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Items: 1 to 50 of 138

1.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.

2.

Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?

Leth JM, Mertens HDT, Leth-Espensen KZ, Jørgensen TJD, Ploug M.

J Biol Chem. 2019 May 3;294(18):7403-7418. doi: 10.1074/jbc.RA119.007847. Epub 2019 Mar 20.

PMID:
30894413
3.

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase.

Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6020-E6029. doi: 10.1073/pnas.1806774115. Epub 2018 Jun 13.

4.

Predicting the Public Health Consequences of a Nuclear Terrorism Attack: Drawing on The Experiences of Hiroshima and Fukushima.

Jorgensen TJ.

Health Phys. 2018 Jul;115(1):121-125. doi: 10.1097/HP.0000000000000870.

PMID:
29787438
5.

Long-Lived Folding Intermediates Predominate the Targeting-Competent Secretome.

Tsirigotaki A, Chatzi KE, Koukaki M, De Geyter J, Portaliou AG, Orfanoudaki G, Sardis MF, Trelle MB, Jørgensen TJD, Karamanou S, Economou A.

Structure. 2018 May 1;26(5):695-707.e5. doi: 10.1016/j.str.2018.03.006. Epub 2018 Apr 5.

6.

Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry.

Petersen M, Madsen JB, Jørgensen TJD, Trelle MB.

Sci Rep. 2017 Jul 26;7(1):6636. doi: 10.1038/s41598-017-06290-0.

7.

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

Merkle PS, Irving M, Hongjian S, Ferber M, Jørgensen TJD, Scholten K, Luescher I, Coukos G, Zoete V, Cuendet MA, Michielin O, Rand KD.

Biochemistry. 2017 Aug 1;56(30):3945-3961. doi: 10.1021/acs.biochem.7b00385. Epub 2017 Jul 19.

PMID:
28671821
8.

Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products.

Elnegaard RLB, Møllegaard NE, Zhang Q, Kjeldsen F, Jørgensen TJD.

Chembiochem. 2017 Jun 19;18(12):1117-1122. doi: 10.1002/cbic.201700103. Epub 2017 May 23.

9.

Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins.

Jensen PF, Comamala G, Trelle MB, Madsen JB, Jørgensen TJ, Rand KD.

Anal Chem. 2016 Dec 20;88(24):12479-12488. doi: 10.1021/acs.analchem.6b03951. Epub 2016 Nov 28.

PMID:
28193043
10.

Analysis of Translocation-Competent Secretory Proteins by HDX-MS.

Tsirigotaki A, Papanastasiou M, Trelle MB, Jørgensen TJ, Economou A.

Methods Enzymol. 2017;586:57-83. doi: 10.1016/bs.mie.2016.09.028. Epub 2016 Nov 8.

PMID:
28137577
11.

Dose coefficients for ICRP reference pediatric phantoms exposed to idealised external gamma fields.

Chang LA, Simon SL, Jorgensen TJ, Schauer DA, Lee C.

J Radiol Prot. 2017 Mar 20;37(1):127-146. doi: 10.1088/1361-6498/aa559e. Epub 2017 Jan 24.

12.

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.

Mysling S, Kristensen KK, Larsson M, Kovrov O, Bensadouen A, Jørgensen TJ, Olivecrona G, Young SG, Ploug M.

Elife. 2016 Dec 8;5. pii: e20958. doi: 10.7554/eLife.20958.

13.

Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2.

Hnida K, Stamnaes J, du Pré MF, Mysling S, Jørgensen TJ, Sollid LM, Iversen R.

J Biol Chem. 2016 Dec 2;291(49):25542-25552. Epub 2016 Oct 26.

14.

An Asymmetric Runaway Domain Swap Antithrombin Dimer as a Key Intermediate for Polymerization Revealed by Hydrogen/Deuterium-Exchange Mass Spectrometry.

Trelle MB, Pedersen S, Østerlund EC, Madsen JB, Kristensen SR, Jørgensen TJ.

Anal Chem. 2017 Jan 3;89(1):616-624. doi: 10.1021/acs.analchem.6b02518. Epub 2016 Dec 15.

