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Items: 1 to 50 of 110

1.

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):522-523. doi: 10.1038/s41571-019-0236-y. No abstract available.

PMID:
31150022
2.

Re-education of macrophages as a therapeutic strategy in cancer.

Kowal J, Kornete M, Joyce JA.

Immunotherapy. 2019 Jun;11(8):677-689. doi: 10.2217/imt-2018-0156.

3.

Challenges to curing primary brain tumours.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):509-520. doi: 10.1038/s41571-019-0177-5. Review.

4.
5.

A Long-Distance Relay-tionship between Tumor and Bone.

Soukup K, Joyce JA.

Immunity. 2018 Jan 16;48(1):13-16. doi: 10.1016/j.immuni.2017.12.011.

6.

Obesity and the tumor microenvironment.

Olson OC, Quail DF, Joyce JA.

Science. 2017 Dec 1;358(6367):1130-1131. doi: 10.1126/science.aao5801. No abstract available.

PMID:
29191893
7.

Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.

Bakst RL, Xiong H, Chen CH, Deborde S, Lyubchik A, Zhou Y, He S, McNamara W, Lee SY, Olson OC, Leiner IM, Marcadis AR, Keith JW, Al-Ahmadie HA, Katabi N, Gil Z, Vakiani E, Joyce JA, Pamer E, Wong RJ.

Cancer Res. 2017 Nov 15;77(22):6400-6414. doi: 10.1158/0008-5472.CAN-17-1612. Epub 2017 Sep 26.

8.

Iron imaging reveals tumor and metastasis macrophage hemosiderin deposits in breast cancer.

Leftin A, Ben-Chetrit N, Klemm F, Joyce JA, Koutcher JA.

PLoS One. 2017 Sep 12;12(9):e0184765. doi: 10.1371/journal.pone.0184765. eCollection 2017.

9.

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.

Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA.

ACS Nano. 2017 Nov 28;11(11):10689-10703. doi: 10.1021/acsnano.7b04743. Epub 2017 Sep 12.

10.

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.

Yan D, Kowal J, Akkari L, Schuhmacher AJ, Huse JT, West BL, Joyce JA.

Oncogene. 2017 Oct 26;36(43):6049-6058. doi: 10.1038/onc.2017.261. Epub 2017 Jul 31.

11.

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.

Quail DF, Olson OC, Bhardwaj P, Walsh LA, Akkari L, Quick ML, Chen IC, Wendel N, Ben-Chetrit N, Walker J, Holt PR, Dannenberg AJ, Joyce JA.

Nat Cell Biol. 2017 Aug;19(8):974-987. doi: 10.1038/ncb3578. Epub 2017 Jul 24.

PMID:
28737771
12.

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.

Olson OC, Kim H, Quail DF, Foley EA, Joyce JA.

Cell Rep. 2017 Apr 4;19(1):101-113. doi: 10.1016/j.celrep.2017.03.038.

13.

The Microenvironmental Landscape of Brain Tumors.

Quail DF, Joyce JA.

Cancer Cell. 2017 Mar 13;31(3):326-341. doi: 10.1016/j.ccell.2017.02.009. Review.

14.

Metabolic origins of spatial organization in the tumor microenvironment.

Carmona-Fontaine C, Deforet M, Akkari L, Thompson CB, Joyce JA, Xavier JB.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2934-2939. doi: 10.1073/pnas.1700600114. Epub 2017 Feb 28.

15.

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies.

Quail DF, Joyce JA.

Clin Cancer Res. 2017 Feb 15;23(4):876-884. doi: 10.1158/1078-0432.CCR-16-0133. Epub 2016 Nov 28. Review.

16.

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA.

Cell Rep. 2016 Nov 22;17(9):2445-2459. doi: 10.1016/j.celrep.2016.10.052. Epub 2016 Nov 10.

17.

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.

Yan D, Wang HW, Bowman RL, Joyce JA.

Cell Rep. 2016 Sep 13;16(11):2914-2927. doi: 10.1016/j.celrep.2016.08.035.

18.

Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11.

19.

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.

20.

Microenvironmental InterFereNce of metabolism regulates chemosensitivity.

Akkari L, Joyce JA.

Cell Res. 2016 Aug;26(8):867-8. doi: 10.1038/cr.2016.82. Epub 2016 Jun 28.

21.

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC, Joyce JA.

Science. 2016 May 20;352(6288):aad3018. doi: 10.1126/science.aad3018.

22.

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy.

Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD.

J Alzheimers Dis. 2016;51(4):1099-109. doi: 10.3233/JAD-151028.

23.

Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.

Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL, Joyce JA.

Genes Dev. 2016 Jan 15;30(2):220-32. doi: 10.1101/gad.270439.115.

24.

High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system.

Curry RC, Faivre G, Akkari L, Joyce JA, Lin O, Rosenblum M, Diamond EL, Fisher R, Omuro A.

Leuk Lymphoma. 2016 Aug;57(8):1961-4. doi: 10.3109/10428194.2015.1120867. Epub 2016 Jan 4. No abstract available.

PMID:
26727454
25.

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.

Olson OC, Joyce JA.

Nat Rev Cancer. 2015 Dec;15(12):712-29. doi: 10.1038/nrc4027. Review.

PMID:
26597527
26.

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy.

Hughes R, Qian BZ, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW, Lewis CE.

Cancer Res. 2015 Sep 1;75(17):3479-91. doi: 10.1158/0008-5472.CAN-14-3587. Epub 2015 Aug 12.

27.

Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.

Sobotič B, Vizovišek M, Vidmar R, Van Damme P, Gocheva V, Joyce JA, Gevaert K, Turk V, Turk B, Fonović M.

Mol Cell Proteomics. 2015 Aug;14(8):2213-28. doi: 10.1074/mcp.M114.044628. Epub 2015 Jun 16.

28.

Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.

Brindle NR, Joyce JA, Rostker F, Lawlor ER, Swigart-Brown L, Evan G, Hanahan D, Shchors K.

PLoS One. 2015 Apr 30;10(4):e0120348. doi: 10.1371/journal.pone.0120348. eCollection 2015.

29.

T cell exclusion, immune privilege, and the tumor microenvironment.

Joyce JA, Fearon DT.

Science. 2015 Apr 3;348(6230):74-80. doi: 10.1126/science.aaa6204. Review.

PMID:
25838376
30.

Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection.

Zhu W, Tao L, Quick ML, Joyce JA, Qu JM, Luo ZQ.

PLoS Pathog. 2015 Mar 4;11(3):e1004704. doi: 10.1371/journal.ppat.1004704. eCollection 2015 Mar.

31.

Microenvironmental regulation of therapeutic response in cancer.

Klemm F, Joyce JA.

Trends Cell Biol. 2015 Apr;25(4):198-213. doi: 10.1016/j.tcb.2014.11.006. Epub 2014 Dec 22. Review.

32.

Pericellular proteolysis in cancer.

Sevenich L, Joyce JA.

Genes Dev. 2014 Nov 1;28(21):2331-47. doi: 10.1101/gad.250647.114. Review.

33.

Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.

Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA.

Genes Dev. 2014 Oct 1;28(19):2134-50. doi: 10.1101/gad.249599.114.

34.

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.

Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massagué J, Leslie CS, Joyce JA.

Nat Cell Biol. 2014 Sep;16(9):876-88. doi: 10.1038/ncb3011. Epub 2014 Aug 3.

35.

Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma.

Bowman RL, Joyce JA.

Immunotherapy. 2014;6(6):663-6. doi: 10.2217/imt.14.48. No abstract available.

PMID:
25041027
36.

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.

Alonso-Curbelo D, Riveiro-Falkenbach E, Pérez-Guijarro E, Cifdaloz M, Karras P, Osterloh L, Megías D, Cañón E, Calvo TG, Olmeda D, Gómez-López G, Graña O, Sánchez-Arévalo Lobo VJ, Pisano DG, Wang HW, Ortiz-Romero P, Tormo D, Hoek K, Rodríguez-Peralto JL, Joyce JA, Soengas MS.

