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Items: 1 to 50 of 232

1.

Seasonal influenza vaccines induced high levels of neutralizing cross-reactive antibody responses against different genetic group influenza A(H1N1)pdm09 viruses.

Haveri A, Ikonen N, Kantele A, Anttila VJ, Ruotsalainen E, Savolainen-Kopra C, Julkunen I.

Vaccine. 2019 May 6;37(20):2731-2740. doi: 10.1016/j.vaccine.2019.03.078. Epub 2019 Apr 4.

PMID:
30954308
2.

Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells.

Jiang M, Österlund P, Westenius V, Guo D, Poranen MM, Bamford DH, Julkunen I.

J Virol. 2019 Feb 5;93(4). pii: e01916-18. doi: 10.1128/JVI.01916-18. Print 2019 Feb 15.

3.

Highly Pathogenic H5N1 Influenza A Virus Spreads Efficiently in Human Primary Monocyte-Derived Macrophages and Dendritic Cells.

Westenius V, Mäkelä SM, Julkunen I, Österlund P.

Front Immunol. 2018 Jul 17;9:1664. doi: 10.3389/fimmu.2018.01664. eCollection 2018.

4.

Interleukin-5, interleukin-6, interferon induced protein-10, procalcitonin and C-reactive protein among mechanically ventilated severe community-acquired viral and bacterial pneumonia patients.

Karhu J, Ala-Kokko TI, Vuorinen T, Ohtonen P, Julkunen I, Syrjälä HT.

Cytokine. 2019 Jan;113:272-276. doi: 10.1016/j.cyto.2018.07.019. Epub 2018 Jul 25.

5.

Narcolepsy Associated with Pandemrix Vaccine.

Sarkanen T, Alakuijala A, Julkunen I, Partinen M.

Curr Neurol Neurosci Rep. 2018 Jun 1;18(7):43. doi: 10.1007/s11910-018-0851-5. Review.

PMID:
29855798
6.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
7.

Influenza virus infections from 0 to 2 years of age: A birth cohort study.

Teros-Jaakkola T, Toivonen L, Schuez-Havupalo L, Karppinen S, Julkunen I, Waris M, Peltola V.

J Microbiol Immunol Infect. 2017 Dec 7. pii: S1684-1182(17)30258-X. doi: 10.1016/j.jmii.2017.10.007. [Epub ahead of print]

8.

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min JY, Bruzzone R, Aittokallio T, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE.

Viruses. 2017 Sep 25;9(10). pii: E271. doi: 10.3390/v9100271.

9.

Ebolavirus protein VP24 interferes with innate immune responses by inhibiting interferon-λ1 gene expression.

He F, Melén K, Maljanen S, Lundberg R, Jiang M, Österlund P, Kakkola L, Julkunen I.

Virology. 2017 Sep;509:23-34. doi: 10.1016/j.virol.2017.06.002. Epub 2017 Jun 5.

10.

Production, purification and immunogenicity of recombinant Ebola virus proteins - A comparison of Freund's adjuvant and adjuvant system 03.

Melén K, Kakkola L, He F, Airenne K, Vapalahti O, Karlberg H, Mirazimi A, Julkunen I.

J Virol Methods. 2017 Apr;242:35-45. doi: 10.1016/j.jviromet.2016.12.014. Epub 2016 Dec 24.

PMID:
28025125
11.

Regulation of kynurenine biosynthesis during influenza virus infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2017 Jan;284(2):222-236. doi: 10.1111/febs.13966. Epub 2016 Dec 14.

12.

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE.

Biochim Biophys Acta. 2016 Nov;1859(11):1440-1448. doi: 10.1016/j.bbagrm.2016.09.005. Epub 2016 Sep 21.

PMID:
27664935
13.

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein.

Ylösmäki L, Fagerlund R, Kuisma I, Julkunen I, Saksela K.

Viruses. 2016 Apr 15;8(4):101. doi: 10.3390/v8040101.

14.

Probiotics and respiratory and gastrointestinal tract infections in Finnish military conscripts - a randomised placebo-controlled double-blinded study.

