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Items: 1 to 50 of 104

1.

Structure-activity investigation of the potentiating effect of cyano substitution on nitroaniline mutagenicity in the ames test.

Josephy PD, Dhanoa J, Elzawy G, Heney K, Petrie L, Senis C.

Environ Mol Mutagen. 2018 Mar;59(2):114-122. doi: 10.1002/em.22161. Epub 2017 Nov 27.

PMID:
29178210
2.

Acetylation of aromatic cysteine conjugates by recombinant human N-acetyltransferase 8.

Deol R, Josephy PD.

Xenobiotica. 2017 Mar;47(3):202-207. doi: 10.1080/00498254.2016.1178410. Epub 2016 May 16.

PMID:
27180734
3.

Potent mutagenicity in the Ames test of 2-cyano-4-nitroaniline and 2,6-dicyano-4-nitroaniline, components of disperse dyes.

Josephy PD, Zahid M, Dhanoa J, de Souza GB, Groom H, Lambie M.

Environ Mol Mutagen. 2016 Jan;57(1):10-6. doi: 10.1002/em.21983. Epub 2015 Sep 22. Erratum in: Environ Mol Mutagen. 2017 Jul;58(6):462.

PMID:
26394367
4.

Inhibition of human glutathione transferases by dinitronaphthalene derivatives.

Groom H, Lee M, Patil P, Josephy PD.

Arch Biochem Biophys. 2014 Aug;555-556:71-6. doi: 10.1016/j.abb.2014.06.002. Epub 2014 Jun 12.

PMID:
24929189
5.

Donor substrate specificity of bovine kidney gamma-glutamyltransferase.

Agblor AA, Josephy PD.

Chem Biol Interact. 2013 Apr 25;203(2):480-5. doi: 10.1016/j.cbi.2013.02.007. Epub 2013 Mar 7.

PMID:
23500672
6.

Reactive electrophilic metabolites of aromatic amine and amide carcinogens.

Josephy PD, Novak M.

Front Biosci (Schol Ed). 2013 Jan 1;5:341-59. Review.

PMID:
23277055
7.

Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase.

Poon JC, Josephy PD.

Xenobiotica. 2012 Dec;42(12):1178-86. doi: 10.3109/00498254.2012.700427. Epub 2012 Jun 29.

PMID:
22742779
8.

Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.

Josephy PD, Pan D, Ianni MD, Mannervik B.

Arch Biochem Biophys. 2011 Sep 15;513(2):87-93. doi: 10.1016/j.abb.2011.07.003. Epub 2011 Jul 14.

PMID:
21781954
9.

Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology.

Josephy PD.

Hum Genomics Proteomics. 2010 Jun 13;2010:876940. doi: 10.4061/2010/876940.

10.

Evaluation of self-reported progression and correlation of imatinib dose to survival in patients with metastatic gastrointestinal stromal tumors: an open cohort study.

Call J, Scherzer NJ, Josephy PD, Walentas C.

J Gastrointest Cancer. 2010 Mar;41(1):60-70. doi: 10.1007/s12029-009-9111-x.

11.

Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.

Josephy PD, Kent M, Mannervik B.

Arch Biochem Biophys. 2009 Oct 1;490(1):24-9. doi: 10.1016/j.abb.2009.07.025. Epub 2009 Aug 6.

PMID:
19664997
12.

Northern exposures, northern risks: toxicology in Canada.

Josephy PD, Cyr DG.

Chem Res Toxicol. 2008 Oct;21(10):1909-12. doi: 10.1021/tx800295w. No abstract available.

PMID:
18928326
13.

Ames test evaluation of two commercially available zero-valent nickel compounds.

Josephy PD, Weadge JJ, Meissner J, Ng F.

Mutat Res. 2008 Jun 30;654(1):64-8. doi: 10.1016/j.mrgentox.2008.05.001. Epub 2008 May 15.

PMID:
18571463
14.
15.

Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen.

Josephy PD, Taylor PL, Vervaet G, Mannervik B.

Environ Mol Mutagen. 2006 Dec;47(9):657-65.

PMID:
16948056
16.

Screening and characterizing human NAT2 variants.

Savulescu MR, Mushtaq A, Josephy PD.

Methods Enzymol. 2005;400:192-215.

PMID:
16399350
17.

Microenvironmental influences on mutagenesis in mammary epithelial cells.

Papp-Szabó E, Josephy PD, Coomber BL.

Int J Cancer. 2005 Sep 20;116(5):679-85.

18.

Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.

Ahn J, Gammon MD, Santella RM, Gaudet MM, Britton JA, Teitelbaum SL, Terry MB, Neugut AI, Josephy PD, Ambrosone CB.

Cancer Res. 2004 Oct 15;64(20):7634-9.

19.

Functional characterization of four allelic variants of human cytochrome P450 1A2.

Zhou H, Josephy PD, Kim D, Guengerich FP.

Arch Biochem Biophys. 2004 Feb 1;422(1):23-30.

PMID:
14725854
20.

Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis.

Summerscales JE, Josephy PD.

Mol Pharmacol. 2004 Jan;65(1):220-6.

PMID:
14722254
21.

Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts.

Papp-Szabó E, Douglas GR, Coomber BL, Josephy PD.

Mutat Res. 2003 Jan 28;522(1-2):107-17.

PMID:
12517416
22.
23.

N-hydroxyarylamine O-acetyltransferase-deficient Escherichia coli strains are resistant to the mutagenicity of nitro compounds.

Josephy PD, Summerscales J, DeBruin LS, Schlaeger C, Ho J.

Biol Chem. 2002 Jun;383(6):977-82.

PMID:
12222687
24.

A comparison of the anticarcinogenic properties of four red wine polyphenols.

Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP.

Clin Biochem. 2002 Mar;35(2):119-24.

PMID:
11983346
25.

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells.

McDiarmid HM, Douglas GR, Coomber BL, Josephy PD.

Environ Mol Mutagen. 2002;39(2-3):245-53. Erratum in: Environ Mol Mutagen 2002;40(1):78.

PMID:
11921195
26.

Evidence for the presence of mutagenic arylamines in human breast milk and DNA adducts in exfoliated breast ductal epithelial cells.

Thompson PA, DeMarini DM, Kadlubar FF, McClure GY, Brooks LR, Green BL, Fares MY, Stone A, Josephy PD, Ambrosone CB.

Environ Mol Mutagen. 2002;39(2-3):134-42.

PMID:
11921181
27.

Perspectives on the chemical etiology of breast cancer.

DeBruin LS, Josephy PD.

Environ Health Perspect. 2002 Feb;110 Suppl 1:119-28. Review.

28.

Analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk.

Puente NW, Josephy PD.

J Anal Toxicol. 2001 Nov-Dec;25(8):711-5.

PMID:
11765029
29.

Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women.

DeBruin LS, Martos PA, Josephy PD.

Chem Res Toxicol. 2001 Nov;14(11):1523-8.

PMID:
11712910
30.

Epithelial and fibroblast cell lines cultured from the transgenic BigBlue rat: an in vitro mutagenesis assay.

McDiarmid HM, Douglas GR, Coomber BL, Josephy PD.

Mutat Res. 2001 Oct 18;497(1-2):39-47.

PMID:
11525906
31.
32.

The Escherichia coli lacZ reversion mutagenicity assay.

Josephy PD.

Mutat Res. 2000 Nov 20;455(1-2):71-80. Review.

PMID:
11113468
33.
34.
35.

Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype.

Guengerich FP, Parikh A, Turesky RJ, Josephy PD.

Mutat Res. 1999 Jul 16;428(1-2):115-24. Review.

PMID:
10517985
36.

Evaluation of Escherichia coli DJ4309 expressing human P450 1A2 in mutagenicity testing of complex food mixtures.

Constable A, Varga N, Josephy PD, Guy P, Turesky RJ.

Mutat Res. 1999 Jun 25;442(2):79-87.

PMID:
10393276
37.

Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties.

Parikh A, Josephy PD, Guengerich FP.

Biochemistry. 1999 Apr 27;38(17):5283-9.

PMID:
10220313
38.
39.

Detection of monocyclic aromatic amines, possible mammary carcinogens, in human milk.

DeBruin LS, Pawliszyn JB, Josephy PD.

Chem Res Toxicol. 1999 Jan;12(1):78-82.

PMID:
9894021
40.

Solid-phase microextraction of monocyclic aromatic amines from biological fluids.

DeBruin LS, Josephy PD, Pawliszyn JB.

Anal Chem. 1998 May 1;70(9):1986-92.

PMID:
9599591
42.

Re: Feigelson, H.S. and Henderson, B.E. (1996) Estrogens and breast cancer. Carcinogenesis, 17, 2279-2284.

Josephy PD.

Carcinogenesis. 1997 Sep;18(9):1859-60. No abstract available.

PMID:
9328188
44.

Recent advances in the construction of bacterial genotoxicity assays.

Josephy PD, Gruz P, Nohmi T.

Mutat Res. 1997 Mar;386(1):1-23. Review.

PMID:
9100853
45.

Chemical carcinogenesis, mutagenesis, and teratogenesis.

O'Brien PJ, Hales BF, Josephy PD, Castonguay A, Yamazoe Y, Guengerich FP.

Can J Physiol Pharmacol. 1996 May;74(5):565-71.

PMID:
8884021
46.

The role of peroxidase-catalyzed activation of aromatic amines in breast cancer.

Josephy PD.

Mutagenesis. 1996 Jan;11(1):3-7. Review.

PMID:
8671708
47.

In vitro formation, disposition and toxicity of N-acetoxy-sulfamethoxazole, a potential mediator of sulfamethoxazole toxicity.

Nakamura H, Uetrecht J, Cribb AE, Miller MA, Zahid N, Hill J, Josephy PD, Grant DM, Spielberg SP.

J Pharmacol Exp Ther. 1995 Sep;274(3):1099-104.

PMID:
7562475
48.
49.
50.

Superoxide dismutase protects Escherichia coli against killing by human serum.

McManus DC, Josephy PD.

Arch Biochem Biophys. 1995 Feb 20;317(1):57-61.

PMID:
7872803

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