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White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?

Jensen BK, Roth LM, Grinspan JB, Jordan-Sciutto KL.

Brain Res. 2019 Aug 20;1724:146397. doi: 10.1016/j.brainres.2019.146397. [Epub ahead of print] Review.


Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS.

Jackson DP, Ting JH, Pozniak PD, Meurice C, Schleidt SS, Dao A, Lee AH, Klinman E, Jordan-Sciutto KL.

Mol Cell Neurosci. 2018 Oct;92:1-11. doi: 10.1016/j.mcn.2018.06.003. Epub 2018 Jun 22.


BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.

Stern AL, Ghura S, Gannon PJ, Akay-Espinoza C, Phan JM, Yee AC, Vassar R, Gelman BB, Kolson DL, Jordan-Sciutto KL.

J Neurosci. 2018 May 2;38(18):4288-4300. doi: 10.1523/JNEUROSCI.1280-17.2018. Epub 2018 Apr 9.


Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation.

Rom S, Zuluaga-Ramirez V, Reichenbach NL, Erickson MA, Winfield M, Gajghate S, Christofidou-Solomidou M, Jordan-Sciutto KL, Persidsky Y.

J Neuroinflammation. 2018 Jan 27;15(1):25. doi: 10.1186/s12974-018-1065-0.



Erickson MA, Jude J, Zhao H, Rhea EM, Salameh TS, Jester W, Pu S, Harowitz J, Nguyen N, Banks WA, Panettieri RA Jr, Jordan-Sciutto KL.

FASEB J. 2018 Jan;32(1):535. doi: 10.1096/fj.201600857RRRERR. No abstract available.


Differential Effects of Antiretroviral Drugs on Neurons In Vitro: Roles for Oxidative Stress and Integrated Stress Response.

Stern AL, Lee RN, Panvelker N, Li J, Harowitz J, Jordan-Sciutto KL, Akay-Espinoza C.

J Neuroimmune Pharmacol. 2018 Mar;13(1):64-76. doi: 10.1007/s11481-017-9761-6. Epub 2017 Aug 31.


Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis.

Erickson MA, Jude J, Zhao H, Rhea EM, Salameh TS, Jester W, Pu S, Harrowitz J, Nguyen N, Banks WA, Panettieri RA Jr, Jordan-Sciutto KL.

FASEB J. 2017 Sep;31(9):3950-3965. doi: 10.1096/fj.201600857RRR. Epub 2017 May 22. Erratum in: FASEB J. 2018 Jan;32(1):535.


HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL.

Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006.


Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro.

Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB.

J Neurochem. 2017 Jan;140(1):53-67. doi: 10.1111/jnc.13721. Epub 2016 Aug 2.


Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage.

Colacurcio DJ, Zyskind JW, Jordan-Sciutto KL, Espinoza CA.

Neurosci Lett. 2015 Nov 16;609:182-8. doi: 10.1016/j.neulet.2015.10.031. Epub 2015 Oct 22.


Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

Jensen BK, Monnerie H, Mannell MV, Gannon PJ, Espinoza CA, Erickson MA, Bruce-Keller AJ, Gelman BB, Briand LA, Pierce RC, Jordan-Sciutto KL, Grinspan JB.

J Neuropathol Exp Neurol. 2015 Nov;74(11):1093-118. doi: 10.1097/NEN.0000000000000255.


E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity.

Zyskind JW, Wang Y, Cho G, Ting JH, Kolson DL, Lynch DR, Jordan-Sciutto KL.

J Neurochem. 2015 Mar;132(6):742-55. doi: 10.1111/jnc.12956. Epub 2014 Nov 10.


Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders.

Gill AJ, Kovacsics CE, Cross SA, Vance PJ, Kolson LL, Jordan-Sciutto KL, Gelman BB, Kolson DL.

J Clin Invest. 2014 Oct;124(10):4459-72. doi: 10.1172/JCI72279. Epub 2014 Sep 9.


Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium.

Al-Harthi L, Buch S, Geiger JD, Gendelman HE, He JJ, Jordan-Sciutto KL, Kolson DL, Rappaport J, Roy S, Zheng J, Fox HS.

