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Items: 1 to 50 of 98

1.

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

Beaudry-Richard A, Nadeau-Vallée M, Prairie É, Maurice N, Heckel É, Nezhady M, Pundir S, Madaan A, Boudreault A, Hou X, Quiniou C, Sierra EM, Beaulac A, Lodygensky G, Robertson SA, Keelan J, Adams-Waldorf K, Olson DM, Rivera JC, Lubell WD, Joyal JS, Bouchard JF, Chemtob S.

Sci Rep. 2018 Aug 8;8(1):11875. doi: 10.1038/s41598-018-30087-4.

2.

The Power of Rare: An Opportunity to Repurpose an Old Drug for Mitochondrial Cardiomyopathy.

Song AT, Joyal JS, Andelfinger G.

Can J Cardiol. 2018 Aug;34(8):950-952. doi: 10.1016/j.cjca.2018.04.025. Epub 2018 Apr 27. No abstract available.

PMID:
30049362
3.

Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome.

Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P.

Sci Immunol. 2018 Mar 16;3(21). pii: eaan4626. doi: 10.1126/sciimmunol.aan4626.

PMID:
29549139
4.

Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism.

Joyal JS, Gantner ML, Smith LEH.

Prog Retin Eye Res. 2018 May;64:131-156. doi: 10.1016/j.preteyeres.2017.11.002. Epub 2017 Nov 22. Review. No abstract available.

5.

Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.

Nadeau-Vallée M, Chin PY, Belarbi L, Brien MÈ, Pundir S, Berryer MH, Beaudry-Richard A, Madaan A, Sharkey DJ, Lupien-Meilleur A, Hou X, Quiniou C, Beaulac A, Boufaied I, Boudreault A, Carbonaro A, Doan ND, Joyal JS, Lubell WD, Olson DM, Robertson SA, Girard S, Chemtob S.

J Immunol. 2017 Mar 1;198(5):2047-2062. doi: 10.4049/jimmunol.1601600. Epub 2017 Feb 1.

6.

Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.

Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE.

Nat Med. 2016 Jun 7;22(6):692. doi: 10.1038/nm0616-692a. No abstract available.

PMID:
27270778
7.

Multiple organ dysfunction syndrome in critically ill children: clinical value of two lists of diagnostic criteria.

Villeneuve A, Joyal JS, Proulx F, Ducruet T, Poitras N, Lacroix J.

Ann Intensive Care. 2016 Dec;6(1):40. doi: 10.1186/s13613-016-0144-6. Epub 2016 Apr 29.

8.

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.

Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE.

Nat Med. 2016 Apr;22(4):439-45. doi: 10.1038/nm.4059. Epub 2016 Mar 14. Erratum in: Nat Med. 2016 Jun 7;22(6):692.

9.

SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth.

Sun Y, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC, Pu WT, Chen J, Stahl A, Joyal JS, Smith LE.

Sci Signal. 2015 Sep 22;8(395):ra94. doi: 10.1126/scisignal.aaa8695.

10.

Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity.

Joyal JS, Bhosle VK, Chemtob S.

Expert Opin Ther Targets. 2015 Jun;19(6):717-21. doi: 10.1517/14728222.2015.1042365.

PMID:
25976229
11.

Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.

Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE.

Am J Clin Nutr. 2015 Apr;101(4):879-88. doi: 10.3945/ajcn.114.099291. Epub 2015 Feb 4.

12.

Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.

Sitaras N, Rivera JC, Noueihed B, Bien-Aimé M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal JS, Chemtob S.

Am J Pathol. 2015 Feb;185(2):581-95. doi: 10.1016/j.ajpath.2014.10.020. Epub 2014 Dec 3.

PMID:
25478809
13.

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer.

Vallabhajosula S, Nikolopoulou A, Babich JW, Osborne JR, Tagawa ST, Lipai I, Solnes L, Maresca KP, Armor T, Joyal JL, Crummet R, Stubbs JB, Goldsmith SJ.

J Nucl Med. 2014 Nov;55(11):1791-8. doi: 10.2967/jnumed.114.140426. Epub 2014 Oct 23.

14.

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.

Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, Hardy P, Bhosle V, Varma DR, Gobeil F Jr, Beauséjour C, Boileau C, Klein W, Hollenberg M, Ribeiro-da-Silva A, Andelfinger G, Chemtob S.

Nat Med. 2014 Oct;20(10):1165-73. doi: 10.1038/nm.3669. Epub 2014 Sep 14.

PMID:
25216639
15.

Inspiring careers in STEM and healthcare fields through medical simulation embedded in high school science education.

Berk LJ, Muret-Wagstaff SL, Goyal R, Joyal JA, Gordon JA, Faux R, Oriol NE.

Adv Physiol Educ. 2014 Sep;38(3):210-5. doi: 10.1152/advan.00143.2013.

16.

Management of neonatal sepsis in term newborns.

Du Pont-Thibodeau G, Joyal JS, Lacroix J.

F1000Prime Rep. 2014 Aug 1;6:67. doi: 10.12703/P6-67. eCollection 2014. Review.

17.

Radiation dosimetry and first therapy results with a (124)I/ (131)I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy.

Zechmann CM, Afshar-Oromieh A, Armor T, Stubbs JB, Mier W, Hadaschik B, Joyal J, Kopka K, Debus J, Babich JW, Haberkorn U.

Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1280-92. doi: 10.1007/s00259-014-2713-y. Epub 2014 Feb 28.

18.

Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.

Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE.

Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):581-6. doi: 10.1161/ATVBAHA.113.302927. Epub 2014 Jan 23.

19.

Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers.

Cavallone LF, Frey K, Montana MC, Joyal J, Regina KJ, Petersen KL, Gereau RW 4th.

J Pain Res. 2013 Nov 7;6:771-84. doi: 10.2147/JPR.S53437. eCollection 2013.

20.

Choroid sprouting assay: an ex vivo model of microvascular angiogenesis.

Shao Z, Friedlander M, Hurst CG, Cui Z, Pei DT, Evans LP, Juan AM, Tahiri H, Duhamel F, Chen J, Sapieha P, Chemtob S, Joyal JS, Smith LE.

PLoS One. 2013 Jul 26;8(7):e69552. doi: 10.1371/journal.pone.0069552. Print 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/c6b85ec4-996d-4daf-863a-44260a888470. Tahir, Houda [corrected to Tahiri, Houda].

21.

Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy.

Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE.

Angiogenesis. 2013 Oct;16(4):985-92. doi: 10.1007/s10456-013-9374-5. Epub 2013 Aug 4.

22.

Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions.

Favret S, Binet F, Lapalme E, Leboeuf D, Carbadillo J, Rubic T, Picard E, Mawambo G, Tetreault N, Joyal JS, Chemtob S, Sennlaub F, Sangiovanni JP, Guimond M, Sapieha P.

Aging (Albany NY). 2013 Jun;5(6):427-44.

23.

Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A.

Rivera JC, Sitaras N, Noueihed B, Hamel D, Madaan A, Zhou T, Honoré JC, Quiniou C, Joyal JS, Hardy P, Sennlaub F, Lubell W, Chemtob S.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1881-91. doi: 10.1161/ATVBAHA.113.301331. Epub 2013 Jun 13.

PMID:
23766263
24.

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer.

Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

J Nucl Med. 2013 Aug;54(8):1369-76. doi: 10.2967/jnumed.112.116624. Epub 2013 Jun 3.

25.

Semaphorin 3F forms an anti-angiogenic barrier in outer retina.

Buehler A, Sitaras N, Favret S, Bucher F, Berger S, Pielen A, Joyal JS, Juan AM, Martin G, Schlunck G, Agostini HT, Klagsbrun M, Smith LE, Sapieha P, Stahl A.

FEBS Lett. 2013 Jun 5;587(11):1650-5. doi: 10.1016/j.febslet.2013.04.008. Epub 2013 Apr 18.

26.

Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.

Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P.

Cell Metab. 2013 Mar 5;17(3):353-71. doi: 10.1016/j.cmet.2013.02.003.

27.

Synthesis and SAR of ⁹⁹mTc/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates.

Lu G, Maresca KP, Hillier SM, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1557-63. doi: 10.1016/j.bmcl.2012.09.014. Epub 2012 Sep 13.

