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Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes.

Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH.

J Med Chem. 2019 Oct 10;62(19):8866-8872. doi: 10.1021/acs.jmedchem.9b00936. Epub 2019 Sep 26.


PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease.

Shao T, Josephson L, Liang SH.

Mol Imaging. 2019 Jan-Dec;18:1536012119871455. doi: 10.1177/1536012119871455.


Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease.

Chen Z, Shao T, Gao W, Fu H, Collier TL, Rong J, Deng X, Yu Q, Zhang X, Davenport AT, Daunais JB, Wey HY, Shao Y, Josephson L, Qiu WW, Liang S.

ChemMedChem. 2019 Sep 4;14(17):1580-1585. doi: 10.1002/cmdc.201900321. Epub 2019 Aug 22.


Author Correction: Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.

Kaittanis C, Shaffer TM, Ogirala A, Santra S, Perez JM, Chiosis G, Li Y, Josephson L, Grimm J.

Nat Commun. 2019 Apr 18;10(1):1867. doi: 10.1038/s41467-019-09887-3.


Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton.

Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH.

J Med Chem. 2019 Apr 11;62(7):3336-3353. doi: 10.1021/acs.jmedchem.8b01778. Epub 2019 Mar 21.


Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.

Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH.

ACS Chem Neurosci. 2019 May 15;10(5):2263-2275. doi: 10.1021/acschemneuro.8b00591. Epub 2019 Feb 27.


Synthesis and Preliminary Evaluation of 11 C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4.

Deng X, Hatori A, Chen Z, Kumata K, Shao T, Zhang X, Yamasaki T, Hu K, Yu Q, Ma L, Wang G, Wang L, Shao Y, Josephson L, Sun S, Zhang MR, Liang S.

ChemMedChem. 2019 Feb 5;14(3):303-309. doi: 10.1002/cmdc.201800710. Epub 2018 Dec 27.


The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils.

Josephson L, Stratman N, Liu Y, Qian F, Liang SH, Vasdev N, Patel S.

Mol Imaging. 2018 Jan-Dec;17:1536012118796297. doi: 10.1177/1536012118796297.


Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

Narayanaswami V, Dahl K, Bernard-Gauthier V, Josephson L, Cumming P, Vasdev N.

Mol Imaging. 2018 Jan-Dec;17:1536012118792317. doi: 10.1177/1536012118792317. Review.


Viscosities and Protein Interactions of Bispecific Antibodies and Their Monospecific Mixtures.

Woldeyes MA, Josephson LL, Leiske DL, Galush WJ, Roberts CJ, Furst EM.

Mol Pharm. 2018 Oct 1;15(10):4745-4755. doi: 10.1021/acs.molpharmaceut.8b00706. Epub 2018 Sep 12.


Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.

Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH.

Eur J Med Chem. 2018 Sep 5;157:898-908. doi: 10.1016/j.ejmech.2018.08.019. Epub 2018 Aug 9.


Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.

Deng X, Rong J, Wang L, Vasdev N, Zhang L, Josephson L, Liang SH.

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2580-2605. doi: 10.1002/anie.201805501. Epub 2019 Jan 14. Review.


Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation.

Panagia M, Chen HH, Croteau D, Iris Chen YC, Ran C, Luptak I, Josephson L, Colucci WS, Sosnovik DE.

Circ Cardiovasc Imaging. 2018 Mar;11(3):e007007. doi: 10.1161/CIRCIMAGING.117.007007. Review.


Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry.

Yuan H, Wilks MQ, Normandin MD, El Fakhri G, Kaittanis C, Josephson L.

Nat Protoc. 2018 Feb;13(2):392-412. doi: 10.1038/nprot.2017.133. Epub 2018 Jan 25.


An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy.

Klein OJ, Yuan H, Nowell NH, Kaittanis C, Josephson L, Evans CL.

Sci Rep. 2017 Oct 17;7(1):13375. doi: 10.1038/s41598-017-13803-4.


Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury.

Chen HH, Yuan H, Cho H, Feng Y, Ngoy S, Kumar AT, Liao R, Chao W, Josephson L, Sosnovik DE.

