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In vitro and in vivo anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules.

Leng KM, Vijayarathna S, Jothy SL, Sasidharan S, Kanwar JR.

Future Sci OA. 2017 Nov 16;4(2):FSO257. doi: 10.4155/fsoa-2017-0085. eCollection 2018 Feb.


Severe Acute Interstitial Nephritis: Response to Therapy With Antithymocyte Globulin.

Shao T, Weinstein J, Jothy S, Goldstein M.

Kidney Int Rep. 2016 Oct 6;2(2):138-141. doi: 10.1016/j.ekir.2016.09.059. eCollection 2017 Mar. No abstract available.


In vitro and in vivo toxicity assessment of alginate/eudragit S 100-enclosed chitosan-calcium phosphate-loaded iron saturated bovine lactoferrin nanocapsules (Fe-bLf NCs).

Leng KM, Vijayarathna S, Jothy SL, Sasidharan S, Kanwar JR.

Biomed Pharmacother. 2018 Jan;97:26-37. doi: 10.1016/j.biopha.2017.10.121. Epub 2017 Nov 6.


Magnetic Resonance Elastography to Assess Fibrosis in Kidney Allografts.

Kirpalani A, Hashim E, Leung G, Kim JK, Krizova A, Jothy S, Deeb M, Jiang NN, Glick L, Mnatzakanian G, Yuen DA.

Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1671-1679. doi: 10.2215/CJN.01830217. Epub 2017 Aug 30.


Role of Magnetic Resonance Elastography as a Noninvasive Measurement Tool of Fibrosis in a Renal Allograft: A Case Report.

Kim JK, Yuen DA, Leung G, Jothy S, Zaltzman J, Ramesh Prasad GV, Prabhudesai V, Mnatzakanian G, Kirpalani A.

Transplant Proc. 2017 Sep;49(7):1555-1559. doi: 10.1016/j.transproceed.2017.04.002.


The role of thrombectomy and diffusion-weighted imaging with MRI in post-transplant renal vein thrombosis: a case report.

Misra P, Kirpalani A, Leung G, Vlachou PA, Lee JY, Jothy S, Zaltzman J, Yuen DA.

BMC Nephrol. 2017 Jul 10;18(1):224. doi: 10.1186/s12882-017-0618-2.


Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.

Van Der Kraak L, Langlais D, Jothy S, Beauchemin N, Gros P.

Mamm Genome. 2016 Jun;27(5-6):213-24. doi: 10.1007/s00335-016-9625-z. Epub 2016 Mar 15.


Exploration of the anticandidal mechanism of Cassia spectabilis in debilitating candidiasis.

Torey A, Vijayarathna S, Jothy SL, Gothai S, Chen Y, Latha LY, Kanwar JR, Dharmaraj S, Sasidharan S.

J Tradit Complement Med. 2015 Jan 19;6(1):97-104. doi: 10.1016/j.jtcme.2014.11.017. eCollection 2016 Jan.


Deactivation of Telomerase Enzyme and Telomere Destabilization by Natural Products: a Potential Target for Cancer Green Therapy.

Sasidharan S, Jothy SL, Kavitha N, Chen Y, Kanwar JR.

Asian Pac J Cancer Prev. 2015;16(18):8671. No abstract available.


Regulating Mitochondrial Biogenesis: from Herbal Remedies to Phytomedicine for Cancer Prevention.

Jothy SL, Vijayarathna S, Chen Y, Kanwar JR, Sasidharan S.

Asian Pac J Cancer Prev. 2015;16(17):8015. No abstract available.


Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets.

Vijayarathna S, Gothai S, Jothy SL, Chen Y, Kanwar JR, Sasidharan S.

Asian Pac J Cancer Prev. 2015;16(17):7435-9. Review.


Radioprotective activity of Polyalthia longifolia standardized extract against X-ray radiation injury in mice.

Jothy SL, Saito T, Kanwar JR, Chen Y, Aziz A, Yin-Hui L, Sasidharan S.

Phys Med. 2016 Jan;32(1):150-61. doi: 10.1016/j.ejmp.2015.10.090. Epub 2015 Oct 30.


Anti-Cancer Natural Products Inducing Cross-talk between Apoptosis and Autophagy Mutual Proteins to Regulate Cancer Cell Death: Design of Future Green Anticancer Therapies.

Vijayarathna S, Jothy SL, Chen Y, Kanwar JR, Sasidharan S.

Asian Pac J Cancer Prev. 2015;16(14):6175-6. No abstract available.


Evaluation of the cytotoxicity, cell-cycle arrest, and apoptotic induction by Euphorbia hirta in MCF-7 breast cancer cells.

Kwan YP, Saito T, Ibrahim D, Al-Hassan FM, Ein Oon C, Chen Y, Jothy SL, Kanwar JR, Sasidharan S.

Pharm Biol. 2016 Jul;54(7):1223-36. doi: 10.3109/13880209.2015.1064451. Epub 2015 Jul 8.


MicroRNAs: association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches.

