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Items: 21

1.

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Jun 26. pii: S2405-4712(19)30190-5. doi: 10.1016/j.cels.2019.05.009. [Epub ahead of print]

PMID:
31302152
Free Article
2.

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.

van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB.

Elife. 2019 May 24;8. pii: e44635. doi: 10.7554/eLife.44635.

3.

Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.

PMID:
30952657
4.

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Feb 27;8(2):163-167.e2. doi: 10.1016/j.cels.2019.01.005. Epub 2019 Feb 20.

PMID:
30797774
5.

Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes.

Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB.

Cancer Res. 2019 Apr 15;79(8):1952-1966. doi: 10.1158/0008-5472.CAN-18-1604. Epub 2019 Feb 12.

PMID:
30755444
6.

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.

Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL, Johnson AJ, Lu FK, Xie XS, Joughin BA, Reddy RJ, Peng S, Abdelmoula WM, Jackson PR, Kolluri A, Kellersberger KA, Agar JN, Lauffenburger DA, Swanson KR, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR.

Nat Commun. 2018 Nov 21;9(1):4904. doi: 10.1038/s41467-018-07334-3.

7.

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.

Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wang X, Wishnok JS, Feng G, Tannenbaum SR.

Mol Psychiatry. 2018 Jul 9. doi: 10.1038/s41380-018-0113-6. [Epub ahead of print]

PMID:
29988084
8.

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.

Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA.

Sci Signal. 2018 Mar 6;11(520). pii: eaal1601. doi: 10.1126/scisignal.aal1601.

9.

Systems Approaches to Cancer Biology.

Archer TC, Fertig EJ, Gosline SJ, Hafner M, Hughes SK, Joughin BA, Meyer AS, Piccolo SR, Shajahan-Haq AN.

Cancer Res. 2016 Dec 1;76(23):6774-6777. Epub 2016 Nov 18.

10.

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD.

Cancer Res. 2017 Jan 1;77(1):198-206. doi: 10.1158/0008-5472.CAN-16-1151. Epub 2016 Oct 28.

11.

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.

Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, Lauffenburger DA, Gertler FB.

Mol Biol Cell. 2015 Nov 1;26(21):3867-78. doi: 10.1091/mbc.E15-06-0442. Epub 2015 Sep 2.

12.

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.

Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ.

Sci Signal. 2015 May 26;8(378):ra51. doi: 10.1126/scisignal.aaa1977.

13.

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.

Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT.

Genes Dev. 2015 Mar 1;29(5):483-8. doi: 10.1101/gad.254151.114.

14.

Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.

Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2574-83. doi: 10.1098/rstb.2012.0010.

15.

Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome.

Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K.

Mol Cell Proteomics. 2011 Nov;10(11):M111.008540. doi: 10.1074/mcp.M111.008540. Epub 2011 Aug 21.

16.

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.

Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB.

Sci Signal. 2011 Jun 28;4(179):ra42. doi: 10.1126/scisignal.2001796.

17.

PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies.

Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM.

Mol Cell Proteomics. 2010 Nov;9(11):2558-70. doi: 10.1074/mcp.M110.001206. Epub 2010 Jul 14.

18.

An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells.

Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM.

Mol Biosyst. 2009 Jan;5(1):59-67. doi: 10.1039/b815075c. Epub 2008 Oct 30.

19.

Action-at-a-distance interactions enhance protein binding affinity.

Joughin BA, Green DF, Tidor B.

Protein Sci. 2005 May;14(5):1363-9. Epub 2005 Mar 31.

20.

A computational method for the analysis and prediction of protein:phosphopeptide-binding sites.

Joughin BA, Tidor B, Yaffe MB.

Protein Sci. 2005 Jan;14(1):131-9. Epub 2004 Dec 2.

21.

Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.

Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR.

Mol Cell Biol. 2003 Aug;23(15):5376-87.

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