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Items: 1 to 50 of 120

1.

Digital PCR-based T Cell Quantification Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma.

de Lange M, Nell RJ, Lalai RN, Versluis M, Jordanova ES, Luyten GP, Jager MJ, van der Burg SH, Zoutman WH, van Hall T, van der Velden PA.

Mol Cancer Res. 2018 Aug 9. pii: molcanres.0114.2018. doi: 10.1158/1541-7786.MCR-18-0114. [Epub ahead of print]

PMID:
30093564
2.

Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer.

Heeren AM, van Dijk I, Berry DRAI, Khelil M, Ferns D, Kole J, Musters RJP, Thijssen VL, Mom CH, Kenter GG, Bleeker MCG, de Gruijl TD, Jordanova ES.

Front Immunol. 2018 Jul 11;9:1598. doi: 10.3389/fimmu.2018.01598. eCollection 2018.

3.

The Prognostic Value of Immune Factors in the Tumor Microenvironment of Penile Squamous Cell Carcinoma.

Ottenhof SR, Djajadiningrat RS, Thygesen HH, Jakobs PJ, Jóźwiak K, Heeren AM, de Jong J, Sanders J, Horenblas S, Jordanova ES.

Front Immunol. 2018 Jun 11;9:1253. doi: 10.3389/fimmu.2018.01253. eCollection 2018.

4.

Sponge-supported cultures of primary head and neck tumors for an optimized preclinical model.

Dohmen AJC, Sanders J, Canisius S, Jordanova ES, Aalbersberg EA, van den Brekel MWM, Neefjes J, Zuur CL.

Oncotarget. 2018 May 18;9(38):25034-25047. doi: 10.18632/oncotarget.25244. eCollection 2018 May 18.

5.

Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target.

Cao J, Pontes KC, Heijkants RC, Brouwer NJ, Groenewoud A, Jordanova ES, Marinkovic M, van Duinen S, Teunisse AF, Verdijk RM, Snaar-Jagalska E, Jochemsen AG, Jager MJ.

J Pathol. 2018 Aug;245(4):433-444. doi: 10.1002/path.5094. Epub 2018 Jun 23.

PMID:
29732557
6.

Tissue Damage Caused by Myeloablative, but Not Non-Myeloablative, Conditioning before Allogeneic Stem Cell Transplantation Results in Dermal Macrophage Recruitment without Active T-Cell Interaction.

van Balen P, van der Zouwen B, Kruisselbrink AB, Eefting M, Szuhai K, Jordanova ES, Falkenburg JHF, Jedema I.

Front Immunol. 2018 Feb 27;9:331. doi: 10.3389/fimmu.2018.00331. eCollection 2018.

7.

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.

Cao J, Brouwer NJ, Jordanova ES, Marinkovic M, van Duinen SG, de Waard NE, Ksander BR, Mulder A, Claas FHJ, Heemskerk MHM, Jager MJ.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1005-1015. doi: 10.1167/iovs.17-23209.

PMID:
29450544
8.

L1 cell adhesion molecule (L1CAM) is a strong predictor for locoregional recurrences in cervical cancer.

Schrevel M, Corver WE, Vegter ME, Ter Haar NT, Dreef EJ, Beltman JJ, Kenter G, Bosse T, de Kroon CD, Jordanova ES.

Oncotarget. 2017 Sep 18;8(50):87568-87581. doi: 10.18632/oncotarget.20976. eCollection 2017 Oct 20.

9.

The landscape of somatic mutations in Indonesian cervical cancer is predominated by the PI3K pathway.

Spaans VM, Nyoman Bayu Mahendra I, Purwoto G, Trietsch MD, Osse M, Ter Haar N, Peters AAW, Fleuren GJ, Jordanova ES.

Gynecol Oncol. 2018 Jan;148(1):189-196. doi: 10.1016/j.ygyno.2017.10.009. Epub 2017 Nov 4.

PMID:
29113722
10.

Intratumoral HPV16-Specific T Cells Constitute a Type I-Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer.