PMID:
23333070
28.

First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer.

Barrett JA, Coleman RE, Goldsmith SJ, Vallabhajosula S, Petry NA, Cho S, Armor T, Stubbs JB, Maresca KP, Stabin MG, Joyal JL, Eckelman WC, Babich JW.

J Nucl Med. 2013 Mar;54(3):380-7. doi: 10.2967/jnumed.112.111203. Epub 2013 Jan 9.

29.

Synthesis and SAR of novel Re/99mTc-labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia.

Lu G, Hillier SM, Maresca KP, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

J Med Chem. 2013 Jan 24;56(2):510-20. doi: 10.1021/jm3015348. Epub 2013 Jan 8.

PMID:
23234246
30.

SOCS3 is an endogenous inhibitor of pathologic angiogenesis.

Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE.

Blood. 2012 Oct 4;120(14):2925-9. doi: 10.1182/blood-2012-04-422527. Epub 2012 Jul 12.

31.

High end-expiratory airway pressures caused by internal obstruction of the Draeger Apollo® scavenger system that is not detected by the workstation self-test and visual inspection.

Joyal JJ, Vannucci A, Kangrga I.

Anesthesiology. 2012 May;116(5):1162-4; discussion 1164-6. doi: 10.1097/ALN.0b013e31824dec32. No abstract available.

PMID:
22531265
32.

Molecular imaging of human ACE-1 expression in transgenic rats.

Dilsizian V, Zynda TK, Petrov A, Ohshima S, Tahara N, Haider N, Donohue A, Aras O, Femia FJ, Hillier SM, Joyal JL, Wong ND, Coleman T, Babich JW, Narula J.

JACC Cardiovasc Imaging. 2012 Apr;5(4):409-18. doi: 10.1016/j.jcmg.2011.10.008.

33.

Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A.

Joyal JS, Omri S, Sitaras N, Rivera JC, Sapieha P, Chemtob S.

Acta Paediatr. 2012 Aug;101(8):819-26. doi: 10.1111/j.1651-2227.2012.02692.x. Epub 2012 May 5. Review.

PMID:
22497252
34.

Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy.

Chen J, Joyal JS, Hatton CJ, Juan AM, Pei DT, Hurst CG, Xu D, Stahl A, Hellstrom A, Smith LE.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):2968-77. doi: 10.1167/iovs.12-9691.

35.

Triazole Appending Agent (TAAG): A New Synthon for Preparing Iodine-Based Molecular Imaging and Radiotherapy Agents.

Darwish A, Blacker M, Janzen N, Rathmann SM, Czorny S, Hillier SM, Joyal JL, Babich JW, Valliant JF.

ACS Med Chem Lett. 2012 Feb 18;3(4):313-6. doi: 10.1021/ml300003v. eCollection 2012 Apr 12.

36.

Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice.

Chen J, Stahl A, Krah NM, Seaward MR, Joyal JS, Juan AM, Hatton CJ, Aderman CM, Dennison RJ, Willett KL, Sapieha P, Smith LE.

PLoS One. 2012;7(1):e30203. doi: 10.1371/journal.pone.0030203. Epub 2012 Jan 17.

37.

Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice.

Sapieha P, Chen J, Stahl A, Seaward MR, Favazza TL, Juan AM, Hatton CJ, Joyal JS, Krah NM, Dennison RJ, Tang J, Kern TS, Akula JD, Smith LE.

Nutr Diabetes. 2012 Jul 23;2:e36. doi: 10.1038/nutd.2012.10.

38.

Understanding retinopathy of prematurity: update on pathogenesis.

Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, Picard E, Zhou E, Lachapelle P, Chemtob S.

Neonatology. 2011;100(4):343-53. doi: 10.1159/000330174. Epub 2011 Oct 3. Review.

39.

123I-MIP-1072, a small-molecule inhibitor of prostate-specific membrane antigen, is effective at monitoring tumor response to taxane therapy.

Hillier SM, Kern AM, Maresca KP, Marquis JC, Eckelman WC, Joyal JL, Babich JW.

J Nucl Med. 2011 Jul;52(7):1087-93. doi: 10.2967/jnumed.110.086751. Epub 2011 Jun 16.

