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Non-specific effects of BCG in protozoal infections: Tegumentary Leishmaniasis and Malaria.

Dos Santos JC, Teodoro MV, Ribeiro-Dias F, Joosten LAB.

Clin Microbiol Infect. 2019 Jun 15. pii: S1198-743X(19)30292-7. doi: 10.1016/j.cmi.2019.06.002. [Epub ahead of print] Review.


Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Bekkering S, Stiekema LCA, Bernelot Moens S, Verweij SL, Novakovic B, Prange K, Versloot M, Roeters van Lennep JE, Stunnenberg H, de Winther M, Stroes ESG, Joosten LAB, Netea MG, Riksen NP.

Cell Metab. 2019 May 29. pii: S1550-4131(19)30254-2. doi: 10.1016/j.cmet.2019.05.014. [Epub ahead of print]


Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration.

Sloot YJE, Rabold K, Ulas T, De Graaf DM, Heinhuis B, Händler K, Schultze JL, Netea MG, Smit JWA, Joosten LAB, Netea-Maier RT.

Cell Oncol (Dordr). 2019 Jun 14. doi: 10.1007/s13402-019-00457-9. [Epub ahead of print]


A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis.

Jaeger M, Pinelli M, Borghi M, Constantini C, Dindo M, van Emst L, Puccetti M, Pariano M, Ricaño-Ponce I, Büll C, Gresnigt MS, Wang X, Gutierrez Achury J, Jacobs CWM, Xu N, Oosting M, Arts P, Joosten LAB, van de Veerdonk FL, Veltman JA, Ten Oever J, Kullberg BJ, Feng M, Adema GJ, Wijmenga C, Kumar V, Sobel J, Gilissen C, Romani L, Netea MG.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaar3558. doi: 10.1126/scitranslmed.aar3558.


Aldosterone induces trained immunity: the role of fatty acid synthesis.

van der Heijden CDCC, Keating ST, Groh L, Joosten LAB, Netea MG, Riksen NP.

Cardiovasc Res. 2019 May 22. pii: cvz137. doi: 10.1093/cvr/cvz137. [Epub ahead of print]


A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, Ter Horst R, Roerink ME, Novakovic B, Joosten LAB, van der Meer JWM, Netea MG, Bleeker-Rovers CP.

J Transl Med. 2019 May 14;17(1):157. doi: 10.1186/s12967-019-1906-3.


High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Ascone G, Di Ceglie I, van den Bosch MHJ, Kruisbergen NNL, Walgreen B, Sloetjes AW, Lindhout E, Joosten LAB, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van Lent PLEM.

Clin Exp Rheumatol. 2019 May 7. [Epub ahead of print]


Immunometabolism orchestrates training of innate immunity in atherosclerosis.

van Tuijl J, Joosten LAB, Netea MG, Bekkering S, Riksen NP.

Cardiovasc Res. 2019 May 3. pii: cvz107. doi: 10.1093/cvr/cvz107. [Epub ahead of print]


Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.

Mirea AM, Toonen EJM, van den Munckhof I, Munsterman ID, Tjwa ETTL, Jaeger M, Oosting M, Schraa K, Rutten JHW, van der Graaf M, Riksen NP, de Graaf J, Netea MG, Tack CJ, Chavakis T, Joosten LAB.

Mol Med. 2019 May 2;25(1):16. doi: 10.1186/s10020-019-0084-3.


Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides.

Neidhart M, Pajak A, Laskari K, Riksen NP, Joosten LAB, Netea MG, Lutgens E, Stroes ESG, Ciurea A, Distler O, Grigorian M, Karouzakis E.

Front Immunol. 2019 Apr 15;10:791. doi: 10.3389/fimmu.2019.00791. eCollection 2019.


A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, van der Meer JWM, Joosten LAB, Netea MG, Bleeker-Rovers CP.

Eur J Immunol. 2019 Apr 18. doi: 10.1002/eji.201848012. [Epub ahead of print]


Prevalence and determinants of persistent symptoms after treatment for Lyme borreliosis: study protocol for an observational, prospective cohort study (LymeProspect).

Vrijmoeth HD, Ursinus J, Harms MG, Zomer TP, Gauw SA, Tulen AD, Kremer K, Sprong H, Knoop H, Vermeeren YM, van Kooten B, Joosten LAB, Kullberg BJ, Hovius JWR, van den Wijngaard CC.

BMC Infect Dis. 2019 Apr 15;19(1):324. doi: 10.1186/s12879-019-3949-8.


Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk.

Kurilshikov A, van den Munckhof ICL, Chen L, Bonder MJ, Schraa K, Rutten JHW, Riksen NP, de Graaf J, Oosting M, Sanna S, Joosten LAB, van der Graaf M, Brand T, Koonen DPY, van Faassen M; LifeLines DEEP Cohort Study, BBMRI Metabolomics Consortium, Slagboom PE, Xavier RJ, Kuipers F, Hofker MH, Wijmenga C, Netea MG, Zhernakova A, Fu J.

Circ Res. 2019 Jun 7;124(12):1808-1820. doi: 10.1161/CIRCRESAHA.118.314642. Epub 2019 Apr 11.


Therapeutic targeting of trained immunity.

Mulder WJM, Ochando J, Joosten LAB, Fayad ZA, Netea MG.

Nat Rev Drug Discov. 2019 Apr 9. doi: 10.1038/s41573-019-0025-4. [Epub ahead of print] Review.



Blok BA, de Bree LCJ, Diavatopoulos DA, Langereis JD, Joosten LAB, Aaby P, van Crevel R, Benn CS, Netea MG.