Cancer Cell. 2014 Jul 14;26(1):61-76. doi: 10.1016/j.ccr.2014.04.030. Epub 2014 Jun 26.

37.

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I, Joyce JA, Li XD, Chen Z, Merghoub T, Shuman S, Deng L.

PLoS Pathog. 2014 Apr 17;10(4):e1003989. doi: 10.1371/journal.ppat.1003989. eCollection 2014 Apr.

38.

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.

Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H.

Neuropharmacology. 2014 Apr;79:307-13. doi: 10.1016/j.neuropharm.2013.11.025. Epub 2013 Dec 8.

PMID:
24326295
39.

Peer Associations and Coping: The Mediating Role of Ethnic Identity for Urban, African American Adolescents.

Joyce JA, O'Neil ME, Stormshak EA, McWhirter EH, Dishion TJ.

J Black Psychol. 2013 Oct 1;39(5). doi: 10.1177/0095798412454681.

40.

Emergence of spatial structure in the tumor microenvironment due to the Warburg effect.

Carmona-Fontaine C, Bucci V, Akkari L, Deforet M, Joyce JA, Xavier JB.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19402-7. doi: 10.1073/pnas.1311939110. Epub 2013 Nov 11.

41.

Microenvironmental regulation of tumor progression and metastasis.

Quail DF, Joyce JA.

Nat Med. 2013 Nov;19(11):1423-37. doi: 10.1038/nm.3394. Review.

42.

mTOR regulates phagosome and entotic vacuole fission.

Krajcovic M, Krishna S, Akkari L, Joyce JA, Overholtzer M.

Mol Biol Cell. 2013 Dec;24(23):3736-45. doi: 10.1091/mbc.E13-07-0408. Epub 2013 Oct 2.

43.

CSF-1R inhibition alters macrophage polarization and blocks glioma progression.

Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, Setty M, Leslie CS, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA.

Nat Med. 2013 Oct;19(10):1264-72. doi: 10.1038/nm.3337. Epub 2013 Sep 22.

44.

Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis.

Hunter KE, Quick ML, Sadanandam A, Hanahan D, Joyce JA.

PLoS One. 2013 May 14;8(5):e64472. doi: 10.1371/journal.pone.0064472. Print 2013.

45.

Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.

Hunter KE, Palermo C, Kester JC, Simpson K, Li JP, Tang LH, Klimstra DS, Vlodavsky I, Joyce JA.

Oncogene. 2014 Apr 3;33(14):1799-808. doi: 10.1038/onc.2013.142. Epub 2013 May 6.

PMID:
23644656
46.

Non-cell-autonomous tumor suppression by p53.

Lujambio A, Akkari L, Simon J, Grace D, Tschaharganeh DF, Bolden JE, Zhao Z, Thapar V, Joyce JA, Krizhanovsky V, Lowe SW.

Cell. 2013 Apr 11;153(2):449-60. doi: 10.1016/j.cell.2013.03.020. Epub 2013 Apr 4.

47.

Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.

Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, Joyce JA, Fagin JA.

PLoS One. 2013;8(1):e54302. doi: 10.1371/journal.pone.0054302. Epub 2013 Jan 23.

48.

A splicing twist on metastasis.

Olson OC, Joyce JA.

Sci Transl Med. 2013 Jan 23;5(169):169fs2. doi: 10.1126/scitranslmed.3005424.

PMID:
23345607
49.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Jacobson LS, Lima H Jr, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS, Joyce JA, Gapp BV, Blomen VA, Chandran K, Brummelkamp TR, Diaz-Griffero F, Brojatsch J.

J Biol Chem. 2013 Mar 15;288(11):7481-91. doi: 10.1074/jbc.M112.400655. Epub 2013 Jan 7.

50.

Microenvironment-mediated resistance to anticancer therapies.

Olson OC, Joyce JA.

Cell Res. 2013 Feb;23(2):179-81. doi: 10.1038/cr.2012.123. Epub 2012 Sep 4.

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