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Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH).

Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M, Schlama T, Liu Y, Chu A, Schmeits J, Huang DJ, Hill R, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Liu B, Richmond W, Sancho-Martinez I, Phimister A, Seidel HM, Badman MK, Joseph SB, Laffitte B, Molteni V.

J Med Chem. 2020 Jan 15. doi: 10.1021/acs.jmedchem.9b01621. [Epub ahead of print]


Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects.

Pflimlin E, Zhou Z, Amso Z, Fu Q, Lee C, Muppiddi A, Joseph SB, Nguyen-Tran V, Shen W.

J Med Chem. 2020 Jan 9;63(1):382-390. doi: 10.1021/acs.jmedchem.9b01862. Epub 2019 Dec 18.


What can characterization of cerebrospinal fluid escape populations teach us about viral reservoirs in the central nervous system?

Joseph SB, Trunfio M, Kincer LP, Calcagno A, Price RW.

AIDS. 2019 Dec 1;33 Suppl 2:S171-S179. doi: 10.1097/QAD.0000000000002253.


Measuring the contribution of γδ T cells to the persistent HIV reservoir.

James KS, Trumble I, Clohosey ML, Moeser M, Roan NR, Adimora AA, Joseph SB, Archin NM, Hudgens M, Soriano-Sarabia N.

AIDS. 2019 Nov 14. doi: 10.1097/QAD.0000000000002434. [Epub ahead of print]


The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation.

Abrahams MR, Joseph SB, Garrett N, Tyers L, Moeser M, Archin N, Council OD, Matten D, Zhou S, Doolabh D, Anthony C, Goonetilleke N, Karim SA, Margolis DM, Pond SK, Williamson C, Swanstrom R.

Sci Transl Med. 2019 Oct 9;11(513). pii: eaaw5589. doi: 10.1126/scitranslmed.aaw5589.


Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure.

Goonetilleke N, Clutton G, Swanstrom R, Joseph SB.

Front Immunol. 2019 Aug 22;10:1966. doi: 10.3389/fimmu.2019.01966. eCollection 2019.


Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.

Hernandez ED, Zheng L, Kim Y, Fang B, Liu B, Valdez RA, Dietrich WF, Rucker PV, Chianelli D, Schmeits J, Bao D, Zoll J, Dubois C, Federe GC, Chen L, Joseph SB, Klickstein LB, Walker J, Molteni V, McNamara P, Meeusen S, Tully DC, Badman MK, Xu J, Laffitte B.

Hepatol Commun. 2019 May 17;3(8):1085-1097. doi: 10.1002/hep4.1368. eCollection 2019 Aug.


Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW.

Sci Transl Med. 2019 May 8;11(491). pii: eaav3523. doi: 10.1126/scitranslmed.aav3523.


Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.

Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, Migueles S, Jones RB, Mota T, Joseph SB, Groen K, Pasternak AO, Hwang WT, Sherman B, Vourekas A, Nunnari G, O'Doherty U.

Nat Commun. 2019 Feb 13;10(1):728. doi: 10.1038/s41467-019-08431-7.


Predicting Efavirenz Concentrations in the Brain Tissue of HIV-Infected Individuals and Exploring their Relationship to Neurocognitive Impairment.

Srinivas N, Joseph SB, Robertson K, Kincer LP, Menezes P, Adamson L, Schauer AP, Blake KH, White N, Sykes C, Luciw P, Eron JJ, Forrest A, Price RW, Spudich S, Swanstrom R, Kashuba ADM.

Clin Transl Sci. 2019 May;12(3):302-311. doi: 10.1111/cts.12620. Epub 2019 Feb 27.


HIV-1 detection in the olfactory mucosa of HIV-1-infected participants.

Bertero L, Joseph SB, Trunfio M, Allice T, Catera S, Imperiale D, Cassoni P, Kincer LP, Pirriatore V, Ghisetti V, Amasio E, Zanusso G, Bonora S, Di Perri G, Calcagno A.

AIDS. 2019 Mar 15;33(4):665-674. doi: 10.1097/QAD.0000000000002102.


Human Immunodeficiency Virus Type 1 RNA Detected in the Central Nervous System (CNS) After Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells.