Kalima K, Lehtoranta L, He L, Pitkäniemi J, Lundell R, Julkunen I, Roivainen M, Närkiö M, Mäkelä MJ, Siitonen S, Korpela R, Pitkäranta A.

Benef Microbes. 2016 Sep;7(4):463-71. doi: 10.3920/BM2015.0172. Epub 2016 Apr 6.

PMID:
27048835
15.

Spectrally and Spatially Multiplexed Serological Array-in-Well Assay Utilizing Two-Color Upconversion Luminescence Imaging.

Kale V, Päkkilä H, Vainio J, Ahomaa A, Sirkka N, Lyytikäinen A, Talha SM, Kutsaya A, Waris M, Julkunen I, Soukka T.

Anal Chem. 2016 Apr 19;88(8):4470-7. doi: 10.1021/acs.analchem.6b00337. Epub 2016 Mar 29.

PMID:
26996057
16.

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM.

PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi: 10.1371/journal.ppat.1005424. eCollection 2016 Feb.

17.

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

Söderholm S, Anastasina M, Islam MM, Tynell J, Poranen MM, Bamford DH, Stenman J, Julkunen I, Šaulienė I, De Brabander JK, Matikainen S, Nyman TA, Saelens X, Kainov D.

Antiviral Res. 2016 Feb;126:69-80. doi: 10.1016/j.antiviral.2015.12.011. Epub 2015 Dec 29.

18.

Prospective clinical and serological follow-up in early childhood reveals a high rate of subclinical RSV infection and a relatively high reinfection rate within the first 3 years of life.

Kutsaya A, Teros-Jaakkola T, Kakkola L, Toivonen L, Peltola V, Waris M, Julkunen I.

Epidemiol Infect. 2016 Jun;144(8):1622-33. doi: 10.1017/S0950268815003143. Epub 2016 Jan 6.

PMID:
26732801
19.

Interferons Induce STAT1-Dependent Expression of Tissue Plasminogen Activator, a Pathogenicity Factor in Puumala Hantavirus Disease.

Strandin T, Hepojoki J, Laine O, Mäkelä S, Klingström J, Lundkvist Å, Julkunen I, Mustonen J, Vaheri A.

J Infect Dis. 2016 May 15;213(10):1632-41. doi: 10.1093/infdis/jiv764. Epub 2015 Dec 23.

PMID:
26704613
20.

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.

Tynell J, Westenius V, Rönkkö E, Munster VJ, Melén K, Österlund P, Julkunen I.

J Gen Virol. 2016 Feb;97(2):344-55. doi: 10.1099/jgv.0.000351. Epub 2015 Nov 24.

21.

RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.

Mäkelä SM, Österlund P, Westenius V, Latvala S, Diamond MS, Gale M Jr, Julkunen I.

J Virol. 2015 Dec;89(23):12014-25. doi: 10.1128/JVI.01576-15. Epub 2015 Sep 16.

22.

[Narcolepsy as an autoimmune disease].

Sarkanen T, Vaarala O, Julkunen I, Partinen M.

Duodecim. 2015;131(12):1153-60. Review. Finnish.

PMID:
26245045
23.

Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014.

Mishel P, Ojala T, Benner C, Lakspere T, Bychkov D, Jalovaara P, Kakkola L, Kallio-Kokko H, Kantele A, Kankainen M, Ikonen N, Ripatti S, Julkunen I, Kainov DE.

Genome Announc. 2015 Jul 30;3(4). pii: e00676-15. doi: 10.1128/genomeA.00676-15.

24.

Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2.

Ahmed SS, Volkmuth W, Duca J, Corti L, Pallaoro M, Pezzicoli A, Karle A, Rigat F, Rappuoli R, Narasimhan V, Julkunen I, Vuorela A, Vaarala O, Nohynek H, Pasini FL, Montomoli E, Trombetta C, Adams CM, Rothbard J, Steinman L.

Sci Transl Med. 2015 Jul 1;7(294):294ra105. doi: 10.1126/scitranslmed.aab2354.

PMID:
26136476
25.

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.

Ibsen MS, Gad HH, Andersen LL, Hornung V, Julkunen I, Sarkar SN, Hartmann R.