Theranostics. 2017 Feb 8;7(4):814-825. doi: 10.7150/thno.17366. eCollection 2017.


Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials.

Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L.

PLoS One. 2017 Feb 22;12(2):e0172722. doi: 10.1371/journal.pone.0172722. eCollection 2017.


Parallel temperature-dependent microrheological measurements in a microfluidic chip.

Josephson LL, Galush WJ, Furst EM.

Biomicrofluidics. 2016 Jun 14;10(4):043503. doi: 10.1063/1.4953863. eCollection 2016 Jul.


Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model.

Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM.

EJNMMI Phys. 2015 Dec;2(1):6. doi: 10.1186/s40658-015-0109-0. Epub 2015 Feb 26.


Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET.

Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L.

Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13002-6. doi: 10.1002/anie.201505525. Epub 2015 Sep 14.


Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models.

Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L.

Bioconjug Chem. 2015 Jun 17;26(6):1061-9. doi: 10.1021/acs.bioconjchem.5b00213. Epub 2015 May 14.


Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug.

Chen HH, Yuan H, Cho H, Sosnovik DE, Josephson L.

Nanoscale. 2015 Feb 14;7(6):2255-9. doi: 10.1039/c4nr06861k.


Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles.

Boros E, Bowen AM, Josephson L, Vasdev N, Holland JP.

Chem Sci. 2015 Jan 1;6(1):225-236. doi: 10.1039/c4sc02778g. Epub 2014 Sep 29.


U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform.

van Oosterom MN, Kreuger R, Buckle T, Mahn WA, Bunschoten A, Josephson L, van Leeuwen FW, Beekman FJ.

EJNMMI Res. 2014 Oct 11;4:56. doi: 10.1186/s13550-014-0056-0. eCollection 2014.


Infective endocarditis: a review for nurses.

Josephson L.

Dimens Crit Care Nurs. 2014 Nov-Dec;33(6):327-40. doi: 10.1097/DCC.0000000000000081. Review.


Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia.

Habibollahi P, Waldron T, Heidari P, Cho HS, Alcantara D, Josephson L, Wang TC, Rustgi AK, Mahmood U.

Mol Imaging. 2014;13:1-11.


PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials.

Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L.

PLoS One. 2014 Apr 29;9(4):e95406. doi: 10.1371/journal.pone.0095406. eCollection 2014.


Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.

Kaittanis C, Shaffer TM, Ogirala A, Santra S, Perez JM, Chiosis G, Li Y, Josephson L, Grimm J.

Nat Commun. 2014 Mar 4;5:3384. doi: 10.1038/ncomms4384. Erratum in: Nat Commun. 2019 Apr 18;10(1):1867.


Feasibility and effectiveness of an automated telehealth intervention to improve illness self-management in people with serious psychiatric and medical disorders.

Pratt SI, Bartels SJ, Mueser KT, Naslund JA, Wolfe R, Pixley HS, Josephson L.

Psychiatr Rehabil J. 2013 Dec;36(4):297-305. doi: 10.1037/prj0000022.


Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria.

Yuan H, Cho H, Chen HH, Panagia M, Sosnovik DE, Josephson L.

Chem Commun (Camb). 2013 Nov 14;49(88):10361-3. doi: 10.1039/c3cc45802d.


Imaging DNA with fluorochrome bearing metals.

Cho H, Guo Y, Sosnovik DE, Josephson L.

Inorg Chem. 2013 Nov 4;52(21):12216-22. doi: 10.1021/ic400404g. Epub 2013 May 6. Review.


Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo.

Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE.

Circ Cardiovasc Imaging. 2013 May 1;6(3):441-7. doi: 10.1161/CIRCIMAGING.112.000074. Epub 2013 Mar 28.


High efficiency diffusion molecular retention tumor targeting.

Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L.

PLoS One. 2013;8(3):e58290. doi: 10.1371/journal.pone.0058290. Epub 2013 Mar 11.


Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems.

Cho H, Alcantara D, Yuan H, Sheth RA, Chen HH, Huang P, Andersson SB, Sosnovik DE, Mahmood U, Josephson L.