Welters MJP, Ma W, Santegoets SJAM, Goedemans R, Ehsan I, Jordanova ES, van Ham VJ, van Unen V, Koning F, van Egmond SI, Charoentong P, Trajanoski Z, van der Velden LA, van der Burg SH.

Clin Cancer Res. 2018 Feb 1;24(3):634-647. doi: 10.1158/1078-0432.CCR-17-2140. Epub 2017 Oct 10.

PMID:
29018052
11.

PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma.

Cao J, Brouwer NJ, Richards KE, Marinkovic M, van Duinen S, Hurkmans D, Verdegaal EME, Jordanova ES, Jager MJ.

Oncotarget. 2017 May 20;8(33):54722-54734. doi: 10.18632/oncotarget.18039. eCollection 2017 Aug 15.

12.
13.

Autocrine expression of the epidermal growth factor receptor ligand heparin-binding EGF-like growth factor in cervical cancer.

Schrevel M, Osse EM, Prins FA, Trimbos JBMZ, Fleuren GJ, Gorter A, Jordanova ES.

Int J Oncol. 2017 Jun;50(6):1947-1954. doi: 10.3892/ijo.2017.3980. Epub 2017 May 3.

14.

HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia.

Samuels S, Marijne Heeren A, Zijlmans HJMAA, Welters MJP, van den Berg JH, Philips D, Kvistborg P, Ehsan I, Scholl SME, Nuijen B, Schumacher TNM, van Beurden M, Jordanova ES, Haanen JBAG, van der Burg SH, Kenter GG.

Cancer Immunol Immunother. 2017 Sep;66(9):1163-1173. doi: 10.1007/s00262-017-2006-y. Epub 2017 Apr 27.

PMID:
28451790
15.

PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma.

Gezgin G, Luk SJ, Cao J, Dogrusöz M, van der Steen DM, Hagedoorn RS, Krijgsman D, van der Velden PA, Field MG, Luyten GPM, Szuhai K, Harbour JW, Jordanova ES, Heemskerk MHM, Jager MJ.

JAMA Ophthalmol. 2017 Jun 1;135(6):541-549. doi: 10.1001/jamaophthalmol.2017.0729.

16.

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition.

Eggink FA, Van Gool IC, Leary A, Pollock PM, Crosbie EJ, Mileshkin L, Jordanova ES, Adam J, Freeman-Mills L, Church DN, Creutzberg CL, De Bruyn M, Nijman HW, Bosse T.

Oncoimmunology. 2016 Dec 9;6(2):e1264565. doi: 10.1080/2162402X.2016.1264565. eCollection 2017.

17.

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review.

Mehta AM, Mooij M, Branković I, Ouburg S, Morré SA, Jordanova ES.

J Immunol Res. 2017;2017:8913860. doi: 10.1155/2017/8913860. Epub 2017 Feb 9. Review.

18.

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma.

Deken MA, Gadiot J, Jordanova ES, Lacroix R, van Gool M, Kroon P, Pineda C, Geukes Foppen MH, Scolyer R, Song JY, Verbrugge I, Hoeller C, Dummer R, Haanen JB, Long GV, Blank CU.

Oncoimmunology. 2016 Oct 14;5(12):e1238557. doi: 10.1080/2162402X.2016.1238557. eCollection 2016.

19.

Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas.

Hoekstra AS, Hensen EF, Jordanova ES, Korpershoek E, van der Horst-Schrivers AN, Cornelisse C, Corssmit EP, Hes FJ, Jansen JC, Kunst HP, Timmers HJ, Bateman A, Eccles D, Bovée JV, Devilee P, Bayley JP.

Oncotarget. 2017 Feb 28;8(9):14525-14536. doi: 10.18632/oncotarget.14649.

20.

Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression.