Nucleic Acids Res. 2015 May 26;43(10):5236-48. doi: 10.1093/nar/gkv389. Epub 2015 Apr 29.

26.

Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland.

Jalovaara P, Mishel P, Kallio-Kokko H, Valkonen M, Kantele A, Ikonen N, Julkunen I, Kakkola L, Kutsaya A, Vuorinen T, Mattila P, Almusa H, Kainov D.

Genome Announc. 2015 Mar 12;3(2). pii: e01523-14. doi: 10.1128/genomeA.01523-14.

27.

Reduced cross-protection against influenza A(H3N2) subgroup 3C.2a and 3C.3a viruses among Finnish healthcare workers vaccinated with 2013/14 seasonal influenza vaccine.

Haveri A, Ikonen N, Julkunen I, Kantele A, Anttila V, Ruotsalainen E, Nohynek H, Lyytikainen O, Savolainen-Kopra C.

Euro Surveill. 2015 Feb 5;20(5):21028. No abstract available.

28.

Practice-based research: the role of HUSK in knowledge development.

Julkunen I.

J Evid Inf Soc Work. 2015;12(1):102-11. Epub 2015 Jan 13.

PMID:
25662086
29.

Blood MxA protein as a marker for respiratory virus infections in young children.

Toivonen L, Schuez-Havupalo L, Rulli M, Ilonen J, Pelkonen J, Melen K, Julkunen I, Peltola V, Waris M.

J Clin Virol. 2015 Jan;62:8-13. doi: 10.1016/j.jcv.2014.11.018. Epub 2014 Nov 18.

PMID:
25542463
30.

Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for pandemrix-associated narcolepsy risk.

Vaarala O, Vuorela A, Partinen M, Baumann M, Freitag TL, Meri S, Saavalainen P, Jauhiainen M, Soliymani R, Kirjavainen T, Olsen P, Saarenpää-Heikkilä O, Rouvinen J, Roivainen M, Nohynek H, Jokinen J, Julkunen I, Kilpi T.

PLoS One. 2014 Dec 15;9(12):e114361. doi: 10.1371/journal.pone.0114361. eCollection 2014.

31.

MAP kinase p38α regulates type III interferon (IFN-λ1) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation.

Jiang M, Österlund P, Fagerlund R, Rios DN, Hoffmann A, Poranen MM, Bamford DH, Julkunen I.

J Leukoc Biol. 2015 Feb;97(2):307-20. doi: 10.1189/jlb.2A0114-059RR. Epub 2014 Dec 3.

PMID:
25473098
32.

Efficient replication and strong induction of innate immune responses by H9N2 avian influenza virus in human dendritic cells.

Westenius V, Mäkelä SM, Ziegler T, Julkunen I, Österlund P.

Virology. 2014 Dec;471-473:38-48. doi: 10.1016/j.virol.2014.10.002. Epub 2014 Oct 25.

33.

Does autoreactivity have a role in narcolepsy?

Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O.

Lancet Neurol. 2014 Nov;13(11):1072-1073. doi: 10.1016/S1474-4422(14)70168-1. No abstract available.

PMID:
25316012
34.

Neuroimmunology: Disease mechanisms in narcolepsy remain elusive.

Julkunen I, Partinen M.

Nat Rev Neurol. 2014 Nov;10(11):616-7. doi: 10.1038/nrneurol.2014.191. Epub 2014 Oct 14. No abstract available.

PMID:
25311588
35.

Effectiveness of pandemic and seasonal influenza vaccines in preventing laboratory-confirmed influenza in adults: a clinical cohort study during epidemic seasons 2009-2010 and 2010-2011 in Finland.

Syrjänen RK, Jokinen J, Ziegler T, Sundman J, Lahdenkari M, Julkunen I, Kilpi TM.

PLoS One. 2014 Sep 29;9(9):e108538. doi: 10.1371/journal.pone.0108538. eCollection 2014.

36.

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.

