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Items: 28

1.

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.

Lin EYS, Silvian LF, Marcotte DJ, Banos CC, Jow F, Chan TR, Arduini RM, Qian F, Baker DP, Bergeron C, Hession CA, Huganir RL, Borenstein CF, Enyedy I, Zou J, Rohde E, Wittmann M, Kumaravel G, Rhodes KJ, Scannevin RH, Dunah AW, Guckian KM.

Sci Rep. 2018 Sep 7;8(1):13438. doi: 10.1038/s41598-018-31680-3.

2.

N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.

Zanaletti R, Bettinetti L, Castaldo C, Ceccarelli I, Cocconcelli G, Comery TA, Dunlop J, Genesio E, Ghiron C, Haydar SN, Jow F, Maccari L, Micco I, Nencini A, Pratelli C, Scali C, Turlizzi E, Valacchi M.

J Med Chem. 2012 Nov 26;55(22):10277-81. doi: 10.1021/jm3013568. Epub 2012 Nov 2.

PMID:
23083093
3.

Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).

Zanaletti R, Bettinetti L, Castaldo C, Cocconcelli G, Comery T, Dunlop J, Gaviraghi G, Ghiron C, Haydar SN, Jow F, Maccari L, Micco I, Nencini A, Scali C, Turlizzi E, Valacchi M.

J Med Chem. 2012 May 24;55(10):4806-23. doi: 10.1021/jm300247y. Epub 2012 May 3.

PMID:
22468936
4.

Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.

Marquis KL, Comery TA, Jow F, Navarra RL, Grauer SM, Pulicicchio C, Kelley C, Brennan JA, Roncarati R, Scali C, Haydar S, Ghiron C, Terstappen GC, Dunlop J.

Psychopharmacology (Berl). 2011 Dec;218(4):635-47. doi: 10.1007/s00213-011-2357-6. Epub 2011 Jun 4.

PMID:
21643676
5.

Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).

Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U.

J Med Chem. 2010 Jun 10;53(11):4379-89. doi: 10.1021/jm901692q.

PMID:
20465311
6.

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide).

Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, Gilbert A, Comery TA, Larocque J, Soloveva V, Brown J, Roncarati R.

J Pharmacol Exp Ther. 2009 Mar;328(3):766-76. doi: 10.1124/jpet.108.146514. Epub 2008 Dec 2.

PMID:
19050173
7.

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.

Dwyer JM, Rizzo SJ, Neal SJ, Lin Q, Jow F, Arias RL, Rosenzweig-Lipson S, Dunlop J, Beyer CE.

Psychopharmacology (Berl). 2009 Mar;203(1):41-52. doi: 10.1007/s00213-008-1373-7. Epub 2008 Oct 24.

PMID:
18949460
8.

Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.

Roncarati R, Seredenina T, Jow B, Jow F, Papini S, Kramer A, Bothmann H, Dunlop J, Terstappen GC.

Assay Drug Dev Technol. 2008 Apr;6(2):181-93. doi: 10.1089/adt.2007.120.

PMID:
18471073
9.

Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).

Lu Q, Peevey J, Jow F, Monaghan MM, Mendoza G, Zhang H, Wu J, Kim CY, Bicksler J, Greenblatt L, Lin SS, Childers W, Bowlby MR.

Bioorg Med Chem. 2008 Mar 15;16(6):3067-75. doi: 10.1016/j.bmc.2007.12.031. Epub 2007 Dec 23.

PMID:
18226531
10.

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.

Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8. Epub 2007 Dec 27.

11.

Validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel enhancers using IonWorks HT.

Jow F, Shen R, Chanda P, Tseng E, Zhang H, Kennedy J, Dunlop J, Bowlby MR.

J Biomol Screen. 2007 Dec;12(8):1059-67.

PMID:
18087070
12.

Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).

Jow F, Tseng E, Maddox T, Shen R, Kowal D, Dunlop J, Mekonnen B, Wang K.

Assay Drug Dev Technol. 2006 Aug;4(4):443-50.

PMID:
16945016
13.

Validation of DRG-like F11 cells for evaluation of KCNQ/M-channel modulators.

Jow F, He L, Kramer A, Hinson J, Bowlby MR, Dunlop J, Wang K.

Assay Drug Dev Technol. 2006 Feb;4(1):49-56.

PMID:
16506888
14.

Identification and characterization of small molecule modulators of KChIP/Kv4 function.

Bowlby MR, Chanda P, Edris W, Hinson J, Jow F, Katz AH, Kennedy J, Krishnamurthy G, Pitts K, Ryan K, Zhang H, Greenblatt L.

Bioorg Med Chem. 2005 Nov 15;13(22):6112-9. Epub 2005 Aug 2.

PMID:
16081294
15.

Validation of an atomic absorption rubidium ion efflux assay for KCNQ/M-channels using the ion Channel Reader 8000.

Wang K, McIlvain B, Tseng E, Kowal D, Jow F, Shen R, Zhang H, Shan QJ, He L, Chen D, Lu Q, Dunlop J.

Assay Drug Dev Technol. 2004 Oct;2(5):525-34.

PMID:
15671650
16.

Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels.

Jow F, Zhang ZH, Kopsco DC, Carroll KC, Wang K.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15535-40. Epub 2004 Oct 14.

17.

Production of GABA by cultured hippocampal glial cells.

Jow F, Chiu D, Lim HK, Novak T, Lin S.

Neurochem Int. 2004 Jul-Aug;45(2-3):273-83.

PMID:
15145543
18.

Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lü Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ.

Neuron. 2004 Feb 19;41(4):587-98.

19.

Cloning and functional expression of rKCNQ2 K(+) channel from rat brain.

Jow F, Wang K.

Brain Res Mol Brain Res. 2000 Sep 15;80(2):269-78.

PMID:
11038262
21.
22.

Induction of Ca2+-activated K+ current and transient outward currents in human capillary endothelial cells.

Jow F, Sullivan K, Sokol P, Numann R.

J Membr Biol. 1999 Jan 1;167(1):53-64.

PMID:
9878075
24.

The airway-epithelium: a novel site of action by guanylin.

Zhang ZH, Jow F, Numann R, Hinson J.

Biochem Biophys Res Commun. 1998 Mar 6;244(1):50-6.

PMID:
9514862
25.

Elevation in intracellular calcium activates both chloride and proton currents in human macrophages.

Holevinsky KO, Jow F, Nelson DJ.

J Membr Biol. 1994 May;140(1):13-30.

PMID:
8051690
27.

Whole-cell currents in macrophages: I. Human monocyte-derived macrophages.

Nelson DJ, Jow B, Jow F.

J Membr Biol. 1990 Jul;117(1):29-44.

PMID:
2402007
28.

Voltage-gated chloride currents in cultured canine tracheal epithelial cells.

Schoppa N, Shorofsky SR, Jow F, Nelson DJ.

J Membr Biol. 1989 Apr;108(1):73-90.

PMID:
2473210

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