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Items: 48


In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice.

Lenhard S, McAlexander A, Virtue A, Fieles W, Skedzielewski T, Rambo M, Trinh H, Cheng SH, Hong H, Isidro-Llobet A, Nadin A, Geske R, Klein JL, Lee D, Jucker BM, Hu E.

J Pharmacol Exp Ther. 2019 Apr 1. pii: jpet.119.257022. doi: 10.1124/jpet.119.257022. [Epub ahead of print]


A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

Karageorgis A, Lenhard SC, Yerby B, Forsgren MF, Liachenko S, Johansson E, Pilling MA, Peterson RA, Yang X, Williams DP, Ungersma SE, Morgan RE, Brouwer KLR, Jucker BM, Hockings PD.

PLoS One. 2018 May 17;13(5):e0197213. doi: 10.1371/journal.pone.0197213. eCollection 2018.


Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis.

Yang W, Wang BH, Wang I, Huang L, Savira F, Kompa A, Jucker BM, Willette RN, Kelly D, Krum H, Li Z, Fu Q.

Heart Lung Circ. 2019 Mar;28(3):495-504. doi: 10.1016/j.hlc.2017.12.001. Epub 2017 Dec 14.


The use of micro-CT imaging to examine and illustrate fetal skeletal abnormalities in Dutch Belted rabbits and to prove concordance with Alizarin Red stained skeletal examination.

Solomon HM, Murzyn S, Rendemonti J, Chapman S, Skedzielewski T, Jucker BM, Stanislaus D, Alsaid H.

Birth Defects Res. 2018 Feb 15;110(3):276-298. doi: 10.1002/bdr2.1168. Epub 2017 Nov 21.


Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome.

Savira F, Cao L, Wang I, Yang W, Huang K, Hua Y, Jucker BM, Willette RN, Huang L, Krum H, Li Z, Fu Q, Wang BH.

PLoS One. 2017 Nov 6;12(11):e0187459. doi: 10.1371/journal.pone.0187459. eCollection 2017.


Multimodal imaging approach to examine biodistribution kinetics of Cabotegravir (GSK1265744) long acting parenteral formulation in rat.

Jucker BM, Alsaid H, Rambo M, Lenhard SC, Hoang B, Xie F, Groseclose MR, Castellino S, Damian V, Bowers G, Gupta M.

J Control Release. 2017 Dec 28;268:102-112. doi: 10.1016/j.jconrel.2017.10.017. Epub 2017 Oct 16.


Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice.

Alsaid H, Skedzielewski T, Rambo MV, Hunsinger K, Hoang B, Fieles W, Long ER, Tunstead J, Vugts DJ, Cleveland M, Clarke N, Matheny C, Jucker BM.

PLoS One. 2017 Apr 27;12(4):e0176075. doi: 10.1371/journal.pone.0176075. eCollection 2017.


Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230.

Blackwell C, Sherk C, Fricko M, Ganji G, Barnette M, Hoang B, Tunstead J, Skedzielewski T, Alsaid H, Jucker BM, Minthorn E, Kumar R, DeYoung MP.

Oncotarget. 2016 Jun 28;7(26):39861-39871. doi: 10.18632/oncotarget.9515.


Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast-enhanced Magnetic Resonance Imaging.

Lenhard SC, Lev M, Webster LO, Peterson RA, Goulbourne CN, Miller RT, Jucker BM.

Toxicol Pathol. 2016 Jan;44(1):51-60. doi: 10.1177/0192623315608509. Epub 2015 Oct 28.


Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart.

Aravindhan K, Bao W, Harpel MR, Willette RN, Lepore JJ, Jucker BM.

PLoS One. 2015 Jun 22;10(6):e0130894. doi: 10.1371/journal.pone.0130894. eCollection 2015.


Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2.

Fenning RS, Burgert ME, Hamamdzic D, Peyster EG, Mohler ER, Kangovi S, Jucker BM, Lenhard SC, Macphee CH, Wilensky RL.

J Am Heart Assoc. 2015 Feb 11;4(2). pii: e001477. doi: 10.1161/JAHA.114.001477.


Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury.

Bao W, Ballard VL, Needle S, Hoang B, Lenhard SC, Tunstead JR, Jucker BM, Willette RN, Pipes GT.

Front Pharmacol. 2013 Nov 29;4:149. doi: 10.3389/fphar.2013.00149. eCollection 2013.


Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat.

Bao W, Holt LJ, Prince RD, Jones GX, Aravindhan K, Szapacs M, Barbour AM, Jolivette LJ, Lepore JJ, Willette RN, DeAngelis E, Jucker BM.

Cardiovasc Diabetol. 2013 Oct 14;12:148. doi: 10.1186/1475-2840-12-148.


Examining the relationship between exercise tolerance and isoproterenol-based cardiac reserve in murine models of heart failure.

Richards DA, Bao W, Rambo MV, Burgert M, Jucker BM, Lenhard SC.

J Appl Physiol (1985). 2013 May;114(9):1202-10. doi: 10.1152/japplphysiol.00556.2012. Epub 2013 Feb 28.


Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.

Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N, Choudhry AE, Alsaid H, Jucker BM, Axten JM, Kumar R.

Cancer Res. 2013 Mar 15;73(6):1993-2002. doi: 10.1158/0008-5472.CAN-12-3109. Epub 2013 Jan 18.


Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice.

Morgan LA, Olzinski AR, Upson JJ, Zhao S, Wang T, Eisennagel SH, Hoang B, Tunstead JR, Marino JP Jr, Willette RN, Jucker BM, Behm DJ.

J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301. doi: 10.1097/FJC.0b013e31827fe59c.


An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.


Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

Costell MH, Ancellin N, Bernard RE, Zhao S, Upson JJ, Morgan LA, Maniscalco K, Olzinski AR, Ballard VL, Herry K, Grondin P, Dodic N, Mirguet O, Bouillot A, Gellibert F, Coatney RW, Lepore JJ, Jucker BM, Jolivette LJ, Willette RN, Schnackenberg CG, Behm DJ.

Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.


Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency.

Bao W, Aravindhan K, Alsaid H, Chendrimada T, Szapacs M, Citerone DR, Harpel MR, Willette RN, Lepore JJ, Jucker BM.

PLoS One. 2011;6(8):e23570. doi: 10.1371/journal.pone.0023570. Epub 2011 Aug 26.


Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction.

Alsaid H, Bao W, Rambo MV, Logan GA, Figueroa DJ, Lenhard SC, Kotzer CJ, Burgert ME, Willette RN, Ferrari VA, Jucker BM.

Magn Reson Med. 2012 Jan;67(1):191-200. doi: 10.1002/mrm.22973. Epub 2011 Jun 10.


Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

Bao W, Qin P, Needle S, Erickson-Miller CL, Duffy KJ, Ariazi JL, Zhao S, Olzinski AR, Behm DJ, Pipes GC, Jucker BM, Hu E, Lepore JJ, Willette RN.

J Cardiovasc Pharmacol. 2010 Aug;56(2):147-55. doi: 10.1097/FJC.0b013e3181e2bfef.


Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment.

Olzinski AR, Turner GH, Bernard RE, Karr H, Cornejo CA, Aravindhan K, Hoang B, Ringenberg MA, Qin P, Goodman KB, Willette RN, Macphee CH, Jucker BM, Sehon CA, Gough PJ.

Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):253-9. doi: 10.1161/ATVBAHA.109.198812. Epub 2009 Dec 3. Erratum in: Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):e170.


In vivo serial assessment of aortic aneurysm formation in apolipoprotein E-deficient mice via MRI.

Turner GH, Olzinski AR, Bernard RE, Aravindhan K, Karr HW, Mirabile RC, Willette RN, Gough PJ, Jucker BM.

Circ Cardiovasc Imaging. 2008 Nov;1(3):220-6. doi: 10.1161/CIRCIMAGING.108.787358. Epub 2008 Sep 17.


Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm.

Turner GH, Olzinski AR, Bernard RE, Aravindhan K, Boyle RJ, Newman MJ, Gardner SD, Willette RN, Gough PJ, Jucker BM.

J Magn Reson Imaging. 2009 Aug;30(2):455-60. doi: 10.1002/jmri.21843.


In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.

Yue TL, Nerurkar SS, Bao W, Jucker BM, Sarov-Blat L, Steplewski K, Ohlstein EH, Willette RN.

J Pharmacol Exp Ther. 2008 May;325(2):466-74. doi: 10.1124/jpet.107.135327. Epub 2008 Feb 20.


p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment.

Morris JB, Olzinski AR, Bernard RE, Aravindhan K, Mirabile RC, Boyce R, Willette RN, Jucker BM.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):265-71. Epub 2007 Dec 27.


Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.

Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28.


PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure.

Jucker BM, Doe CP, Schnackenberg CG, Olzinski AR, Maniscalco K, Williams C, Hu TC, Lenhard SC, Costell M, Bernard R, Sarov-Blat L, Steplewski K, Willette RN.

J Cardiovasc Pharmacol. 2007 Jul;50(1):25-34.


Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging.

Lenhard SC, Haimbach RE, Sulpizio AC, Brooks DP, Bray JD, Jucker BM.

Fertil Steril. 2007 Oct;88(4 Suppl):1058-64. Epub 2007 Mar 23.


Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.

Aravindhan K, Webb CL, Jaye M, Ghosh A, Willette RN, DiNardo NJ, Jucker BM.

J Lipid Res. 2006 Jun;47(6):1250-60. Epub 2006 Mar 27.


Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque labeling.

Yancy AD, Olzinski AR, Hu TC, Lenhard SC, Aravindhan K, Gruver SM, Jacobs PM, Willette RN, Jucker BM.

J Magn Reson Imaging. 2005 Apr;21(4):432-42.


p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging.

Lenhard SC, Nerurkar SS, Schaeffer TR, Mirabile RC, Boyce RW, Adams DF, Jucker BM, Willette RN.

J Pharmacol Exp Ther. 2003 Dec;307(3):939-46. Epub 2003 Oct 15.


Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury.

Yue TL, Bao W, Jucker BM, Gu JL, Romanic AM, Brown PJ, Cui J, Thudium DT, Boyce R, Burns-Kurtis CL, Mirabile RC, Aravindhan K, Ohlstein EH.

Circulation. 2003 Nov 11;108(19):2393-9. Epub 2003 Oct 13.


Reduction of intramyocellular lipid following short-term rosiglitazone treatment in Zucker fatty rats: an in vivo nuclear magnetic resonance study.

Jucker BM, Schaeffer TR, Haimbach RE, Mayer ME, Ohlstein DH, Smith SA, Cobitz AR, Sarkar SK.

Metabolism. 2003 Feb;52(2):218-25.


Normalization of skeletal muscle glycogen synthesis and glycolysis in rosiglitazone-treated Zucker fatty rats: an in vivo nuclear magnetic resonance study.

Jucker BM, Schaeffer TR, Haimbach RE, McIntosh TS, Chun D, Mayer M, Ohlstein DH, Davis HM, Smith SA, Cobitz AR, Sarkar SK.

Diabetes. 2002 Jul;51(7):2066-73.


Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle.

Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI.

J Clin Invest. 2001 Sep;108(5):733-7.


13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression.

Jucker BM, Ren J, Dufour S, Cao X, Previs SF, Cadman KS, Shulman GI.

J Biol Chem. 2000 Dec 15;275(50):39279-86.


Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR.

Jucker BM, Dufour S, Ren J, Cao X, Previs SF, Underhill B, Cadman KS, Shulman GI.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6880-4. Erratum in: Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3624.


Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle.

Jucker BM, Barucci N, Shulman GI.

Am J Physiol. 1999 Sep;277(3):E505-12. doi: 10.1152/ajpendo.1999.277.3.E505.


In vivo 13C NMR measurements of hepatocellular tricarboxylic acid cycle flux.

Jucker BM, Lee JY, Shulman RG.

J Biol Chem. 1998 May 15;273(20):12187-94.


A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo.

Cline GW, Jucker BM, Trajanoski Z, Rennings AJ, Shulman GI.

Am J Physiol. 1998 Feb;274(2):E381-9. doi: 10.1152/ajpendo.1998.274.2.E381.


In vivo NMR investigation of intramuscular glucose metabolism in conscious rats.

Jucker BM, Rennings AJ, Cline GW, Petersen KF, Shulman GI.

Am J Physiol. 1997 Jul;273(1 Pt 1):E139-48.


NMR investigation of the futile cycling of ethanol in chronic alcoholic rats.

Jucker BM, Barnard ML, Shulman RG.

Alcohol Clin Exp Res. 1994 Dec;18(6):1377-85.


13C NMR assignments of the bases in oligodeoxynucleotides: an automated procedure using Bayesian statistics.

Hyman TJ, Boudreau EA, Martin GG, Jucker BM, Borer PN, Levy GC.

J Chem Inf Comput Sci. 1988 Nov;28(4):226-30.


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