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Items: 1 to 50 of 141

1.

Structural insights into TRPM8 inhibition and desensitization.

Diver MM, Cheng Y, Julius D.

Science. 2019 Sep 27;365(6460):1434-1440. doi: 10.1126/science.aax6672. Epub 2019 Sep 5.

PMID:
31488702
2.

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.

Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D.

Cell. 2019 Sep 5;178(6):1362-1374.e16. doi: 10.1016/j.cell.2019.07.014. Epub 2019 Aug 22.

PMID:
31447178
3.

Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment.

Autzen HE, Julius D, Cheng Y.

Curr Opin Struct Biol. 2019 Oct;58:259-268. doi: 10.1016/j.sbi.2019.05.022. Epub 2019 Jul 3. Review.

PMID:
31279500
4.

Structural insight into TRPV5 channel function and modulation.

Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8869-8878. doi: 10.1073/pnas.1820323116. Epub 2019 Apr 11.

5.

Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.

Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12091-E12100. doi: 10.1073/pnas.1814132115. Epub 2018 Nov 21.

6.

Molecular tuning of electroreception in sharks and skates.

Bellono NW, Leitch DB, Julius D.

Nature. 2018 Jun;558(7708):122-126. doi: 10.1038/s41586-018-0160-9. Epub 2018 May 30.

7.

[Dyspnea after instillation therapy for bladder cancer].

Julius D, Geerdes Fenge HF, Weber MA.

Radiologe. 2018 May;58(5):482-486. doi: 10.1007/s00117-018-0382-8. German. No abstract available.

PMID:
29675695
8.

Structure of the human TRPM4 ion channel in a lipid nanodisc.

Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y.

Science. 2018 Jan 12;359(6372):228-232. doi: 10.1126/science.aar4510. Epub 2017 Dec 7.

9.

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D.

Cell. 2017 Jun 29;170(1):185-198.e16. doi: 10.1016/j.cell.2017.05.034. Epub 2017 Jun 22.

10.

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.

Osteen JD, Sampson K, Iyer V, Julius D, Bosmans F.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6836-6841. doi: 10.1073/pnas.1621263114. Epub 2017 Jun 12.

11.

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.

Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2524-E2532. doi: 10.1073/pnas.1615484114. Epub 2017 Mar 6.

12.

Molecular basis of ancestral vertebrate electroreception.

Bellono NW, Leitch DB, Julius D.

Nature. 2017 Mar 16;543(7645):391-396. doi: 10.1038/nature21401. Epub 2017 Mar 6.

13.

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.

Gao Y, Cao E, Julius D, Cheng Y.

Nature. 2016 Jun 16;534(7607):347-51. doi: 10.1038/nature17964. Epub 2016 May 18.

14.

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D.

Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.

15.

Introduction.

Julius D.

Annu Rev Physiol. 2016;78:v-vi. doi: 10.1146/annurev-ph-78-012516-100001. No abstract available.

PMID:
26863328
16.

Editorial overview: molecular biology of sensation.

Julius D, Carlson JR.

Curr Opin Neurobiol. 2015 Oct;34:v-vi. doi: 10.1016/j.conb.2015.07.001. Epub 2015 Jul 21. No abstract available.

PMID:
26209561
17.

Structure of the TRPA1 ion channel suggests regulatory mechanisms.

Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D.

Nature. 2015 Sep 24;525(7570):552. doi: 10.1038/nature14871. Epub 2015 Jul 22. No abstract available.

PMID:
26200340
18.

Structure of the TRPA1 ion channel suggests regulatory mechanisms.

Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D.

Nature. 2015 Apr 23;520(7548):511-7. doi: 10.1038/nature14367. Epub 2015 Apr 8. Erratum in: Nature. 2015 Sep 24;525(7570):552.

19.

Stephen F. Heinemann: A true original.

Lemke G, Julius D.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14314-5. doi: 10.1073/pnas.1416208111. Epub 2014 Sep 25. No abstract available.

20.

Single particle electron cryo-microscopy of a mammalian ion channel.

Liao M, Cao E, Julius D, Cheng Y.

Curr Opin Struct Biol. 2014 Aug;27:1-7. doi: 10.1016/j.sbi.2014.02.005. Epub 2014 Mar 25. Review.

21.

X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel.

Baconguis I, Bohlen CJ, Goehring A, Julius D, Gouaux E.

Cell. 2014 Feb 13;156(4):717-29. doi: 10.1016/j.cell.2014.01.011. Epub 2014 Feb 6.

22.

TRPV1 structures in distinct conformations reveal activation mechanisms.

Cao E, Liao M, Cheng Y, Julius D.

Nature. 2013 Dec 5;504(7478):113-8. doi: 10.1038/nature12823.

23.

Structure of the TRPV1 ion channel determined by electron cryo-microscopy.

Liao M, Cao E, Julius D, Cheng Y.

Nature. 2013 Dec 5;504(7478):107-12. doi: 10.1038/nature12822.

24.

TRP channels and pain.

Julius D.

Annu Rev Cell Dev Biol. 2013;29:355-84. doi: 10.1146/annurev-cellbio-101011-155833. Review.

PMID:
24099085
25.

TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids.

Cao E, Cordero-Morales JF, Liu B, Qin F, Julius D.

