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Folia Microbiol (Praha). 2018 Jul;63(4):517-523. doi: 10.1007/s12223-018-0592-5. Epub 2018 Feb 27.

First report of Candida bracarensis in Mexico: hydrolytic enzymes and antifungal susceptibility pattern.

Author information

1
Department of Microbiology, School of Medicine, Universidad Autónoma de Nuevo León, Av. Francisco I. Madero and Dr. Eduardo A. Pequeño, s/n. Mitras Centro, 64460, Monterrey, NL, Mexico.
2
Dermatology Service and Mycology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.
3
Department of Microbiology, School of Medicine, Universidad Autónoma de Nuevo León, Av. Francisco I. Madero and Dr. Eduardo A. Pequeño, s/n. Mitras Centro, 64460, Monterrey, NL, Mexico. gmglez@yahoo.com.mx.

Abstract

Candida bracarensis is an emerging cryptic species within the Candida glabrata clade. To date, little is known about its epidemiology, virulence, and antifungal susceptibility. This study documents the occurrence of C. bracarensis for the first time in Mexico and focuses on its in vitro production of hydrolytic enzymes, as well as antifungal susceptibility to echinocandins. This strain was isolated from a vaginal swab of a female with vulvovaginal candidosis; exhibited a very strong activity of aspartyl proteinase, phospholipase, and hemolysin; and was susceptible to caspofungin, anidulafungin, and micafungin (MIC = 0.031 μg/mL). Data obtained could contribute to the knowledge of the epidemiology and virulence attributes of this yeast as a fungal opportunistic human pathogen.

PMID:
29488180
DOI:
10.1007/s12223-018-0592-5
[Indexed for MEDLINE]

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