Baglio SR, Lagerweij T, Pérez-Lanzón M, Ho XD, Léveillé N, Melo SA, Cleton-Jansen AM, Jordanova ES, Roncuzzi L, Greco M, van Eijndhoven MAJ, Grisendi G, Dominici M, Bonafede R, Lougheed SM, de Gruijl TD, Zini N, Cervo S, Steffan A, Canzonieri V, Martson A, Maasalu K, Köks S, Wurdinger T, Baldini N, Pegtel DM.

Clin Cancer Res. 2017 Jul 15;23(14):3721-3733. doi: 10.1158/1078-0432.CCR-16-2726. Epub 2017 Jan 4. Erratum in: Clin Cancer Res. 2018 Feb 1;24(3):724.

21.

Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases.

Ferns DM, Heeren AM, Samuels S, Bleeker MCG, de Gruijl TD, Kenter GG, Jordanova ES.

J Immunother Cancer. 2016 Nov 15;4:78. doi: 10.1186/s40425-016-0184-3. eCollection 2016.

22.

Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study.

Samuels S, Balint B, von der Leyen H, Hupé P, de Koning L, Kamoun C, Luscap-Rondof W, Wittkop U, Bagrintseva K, Popovic M, Kereszt A, Berns E, Kenter GG, Jordanova ES, Kamal M, Scholl S.

Br J Cancer. 2016 Dec 6;115(12):1575-1583. doi: 10.1038/bjc.2016.340. Epub 2016 Nov 22.

23.

High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status.

Veluchamy JP, Heeren AM, Spanholtz J, van Eendenburg JD, Heideman DA, Kenter GG, Verheul HM, van der Vliet HJ, Jordanova ES, de Gruijl TD.

Cancer Immunol Immunother. 2017 Jan;66(1):51-61. doi: 10.1007/s00262-016-1919-1. Epub 2016 Oct 25.

24.

Expression of Programmed Death Ligand 1 in Penile Cancer is of Prognostic Value and Associated with HPV Status.

Ottenhof SR, Djajadiningrat RS, de Jong J, Thygesen HH, Horenblas S, Jordanova ES.

J Urol. 2017 Mar;197(3 Pt 1):690-697. doi: 10.1016/j.juro.2016.09.088. Epub 2016 Sep 30.

PMID:
27697578
25.

Human Leukocyte Antigen-DR Expression is Significantly Related to an Increased Disease-Free and Disease-Specific Survival in Patients With Cervical Adenocarcinoma.

Samuels S, Spaans VM, Osse M, Peters LA, Kenter GG, Fleuren GJ, Jordanova ES.

Int J Gynecol Cancer. 2016 Oct;26(8):1503-1509.

PMID:
27654088
26.

High myeloid-derived suppressor cell frequencies in the duodenum are associated with enteropathy associated T-cell lymphoma and its precursor lesions.

Bontkes HJ, Jordanova ES, Nijeboer P, Neefjes-Borst EA, Cillessen SAGM, Hayat A, Mulder CJ, Bouma G, von Blomberg BM, de Gruijl TD.

Br J Haematol. 2017 Sep;178(6):988-991. doi: 10.1111/bjh.14186. Epub 2016 Jun 24. No abstract available.

PMID:
27341082
27.

Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix.

Heeren AM, Punt S, Bleeker MC, Gaarenstroom KN, van der Velden J, Kenter GG, de Gruijl TD, Jordanova ES.

Mod Pathol. 2016 Jul;29(7):753-63. doi: 10.1038/modpathol.2016.64. Epub 2016 Apr 8.

28.

A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency.

Punt S, Dronkers EA, Welters MJ, Goedemans R, Koljenović S, Bloemena E, Snijders PJ, Gorter A, van der Burg SH, Baatenburg de Jong RJ, Jordanova ES.

Cancer Immunol Immunother. 2016 Apr;65(4):393-403. doi: 10.1007/s00262-016-1805-x. Epub 2016 Feb 22.

29.

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.