Neuron. 2013 Feb 20;77(4):667-79. doi: 10.1016/j.neuron.2012.12.016.

26.

Ion pair reinforced semi-interpenetrating polymer network for direct methanol fuel cell applications.

Fang C, Julius D, Tay SW, Hong L, Lee JY.

J Phys Chem B. 2012 Jun 7;116(22):6416-24. doi: 10.1021/jp2081353. Epub 2012 May 24.

PMID:
22594641
27.

Receptor-targeting mechanisms of pain-causing toxins: How ow?

Bohlen CJ, Julius D.

Toxicon. 2012 Sep 1;60(3):254-64. doi: 10.1016/j.toxicon.2012.04.336. Epub 2012 Apr 14. Review.

28.

Signaling by sensory receptors.

Julius D, Nathans J.

Cold Spring Harb Perspect Biol. 2012 Jan 1;4(1):a005991. doi: 10.1101/cshperspect.a005991.

29.

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.

Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D.

Nature. 2011 Nov 16;479(7373):410-4. doi: 10.1038/nature10607.

30.

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli.

Cordero-Morales JF, Gracheva EO, Julius D.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1184-91. doi: 10.1073/pnas.1114124108. Epub 2011 Sep 19.

31.

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats.

Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D.

Nature. 2011 Aug 3;476(7358):88-91. doi: 10.1038/nature10245.

32.

Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons.

Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI.

J Neurosci. 2011 Jul 13;31(28):10119-27. doi: 10.1523/JNEUROSCI.1299-11.2011.

33.

Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.

Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI.

J Neurosci. 2011 Mar 30;31(13):5067-77. doi: 10.1523/JNEUROSCI.6451-10.2011.

34.

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain.

Bohlen CJ, Priel A, Zhou S, King D, Siemens J, Julius D.

Cell. 2010 May 28;141(5):834-45. doi: 10.1016/j.cell.2010.03.052.

35.

Molecular basis of infrared detection by snakes.

Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D.

Nature. 2010 Apr 15;464(7291):1006-11. doi: 10.1038/nature08943. Epub 2010 Mar 14.

36.

Cellular and molecular mechanisms of pain.

Basbaum AI, Bautista DM, Scherrer G, Julius D.

Cell. 2009 Oct 16;139(2):267-84. doi: 10.1016/j.cell.2009.09.028. Review.

37.

Evolution of thermal response properties in a cold-activated TRP channel.

Myers BR, Sigal YM, Julius D.

PLoS One. 2009 May 29;4(5):e5741. doi: 10.1371/journal.pone.0005741.

38.

Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons.

Bhattacharya MR, Bautista DM, Wu K, Haeberle H, Lumpkin EA, Julius D.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20015-20. doi: 10.1073/pnas.0810801105. Epub 2008 Dec 5.

39.

Multiple unbiased prospective screens identify TRP channels and their conserved gating elements.

Myers BR, Saimi Y, Julius D, Kung C.

J Gen Physiol. 2008 Nov;132(5):481-6. doi: 10.1085/jgp.200810104. Review. No abstract available.

40.

Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.

Prober DA, Zimmerman S, Myers BR, McDermott BM Jr, Kim SH, Caron S, Rihel J, Solnica-Krezel L, Julius D, Hudspeth AJ, Schier AF.

J Neurosci. 2008 Oct 1;28(40):10102-10. doi: 10.1523/JNEUROSCI.2740-08.2008.

41.

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels.

Bautista DM, Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, Nicoll RA, Julius D.

Nat Neurosci. 2008 Jul;11(7):772-9. doi: 10.1038/nn.2143. Epub 2008 Jun 22.

42.

A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating.

Myers BR, Bohlen CJ, Julius D.

Neuron. 2008 May 8;58(3):362-73. doi: 10.1016/j.neuron.2008.04.012.

43.

Fire in the hole: pore dilation of the capsaicin receptor TRPV1.

Bautista D, Julius D.

Nat Neurosci. 2008 May;11(5):528-9. doi: 10.1038/nn0508-528. No abstract available.

PMID:
18437189
44.

From peppers to peppermints: natural products as probes of the pain pathway.

Julius D.

Harvey Lect. 2005-2006;101:89-115. Review. No abstract available.

PMID:
18030977
45.

Posttraumatic stress disorder as a risk factor for obesity among male military veterans.

Vieweg WV, Julius DA, Bates J, Quinn JF 3rd, Fernandez A, Hasnain M, Pandurangi AK.

Acta Psychiatr Scand. 2007 Dec;116(6):483-7.

PMID:
17997727
46.

TRPA1 mediates formalin-induced pain.

McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30. Epub 2007 Aug 8.

47.

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.

Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. Epub 2007 Aug 7.

48.

TRP channel structural biology: new roles for an old fold.

Myers BR, Julius D.

Neuron. 2007 Jun 21;54(6):847-50.

49.

The menthol receptor TRPM8 is the principal detector of environmental cold.

Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D.

Nature. 2007 Jul 12;448(7150):204-8. Epub 2007 May 30.

PMID:
17538622
50.

Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.

Kayser V, Elfassi IE, Aubel B, Melfort M, Julius D, Gingrich JA, Hamon M, Bourgoin S.

Pain. 2007 Aug;130(3):235-48. Epub 2007 Jan 23.

PMID:
17250964

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