Bergman P, Adori C, Vas S, Kai-Larsen Y, Sarkanen T, Cederlund A, Agerberth B, Julkunen I, Horvath B, Kostyalik D, Kalmár L, Bagdy G, Huutoniemi A, Partinen M, Hökfelt T.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3735-44. doi: 10.1073/pnas.1412189111. Epub 2014 Aug 18.

37.

Dynamin inhibition interferes with inflammasome activation and cytokine gene expression in Streptococcus pyogenes-infected human macrophages.

Latvala S, Mäkelä SM, Miettinen M, Charpentier E, Julkunen I.

Clin Exp Immunol. 2014 Nov;178(2):320-33. doi: 10.1111/cei.12425.

38.

Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication.

Tynell J, Melén K, Julkunen I.

Virol J. 2014 Jul 14;11:128. doi: 10.1186/1743-422X-11-128.

39.

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.

Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O.

Lancet Neurol. 2014 Jun;13(6):600-13. doi: 10.1016/S1474-4422(14)70075-4. Review.

PMID:
24849861
40.

Novel avian influenza A (H7N9) virus induces impaired interferon responses in human dendritic cells.

Arilahti V, Mäkelä SM, Tynell J, Julkunen I, Österlund P.

PLoS One. 2014 May 7;9(5):e96350. doi: 10.1371/journal.pone.0096350. eCollection 2014.

41.

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

Denisova OV, Söderholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE.

Antimicrob Agents Chemother. 2014 Jul;58(7):3689-96. doi: 10.1128/AAC.02798-13. Epub 2014 Apr 21.

42.

Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013.

Lakspere T, Tynell J, Kaloinen M, Vanlede M, Parsons A, Ikonen N, Kallio-Kokko H, Kantele A, Mattila P, Almusa H, Julkunen I, Kainov D, Kakkola L.

Genome Announc. 2014 Jan 16;2(1). pii: e01004-13. doi: 10.1128/genomeA.01004-13.

43.

No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland.

Melén K, Partinen M, Tynell J, Sillanpää M, Himanen SL, Saarenpää-Heikkilä O, Hublin C, Olsen P, Ilonen J, Nohynek H, Syrjänen R, Kilpi T, Vuorela A, Kirjavainen T, Vaarala O, Julkunen I.

PLoS One. 2013 Aug 8;8(8):e68402. doi: 10.1371/journal.pone.0068402. eCollection 2013.

44.

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.

Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE.

Cell Death Dis. 2013 Jul 25;4:e742. doi: 10.1038/cddis.2013.267.

45.

Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression.

Nousiainen L, Sillanpää M, Jiang M, Thompson J, Taipale J, Julkunen I.

Innate Immun. 2013 Oct;19(5):516-30. doi: 10.1177/1753425912473345. Epub 2013 Feb 12.

PMID:
23405030
46.

Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.

Kaukinen P, Sillanpää M, Nousiainen L, Melén K, Julkunen I.

J Med Virol. 2013 Jan;85(1):71-82. doi: 10.1002/jmv.23442. Epub 2012 Oct 23.

PMID:
23096996
47.

[Influenza viruses--a challenge for vaccinations].

Julkunen I, Ikonen N, Strengell M, Ziegler T.

Duodecim. 2012;128(18):1919-28. Review. Finnish.

PMID:
23088004
48.

Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals.

Strengell M, Ikonen N, Ziegler T, Kantele A, Anttila VJ, Julkunen I.

Influenza Other Respir Viruses. 2013 May;7(3):431-8. doi: 10.1111/j.1750-2659.2012.00415.x. Epub 2012 Aug 23.

49.

Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.

Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T, Kuivanen S, Vapalahti O, Kantele A, Tynell J, Julkunen I, Kallio-Kokko H, Paavilainen H, Hukkanen V, Elliott RM, De Brabander JK, Saelens X, Kainov DE.

J Biol Chem. 2012 Oct 12;287(42):35324-32. doi: 10.1074/jbc.M112.392142. Epub 2012 Aug 21.

50.

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.

Melén K, Tynell J, Fagerlund R, Roussel P, Hernandez-Verdun D, Julkunen I.

Virol J. 2012 Aug 21;9:167. doi: 10.1186/1743-422X-9-167.

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