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High-salt-recovered sequences are associated with the active chromosomal compartment and with large ribonucleoprotein complexes including nuclear bodies.

Baudement MO, Cournac A, Court F, Seveno M, Parrinello H, Reynes C, Sabatier R, Bouschet T, Yi Z, Sallis S, Tancelin M, Rebouissou C, Cathala G, Lesne A, Mozziconacci J, Journot L, Forné T.

Genome Res. 2018 Nov;28(11):1733-1746. doi: 10.1101/gr.237073.118. Epub 2018 Oct 4.


Mouse Parthenogenetic Embryonic Stem Cells with Biparental-Like Expression of Imprinted Genes Generate Cortical-Like Neurons That Integrate into the Injured Adult Cerebral Cortex.

Varrault A, Eckardt S, Girard B, Le Digarcher A, Sassetti I, Meusnier C, Ripoll C, Badalyan A, Bertaso F, McLaughlin KJ, Journot L, Bouschet T.

Stem Cells. 2018 Feb;36(2):192-205. doi: 10.1002/stem.2721. Epub 2017 Nov 10.


Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.

Varrault A, Dantec C, Le Digarcher A, Chotard L, Bilanges B, Parrinello H, Dubois E, Rialle S, Severac D, Bouschet T, Journot L.

Nucleic Acids Res. 2017 Oct 13;45(18):10466-10480. doi: 10.1093/nar/gkx672.


Evolution of gene expression after whole-genome duplication: New insights from the spotted gar genome.

Pasquier J, Braasch I, Batzel P, Cabau C, Montfort J, Nguyen T, Jouanno E, Berthelot C, Klopp C, Journot L, Postlethwait JH, Guiguen Y, Bobe J.

J Exp Zool B Mol Dev Evol. 2017 Nov;328(7):709-721. doi: 10.1002/jez.b.22770. Epub 2017 Sep 25.


Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.

Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J.

BMC Genomics. 2016 May 18;17:368. doi: 10.1186/s12864-016-2709-z.


In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression.

Bouschet T, Dubois E, Reynès C, Kota SK, Rialle S, Maupetit-Méhouas S, Pezet M, Le Digarcher A, Nidelet S, Demolombe V, Cavelier P, Meusnier C, Maurizy C, Sabatier R, Feil R, Arnaud P, Journot L, Varrault A.

Cereb Cortex. 2017 Mar 1;27(3):2418-2433. doi: 10.1093/cercor/bhw102.


Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1.

Adnani L, Langevin LM, Gautier E, Dixit R, Parsons K, Li S, Kaushik G, Wilkinson G, Wilson R, Childs S, Nguyen MD, Journot L, Dehay C, Schuurmans C.

J Neurosci. 2015 Sep 30;35(39):13430-47. doi: 10.1523/JNEUROSCI.0777-15.2015. Erratum in: J Neurosci. 2015 Nov 25;35(47):15767.


A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation.

Al Adhami H, Evano B, Le Digarcher A, Gueydan C, Dubois E, Parrinello H, Dantec C, Bouschet T, Varrault A, Journot L.

Genome Res. 2015 Mar;25(3):353-67. doi: 10.1101/gr.175919.114. Epub 2015 Jan 22.


ICR noncoding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain.

Kota SK, Llères D, Bouschet T, Hirasawa R, Marchand A, Begon-Pescia C, Sanli I, Arnaud P, Journot L, Girardot M, Feil R.

Dev Cell. 2014 Oct 13;31(1):19-33. doi: 10.1016/j.devcel.2014.08.009. Epub 2014 Sep 25.


Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies.

Bousquet J, Jorgensen C, Dauzat M, Cesario A, Camuzat T, Bourret R, Best N, Anto JM, Abecassis F, Aubas P, Avignon A, Badin M, Bedbrook A, Blain H, Bourdin A, Bringer J, Camu W, Cayla G, Costa DJ, Courtet P, Cristol JP, Demoly P, de la Coussaye JE, Fesler P, Gouzi F, Gris JC, Guillot B, Hayot M, Jeandel C, Jonquet O, Journot L, Lehmann S, Mathieu G, Morel J, Ninot G, Pelissier J, Picot MC, Radier-Pontal F, Robine JM, Rodier M, Roubille F, Sultan A, Wojtusciszyn A, Auffray C, Balling R, Barbara C, Cambon-Thomsen A, Chavannes NH, Chuchalin A, Crooks G, Dedeu A, Fabbri LM, Garcia-Aymerich J, Hajjam J, Melo Gomes E, Palkonen S, Piette F, Pison C, Price D, Samolinski B, Schunemann HJ, Sterk PJ, Yiallouros P, Roca J, Van de Perre P, Mercier J.