Baglio SR, van Eijndhoven MA, Koppers-Lalic D, Berenguer J, Lougheed SM, Gibbs S, Léveillé N, Rinkel RN, Hopmans ES, Swaminathan S, Verkuijlen SA, Scheffer GL, van Kuppeveld FJ, de Gruijl TD, Bultink IE, Jordanova ES, Hackenberg M, Piersma SR, Knol JC, Voskuyl AE, Wurdinger T, Jiménez CR, Middeldorp JM, Pegtel DM.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E587-96. doi: 10.1073/pnas.1518130113. Epub 2016 Jan 14.

30.

Targetable genetic features of primary testicular and primary central nervous system lymphomas.

Chapuy B, Roemer MG, Stewart C, Tan Y, Abo RP, Zhang L, Dunford AJ, Meredith DM, Thorner AR, Jordanova ES, Liu G, Feuerhake F, Ducar MD, Illerhaus G, Gusenleitner D, Linden EA, Sun HH, Homer H, Aono M, Pinkus GS, Ligon AH, Ligon KL, Ferry JA, Freeman GJ, van Hummelen P, Golub TR, Getz G, Rodig SJ, de Jong D, Monti S, Shipp MA.

Blood. 2016 Feb 18;127(7):869-81. doi: 10.1182/blood-2015-10-673236. Epub 2015 Dec 23.

31.

Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma.

de Lange MJ, van Pelt SI, Versluis M, Jordanova ES, Kroes WG, Ruivenkamp C, van der Burg SH, Luyten GP, van Hall T, Jager MJ, van der Velden PA.

Oncotarget. 2015 Nov 10;6(35):37824-35. doi: 10.18632/oncotarget.5637.

32.

Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area.

Heeren AM, de Boer E, Bleeker MC, Musters RJ, Buist MR, Kenter GG, de Gruijl TD, Jordanova ES.

Oncotarget. 2015 Oct 20;6(32):32484-93. doi: 10.18632/oncotarget.5398.

33.

Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival.

Punt S, Corver WE, van der Zeeuw SA, Kielbasa SM, Osse EM, Buermans HP, de Kroon CD, Jordanova ES, Gorter A.

Oncotarget. 2015 Nov 17;6(36):38681-94. doi: 10.18632/oncotarget.4526.

34.

Presence of human papillomavirus in semen of healthy men is firmly associated with HPV infections of the penile epithelium.

Luttmer R, Dijkstra MG, Snijders PJF, Jordanova ES, King AJ, Pronk DTM, Foresta C, Garolla A, Hompes PGA, Berkhof J, Bleeker MCG, Doorbar J, Heideman DAM, Meijer CJLM.

Fertil Steril. 2015 Oct;104(4):838-844.e8. doi: 10.1016/j.fertnstert.2015.06.028. Epub 2015 Jul 23.

PMID:
26211884
35.

Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome.

Spaans VM, Trietsch MD, Peters AA, Osse M, Ter Haar N, Fleuren GJ, Jordanova ES.

PLoS One. 2015 Jul 21;10(7):e0133670. doi: 10.1371/journal.pone.0133670. eCollection 2015.

36.

CD14+ macrophage-like cells as the linchpin of cervical cancer perpetrated immune suppression and early metastatic spread: A new therapeutic lead?

Heeren AM, Kenter GG, Jordanova ES, de Gruijl TD.

Oncoimmunology. 2015 May 7;4(6):e1009296. eCollection 2015 Jun.

37.

Molecular backgrounds of ERAP1 downregulation in cervical carcinoma.

Mehta AM, Osse M, Kolkman-Uljee S, Fleuren GJ, Jordanova ES.

Anal Cell Pathol (Amst). 2015;2015:367837. doi: 10.1155/2015/367837. Epub 2015 Jun 4.

38.

Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma.

Guislain A, Gadiot J, Kaiser A, Jordanova ES, Broeks A, Sanders J, van Boven H, de Gruijl TD, Haanen JB, Bex A, Blank CU.

Cancer Immunol Immunother. 2015 Oct;64(10):1241-50. doi: 10.1007/s00262-015-1735-z. Epub 2015 Jun 24.

PMID:
26105626
39.

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer.

Punt S, Thijssen VL, Vrolijk J, de Kroon CD, Gorter A, Jordanova ES.

