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COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis.

Warden CD, Lee H, Tompkins JD, Li X, Wang C, Riggs AD, Yu H, Jove R, Yuan YC.

Nucleic Acids Res. 2019 Sep 5;47(15):8335-8336. doi: 10.1093/nar/gkz663. No abstract available.


Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer.

Wen W, Han ES, Dellinger TH, Wu J, Guo Y, Buettner R, Horne DA, Jove R, Yim JH.

Transl Oncol. 2019 Aug;12(8):1015-1025. doi: 10.1016/j.tranon.2019.05.003. Epub 2019 May 26.


In silico prediction and characterisation of secondary metabolite clusters in the plant pathogenic fungus Verticillium dahliae.

Shi-Kunne X, Jové RP, Depotter JRL, Ebert MK, Seidl MF, Thomma BPHJ.

FEMS Microbiol Lett. 2019 Apr 1;366(7). pii: fnz081. doi: 10.1093/femsle/fnz081.


Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach.

Tchoumtchoua J, Halabalaki M, Gikas E, Tsarbopoulos A, Fotaki N, Liu L, Nam S, Jove R, Skaltsounis LA.

J Pharm Biomed Anal. 2019 Feb 5;164:317-325. doi: 10.1016/j.jpba.2018.10.039. Epub 2018 Oct 25.


Regenerative Medicine in the State of Florida: Letter Outlining the Florida Organization for Regenerative Medicine.

Bruce CJ, Bu G, Centanni JM, Davis MD, Dobson J, Hare JM, Fields GB, Jove R, Kenyon N, Khan A, March K, Matosevic S, Mahmood A, Pepine CJ, Ricordi C, Shapiro SA, Zylberberg C, Zylberberg E.

Stem Cells Transl Med. 2018 Jul;7(7):511-512. doi: 10.1002/sctm.18-0066. No abstract available.


JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.

Wang T, Fahrmann JF, Lee H, Li YJ, Tripathi SC, Yue C, Zhang C, Lifshitz V, Song J, Yuan Y, Somlo G, Jandial R, Ann D, Hanash S, Jove R, Yu H.

Cell Metab. 2018 Jun 5;27(6):1357. doi: 10.1016/j.cmet.2018.04.018. No abstract available.


Ruxolitinib synergistically enhances the anti-tumor activity of paclitaxel in human ovarian cancer.

Han ES, Wen W, Dellinger TH, Wu J, Lu SA, Jove R, Yim JH.

Oncotarget. 2018 Jan 31;9(36):24304-24319. doi: 10.18632/oncotarget.24368. eCollection 2018 May 11.


JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.

Wang T, Fahrmann JF, Lee H, Li YJ, Tripathi SC, Yue C, Zhang C, Lifshitz V, Song J, Yuan Y, Somlo G, Jandial R, Ann D, Hanash S, Jove R, Yu H.

Cell Metab. 2018 Jan 9;27(1):136-150.e5. doi: 10.1016/j.cmet.2017.11.001. Epub 2017 Dec 14. Erratum in: Cell Metab. 2018 Jun 5;27(6):1357.


Prognostic Significance of Neutrophilic Infiltration in Benign Lymph Nodes in Patients with Muscle-invasive Bladder Cancer.

Pal SK, Pham A, Vuong W, Liu X, Lin Y, Ruel N, Yuh BE, Chan K, Wilson T, Lerner SP, McConkey D, Jove R, Liang W.

Eur Urol Focus. 2017 Feb;3(1):130-135. doi: 10.1016/j.euf.2016.03.003. Epub 2016 Mar 25.


Synthesis and antiproliferative activity of new pyrazolo[3,4-c]pyridines.

Gavriil ES, Lougiakis N, Pouli N, Marakos P, Skaltsounis AL, Nam S, Jove R, Horne D, Gioti K, Pratsinis H, Kletsas D, Tenta R.

Med Chem. 2016 Dec 13. [Epub ahead of print]


Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.

Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ.

J Biol Chem. 2016 Oct 21;291(43):22844. No abstract available.


Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src.

Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, Nicosia SV, Cheng JQ.