PMID:
27783482
15.

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP, Montasser ME, Landenvall C, Staiger H, Luan J, Frayling TM, Weedon MN, Xie W, Morcillo S, Martínez-Larrad MT, Biggs ML, Chen YD, Corbaton-Anchuelo A, Færch K, Gómez-Zumaquero JM, Goodarzi MO, Kizer JR, Koistinen HA, Leong A, Lind L, Lindgren C, Machicao F, Manning AK, Martín-Núñez GM, Rojo-Martínez G, Rotter JI, Siscovick DS, Zmuda JM, Zhang Z, Serrano-Rios M, Smith U, Soriguer F, Hansen T, Jørgensen TJ, Linnenberg A, Pedersen O, Walker M, Langenberg C, Scott RA, Wareham NJ, Fritsche A, Häring HU, Stefan N, Groop L, O'Connell JR, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, März W, Kovacs P, Stumvoll M, Psaty BM, Kuusisto J, Laakso M, Meigs JB, Dupuis J, Ingelsson E, Florez JC.

Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. Epub 2016 Jul 14.

16.

Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability.

Bucci JC, Trelle MB, McClintock CS, Qureshi T, Jørgensen TJ, Peterson CB.

Biochemistry. 2016 Aug 9;55(31):4386-98. doi: 10.1021/acs.biochem.6b00256. Epub 2016 Jul 27.

PMID:
27416303
17.

Dissecting the interaction between transglutaminase 2 and fibronectin.

Cardoso I, Østerlund EC, Stamnaes J, Iversen R, Andersen JT, Jørgensen TJ, Sollid LM.

Amino Acids. 2017 Mar;49(3):489-500. doi: 10.1007/s00726-016-2296-y. Epub 2016 Jul 9.

PMID:
27394141
18.

The New "Normal": Stakeholders and Radiation Protection Limits in a Post-9/11 World.

Jorgensen TJ.

Health Phys. 2016 Aug;111(2):227-31. doi: 10.1097/HP.0000000000000457.

PMID:
27356070
19.

An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin.

Madsen JB, Andersen LM, Dupont DM, Trelle MB, Johansen JS, Jensen JK, Jørgensen TJ, Andreasen PA.

Cell Chem Biol. 2016 Jun 23;23(6):700-8. doi: 10.1016/j.chembiol.2016.04.013. Epub 2016 Jun 2.

20.

Re: Thyroid Cancer Among Young People in Fukushima.

Jorgensen TJ.

Epidemiology. 2016 May;27(3):e17. doi: 10.1097/EDE.0000000000000465. No abstract available.

PMID:
26841060
21.

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

Mysling S, Kristensen KK, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJ, Young SG, Ploug M.

Elife. 2016 Jan 3;5:e12095. doi: 10.7554/eLife.12095.

22.

Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow.

Trabjerg E, Jakobsen RU, Mysling S, Christensen S, Jørgensen TJ, Rand KD.

Anal Chem. 2015 Sep 1;87(17):8880-8. doi: 10.1021/acs.analchem.5b01996. Epub 2015 Aug 18.

PMID:
26249042
23.

Effect of Metals in Biomimetic Dimetal Complexes on Affinity and Gas-Phase Protection of Phosphate Esters.

Svane S, Jørgensen TJ, McKenzie CJ, Kjeldsen F.

Anal Chem. 2015 Jul 21;87(14):7060-8. doi: 10.1021/acs.analchem.5b00257. Epub 2015 Jun 26.

PMID:
26068532
24.

Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.

Iversen R, Mysling S, Hnida K, Jørgensen TJ, Sollid LM.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17146-51. doi: 10.1073/pnas.1407457111. Epub 2014 Nov 17.

25.

Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.

Rand KD, Zehl M, Jørgensen TJ.

Acc Chem Res. 2014 Oct 21;47(10):3018-27. doi: 10.1021/ar500194w. Epub 2014 Aug 29. Review.

PMID:
25171396
26.

Local transient unfolding of native state PAI-1 associated with serpin metastability.