Jothy SL, Chen Y, Vijayarathna S, Kanwar JR, Sasidharan S.

Curr Gene Ther. 2015;15(1):15-20. Review.


In vitro and in vivo antifungal activity of Cassia surattensis flower against Aspergillus niger.

Sumathy V, Zakaria Z, Jothy SL, Gothai S, Vijayarathna S, Yoga Latha L, Chen Y, Sasidharan S.

Microb Pathog. 2014 Dec;77:7-12. doi: 10.1016/j.micpath.2014.10.004. Epub 2014 Oct 13.


A clinical and pathological variant of acute transplant glomerulopathy.

Molnar MZ, Prasad GV, Yuen DA, Jothy S, Zaltzman JS.

Case Rep Pathol. 2014;2014:961987. doi: 10.1155/2014/961987. Epub 2014 Sep 11.


MicroRNAs: biogenesis, roles for carcinogenesis and as potential biomarkers for cancer diagnosis and prognosis.

Kavitha N, Vijayarathna S, Jothy SL, Oon CE, Chen Y, Kanwar JR, Sasidharan S.

Asian Pac J Cancer Prev. 2014;15(18):7489-97. Review.


Injurious mechanical ventilation causes kidney apoptosis and dysfunction during sepsis but not after intra-tracheal acid instillation: an experimental study.

Kuiper JW, Groeneveld AB, Haitsma JJ, Smeding L, Begieneman MP, Jothy S, Vaschetto R, Plötz FB.

BMC Nephrol. 2014 Jul 29;15:126. doi: 10.1186/1471-2369-15-126.


Natural pro-oxidants: an alternative remedy to explore as novel cancer therapeutic agents.

Jothy SL, Oon CE, Sasidharan S.

Asian Pac J Cancer Prev. 2014;15(3):1501. No abstract available.


MicroRNA pathways: an emerging role in identification of therapeutic strategies.

Vijayarathna S, Oon CE, Jothy SL, Chen Y, Kanwar JR, Sasidharan S.

Curr Gene Ther. 2014;14(2):112-20. Review.


Evaluation of the Genotoxic Potential against H2O2-Radical-Mediated DNA Damage and Acute Oral Toxicity of Standardized Extract of Polyalthia longifolia Leaf.

Jothy SL, Chen Y, Kanwar JR, Sasidharan S.

Evid Based Complement Alternat Med. 2013;2013:925380. doi: 10.1155/2013/925380. Epub 2013 Jun 24.


Evaluation of the effect of Cassia surattensis Burm. f., flower methanolic extract on the growth and morphology of Aspergillus niger.

Sumathy V, Zakaria Z, Chen Y, Latha LY, Jothy SL, Vijayarathna S, Sasidharan S.

Eur Rev Med Pharmacol Sci. 2013 Jun;17(12):1648-54.


Digital pathology: Attitudes and practices in the Canadian pathology community.

Bellis M, Metias S, Naugler C, Pollett A, Jothy S, Yousef GM.

J Pathol Inform. 2013 Mar 14;4:3. doi: 10.4103/2153-3539.108540. Print 2013.


Antioxidant activity of methanol extracts of different parts of Lantana camara.

Mahdi-Pour B, Jothy SL, Latha LY, Chen Y, Sasidharan S.

Asian Pac J Trop Biomed. 2012 Dec;2(12):960-5. doi: 10.1016/S2221-1691(13)60007-6.


Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury.

Jothy SL, Aziz A, Chen Y, Sasidharan S.

Evid Based Complement Alternat Med. 2012;2012:561284. doi: 10.1155/2012/561284. Epub 2012 Nov 8.


Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage.

Grace-Lynn C, Chen Y, Latha LY, Kanwar JR, Jothy SL, Vijayarathna S, Sasidharan S.

Molecules. 2012 Nov 23;17(12):13937-47. doi: 10.3390/molecules171213937. Retraction in: Sasidharan S. Molecules. 2013;18(4):3839-40.


In vitro antioxidant activity potential of lantadene A, a pentacyclic triterpenoid of Lantana plants.

Grace-Lynn C, Darah I, Chen Y, Latha LY, Jothy SL, Sasidharan S.

Molecules. 2012 Sep 19;17(9):11185-98.


Cassia spectabilis (DC) Irwin et Barn: a promising traditional herb in health improvement.

Jothy SL, Torey A, Darah I, Choong YS, Saravanan D, Chen Y, Latha LY, Deivanai S, Sasidharan S.

Molecules. 2012 Aug 29;17(9):10292-305. doi: 10.3390/molecules170910292. Review.


Acute toxicity impacts of Euphorbia hirta L extract on behavior, organs body weight index and histopathology of organs of the mice and Artemia salina.

Rajeh MA, Kwan YP, Zakaria Z, Latha LY, Jothy SL, Sasidharan S.

Pharmacognosy Res. 2012 Jul;4(3):170-7. doi: 10.4103/0974-8490.99085.


Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation.

