Y, Ledderose C, Li L, Junger WG.

J Biol Chem. 2013 Aug 2;288(31):22650-7. doi: 10.1074/jbc.M113.476283. Epub 2013 Jun 24.

27.

P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death.

Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y.

PLoS One. 2013;8(4):e60184. doi: 10.1371/journal.pone.0060184. Epub 2013 Apr 2.

28.

Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors.

Sun D, Junger WG, Yuan C, Zhang W, Bao Y, Qin D, Wang C, Tan L, Qi B, Zhu D, Zhang X, Yu T.

Stem Cells. 2013 Jun;31(6):1170-80. doi: 10.1002/stem.1356.

29.

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice.

Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC.

Hepatology. 2013 Jan;57(1):205-16. doi: 10.1002/hep.25989.

30.

Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation.

Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB, Bulger EM.

Shock. 2012 Oct;38(4):341-50.

31.

ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.

Manohar M, Hirsh MI, Chen Y, Woehrle T, Karande AA, Junger WG.

J Leukoc Biol. 2012 Oct;92(4):787-94. doi: 10.1189/jlb.0312121. Epub 2012 Jun 29.

32.

Measurement of oxidative burst in neutrophils.

Chen Y, Junger WG.

Methods Mol Biol. 2012;844:115-24. doi: 10.1007/978-1-61779-527-5_8.

33.

Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients.

Bulger EM, Tower CM, Warner KJ, Garland T, Cuschieri J, Rizoli S, Rhind S, Junger WG.

Shock. 2011 Nov;36(5):435-9. doi: 10.1097/SHK.0b013e318231ee2e.

34.

Immune cell regulation by autocrine purinergic signalling.

Junger WG.

Nat Rev Immunol. 2011 Mar;11(3):201-12. doi: 10.1038/nri2938. Epub 2011 Feb 18. Review.

35.

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors.

Woehrle T, Yip L, Manohar M, Sumi Y, Yao Y, Chen Y, Junger WG.

J Leukoc Biol. 2010 Dec;88(6):1181-9. doi: 10.1189/jlb.0410211. Epub 2010 Sep 30.

36.

Adrenergic receptor activation involves ATP release and feedback through purinergic receptors.

Sumi Y, Woehrle T, Chen Y, Yao Y, Li A, Junger WG.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1118-26. doi: 10.1152/ajpcell.00122.2010. Epub 2010 Jul 28.

37.

A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation.

Inoue Y, Tanaka H, Sumi Y, Woehrle T, Chen Y, Hirsh MI, Junger WG.

Shock. 2011 Feb;35(2):178-83. doi: 10.1097/SHK.0b013e3181f221fb.

38.

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.

Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG.

Blood. 2010 Nov 4;116(18):3475-84. doi: 10.1182/blood-2010-04-277707. Epub 2010 Jul 21.

39.

Purinergic signaling: a fundamental mechanism in neutrophil activation.

Chen Y, Yao Y, Sumi Y, Li A, To UK, Elkhal A, Inoue Y, Woehrle T, Zhang Q, Hauser C, Junger WG.

Sci Signal. 2010 Jun 8;3(125):ra45. doi: 10.1126/scisignal.2000549.

40.

Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice.

Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, Rellstab A, Nowak M, Enjyoji K, Li X, Junger WG, Candinas D, Robson SC.

Hepatology. 2010 May;51(5):1702-11. doi: 10.1002/hep.23510.

41.

Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.

Yu T, Junger WG, Yuan C, Jin A, Zhao Y, Zheng X, Zeng Y, Liu J.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C457-64. doi: 10.1152/ajpcell.00342.2009. Epub 2009 Nov 4.

42.

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors.

Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG.

FASEB J. 2009 Jun;23(6):1685-93. doi: 10.1096/fj.08-126458. Epub 2009 Feb 11.

43.

Hypertonic saline increases gammadeltaT cell-mediated killing of activated neutrophils.

Hirsh MI, Hashiguchi N, Junger WG.

Crit Care Med. 2008 Dec;36(12):3220-5. doi: 10.1097/CCM.0b013e31818f238e.

44.

Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis.

Tillinger W, McCole DF, Keely SJ, Bertelsen LS, Wolf PL, Junger WG, Barrett KE.

Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1839-45. doi: 10.1152/ajpregu.00412.2007. Epub 2008 Oct 1.

45.

Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine.

Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG.

J Biol Chem. 2008 Oct 17;283(42):28480-6. doi: 10.1074/jbc.M800039200. Epub 2008 Aug 18.

46.

Hypertonic saline up-regulates A3 adenosine receptor expression of activated neutrophils and increases acute lung injury after sepsis.

Inoue Y, Chen Y, Pauzenberger R, Hirsh MI, Junger WG.

Crit Care Med. 2008 Sep;36(9):2569-75. doi: 10.1097/CCM.0b013e3181841a91.

47.

Roles of heat shock proteins and gamma delta T cells in inflammation.

Hirsh MI, Junger WG.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):509-13. doi: 10.1165/rcmb.2008-0090TR. Epub 2008 Jun 19. Review.

48.

Purinergic regulation of neutrophil chemotaxis.

Junger WG.

Cell Mol Life Sci. 2008 Aug;65(16):2528-40. doi: 10.1007/s00018-008-8095-1. Review.

49.
50.

A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells.

Corriden R, Insel PA, Junger WG.

Am J Physiol Cell Physiol. 2007 Oct;293(4):C1420-5. Epub 2007 Aug 15.

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