Trelle MB, Madsen JB, Andreasen PA, Jørgensen TJ.

Angew Chem Int Ed Engl. 2014 Sep 8;53(37):9751-4. doi: 10.1002/anie.201402796. Epub 2014 Jul 22.

PMID:
25049220
27.

On the photostability of peptides after selective photoexcitation of the backbone: prompt versus slow dissociation.

Byskov CS, Jensen F, Jørgensen TJ, Nielsen SB.

Phys Chem Chem Phys. 2014 Aug 14;16(30):15831-8. doi: 10.1039/c4cp02015d.

PMID:
24945849
28.

Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound.

Zhang H, Neimanis S, Lopez-Garcia LA, Arencibia JM, Amon S, Stroba A, Zeuzem S, Proschak E, Stark H, Bauer AF, Busschots K, Jørgensen TJ, Engel M, Schulze JO, Biondi RM.

Chem Biol. 2014 Jun 19;21(6):754-65. doi: 10.1016/j.chembiol.2014.04.007. Epub 2014 May 15.

29.

Co-existence of two different α-synuclein oligomers with different core structures determined by hydrogen/deuterium exchange mass spectrometry.

Paslawski W, Mysling S, Thomsen K, Jørgensen TJ, Otzen DE.

Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7560-3. doi: 10.1002/anie.201400491. Epub 2014 Apr 16.

PMID:
24740651
30.

Mitigating the risk of radiation-induced cancers: limitations and paradigms in drug development.

Yoo SS, Jorgensen TJ, Kennedy AR, Boice JD Jr, Shapiro A, Hu TC, Moyer BR, Grace MB, Kelloff GJ, Fenech M, Prasanna PG, Coleman CN.

J Radiol Prot. 2014 Jun;34(2):R25-52. doi: 10.1088/0952-4746/34/2/R25. Epub 2014 Apr 14. Review.

PMID:
24727460
31.

A phosphorylation tag for uranyl mediated protein purification and photo assisted tag removal.

Zhang Q, Jørgensen TJ, Nielsen PE, Møllegaard NE.

PLoS One. 2014 Mar 5;9(3):e91138. doi: 10.1371/journal.pone.0091138. eCollection 2014.

32.

Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry.

Mysling S, Salbo R, Ploug M, Jørgensen TJ.

Anal Chem. 2014 Jan 7;86(1):340-5. doi: 10.1021/ac403269a. Epub 2013 Dec 23.

PMID:
24251601
33.

Characterizing the dynamics of α-synuclein oligomers using hydrogen/deuterium exchange monitored by mass spectrometry.

Mysling S, Betzer C, Jensen PH, Jorgensen TJ.

Biochemistry. 2013 Dec 23;52(51):9097-103. doi: 10.1021/bi4009193. Epub 2013 Dec 11.

PMID:
24191706
34.

Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.

Henriksen ML, Brandt J, Andrieu JP, Nielsen C, Jensen PH, Holmskov U, Jorgensen TJ, Palarasah Y, Thielens NM, Hansen S.

J Immunol. 2013 Dec 15;191(12):6117-27. doi: 10.4049/jimmunol.1302121. Epub 2013 Oct 30.

35.

Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry.

Trelle MB, Dupont DM, Madsen JB, Andreasen PA, Jørgensen TJ.

ACS Chem Biol. 2014 Jan 17;9(1):174-82. doi: 10.1021/cb400619v. Epub 2013 Nov 14.

PMID:
24138169
36.

Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies.

Persson M, Hosseini M, Madsen J, Jørgensen TJ, Jensen KJ, Kjaer A, Ploug M.

Theranostics. 2013 Aug 3;3(9):618-32. doi: 10.7150/thno.6810. eCollection 2013.

37.

Affinity capture of biotinylated proteins at acidic conditions to facilitate hydrogen/deuterium exchange mass spectrometry analysis of multimeric protein complexes.

Jensen PF, Jørgensen TJ, Koefoed K, Nygaard F, Sen JW.

Anal Chem. 2013 Aug 6;85(15):7052-9. doi: 10.1021/ac303442y. Epub 2013 Jul 22.