Joseph SB, Kincer LP, Bowman NM, Evans C, Vinikoor MJ, Lippincott CK, Gisslén M, Spudich S, Menezes P, Robertson K, Archin N, Kashuba A, Eron JJ, Price RW, Swanstrom R.

Clin Infect Dis. 2019 Sep 27;69(8):1345-1352. doi: 10.1093/cid/ciy1066.


Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology.

Mandikian D, Figueroa I, Oldendorp A, Rafidi H, Ulufatu S, Schweiger MG, Couch JA, Dybdal N, Joseph SB, Prabhu S, Ferl GZ, Boswell CA.

AAPS J. 2018 Oct 8;20(6):107. doi: 10.1208/s12248-018-0264-z.


The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.

Janes J, Young ME, Chen E, Rogers NH, Burgstaller-Muehlbacher S, Hughes LD, Love MS, Hull MV, Kuhen KL, Woods AK, Joseph SB, Petrassi HM, McNamara CW, Tremblay MS, Su AI, Schultz PG, Chatterjee AK.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10750-10755. doi: 10.1073/pnas.1810137115. Epub 2018 Oct 3.


Editorial: The HIV/SIV Envelope Protein: From Structure To Function To Host Evasion.

Swanstrom R, Joseph SB.

Curr HIV Res. 2018;16(1):3-4. doi: 10.2174/1570162X1601180419095704. No abstract available.


The evolution of HIV-1 entry phenotypes as a guide to changing target cells.

Joseph SB, Swanstrom R.

J Leukoc Biol. 2018 Mar;103(3):421-431. doi: 10.1002/JLB.2RI0517-200R. Epub 2018 Feb 1. Review.


Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model.

Mandikian D, Takahashi N, Lo AA, Li J, Eastham-Anderson J, Slaga D, Ho J, Hristopoulos M, Clark R, Totpal K, Lin K, Joseph SB, Dennis MS, Prabhu S, Junttila TT, Boswell CA.

Mol Cancer Ther. 2018 Apr;17(4):776-785. doi: 10.1158/1535-7163.MCT-17-0657. Epub 2018 Jan 16.


Evolution of Host Target Cell Specificity During HIV-1 Infection.

Council OD, Joseph SB.

Curr HIV Res. 2018;16(1):13-20. doi: 10.2174/1570162X16666171222105721. Review.


Symptomatic cerebrospinal fluid HIV-1 escape with no resistance-associated mutations following low-level plasma viremia.

Trunfio M, Joseph SB, Ghisetti V, Romito A, Martini C, Cusato J, Audagnotto S, Pesci Kincer L, Ferrara M, Sala A, Imperiale D, Di Perri G, Calcagno A.

J Neurovirol. 2018 Feb;24(1):132-136. doi: 10.1007/s13365-017-0605-1. Epub 2017 Dec 14.


Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

Tully DC, Rucker PV, Chianelli D, Williams J, Vidal A, Alper PB, Mutnick D, Bursulaya B, Schmeits J, Wu X, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Seidel HM, Molteni V, Liu B, Phimister A, Joseph SB, Laffitte B.

J Med Chem. 2017 Dec 28;60(24):9960-9973. doi: 10.1021/acs.jmedchem.7b00907. Epub 2017 Dec 8.


Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S.

Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25.


Evaluation of Fluorophotometry to Assess the Vitreal Pharmacokinetics of Protein Therapeutics.

Dickmann LJ, Yip V, Li C, Abundes J Jr, Maia M, Young C, Stainton S, Hass PE, Joseph SB, Prabhu S, Boswell CA.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6991-9. doi: 10.1167/iovs.15-17457.


Phenotypic Correlates of HIV-1 Macrophage Tropism.

Arrildt KT, LaBranche CC, Joseph SB, Dukhovlinova EN, Graham WD, Ping LH, Schnell G, Sturdevant CB, Kincer LP, Mallewa M, Heyderman RS, Rie AV, Cohen MS, Spudich S, Price RW, Montefiori DC, Swanstrom R.

J Virol. 2015 Nov;89(22):11294-311. doi: 10.1128/JVI.00946-15. Epub 2015 Sep 2.


Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.

Joseph SB, Swanstrom R, Kashuba AD, Cohen MS.