J Biol Chem. 2016 Oct 21;291(43):22841. No abstract available.


Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.

Gaboriaud-Kolar N, Myrianthopoulos V, Vougogiannopoulou K, Gerolymatos P, Horne DA, Jove R, Mikros E, Nam S, Skaltsounis AL.

J Nat Prod. 2016 Oct 28;79(10):2464-2471. Epub 2016 Oct 11.


The discovery of new cytotoxic pyrazolopyridine derivatives.

Giannouli V, Lougiakis N, Kostakis IK, Pouli N, Marakos P, Skaltsounis AL, Nam S, Jove R, Horne D, Tenta R, Pratsinis H, Kletsas D.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5229-5233. doi: 10.1016/j.bmcl.2016.09.056. Epub 2016 Sep 24.


CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

Zhang C, Xin H, Zhang W, Yazaki PJ, Zhang Z, Le K, Li W, Lee H, Kwak L, Forman S, Jove R, Yu H.

Immunity. 2016 Apr 19;44(4):913-923. doi: 10.1016/j.immuni.2016.04.003.


Convection-enhanced delivery of sorafenib and suppression of tumor progression in a murine model of brain melanoma through the inhibition of signal transducer and activator of transcription 3.

Zou Z, Yin Y, Lin J, Hsu LC, Brandon VL, Yang F, Jove R, Jandial R, Li G, Chen MY.

J Neurosurg. 2016 May;124(5):1310-8. doi: 10.3171/2015.3.JNS132040. Epub 2015 Nov 6.


MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.

Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W.

J Clin Invest. 2015 Jun;125(6):2497-509. doi: 10.1172/JCI75438. Epub 2015 May 11.


Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer.

Wen W, Wu J, Liu L, Tian Y, Buettner R, Hsieh MY, Horne D, Dellinger TH, Han ES, Jove R, Yim JH.

Mol Cancer. 2015 May 1;14:100. doi: 10.1186/s12943-015-0366-5.


Revisiting STAT3 signalling in cancer: new and unexpected biological functions.

Yu H, Lee H, Herrmann A, Buettner R, Jove R.

Nat Rev Cancer. 2014 Nov;14(11):736-46. doi: 10.1038/nrc3818. Review.


Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer.

Wen W, Liang W, Wu J, Kowolik CM, Buettner R, Scuto A, Hsieh MY, Hong H, Brown CE, Forman SJ, Horne D, Morgan R, Wakabayashi M, Dellinger TH, Han ES, Yim JH, Jove R.

Mol Cancer Ther. 2014 Dec;13(12):3037-48. doi: 10.1158/1535-7163.MCT-14-0077. Epub 2014 Oct 15.


TLR9 is critical for glioma stem cell maintenance and targeting.

Herrmann A, Cherryholmes G, Schroeder A, Phallen J, Alizadeh D, Xin H, Wang T, Lee H, Lahtz C, Swiderski P, Armstrong B, Kowolik C, Gallia GL, Lim M, Brown C, Badie B, Forman S, Kortylewski M, Jove R, Yu H.

Cancer Res. 2014 Sep 15;74(18):5218-28. doi: 10.1158/0008-5472.CAN-14-1151. Epub 2014 Jul 21.


A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling.

Yang F, Nam S, Brown CE, Zhao R, Starr R, Ma Y, Xie J, Horne DA, Malkas LH, Jove R, Hickey RJ.

PLoS One. 2014 Apr 14;9(4):e94443. doi: 10.1371/journal.pone.0094443. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e100708. Ma, Yuelong [added]; Xie, Jun [added].


Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells.

Cook AM, Li L, Ho Y, Lin A, Li L, Stein A, Forman S, Perrotti D, Jove R, Bhatia R.

Blood. 2014 May 1;123(18):2826-37. doi: 10.1182/blood-2013-05-505735. Epub 2014 Mar 25.


Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling.

Schroeder A, Herrmann A, Cherryholmes G, Kowolik C, Buettner R, Pal S, Yu H, Müller-Newen G, Jove R.

Cancer Res. 2014 Feb 15;74(4):1227-37. doi: 10.1158/0008-5472.CAN-13-0594. Epub 2013 Oct 31.


MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells.

Liu L, Gaboriaud N, Vougogianopoulou K, Tian Y, Wu J, Wen W, Skaltsounis L, Jove R.

Cancer Biol Ther. 2014 Feb;15(2):178-84. doi: 10.4161/cbt.26721. Epub 2013 Nov 1.


miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis.

Fu X, Meng Z, Liang W, Tian Y, Wang X, Han W, Lou G, Wang X, Lou F, Yen Y, Yu H, Jove R, Huang W.

Oncogene. 2014 Aug 21;33(34):4296-306. doi: 10.1038/onc.2013.385. Epub 2013 Sep 23.


A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling.

Yang F, Nam S, Zhao R, Tian Y, Liu L, Horne DA, Jove R.

Cancer Biol Ther. 2013 Nov;14(11):1024-31. doi: 10.4161/cbt.26045. Epub 2013 Aug 28.


3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells.

Li MY, Tian Y, Shen L, Buettner R, Li HZ, Liu L, Yuan YC, Xiao Q, Wu J, Jove R.

Biochem Pharmacol. 2013 Nov 15;86(10):1411-8. doi: 10.1016/j.bcp.2013.08.065. Epub 2013 Sep 7.


[Cauda equina syndrome caused by paraganglioma of the filum terminale].

Undabeitia-Huertas J, Noboa R, Jové R, Boix M, Gatius S, Nogues P.

An Sist Sanit Navar. 2013 Sep 6;36(2):347-51. Spanish.


Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance.

Priceman SJ, Kujawski M, Shen S, Cherryholmes GA, Lee H, Zhang C, Kruper L, Mortimer J, Jove R, Riggs AD, Yu H.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13079-84. doi: 10.1073/pnas.1311557110. Epub 2013 Jul 22.


SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells.

Scuto A, Kirschbaum M, Buettner R, Kujawski M, Cermak JM, Atadja P, Jove R.

Cell Death Dis. 2013 May 16;4:e635. doi: 10.1038/cddis.2013.159.


Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma.

Ara T, Nakata R, Sheard MA, Shimada H, Buettner R, Groshen SG, Ji L, Yu H, Jove R, Seeger RC, DeClerck YA.

Cancer Res. 2013 Jul 1;73(13):3852-64. doi: 10.1158/0008-5472.CAN-12-2353. Epub 2013 Apr 30.


COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis.

Warden CD, Lee H, Tompkins JD, Li X, Wang C, Riggs AD, Yu H, Jove R, Yuan YC.

Nucleic Acids Res. 2013 Jun;41(11):e117. doi: 10.1093/nar/gkt242. Epub 2013 Apr 17. Erratum in: Nucleic Acids Res. 2019 Sep 5;47(15):8335-8336.


G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

Xin H, Lu R, Lee H, Zhang W, Zhang C, Deng J, Liu Y, Shen S, Wagner KU, Forman S, Jove R, Yu H.

J Biol Chem. 2013 May 10;288(19):13842-9. doi: 10.1074/jbc.M113.450049. Epub 2013 Apr 2.


General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.

DeLorbe JE, Horne D, Jove R, Mennen SM, Nam S, Zhang FL, Overman LE.

J Am Chem Soc. 2013 Mar 13;135(10):4117-28. doi: 10.1021/ja400315y. Epub 2013 Mar 1.


Amphidinolide B: total synthesis, structural investigation, and biological evaluation.

Lu L, Zhang W, Nam S, Horne DA, Jove R, Carter RG.

J Org Chem. 2013 Mar 15;78(6):2213-47. doi: 10.1021/jo3026077. Epub 2013 Feb 13.


The international translational regenerative medicine center.

Alexis Mde V, Grinnemo KH, Jove R.

Regen Med. 2012 Nov;7(6 Suppl):74-5. doi: 10.2217/rme.12.72.


Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.

Nam S, Wen W, Schroeder A, Herrmann A, Yu H, Cheng X, Merz KH, Eisenbrand G, Li H, Yuan YC, Jove R.

