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Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.

Liu B, Tai Y, Liu B, Caceres AI, Yin C, Jordt SE.

JCI Insight. 2019 Jun 11;5. pii: 124497. doi: 10.1172/jci.insight.124497.


Tobacco industry's investment in sweetness comes full circle.

Jordt SE, Jabba S.

BMJ. 2019 Jun 10;365:l2338. doi: 10.1136/bmj.l2338. No abstract available.


ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.

Zheng X, Tai Y, He D, Liu B, Wang C, Shao X, Jordt SE, Liu B.

Mol Pain. 2019 Jan-Dec;15:1744806919842473. doi: 10.1177/1744806919842473.


Sweeteners are added to modify consumer behaviour.

Jordt SE, Jabba S.

BMJ. 2019 Jan 25;364:l366. doi: 10.1136/bmj.l366. No abstract available.


Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids.

Erythropel HC, Jabba SV, DeWinter TM, Mendizabal M, Anastas PT, Jordt SE, Zimmerman JB.

Nicotine Tob Res. 2018 Oct 18. doi: 10.1093/ntr/nty192. [Epub ahead of print]


Presence of High-Intensity Sweeteners in Popular Cigarillos of Varying Flavor Profiles.

Erythropel HC, Kong G, deWinter TM, O'Malley SS, Jordt SE, Anastas PT, Zimmerman JB.

JAMA. 2018 Oct 2;320(13):1380-1383. doi: 10.1001/jama.2018.11187. No abstract available.


Cooling the Itch via TRPM8.

Liu B, Jordt SE.

J Invest Dermatol. 2018 Jun;138(6):1254-1256. doi: 10.1016/j.jid.2018.01.020.


Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

Zhang L, Terrando N, Xu ZZ, Bang S, Jordt SE, Maixner W, Serhan CN, Ji RR.

Front Pharmacol. 2018 May 1;9:412. doi: 10.3389/fphar.2018.00412. eCollection 2018.


TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.

Achanta S, Chintagari NR, Brackmann M, Balakrishna S, Jordt SE.

Toxicol Lett. 2018 Sep 1;293:140-148. doi: 10.1016/j.toxlet.2018.03.007. Epub 2018 Mar 10.


Regulation of Pain and Itch by TRP Channels.

Moore C, Gupta R, Jordt SE, Chen Y, Liedtke WB.

Neurosci Bull. 2018 Feb;34(1):120-142. doi: 10.1007/s12264-017-0200-8. Epub 2017 Dec 27. Review.


Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.

Tai Y, Wang C, Wang Z, Liang Y, Du J, He D, Fan X, Jordt SE, Liu B.

Sci Rep. 2017 Aug 8;7(1):7532. doi: 10.1038/s41598-017-07651-5.


Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice.

Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS.

Behav Brain Res. 2017 Sep 15;334:72-77. doi: 10.1016/j.bbr.2017.07.027. Epub 2017 Jul 22.


An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.

Summerhill EM, Hoyle GW, Jordt SE, Jugg BJ, Martin JG, Matalon S, Patterson SE, Prezant DJ, Sciuto AM, Svendsen ER, White CW, Veress LA; ATS Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly.

Ann Am Thorac Soc. 2017 Jun;14(6):1060-1072. doi: 10.1513/AnnalsATS.201704-297WS.


TRPA1: Acrolein meets its target.

Achanta S, Jordt SE.

Toxicol Appl Pharmacol. 2017 Jun 1;324:45-50. doi: 10.1016/j.taap.2017.03.007. Epub 2017 Mar 8. No abstract available.


Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Caceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt SE.

Br J Pharmacol. 2017 May;174(9):867-879. doi: 10.1111/bph.13760. Epub 2017 Mar 23.


Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.

Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg FW, Schwede F, Stein C, Jordt SE, Brackmann M, Spahn V.

Eur J Pain. 2017 Jul;21(6):1072-1086. doi: 10.1002/ejp.1008. Epub 2017 Feb 9.


IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Liu B, Tai Y, Achanta S, Kaelberer MM, Caceres AI, Shao X, Fang J, Jordt SE.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7572-E7579. Epub 2016 Nov 7.


Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.

Liu B, Tai Y, Caceres AI, Achanta S, Balakrishna S, Shao X, Fang J, Jordt SE.

PLoS One. 2016 Nov 3;11(11):e0165200. doi: 10.1371/journal.pone.0165200. eCollection 2016.


Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.

Fan L, Balakrishna S, Jabba SV, Bonner PE, Taylor SR, Picciotto MR, Jordt SE.

Tob Control. 2016 Nov;25(Suppl 2):ii50-ii54. doi: 10.1136/tobaccocontrol-2016-053209. Epub 2016 Oct 3.


Tear gas: an epidemiological and mechanistic reassessment.

Rothenberg C, Achanta S, Svendsen ER, Jordt SE.

Ann N Y Acad Sci. 2016 Aug;1378(1):96-107. doi: 10.1111/nyas.13141. Epub 2016 Jul 8. Review.


High-Intensity Sweeteners in Alternative Tobacco Products.

Miao S, Beach ES, Sommer TJ, Zimmerman JB, Jordt SE.