Nat Rev Microbiol. 2015 Jul;13(7):414-25. doi: 10.1038/nrmicro3471. Epub 2015 Jun 8. Review.


Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection.

Sturdevant CB, Joseph SB, Schnell G, Price RW, Swanstrom R, Spudich S.

PLoS Pathog. 2015 Mar 26;11(3):e1004720. doi: 10.1371/journal.ppat.1004720. eCollection 2015 Mar.


Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.

Azimioara M, Alper P, Cow C, Mutnick D, Nikulin V, Lelais G, Mecom J, McNeill M, Michellys PY, Wang Z, Reding E, Paliotti M, Li J, Bao D, Zoll J, Kim Y, Zimmerman M, Groessl T, Tuntland T, Joseph SB, McNamara P, Seidel HM, Epple R.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5478-83. doi: 10.1016/j.bmcl.2014.10.010. Epub 2014 Oct 13.


HIV-1 target cells in the CNS.

Joseph SB, Arrildt KT, Sturdevant CB, Swanstrom R.

J Neurovirol. 2015 Jun;21(3):276-89. doi: 10.1007/s13365-014-0287-x. Epub 2014 Sep 19. Review.


Affinofile Assay for Identifying Macrophage-Tropic HIV-1.

Joseph SB, Lee B, Swanstrom R.

Bio Protoc. 2014 Jul 20;4(14). pii: e1184. doi: 10.21769/BioProtoc.1184.


HIV/AIDS. A fitness bottleneck in HIV-1 transmission.

Joseph SB, Swanstrom R.

Science. 2014 Jul 11;345(6193):136-7. doi: 10.1126/science.1257425. No abstract available.


Dominance effects of deleterious and beneficial mutations in a single gene of the RNA virus ϕ6.

Joseph SB, Peck KM, Burch CL.

PLoS One. 2014 Jun 19;9(6):e97717. doi: 10.1371/journal.pone.0097717. eCollection 2014.


Discovery of structurally novel, potent and orally efficacious GPR119 agonists.

Alper P, Azimioara M, Cow C, Mutnick D, Nikulin V, Michellys PY, Wang Z, Reding E, Paliotti M, Li J, Bao D, Zoll J, Kim Y, Zimmerman M, Groessel T, Tuntland T, Joseph SB, McNamara P, Seidel HM, Epple R.

Bioorg Med Chem Lett. 2014 May 15;24(10):2383-7. doi: 10.1016/j.bmcl.2014.03.023. Epub 2014 Mar 27.


Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.

Phillips DP, Gao W, Yang Y, Zhang G, Lerario IK, Lau TL, Jiang J, Wang X, Nguyen DG, Bhat BG, Trotter C, Sullivan H, Welzel G, Landry J, Chen Y, Joseph SB, Li C, Gordon WP, Richmond W, Johnson K, Bretz A, Bursulaya B, Pan S, McNamara P, Seidel HM.

J Med Chem. 2014 Apr 24;57(8):3263-82. doi: 10.1021/jm401731q. Epub 2014 Apr 4.


Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities.

Joseph SB, Arrildt KT, Swanstrom AE, Schnell G, Lee B, Hoxie JA, Swanstrom R.

J Virol. 2014 Feb;88(4):1858-69. doi: 10.1128/JVI.02477-13. Epub 2013 Dec 4.


The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells.

Gupta S, Gach JS, Becerra JC, Phan TB, Pudney J, Moldoveanu Z, Joseph SB, Landucci G, Supnet MJ, Ping LH, Corti D, Moldt B, Hel Z, Lanzavecchia A, Ruprecht RM, Burton DR, Mestecky J, Anderson DJ, Forthal DN.

PLoS Pathog. 2013;9(11):e1003776. doi: 10.1371/journal.ppat.1003776. Epub 2013 Nov 21. Erratum in: PLoS Pathog. 2013 Nov;9(11). doi:10.1371/annotation/31430955-703b-484a-96eb-e180f917d683.


E-prescribing adoption and use increased substantially following the start of a federal incentive program.

Joseph SB, Sow MJ, Furukawa MF, Posnack S, Daniel JG.

Health Aff (Millwood). 2013 Jul;32(7):1221-7. doi: 10.1377/hlthaff.2012.1197.


Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.