PMID:
23534402
38.

Dental x-rays and risk of meningioma.

Jorgensen TJ.

Cancer. 2013 Jan 15;119(2):463. doi: 10.1002/cncr.27710. Epub 2012 Dec 18. No abstract available.

39.

DNA repair gene variants in relation to overall cancer risk: a population-based study.

Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT.

Carcinogenesis. 2013 Jan;34(1):86-92. doi: 10.1093/carcin/bgs304. Epub 2012 Oct 1.

40.

Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin.

Trelle MB, Hirschberg D, Jansson A, Ploug M, Roepstorff P, Andreasen PA, Jørgensen TJ.

Biochemistry. 2012 Oct 16;51(41):8256-66. doi: 10.1021/bi3008998. Epub 2012 Oct 4.

PMID:
22957734
41.

A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR).

Mertens HD, Kjaergaard M, Mysling S, Gårdsvoll H, Jørgensen TJ, Svergun DI, Ploug M.

J Biol Chem. 2012 Oct 5;287(41):34304-15. doi: 10.1074/jbc.M112.398404. Epub 2012 Aug 15.

42.

A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer.

Jorgensen TJ, Ruczinski I, Yao Shugart Y, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ.

Cancer Epidemiol. 2012 Oct;36(5):e288-93. doi: 10.1016/j.canep.2012.05.001. Epub 2012 Jun 5.

43.

A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype.

Ruczinski I, Jorgensen TJ, Shugart YY, Schaad YB, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ.

Carcinogenesis. 2012 Sep;33(9):1692-8. doi: 10.1093/carcin/bgs170. Epub 2012 May 11.

44.

The interaction of the antitoxin DM43 with a snake venom metalloproteinase analyzed by mass spectrometry and surface plasmon resonance.

Brand GD, Salbo R, Jørgensen TJ, Bloch C Jr, Boeri Erba E, Robinson CV, Tanjoni I, Moura-da-Silva AM, Roepstorff P, Domont GB, Perales J, Valente RH, Neves-Ferreira AG.

J Mass Spectrom. 2012 May;47(5):567-73. doi: 10.1002/jms.2990.

PMID:
22549991
45.

Spatially resolved protein hydrogen exchange measured by subzero-cooled chip-based nanoelectrospray ionization tandem mass spectrometry.

Amon S, Trelle MB, Jensen ON, Jørgensen TJ.

Anal Chem. 2012 May 15;84(10):4467-73. doi: 10.1021/ac300268r. Epub 2012 Apr 26.

PMID:
22536891
46.

Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers.

Salbo R, Bush MF, Naver H, Campuzano I, Robinson CV, Pettersson I, Jørgensen TJ, Haselmann KF.

Rapid Commun Mass Spectrom. 2012 May 30;26(10):1181-93. doi: 10.1002/rcm.6211.

PMID:
22499193
47.

A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer.

Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WH, Alani RM, Smith MW, Alberg AJ.

J Invest Dermatol. 2012 May;132(5):1354-62. doi: 10.1038/jid.2012.4. Epub 2012 Feb 16.

48.

An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1).

Selman L, Henriksen ML, Brandt J, Palarasah Y, Waters A, Beales PL, Holmskov U, Jørgensen TJ, Nielsen C, Skjodt K, Hansen S.

J Immunol Methods. 2012 Jan 31;375(1-2):182-8. doi: 10.1016/j.jim.2011.10.010. Epub 2011 Oct 20.

49.

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket.

Lopez-Garcia LA, Schulze JO, Fröhner W, Zhang H, Süss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jørgensen TJ, Alzari PM, Neimanis S, Engel M, Biondi RM.

Chem Biol. 2011 Nov 23;18(11):1463-73. doi: 10.1016/j.chembiol.2011.08.010.

50.

Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay.

Rand KD, Bache N, Nedertoft MM, Jørgensen TJ.

Anal Chem. 2011 Dec 1;83(23):8859-62. doi: 10.1021/ac202468v. Epub 2011 Nov 9.

PMID:
22054221

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