Mol Oncol. 2013 Jun;7(3):369-78. doi: 10.1016/j.molonc.2012.10.013. Epub 2012 Nov 16.


Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.

Tian Y, Nam S, Liu L, Yakushijin F, Yakushijin K, Buettner R, Liang W, Yang F, Ma Y, Horne D, Jove R.

PLoS One. 2012;7(11):e49306. doi: 10.1371/journal.pone.0049306. Epub 2012 Nov 16.


Evaluation of a vancomycin dosing regimen for patients on high flux hemodialysis: an observational study.

Soto Guerrero Y, Hernández Castillo R, Santiago E, Ramírez Yuch N, Jaume Anselmi F, Jové R, Flores R, Lebrón R, Ramírez Rivera J.

Bol Asoc Med P R. 2012 Jul-Sep;104(3):10-4.


1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.

Singhal SS, Figarola J, Singhal J, Leake K, Nagaprashantha L, Lincoln C, Gabriel Gugiu B, Horne D, Jove R, Awasthi S, Rahbar S.

Biochem Pharmacol. 2012 Dec 1;84(11):1419-27. doi: 10.1016/j.bcp.2012.08.020. Epub 2012 Aug 28.


A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling.

Liu L, Kritsanida M, Magiatis P, Gaboriaud N, Wang Y, Wu J, Buettner R, Yang F, Nam S, Skaltsounis L, Jove R.

Cancer Biol Ther. 2012 Nov;13(13):1255-61. doi: 10.4161/cbt.21781. Epub 2012 Aug 16.


Synthesis and in vitro biological evaluation of novel pyrazole derivatives as potential antitumor agents.

Christodoulou MS, Fokialakis N, Nam S, Jove R, Skaltsounis AL, Haroutounian SA.

Med Chem. 2012 Sep;8(5):779-88.


Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells.

Nam S, Xie J, Perkins A, Ma Y, Yang F, Wu J, Wang Y, Xu RZ, Huang W, Horne DA, Jove R.

Mol Oncol. 2012 Oct;6(5):484-93. doi: 10.1016/j.molonc.2012.05.002. Epub 2012 Jun 2.


Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.

Kouloura E, Halabalaki M, Lallemand MC, Nam S, Jove R, Litaudon M, Awang K, Hadi HA, Skaltsounis AL.

J Nat Prod. 2012 Jul 27;75(7):1270-6. doi: 10.1021/np201007a. Epub 2012 Jun 18.


S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

Deng J, Liu Y, Lee H, Herrmann A, Zhang W, Zhang C, Shen S, Priceman SJ, Kujawski M, Pal SK, Raubitschek A, Hoon DS, Forman S, Figlin RA, Liu J, Jove R, Yu H.

Cancer Cell. 2012 May 15;21(5):642-54. doi: 10.1016/j.ccr.2012.03.039.


Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

Lee H, Zhang P, Herrmann A, Yang C, Xin H, Wang Z, Hoon DS, Forman SJ, Jove R, Riggs AD, Yu H.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7765-9. doi: 10.1073/pnas.1205132109. Epub 2012 Apr 30.


Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.

Yang F, Jove V, Buettner R, Xin H, Wu J, Wang Y, Nam S, Xu Y, Ara T, DeClerck YA, Seeger R, Yu H, Jove R.

Cancer Biol Ther. 2012 May;13(7):534-41. doi: 10.4161/cbt.19603. Epub 2012 May 1.


Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.

Nam S, Scuto A, Yang F, Chen W, Park S, Yoo HS, Konig H, Bhatia R, Cheng X, Merz KH, Eisenbrand G, Jove R.

Mol Oncol. 2012 Jun;6(3):276-83. doi: 10.1016/j.molonc.2012.02.002. Epub 2012 Feb 17.


Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor.

Yang F, Jove V, Chang S, Hedvat M, Liu L, Buettner R, Tian Y, Scuto A, Wen W, Yip ML, Van Meter T, Yen Y, Jove R.

Cancer Biol Ther. 2012 Apr;13(6):349-57. doi: 10.4161/cbt.19239. Epub 2012 Apr 1.

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