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Items: 1 to 50 of 69


High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.

Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12828-12832. doi: 10.1073/pnas.1903562116. Epub 2019 Jun 10.


Decoding the 5' nucleotide bias of PIWI-interacting RNAs.

Stein CB, Genzor P, Mitra S, Elchert AR, Ipsaro JJ, Benner L, Sobti S, Su Y, Hammell M, Joshua-Tor L, Haase AD.

Nat Commun. 2019 Feb 19;10(1):828. doi: 10.1038/s41467-019-08803-z.


ELTA: Enzymatic Labeling of Terminal ADP-Ribose.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL.

Mol Cell. 2019 Feb 21;73(4):845-856.e5. doi: 10.1016/j.molcel.2018.12.022. Epub 2019 Jan 31.


A structural view of the initiators for chromosome replication.

On KF, Jaremko M, Stillman B, Joshua-Tor L.

Curr Opin Struct Biol. 2018 Dec;53:131-139. doi: 10.1016/ Epub 2018 Sep 12. Review. No abstract available.


FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.

Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J.

Mol Cell. 2018 Mar 1;69(5):787-801.e8. doi: 10.1016/j.molcel.2018.02.001.


Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference.

Li J, Wu C, Wang W, He Y, Elkayam E, Joshua-Tor L, Hammond PT.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2696-E2705. doi: 10.1073/pnas.1719565115. Epub 2018 Feb 5.


Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.

Krishnan N, Bonham CA, Rus IA, Shrestha OK, Gauss CM, Haque A, Tocilj A, Joshua-Tor L, Tonks NK.

Nat Commun. 2018 Jan 18;9(1):283. doi: 10.1038/s41467-017-02252-2.


Multivalent Recruitment of Human Argonaute by GW182.

Elkayam E, Faehnle CR, Morales M, Sun J, Li H, Joshua-Tor L.

Mol Cell. 2017 Aug 17;67(4):646-658.e3. doi: 10.1016/j.molcel.2017.07.007. Epub 2017 Aug 3.


Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.

Faehnle CR, Walleshauser J, Joshua-Tor L.

Nat Struct Mol Biol. 2017 Aug;24(8):658-665. doi: 10.1038/nsmb.3428. Epub 2017 Jul 3.


Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.

Ipsaro JJ, Shen C, Arai E, Xu Y, Kinney JB, Joshua-Tor L, Vakoc CR, Shi J.

PLoS One. 2017 Feb 23;12(2):e0172177. doi: 10.1371/journal.pone.0172177. eCollection 2017.


Structure of the active form of human origin recognition complex and its ATPase motor module.

Tocilj A, On KF, Yuan Z, Sun J, Elkayam E, Li H, Stillman B, Joshua-Tor L.

Elife. 2017 Jan 23;6. pii: e20818. doi: 10.7554/eLife.20818.


siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 May 5;45(8):5008. doi: 10.1093/nar/gkw1298. No abstract available.


siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 Apr 7;45(6):3528-3536. doi: 10.1093/nar/gkw1171.


NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR.

Mol Cell. 2015 Dec 17;60(6):847-59. doi: 10.1016/j.molcel.2015.10.033. Epub 2015 Nov 25.


PTEN functions by recruitment to cytoplasmic vesicles.

Naguib A, Bencze G, Cho H, Zheng W, Tocilj A, Elkayam E, Faehnle CR, Jaber N, Pratt CP, Chen M, Zong WX, Marks MS, Joshua-Tor L, Pappin DJ, Trotman LC.

Mol Cell. 2015 Apr 16;58(2):255-68. doi: 10.1016/j.molcel.2015.03.011. Epub 2015 Apr 9.


On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme.

Kuhn CD, Wilusz JE, Zheng Y, Beal PA, Joshua-Tor L.

Cell. 2015 Feb 12;160(4):644-658. doi: 10.1016/j.cell.2015.01.005. Epub 2015 Jan 29.


From guide to target: molecular insights into eukaryotic RNA-interference machinery.

Ipsaro JJ, Joshua-Tor L.

Nat Struct Mol Biol. 2015 Jan;22(1):20-8. doi: 10.1038/nsmb.2931. Review.


Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.

Faehnle CR, Walleshauser J, Joshua-Tor L.

Nature. 2014 Oct 9;514(7521):252-256. doi: 10.1038/nature13553. Epub 2014 Aug 3.


Dynamic look at DNA unwinding by a replicative helicase.

Lee SJ, Syed S, Enemark EJ, Schuck S, Stenlund A, Ha T, Joshua-Tor L.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E827-35. doi: 10.1073/pnas.1322254111. Epub 2014 Feb 18.


CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing.

Kuscu C, Zaratiegui M, Kim HS, Wah DA, Martienssen RA, Schalch T, Joshua-Tor L.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1795-800. doi: 10.1073/pnas.1313096111. Epub 2014 Jan 21. Erratum in: Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14307.


The making of a slicer: activation of human Argonaute-1.

Faehnle CR, Elkayam E, Haase AD, Hannon GJ, Joshua-Tor L.

Cell Rep. 2013 Jun 27;3(6):1901-9. doi: 10.1016/j.celrep.2013.05.033. Epub 2013 Jun 6.


Eukaryotic Argonautes come into focus.

Kuhn CD, Joshua-Tor L.

Trends Biochem Sci. 2013 May;38(5):263-71. doi: 10.1016/j.tibs.2013.02.008. Epub 2013 Mar 29. Review.


Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

Paul S, Kuo A, Schalch T, Vogel H, Joshua-Tor L, McCombie WR, Gozani O, Hammell M, Mills AA.

Cell Rep. 2013 Jan 31;3(1):92-102. doi: 10.1016/j.celrep.2012.12.009. Epub 2013 Jan 10.


A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails.

Wilusz JE, JnBaptiste CK, Lu LY, Kuhn CD, Joshua-Tor L, Sharp PA.

Genes Dev. 2012 Nov 1;26(21):2392-407. doi: 10.1101/gad.204438.112. Epub 2012 Oct 16.


The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ.

Nature. 2012 Nov 8;491(7423):279-83. doi: 10.1038/nature11502. Epub 2012 Oct 14.


The structure of human argonaute-2 in complex with miR-20a.

Elkayam E, Kuhn CD, Tocilj A, Haase AD, Greene EM, Hannon GJ, Joshua-Tor L.

Cell. 2012 Jul 6;150(1):100-10. doi: 10.1016/j.cell.2012.05.017. Epub 2012 Jun 7. Erratum in: Cell. 2012 Jul 6;150(1):233.


The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.

Lavy T, Kumar PR, He H, Joshua-Tor L.

Genes Dev. 2012 Feb 1;26(3):294-303. doi: 10.1101/gad.182691.111.


The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.

Schalch T, Job G, Shanker S, Partridge JF, Joshua-Tor L.

Nat Struct Mol Biol. 2011 Nov 13;18(12):1351-7. doi: 10.1038/nsmb.2151.


Ancestral roles of small RNAs: an Ago-centric perspective.

Joshua-Tor L, Hannon GJ.

Cold Spring Harb Perspect Biol. 2011 Oct 1;3(10):a003772. doi: 10.1101/cshperspect.a003772. Review.


Argonaute MID domain takes centre stage.

Faehnle CR, Joshua-Tor L.

EMBO Rep. 2010 Aug;11(8):564-5. doi: 10.1038/embor.2010.110. Epub 2010 Jul 16. No abstract available.


High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin.

Schalch T, Job G, Noffsinger VJ, Shanker S, Kuscu C, Joshua-Tor L, Partridge JF.

Mol Cell. 2009 Apr 10;34(1):36-46. doi: 10.1016/j.molcel.2009.02.024.


On helicases and other motor proteins.

Enemark EJ, Joshua-Tor L.

Curr Opin Struct Biol. 2008 Apr;18(2):243-57. doi: 10.1016/ Epub 2008 Mar 10. Review.


NADP regulates the yeast GAL induction system.

Kumar PR, Yu Y, Sternglanz R, Johnston SA, Joshua-Tor L.

Science. 2008 Feb 22;319(5866):1090-2. doi: 10.1126/science.1151903.


Argonautes confront new small RNAs.

Faehnle CR, Joshua-Tor L.

Curr Opin Chem Biol. 2007 Oct;11(5):569-77. Review.


The Argonautes.

Joshua-Tor L.

Cold Spring Harb Symp Quant Biol. 2006;71:67-72. Review.


Slicer and the argonautes.

Tolia NH, Joshua-Tor L.

Nat Chem Biol. 2007 Jan;3(1):36-43. Review.


Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.

Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC.

Cell. 2006 Nov 17;127(4):747-57.


Argonaute slicing is required for heterochromatic silencing and spreading.

Irvine DV, Zaratiegui M, Tolia NH, Goto DB, Chitwood DH, Vaughn MW, Joshua-Tor L, Martienssen RA.

Science. 2006 Aug 25;313(5790):1134-7.


Mechanism of DNA translocation in a replicative hexameric helicase.

Enemark EJ, Joshua-Tor L.

Nature. 2006 Jul 20;442(7100):270-5.


Argonaute and RNA--getting into the groove.

Song JJ, Joshua-Tor L.

Curr Opin Struct Biol. 2006 Feb;16(1):5-11. Epub 2006 Jan 24. Review.


Strategies for protein coexpression in Escherichia coli.

Tolia NH, Joshua-Tor L.

Nat Methods. 2006 Jan;3(1):55-64. No abstract available.


Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum.

Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L.

Cell. 2005 Jul 29;122(2):183-93. Erratum in: Cell. 2005 Aug 12;122(3):485.


Purified Argonaute2 and an siRNA form recombinant human RISC.

Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L.

Nat Struct Mol Biol. 2005 Apr;12(4):340-9. Epub 2005 Mar 30.


Argonaute2 is the catalytic engine of mammalian RNAi.

Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ.

Science. 2004 Sep 3;305(5689):1437-41. Epub 2004 Jul 29.


Crystal structure of Argonaute and its implications for RISC slicer activity.

Song JJ, Smith SK, Hannon GJ, Joshua-Tor L.

Science. 2004 Sep 3;305(5689):1434-7. Epub 2004 Jul 29.


siRNAs at RISC.

Joshua-Tor L.

Structure. 2004 Jul;12(7):1120-2. No abstract available.


The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L.

Nat Struct Biol. 2003 Dec;10(12):1026-32. Epub 2003 Nov 16.


The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding.

Auster AS, Joshua-Tor L.

J Biol Chem. 2004 Jan 30;279(5):3733-42. Epub 2003 Oct 30.


Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution.

van Aalten DM, Crielaard W, Hellingwerf KJ, Joshua-Tor L.

Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):585-90. Epub 2002 Mar 22.


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