Curr Pharm Des. 2014;20(38):5928-44. Review.


Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon.

Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, Guillemot F, Vanderhaeghen P, Bouschet T.

PLoS One. 2012;7(11):e48675. doi: 10.1371/journal.pone.0048675. Epub 2012 Nov 6.


Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression.

Borensztein M, Viengchareun S, Montarras D, Journot L, Binart N, Lombès M, Dandolo L.

FASEB J. 2012 Nov;26(11):4584-91. doi: 10.1096/fj.12-208496. Epub 2012 Aug 2.


Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling.

Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3047-52. doi: 10.1073/pnas.1109457109. Epub 2012 Feb 6.


Genome-wide profiling of G protein-coupled receptors in cerebellar granule neurons using high-throughput, real-time PCR.

Maurel B, Le Digarcher A, Dantec C, Journot L.

BMC Genomics. 2011 May 16;12:241. doi: 10.1186/1471-2164-12-241.


The 'PUCE CAFE' Project: the first 15K coffee microarray, a new tool for discovering candidate genes correlated to agronomic and quality traits.

Privat I, Bardil A, Gomez AB, Severac D, Dantec C, Fuentes I, Mueller L, Joët T, Pot D, Foucrier S, Dussert S, Leroy T, Journot L, de Kochko A, Campa C, Combes MC, Lashermes P, Bertrand B.

BMC Genomics. 2011 Jan 5;12:5. doi: 10.1186/1471-2164-12-5.


Viral induction of Zac1b through TLR3- and IRF3-dependent pathways.

Warzée B, Mesnil C, Hober D, Caloone D, Pirottin D, Garigliany MM, Desmecht D, Drion PV, Journot L, Lekeux P, Bureau F, Desmet CJ.

Mol Immunol. 2010 Nov-Dec;48(1-3):119-27. doi: 10.1016/j.molimm.2010.09.004. Epub 2010 Oct 13.


In vitro fertilization and embryo culture strongly impact the placental transcriptome in the mouse model.

Fauque P, Mondon F, Letourneur F, Ripoche MA, Journot L, Barbaux S, Dandolo L, Patrat C, Wolf JP, Jouannet P, Jammes H, Vaiman D.

PLoS One. 2010 Feb 15;5(2):e9218. doi: 10.1371/journal.pone.0009218.


Modulation of imprinted gene network in placenta results in normal development of in vitro manipulated mouse embryos.

Fauque P, Ripoche MA, Tost J, Journot L, Gabory A, Busato F, Le Digarcher A, Mondon F, Gut I, Jouannet P, Vaiman D, Dandolo L, Jammes H.

Hum Mol Genet. 2010 May 1;19(9):1779-90. doi: 10.1093/hmg/ddq059. Epub 2010 Feb 11.


H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.

Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forné T, Jammes H, Ainscough JF, Surani MA, Journot L, Dandolo L.

Development. 2009 Oct;136(20):3413-21. doi: 10.1242/dev.036061. Epub 2009 Sep 17.


Identification of potential pharmacological targets by analysis of the comprehensive G protein-coupled receptor repertoire in the four cardiac chambers.

Moore-Morris T, Varrault A, Mangoni ME, Le Digarcher A, Negre V, Dantec C, Journot L, Nargeot J, Couette B.

Mol Pharmacol. 2009 May;75(5):1108-16. doi: 10.1124/mol.108.054155. Epub 2009 Feb 19.


Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.

Ma L, Cantrup R, Varrault A, Colak D, Klenin N, Götz M, McFarlane S, Journot L, Schuurmans C.

Neural Dev. 2007 Jun 8;2:11.


Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth.

Varrault A, Gueydan C, Delalbre A, Bellmann A, Houssami S, Aknin C, Severac D, Chotard L, Kahli M, Le Digarcher A, Pavlidis P, Journot L.

Dev Cell. 2006 Nov;11(5):711-22.


The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas.

Basyuk E, Coulon V, Le Digarcher A, Coisy-Quivy M, Moles JP, Gandarillas A, Journot L.