PLoS One. 2015 Jun 12;10(6):e0129119. doi: 10.1371/journal.pone.0129119. eCollection 2015.

40.

The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation.

Tummers B, Goedemans R, Pelascini LP, Jordanova ES, van Esch EM, Meyers C, Melief CJ, Boer JM, van der Burg SH.

Nat Commun. 2015 Mar 13;6:6537. doi: 10.1038/ncomms7537.

41.

Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer.

Wouters M, Dijkgraaf EM, Kuijjer ML, Jordanova ES, Hollema H, Welters M, van der Hoeven J, Daemen T, Kroep JR, Nijman HW, van der Burg SH.

Oncoimmunology. 2015 Jan 7;3(12):e962397. eCollection 2014 Dec.

42.

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review.

Punt S, Langenhoff JM, Putter H, Fleuren GJ, Gorter A, Jordanova ES.

Oncoimmunology. 2015 Mar 6;4(2):e984547. eCollection 2015 Feb. Review.

43.

Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival.

Ferns DM, Kema IP, Buist MR, Nijman HW, Kenter GG, Jordanova ES.

Oncoimmunology. 2015 Feb 25;4(2):e981457. eCollection 2015 Feb.

44.

Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer.

Punt S, Fleuren GJ, Kritikou E, Lubberts E, Trimbos JB, Jordanova ES, Gorter A.

Oncoimmunology. 2015 Feb 3;4(1):e984539. eCollection 2015 Jan.

45.

Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer.

Punt S, Houwing-Duistermaat JJ, Schulkens IA, Thijssen VL, Osse EM, de Kroon CD, Griffioen AW, Fleuren GJ, Gorter A, Jordanova ES.

Mol Cancer. 2015 Mar 31;14:71. doi: 10.1186/s12943-015-0350-0.

46.

High levels of soluble MICA are significantly related to increased disease-free and disease-specific survival in patients with cervical adenocarcinoma.

Samuels S, Ferns DM, Meijer D, van Straalen JP, Buist MR, Zijlmans HJ, Kenter GG, Jordanova ES.

Tissue Antigens. 2015 Jun;85(6):476-83. doi: 10.1111/tan.12562. Epub 2015 Apr 14.

PMID:
25871737
47.

Differences in genetic variation in antigen-processing machinery components and association with cervical carcinoma risk in two Indonesian populations.

Mehta AM, Spaans VM, Mahendra NB, Osse EM, Vet JN, Purwoto G, Surya IG, Cornian S, Peters AA, Fleuren GJ, Jordanova ES.

Immunogenetics. 2015 Jun;67(5-6):267-75. doi: 10.1007/s00251-015-0834-5. Epub 2015 Mar 22.

48.

FoxP3(+) and IL-17(+) cells are correlated with improved prognosis in cervical adenocarcinoma.

Punt S, van Vliet ME, Spaans VM, de Kroon CD, Fleuren GJ, Gorter A, Jordanova ES.

Cancer Immunol Immunother. 2015 Jun;64(6):745-53. doi: 10.1007/s00262-015-1678-4. Epub 2015 Mar 21.

49.

A Murine Model for Metastatic Conjunctival Melanoma.

de Waard NE, Cao J, McGuire SP, Kolovou PE, Jordanova ES, Ksander BR, Jager MJ.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2325-33. doi: 10.1167/iovs.14-15239.

PMID:
25722211
50.

Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.

Massink MP, Kooi IE, van Mil SE, Jordanova ES, Ameziane N, Dorsman JC, van Beek DM, van der Voorn JP, Sie D, Ylstra B, van Deurzen CH, Martens JW, Smid M, Sieuwerts AM, de Weerd V, Foekens JA, van den Ouweland AM, van Dyk E, Nederlof PM, Waisfisz Q, Meijers-Heijboer H.

Mol Oncol. 2015 Apr;9(4):877-88. doi: 10.1016/j.molonc.2014.12.012. Epub 2015 Jan 13.

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