ACS Nano. 2013 Mar 26;7(3):2032-41. doi: 10.1021/nn305962n. Epub 2013 Feb 7.


Barriers to clinical translation with diagnostic drugs.

Josephson L, Rudin M.

J Nucl Med. 2013 Mar;54(3):329-32. doi: 10.2967/jnumed.112.107615. Epub 2013 Jan 28.


Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS.

Buckle T, Kuil J, van den Berg NS, Bunschoten A, Lamb HJ, Yuan H, Josephson L, Jonkers J, Borowsky AD, van Leeuwen FW.

PLoS One. 2013;8(1):e48324. doi: 10.1371/journal.pone.0048324. Epub 2013 Jan 11.


The PEG-fluorochrome shielding approach for targeted probe design.

Guo Y, Yuan H, Rice WL, Kumar AT, Goergen CJ, Jokivarsi K, Josephson L.

J Am Chem Soc. 2012 Nov 28;134(47):19338-41. doi: 10.1021/ja309085b. Epub 2012 Nov 14.


Multispectral visualization of surgical safety-margins using fluorescent marker seeds.

Chin PT, Beekman CA, Buckle T, Josephson L, van Leeuwen FW.

Am J Nucl Med Mol Imaging. 2012;2(2):151-62. Epub 2012 Mar 28.


The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges.

Pelaz B, Jaber S, de Aberasturi DJ, Wulf V, Aida T, de la Fuente JM, Feldmann J, Gaub HE, Josephson L, Kagan CR, Kotov NA, Liz-Marzán LM, Mattoussi H, Mulvaney P, Murray CB, Rogach AL, Weiss PS, Willner I, Parak WJ.

ACS Nano. 2012 Oct 23;6(10):8468-83. doi: 10.1021/nn303929a. Epub 2012 Sep 27.


Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance.

Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6904-7. doi: 10.1002/anie.201201661. Epub 2012 Jun 8.


Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting αvβ3 integrin.

Bunschoten A, Buckle T, Visser NL, Kuil J, Yuan H, Josephson L, Vahrmeijer AL, van Leeuwen FW.

Chembiochem. 2012 May 7;13(7):1039-45. doi: 10.1002/cbic.201200034. Epub 2012 Apr 13.


Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival.

Chen HH, Yuan H, Josephson L, Sosnovik DE.

Theranostics. 2012;2(2):148-55. doi: 10.7150/thno.4077. Epub 2012 Feb 8.


Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer.

Thomas S, Waterman P, Chen S, Marinelli B, Seaman M, Rodig S, Ross RW, Josephson L, Weissleder R, Kelly KA.

J Nanomed Nanotechnol. 2011 Aug;2(112). pii: 2157-7439-2-112.


Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression.

Kuil J, Buckle T, Oldenburg J, Yuan H, Borowsky AD, Josephson L, van Leeuwen FW.

Mol Pharm. 2011 Dec 5;8(6):2444-53. doi: 10.1021/mp200401p. Epub 2011 Nov 15.


Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium.

Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE.

Circ Cardiovasc Imaging. 2011 Nov;4(6):729-37. doi: 10.1161/CIRCIMAGING.111.966374. Epub 2011 Aug 11.


A magnetofluorescent nanoparticle for ex-vivo cell labeling by covalently linking the drugs protamine and Feraheme.

Chen S, Alcantara D, Josephson L.

J Nanosci Nanotechnol. 2011 Apr;11(4):3058-64.


Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5.

Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE.

Nanomedicine. 2012 Apr;8(3):291-8. doi: 10.1016/j.nano.2011.06.012. Epub 2011 Jun 24.


Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.

Kuil J, Buckle T, Yuan H, van den Berg NS, Oishi S, Fujii N, Josephson L, van Leeuwen FW.

Bioconjug Chem. 2011 May 18;22(5):859-64. doi: 10.1021/bc2000947. Epub 2011 Apr 19.


Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores.

Shao F, Yuan H, Josephson L, Weissleder R, Hilderbrand SA.

Dyes Pigm. 2011 Apr 1;90(2):119-122.

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