Marsilje TH, Pei W, Chen B, Lu W, Uno T, Jin Y, Jiang T, Kim S, Li N, Warmuth M, Sarkisova Y, Sun F, Steffy A, Pferdekamper AC, Li AG, Joseph SB, Kim Y, Liu B, Tuntland T, Cui X, Gray NS, Steensma R, Wan Y, Jiang J, Chopiuk G, Li J, Gordon WP, Richmond W, Johnson K, Chang J, Groessl T, He YQ, Phimister A, Aycinena A, Lee CC, Bursulaya B, Karanewsky DS, Seidel HM, Harris JL, Michellys PY.

J Med Chem. 2013 Jul 25;56(14):5675-90. doi: 10.1021/jm400402q. Epub 2013 Jun 26.


Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design.

Ping LH, Joseph SB, Anderson JA, Abrahams MR, Salazar-Gonzalez JF, Kincer LP, Treurnicht FK, Arney L, Ojeda S, Zhang M, Keys J, Potter EL, Chu H, Moore P, Salazar MG, Iyer S, Jabara C, Kirchherr J, Mapanje C, Ngandu N, Seoighe C, Hoffman I, Gao F, Tang Y, Labranche C, Lee B, Saville A, Vermeulen M, Fiscus S, Morris L, Karim SA, Haynes BF, Shaw GM, Korber BT, Hahn BH, Cohen MS, Montefiori D, Williamson C, Swanstrom R; CAPRISA Acute Infection Study and the Center for HIV-AIDS Vaccine Immunology Consortium.

J Virol. 2013 Jul;87(13):7218-33. doi: 10.1128/JVI.03577-12. Epub 2013 Apr 24.


Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children.

Sturdevant CB, Dow A, Jabara CB, Joseph SB, Schnell G, Takamune N, Mallewa M, Heyderman RS, Van Rie A, Swanstrom R.

PLoS Pathog. 2012 Dec;8(12):e1003094. doi: 10.1371/journal.ppat.1003094. Epub 2012 Dec 27.


The HIV-1 env protein: a coat of many colors.

Arrildt KT, Joseph SB, Swanstrom R.

Curr HIV/AIDS Rep. 2012 Mar;9(1):52-63. doi: 10.1007/s11904-011-0107-3. Review.


A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae.

Hall DW, Joseph SB.

Genetics. 2010 Aug;185(4):1397-409. doi: 10.1534/genetics.110.118307. Epub 2010 Jun 1.


Coinfection rates in Φ6 bacteriophage are enhanced by virus-induced changes in host cells.

Joseph SB, Hanley KA, Chao L, Burch CL.

Evol Appl. 2009 Feb;2(1):24-31. doi: 10.1111/j.1752-4571.2008.00055.x. Epub 2008 Dec 23.


LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P.

Cell. 2008 Jul 11;134(1):97-111. doi: 10.1016/j.cell.2008.04.052.


Spontaneous mutations in diploid Saccharomyces cerevisiae: another thousand cell generations.

Hall DW, Mahmoudizad R, Hurd AW, Joseph SB.

Genet Res (Camb). 2008 Jun;90(3):229-41. doi: 10.1017/S0016672308009324. Erratum in: Genet Res. 2009 Jun;91(3):223.


Effects of the [PSI+] prion on rates of adaptation in yeast.

Joseph SB, Kirkpatrick M.

J Evol Biol. 2008 May;21(3):773-80. doi: 10.1111/j.1420-9101.2008.01515.x. Epub 2008 Feb 29.


Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P.

J Clin Invest. 2007 Aug;117(8):2337-46.


LXR-dependent gene expression is important for macrophage survival and the innate immune response.

Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P.

Cell. 2004 Oct 15;119(2):299-309.


Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.

Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P.

J Biol Chem. 2004 Mar 12;279(11):9905-11. Epub 2003 Dec 29.


Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux.

Xu J, Chang V, Joseph SB, Trujillo C, Bassilian S, Saad MF, Lee WN, Kurland IJ.

Endocrinology. 2004 Mar;145(3):1087-95. Epub 2003 Dec 11.


Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism.

Castrillo A, Joseph SB, Vaidya SA, Haberland M, Fogelman AM, Cheng G, Tontonoz P.

Mol Cell. 2003 Oct;12(4):805-16.

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