Glinka Y, Mohammed N, Subramaniam V, Jothy S, Prud'homme GJ.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):775-80. doi: 10.1016/j.bbrc.2012.07.151. Epub 2012 Aug 2.


In vitro, in situ and in vivo studies on the anticandidal activity of Cassia fistula seed extract.

Jothy SL, Zakariah Z, Chen Y, Sasidharan S.

Molecules. 2012 Jun 7;17(6):6997-7009. doi: 10.3390/molecules17066997.


High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study.

Kuiper JW, Plötz FB, Groeneveld AJ, Haitsma JJ, Jothy S, Vaschetto R, Zhang H, Slutsky AS.

BMC Anesthesiol. 2011 Dec 28;11:26. doi: 10.1186/1471-2253-11-26.


Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.

Nithianantham K, Shyamala M, Chen Y, Latha LY, Jothy SL, Sasidharan S.

Molecules. 2011 Dec 6;16(12):10134-45. doi: 10.3390/molecules161210134.


Bioassay-directed isolation of active compounds with antiyeast activity from a Cassia fistula seed extract.

Jothy SL, Zakaria Z, Chen Y, Lau YL, Latha LY, Shin LN, Sasidharan S.

Molecules. 2011 Sep 5;16(9):7583-92. doi: 10.3390/molecules16097583.


Acute oral toxicity of methanolic seed extract of Cassia fistula in mice.

Jothy SL, Zakaria Z, Chen Y, Lau YL, Latha LY, Sasidharan S.

Molecules. 2011 Jun 23;16(6):5268-82. doi: 10.3390/molecules16065268.


A two-locus system controls susceptibility to colitis-associated colon cancer in mice.

Van Der Kraak L, Meunier C, Turbide C, Jothy S, Gaboury L, Marcus V, Chang SY, Beauchemin N, Gros P.

Oncotarget. 2010 Oct;1(6):436-46.


Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist.

Prud'homme GJ, Glinka Y, Toulina A, Ace O, Subramaniam V, Jothy S.

PLoS One. 2010 Nov 3;5(11):e13831. doi: 10.1371/journal.pone.0013831.


Tranilast treatment decreases cell growth, migration and inhibits colony formation of human breast cancer cells.

Subramaniam V, Ace O, Prud'homme GJ, Jothy S.

Exp Mol Pathol. 2011 Feb;90(1):116-22. doi: 10.1016/j.yexmp.2010.10.012. Epub 2010 Oct 30.



Gupta AK, Jothy S, Somerville P, Zaltzman JS.

NDT Plus. 2010 Jun;3(3):326-327. doi: 10.1093/ndtplus/sfq040. Epub 2010 Feb 28. No abstract available.


Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer.

Subramaniam V, Chakrabarti R, Prud'homme GJ, Jothy S.

Anticancer Drugs. 2010 Apr;21(4):351-61. doi: 10.1097/CAD.0b013e328334992c.


Hypocomplementaemic immune complex tubulointerstitial nephritis.

Gupta A, Jothy S, Somerville P, Zaltzman JS.

NDT Plus. 2010 Feb;3(1):78-80. doi: 10.1093/ndtplus/sfp141. Epub 2009 Oct 7.


Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.

Meunier C, Cai J, Fortin A, Kwan T, Marquis JF, Turbide C, Van Der Kraak L, Jothy S, Beauchemin N, Gros P.

Oncogene. 2010 Feb 4;29(5):647-61. doi: 10.1038/onc.2009.369. Epub 2009 Nov 16.


Tranilast inhibits the growth and metastasis of mammary carcinoma.

Chakrabarti R, Subramaniam V, Abdalla S, Jothy S, Prud'homme GJ.

Anticancer Drugs. 2009 Jun;20(5):334-45. doi: 10.1097/CAD.0b013e328327994e.


Glypican-3 is overexpressed in lung squamous cell carcinoma, but not in adenocarcinoma.

Aviel-Ronen S, Lau SK, Pintilie M, Lau D, Liu N, Tsao MS, Jothy S.

Mod Pathol. 2008 Jul;21(7):817-25. doi: 10.1038/modpathol.2008.37. Epub 2008 May 9.


Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells.

Subramaniam V, Gardner H, Jothy S.

Exp Mol Pathol. 2007 Dec;83(3):341-6. Epub 2007 Sep 7.


Suppression of human colon cancer tumors in nude mice by siRNA CD44 gene therapy.

Subramaniam V, Vincent IR, Gilakjan M, Jothy S.

Exp Mol Pathol. 2007 Dec;83(3):332-40. Epub 2007 Sep 7.


CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation.

Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S.

Exp Mol Pathol. 2007 Oct;83(2):207-15. Epub 2007 May 13.


Glypican-3: from the mutations of Simpson-Golabi-Behmel genetic syndrome to a tumor marker for hepatocellular carcinoma.

Jakubovic BD, Jothy S.

Exp Mol Pathol. 2007 Apr;82(2):184-9. Epub 2007 Jan 26. Review. No abstract available.


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