40.

Choroidal involution is a key component of oxygen-induced retinopathy.

Shao Z, Dorfman AL, Seshadri S, Djavari M, Kermorvant-Duchemin E, Sennlaub F, Blais M, Polosa A, Varma DR, Joyal JS, Lachapelle P, Hardy P, Sitaras N, Picard E, Mancini J, Sapieha P, Chemtob S.

Invest Ophthalmol Vis Sci. 2011 Aug 5;52(9):6238-48. doi: 10.1167/iovs.10-6742.

PMID:
21546530
41.

Diagnostic and therapeutic imaging for cancer: therapeutic considerations and future directions.

Roach M 3rd, Alberini JL, Pecking AP, Testori A, Verrecchia F, Soteldo J, Ganswindt U, Joyal JL, Babich JW, Witte RS, Unger E, Gottlieb R.

J Surg Oncol. 2011 May 1;103(6):587-601. doi: 10.1002/jso.21805. Review.

PMID:
21480253
42.

Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes.

Bartholomä MD, Vortherms AR, Hillier S, Joyal J, Babich J, Doyle RP, Zubieta J.

Dalton Trans. 2011 Jun 21;40(23):6216-25. doi: 10.1039/c0dt01452d. Epub 2011 Mar 3.

PMID:
21369609
43.

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P.

Blood. 2011 Jun 2;117(22):6024-35. doi: 10.1182/blood-2010-10-311589. Epub 2011 Feb 25.

44.

Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration.

Zhu T, Mancini JA, Sapieha P, Yang C, Joyal JS, Honoré JC, Leduc M, Zaniolo K, Hardy P, Shao Z, Fan L, Hou X, Rivard GE, Chemtob S.

Am J Physiol Regul Integr Comp Physiol. 2011 Mar;300(3):R577-85. doi: 10.1152/ajpregu.00137.2010. Epub 2010 Dec 15.

45.

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.

Sapieha P, Joyal JS, Rivera JC, Kermorvant-Duchemin E, Sennlaub F, Hardy P, Lachapelle P, Chemtob S.

J Clin Invest. 2010 Sep;120(9):3022-32. doi: 10.1172/JCI42142. Epub 2010 Sep 1. Review.

46.

Synthesis, cytotoxicity, and insight into the mode of action of Re(CO)3 thymidine complexes.

Bartholomä MD, Vortherms AR, Hillier S, Ploier B, Joyal J, Babich J, Doyle RP, Zubieta J.

ChemMedChem. 2010 Sep 3;5(9):1513-29. doi: 10.1002/cmdc.201000196.

PMID:
20652929
47.

Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution.

Barrett JA, Joyal JL, Hillier SM, Maresca KP, Femia FJ, Kronauge JF, Boyd M, Mairs RJ, Babich JW.

Cancer Biother Radiopharm. 2010 Jun;25(3):299-308. doi: 10.1089/cbr.2009.0695.

PMID:
20578835
48.

Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.

Albaugh VL, Vary TC, Ilkayeva O, Wenner BR, Maresca KP, Joyal JL, Breazeale S, Elich TD, Lang CH, Lynch CJ.

Schizophr Bull. 2012 Jan;38(1):153-66. doi: 10.1093/schbul/sbq053. Epub 2010 May 21.

49.

Preclinical evaluation of an 131I-labeled benzamide for targeted radiotherapy of metastatic melanoma.

Joyal JL, Barrett JA, Marquis JC, Chen J, Hillier SM, Maresca KP, Boyd M, Gage K, Nimmagadda S, Kronauge JF, Friebe M, Dinkelborg L, Stubbs JB, Stabin MG, Mairs R, Pomper MG, Babich JW.

Cancer Res. 2010 May 15;70(10):4045-53. doi: 10.1158/0008-5472.CAN-09-4414. Epub 2010 May 4.

50.

Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: application to octreotide.

Maresca KP, Marquis JC, Hillier SM, Lu G, Femia FJ, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW.

Bioconjug Chem. 2010 Jun 16;21(6):1032-42. doi: 10.1021/bc900517x.

PMID:
20402463

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