J Neuroimmune Pharmacol. 2014 Jun;9(3):269-76. doi: 10.1007/s11481-014-9545-1. Epub 2014 May 2.


Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.

Ting JH, Marks DR, Schleidt SS, Wu JN, Zyskind JW, Lindl KA, Blendy JA, Pierce RC, Jordan-Sciutto KL.

J Neurochem. 2014 Jun;129(5):850-63. doi: 10.1111/jnc.12655. Epub 2014 Feb 12.


Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system.

Akay C, Cooper M, Odeleye A, Jensen BK, White MG, Vassoler F, Gannon PJ, Mankowski J, Dorsey JL, Buch AM, Cross SA, Cook DR, Peña MM, Andersen ES, Christofidou-Solomidou M, Lindl KA, Zink MC, Clements J, Pierce RC, Kolson DL, Jordan-Sciutto KL.

J Neurovirol. 2014 Feb;20(1):39-53. doi: 10.1007/s13365-013-0227-1. Epub 2014 Jan 14.


Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage.

Colacurcio DJ, Yeager A, Kolson DL, Jordan-Sciutto KL, Akay C.

Mol Cell Neurosci. 2013 Nov;57:54-62. doi: 10.1016/j.mcn.2013.10.003. Epub 2013 Oct 12.


Differential roles for caspase-mediated and calpain-mediated cell death in 1- and 3-week-old rat cortical cultures.

Wang Y, Zyskind JW, Colacurcio DJ, Lindl KA, Ting JH, Grigoriev G, Jordan-Sciutto KL.

Neuroreport. 2012 Dec 19;23(18):1052-8. doi: 10.1097/WNR.0b013e32835ad25d.


Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection.

Cross SA, Cook DR, Chi AW, Vance PJ, Kolson LL, Wong BJ, Jordan-Sciutto KL, Kolson DL.

J Immunol. 2011 Nov 15;187(10):5015-25. doi: 10.4049/jimmunol.1101868. Epub 2011 Oct 5.


Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex.

Akay C, Lindl KA, Shyam N, Nabet B, Goenaga-Vazquez Y, Ruzbarsky J, Wang Y, Kolson DL, Jordan-Sciutto KL.

Neuropathol Appl Neurobiol. 2012 Apr;38(2):175-200. doi: 10.1111/j.1365-2990.2011.01215.x.


Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction.

Dong L, Guarino BB, Jordan-Sciutto KL, Winkelstein BA.

Neuroscience. 2011 Oct 13;193:377-86. doi: 10.1016/j.neuroscience.2011.07.059. Epub 2011 Jul 28.


NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury.

Cook DR, Gleichman AJ, Cross SA, Doshi S, Ho W, Jordan-Sciutto KL, Lynch DR, Kolson DL.

J Neurochem. 2011 Sep;118(6):1113-23. doi: 10.1111/j.1471-4159.2011.07383.x. Epub 2011 Aug 8.


p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors.

Venneti S, Le P, Martinez D, Eaton KW, Shyam N, Jordan-Sciutto KL, Pawel B, Biegel JA, Judkins AR.

J Neuropathol Exp Neurol. 2011 Jul;70(7):596-609. doi: 10.1097/NEN.0b013e31822146ca.


Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity.

Akay C, Lindl KA, Wang Y, White MG, Isaacman-Beck J, Kolson DL, Jordan-Sciutto KL.

Mol Cell Neurosci. 2011 Jun;47(2):154-65. doi: 10.1016/j.mcn.2011.04.001. Epub 2011 Apr 12.


Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration.

White MG, Wang Y, Akay C, Lindl KA, Kolson DL, Jordan-Sciutto KL.

Neurosci Res. 2011 Jun;70(2):220-9. doi: 10.1016/j.neures.2011.01.013. Epub 2011 Feb 1.


E2F1 localizes predominantly to neuronal cytoplasm and fails to induce expression of its transcriptional targets in human immunodeficiency virus-induced neuronal damage.

Wang Y, Shyam N, Ting JH, Akay C, Lindl KA, Jordan-Sciutto KL.

Neurosci Lett. 2010 Jul 26;479(2):97-101. doi: 10.1016/j.neulet.2010.05.032. Epub 2010 May 16.


HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities.

Lindl KA, Marks DR, Kolson DL, Jordan-Sciutto KL.

J Neuroimmune Pharmacol. 2010 Sep;5(3):294-309. doi: 10.1007/s11481-010-9205-z. Epub 2010 Apr 16. Review.


Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue.

Lindl KA, Jordan-Sciutto KL.

Methods Mol Biol. 2008;477:229-43. doi: 10.1007/978-1-60327-517-0_18.


Painful facet joint injury induces neuronal stress activation in the DRG: implications for cellular mechanisms of pain.

Dong L, Odeleye AO, Jordan-Sciutto KL, Winkelstein BA.

Neurosci Lett. 2008 Oct 3;443(2):90-4. doi: 10.1016/j.neulet.2008.07.059. Epub 2008 Jul 26.


Expression of the endoplasmic reticulum stress response marker, BiP, in the central nervous system of HIV-positive individuals.

Lindl KA, Akay C, Wang Y, White MG, Jordan-Sciutto KL.

Neuropathol Appl Neurobiol. 2007 Dec;33(6):658-69. Epub 2007 Oct 11.


Location, location, location: altered transcription factor trafficking in neurodegeneration.

Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL.

J Neuropathol Exp Neurol. 2007 Oct;66(10):873-83. Review.


Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.

Wang Y, White MG, Akay C, Chodroff RA, Robinson J, Lindl KA, Dichter MA, Qian Y, Mao Z, Kolson DL, Jordan-Sciutto KL.

J Neurochem. 2007 Oct;103(2):439-55.


Expression of Nrf2 in neurodegenerative diseases.

Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL.

J Neuropathol Exp Neurol. 2007 Jan;66(1):75-85.


Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist.

Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang Y.

Exp Neurol. 2006 Dec;202(2):313-23. Epub 2006 Aug 1.


Identification of interacting proteins using the yeast two-hybrid screen.

Jordan-Sciutto KL, Montgomery MB.

Methods Mol Biol. 2006;332:211-31.


Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes.

O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL.

J Neurosci. 2006 Jan 18;26(3):981-90.


Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis.

Chalovich EM, Koike MA, Aras MA, Murphey-Corb M, Wiley CA, Jordan-Sciutto KL.

Neuropathology. 2005 Dec;25(4):315-25.


Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death.

Strachan GD, Ostrow LA, Jordan-Sciutto KL.

Biochem Biophys Res Commun. 2005 Oct 21;336(2):490-5.


E2F4 expression patterns in SIV encephalitis.

Morgan KL, Chalovich EM, Strachan GD, Otis LL, Jordan-Sciutto KL.

Neurosci Lett. 2005 Jul 15;382(3):259-64. Epub 2005 Apr 14.


Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact.

Thangam EB, Venkatesha RT, Zaidi AK, Jordan-Sciutto KL, Goncharov DA, Krymskaya VP, Amrani Y, Panettieri RA Jr, Ali H.

FASEB J. 2005 May;19(7):798-800. Epub 2005 Mar 9.


Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.

Strachan GD, Morgan KL, Otis LL, Caltagarone J, Gittis A, Bowser R, Jordan-Sciutto KL.

Biochemistry. 2004 Sep 28;43(38):12113-22.


Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.

Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13650-5. Epub 2003 Oct 31.


Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells.

Rhodes J, Lutka FA, Jordan-Sciutto KL, Bowser R.

Neuroreport. 2003 Mar 3;14(3):449-52.


The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein.

Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ.

J Cell Biochem. 2003 Feb 15;88(3):557-68.


Expression patterns of retinoblastoma protein in Parkinson disease.

Jordan-Sciutto KL, Dorsey R, Chalovich EM, Hammond RR, Achim CL.

J Neuropathol Exp Neurol. 2003 Jan;62(1):68-74.


Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease.

Jordan-Sciutto KL, Morgan K, Bowser R.

J Alzheimers Dis. 1999 Dec;1(6):409-417.


Altered distribution of cell cycle transcriptional regulators during Alzheimer disease.

Jordan-Sciutto KL, Malaiyandi LM, Bowser R.

J Neuropathol Exp Neurol. 2002 Apr;61(4):358-67.

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