Nicotine Tob Res. 2016 Nov;18(11):2169-2173. doi: 10.1093/ntr/ntw141. Epub 2016 May 23.


A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice.

Kaelberer MM, Jordt SE.

J Vis Exp. 2016 Apr 19;(110). doi: 10.3791/53917.


Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.

Smith GJ, Cichocki JA, Doughty BJ, Manautou JE, Jordt SE, Morris JB.

Environ Health Perspect. 2016 May;124(5):642-50. doi: 10.1289/ehp.1509851. Epub 2015 Oct 9.


Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.

Ha MA, Smith GJ, Cichocki JA, Fan L, Liu YS, Caceres AI, Jordt SE, Morris JB.

PLoS One. 2015 Feb 13;10(2):e0117128. doi: 10.1371/journal.pone.0117128. eCollection 2015.


TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

Balakrishna S, Song W, Achanta S, Doran SF, Liu B, Kaelberer MM, Yu Z, Sui A, Cheung M, Leishman E, Eidam HS, Ye G, Willette RN, Thorneloe KS, Bradshaw HB, Matalon S, Jordt SE.

Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15;307(2):L158-72. doi: 10.1152/ajplung.00065.2014. Epub 2014 May 16.


A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN.

Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.


TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.

Liu B, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.

Pain. 2013 Oct;154(10):2169-77. doi: 10.1016/j.pain.2013.06.043. Epub 2013 Jun 29.


TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.

Liu B, Escalera J, Balakrishna S, Fan L, Caceres AI, Robinson E, Sui A, McKay MC, McAlexander MA, Herrick CA, Jordt SE.

FASEB J. 2013 Sep;27(9):3549-63. doi: 10.1096/fj.13-229948. Epub 2013 May 30.


Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants.

Willis DN, Liu B, Ha MA, Jordt SE, Morris JB.

FASEB J. 2011 Dec;25(12):4434-44. doi: 10.1096/fj.11-188383. Epub 2011 Sep 8.


Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy.

Schulze C, McGowan M, Jordt SE, Ehrlich BE.

Clin Colorectal Cancer. 2011 Jun;10(2):126-33. doi: 10.1016/j.clcc.2011.03.010. Epub 2011 Apr 22.


TRPA1 : A Sensory Channel of Many Talents.

Guimaraes MZP, Jordt SE.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 11.


Trigeminal TRPs and the scent of pain.

Jordt SE.

Pain. 2011 Jan;152(1):4-5. doi: 10.1016/j.pain.2010.10.026. Epub 2010 Nov 30. No abstract available.


Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures.

Bessac BF, Jordt SE.

Proc Am Thorac Soc. 2010 Jul;7(4):269-77. doi: 10.1513/pats.201001-004SM. Review.


Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene.

Lanosa MJ, Willis DN, Jordt S, Morris JB.

Toxicol Sci. 2010 Jun;115(2):589-95. doi: 10.1093/toxsci/kfq057. Epub 2010 Feb 22.


A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.

Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9099-104. doi: 10.1073/pnas.0900591106. Epub 2009 May 19.


Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.

Bessac BF, Jordt SE.

Physiology (Bethesda). 2008 Dec;23:360-70. doi: 10.1152/physiol.00026.2008. Review.


Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.

Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE.

FASEB J. 2009 Apr;23(4):1102-14. doi: 10.1096/fj.08-117812. Epub 2008 Nov 26.


TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.

Escalera J, von Hehn CA, Bessac BF, Sivula M, Jordt SE.

J Biol Chem. 2008 Aug 29;283(35):24136-44. doi: 10.1074/jbc.M710280200. Epub 2008 Jun 11.


TRPA1 is a major oxidant sensor in murine airway sensory neurons.

Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE.

J Clin Invest. 2008 May;118(5):1899-910. doi: 10.1172/JCI34192.


TRP channels in disease.

Jordt SE, Ehrlich BE.

Subcell Biochem. 2007;45:253-71. Review.


Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.

Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Högestätt ED, Zygmunt PM.

Eur Urol. 2008 Feb;53(2):391-9. Epub 2007 Oct 22.


Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.

Boehmerle W, Zhang K, Sivula M, Heidrich FM, Lee Y, Jordt SE, Ehrlich BE.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11103-8. Epub 2007 Jun 20.


The menthol receptor TRPM8 is the principal detector of environmental cold.

Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D.

Nature. 2007 Jul 12;448(7150):204-8. Epub 2007 May 30.


TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.

Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D.

Cell. 2006 Mar 24;124(6):1269-82.


Pungent products from garlic activate the sensory ion channel TRPA1.

Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12248-52. Epub 2005 Aug 15.


Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.

Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D.

Nature. 2004 Jan 15;427(6971):260-5. Epub 2004 Jan 7.


Lessons from peppers and peppermint: the molecular logic of thermosensation.

Jordt SE, McKemy DD, Julius D.

Curr Opin Neurobiol. 2003 Aug;13(4):487-92. Review.


Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.

Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D.

Nature. 2001 Jun 21;411(6840):957-62.


Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.

Bösl MR, Stein V, Hübner C, Zdebik AA, Jordt SE, Mukhopadhyay AK, Davidoff MS, Holstein AF, Jentsch TJ.

EMBO J. 2001 Mar 15;20(6):1289-99.

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