Mol Cancer Res. 2005 Sep;3(9):483-92.


Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylInositol 3-kinase inhibition.

Perez V, Bouschet T, Fernandez C, Bockaert J, Journot L.

Eur J Neurosci. 2005 Jan;21(1):26-32.


Genes regulated in neurons undergoing transcription-dependent apoptosis belong to signaling pathways rather than the apoptotic machinery.

Desagher S, Severac D, Lipkin A, Bernis C, Ritchie W, Le Digarcher A, Journot L.

J Biol Chem. 2005 Feb 18;280(7):5693-702. Epub 2004 Nov 12.


Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation.

Valente T, Domínguez MI, Bellmann A, Journot L, Ferrer I, Auladell C.

Neuroscience. 2004;128(2):323-36.


Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding.

Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D.

Mol Cell Biol. 2003 Feb;23(3):988-1003.


Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells.

Bouschet T, Perez V, Fernandez C, Bockaert J, Eychene A, Journot L.

J Biol Chem. 2003 Feb 14;278(7):4778-85. Epub 2002 Dec 6.


Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

Desagher S, Osen-Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, Journot L, Antonsson B, Martinou JC.

Mol Cell. 2001 Sep;8(3):601-11.


Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities.

Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L.

Oncogene. 2001 Mar 8;20(10):1246-53.


Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.

Varrault A, Bilanges B, Mackay DJ, Basyuk E, Ahr B, Fernandez C, Robinson DO, Bockaert J, Journot L.

J Biol Chem. 2001 Jun 1;276(22):18653-6. Epub 2001 Apr 10.


The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.

Pagotto U, Arzberger T, Theodoropoulou M, Grübler Y, Pantaloni C, Saeger W, Losa M, Journot L, Stalla GK, Spengler D.

Cancer Res. 2000 Dec 15;60(24):6794-9.


Alkaline fixation drastically improves the signal of in situ hybridization.

Basyuk E, Bertrand E, Journot L.

Nucleic Acids Res. 2000 May 15;28(10):E46.


Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.

Bilanges B, Varrault A, Basyuk E, Rodriguez C, Mazumdar A, Pantaloni C, Bockaert J, Theillet C, Spengler D, Journot L.

Oncogene. 1999 Jul 8;18(27):3979-88.


Induction of the PAC1-R (PACAP-type I receptor) gene by p53 and Zac.

Ciani E, Hoffmann A, Schmidt P, Journot L, Spengler D.

Brain Res Mol Brain Res. 1999 Jun 8;69(2):290-4.


PACAP-38 protects cerebellar granule cells from apoptosis.

Journot L, Villalba M, Bockaert J.

Ann N Y Acad Sci. 1998 Dec 11;865:100-10. Review.


Induction of type I PACAP receptor expression by the new zinc finger protein Zac1 and p53.

Hoffmann A, Ciani E, Houssami S, Brabet P, Journot L, Spengler D.

Ann N Y Acad Sci. 1998 Dec 11;865:49-58. Review.


Inhibition of Zac1, a new gene differentially expressed in the anterior pituitary, increases cell proliferation.

Pagotto U, Arzberger T, Ciani E, Lezoualc'h F, Pilon C, Journot L, Spengler D, Stalla GK.

Endocrinology. 1999 Feb;140(2):987-96.


hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer.

Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8835-40.


International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.

Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings SR, Robberecht P, Said SI, Sreedharan SP, Wank SA, Waschek JA.

Pharmacol Rev. 1998 Jun;50(2):265-70. Review. No abstract available.


Do recombinant receptor assays provide affinity and potency estimates?

Bockaert J, Brand C, Journot L.

Ann N Y Acad Sci. 1997 May 30;812:55-70. Review. No abstract available.


Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain.

Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L.

EMBO J. 1997 May 15;16(10):2814-25.


PACAP/VIP receptor subtypes, signal transducers, and effectors in pituitary cells.

Hezareh M, Journot L, Bépoldin L, Schlegel W, Rawlings SR.

Ann N Y Acad Sci. 1996 Dec 26;805:315-27; discussion 327-8. Review.


Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.

Claeysen S, Sebben M, Journot L, Bockaert J, Dumuis A.

FEBS Lett. 1996 Nov 25;398(1):19-25.


Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization.

Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S.

Genomics. 1996 Nov 15;38(1):100-2. No abstract available.


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