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Stem Cell Res. 2019 Oct 8;41:101584. doi: 10.1016/j.scr.2019.101584. [Epub ahead of print]

Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection.

Author information

1
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.
2
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia. Electronic address: k.junday@victorchang.edu.au.
3
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia. Electronic address: claire.wong@health.nsw.gov.au.
4
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia. Electronic address: a.chan@victorchang.edu.au.
5
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia. Electronic address: s.hesselson@victorchang.edu.au.
6
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia. Electronic address: dmuller19@me.com.
7
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia. Electronic address: s.iismaa@victorchang.edu.au.
8
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia.
9
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, New South Wales 2052, Australia. Electronic address: b.graham@victorchang.edu.au.

Abstract

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells.

KEYWORDS:

Cardiovascular biology; Disease modeling; Induced pluripotent stem cells; Reprogramming; SCAD

PMID:
31707208
DOI:
10.1016/j.scr.2019.101584
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