Clin Infect Dis. 2019 Mar 28. pii: ciz246. doi: 10.1093/cid/ciz246. [Epub ahead of print]


Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity.

Huang Z, Wang J, Xu X, Wang H, Qiao Y, Chu WC, Xu S, Chai L, Cottier F, Pavelka N, Oosting M, Joosten LAB, Netea M, Ng CYL, Leong KP, Kundu P, Lam KP, Pettersson S, Wang Y.

Nat Microbiol. 2019 May;4(5):766-773. doi: 10.1038/s41564-019-0381-1. Epub 2019 Mar 4.


Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.

Sanna S, van Zuydam NR, Mahajan A, Kurilshikov A, Vich Vila A, Võsa U, Mujagic Z, Masclee AAM, Jonkers DMAE, Oosting M, Joosten LAB, Netea MG, Franke L, Zhernakova A, Fu J, Wijmenga C, McCarthy MI.

Nat Genet. 2019 Apr;51(4):600-605. doi: 10.1038/s41588-019-0350-x. Epub 2019 Feb 18.


Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Tweehuysen L, den Broeder AA, Schraa K, Netea MG, van den Hoogen FHJ, Joosten LAB.

Clin Exp Rheumatol. 2019 May-Jun;37(3):367-372. Epub 2019 Feb 7.


Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression.

Cleophas MCP, Crişan TO, Klück V, Hoogerbrugge N, Netea-Maier RT, Dinarello CA, Netea MG, Joosten LAB.

Arthritis Res Ther. 2019 Feb 6;21(1):50. doi: 10.1186/s13075-019-1834-x.


Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males.

Cleophas MCP, Ratter JM, Bekkering S, Quintin J, Schraa K, Stroes ES, Netea MG, Joosten LAB.

Sci Rep. 2019 Jan 28;9(1):775. doi: 10.1038/s41598-018-37246-7.


Cytokine profiles in patients with Q fever fatigue syndrome.

Raijmakers RPH, Koeken VACM, Jansen AFM, Keijmel SP, Roerink ME, Joosten LAB, Netea MG, van der Meer JWM, Bleeker-Rovers CP.

J Infect. 2019 May;78(5):349-357. doi: 10.1016/j.jinf.2019.01.006. Epub 2019 Jan 23.


Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens.

Netea MG, Schlitzer A, Placek K, Joosten LAB, Schultze JL.

Cell Host Microbe. 2019 Jan 9;25(1):13-26. doi: 10.1016/j.chom.2018.12.006. Review.


Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q fever.

Jansen AFM, Schoffelen T, Bleeker-Rovers CP, Wever PC, Jaeger M, Oosting M, Adriaans A, Joosten LAB, Netea MG, van Deuren M, van de Vosse E.

Clin Microbiol Infect. 2019 May;25(5):631.e11-631.e15. doi: 10.1016/j.cmi.2018.08.011. Epub 2019 Jan 4.


Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

Noz MP, Ter Telgte A, Wiegertjes K, Joosten LAB, Netea MG, de Leeuw FE, Riksen NP.

Stroke. 2018 Dec;49(12):2910-2917. doi: 10.1161/STROKEAHA.118.023192.


Prevalence and associated risk factors for Kaposi's sarcoma among HIV-positive patients in a referral hospital in Northern Tanzania: a retrospective hospital-based study.

Semango GP, Charles RM, Swai CI, Mremi A, Amsi P, Sonda T, Shao ER, Mavura DR, Joosten LAB, Sauli E, Nyindo M.

BMC Cancer. 2018 Dec 17;18(1):1258. doi: 10.1186/s12885-018-5155-2.


Intracellular Alarmins: Hidden dangers signals crucial for cancer, host defense and inflammatory processes.

Joosten LAB, Netea MG.

Semin Immunol. 2018 Aug;38:1-2. doi: 10.1016/j.smim.2018.10.007. Epub 2018 Oct 26. No abstract available.


Role of Glutamine Metabolism in Host Defense Against Mycobacterium tuberculosis Infection.

Koeken VACM, Lachmandas E, Riza A, Matzaraki V, Li Y, Kumar V, Oosting M, Joosten LAB, Netea MG, van Crevel R.

J Infect Dis. 2019 Apr 19;219(10):1662-1670. doi: 10.1093/infdis/jiy709.


Trained Immunity and Local Innate Immune Memory in the Lung.

Netea MG, Joosten LAB.

Cell. 2018 Nov 29;175(6):1463-1465. doi: 10.1016/j.cell.2018.11.007.


DEL-1 promotes macrophage efferocytosis and clearance of inflammation.

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T.

Nat Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.


The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans.

Tunjungputri RN, Li Y, de Groot PG, Dinarello CA, Smeekens SP, Jaeger M, Doppenberg-Oosting M, Cruijsen M, Lemmers H, Toenhake-Dijkstra H, Aguirre-Gamboa R, Kumar V, Wijmenga C, Joosten LAB, Netea MG, van der Ven A, de Mast Q.

Thromb Haemost. 2018 Dec;118(12):2112-2125. doi: 10.1055/s-0038-1675603. Epub 2018 Nov 19.


Corrigendum: Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice.

de Bree LCJ, Marijnissen RJ, Kel JM, Rosendahl Huber SK, Aaby P, Benn CS, Wijnands MVW, Diavatopoulos DA, van Crevel R, Joosten LAB, Netea MG, Dulos J.

Front Immunol. 2018 Oct 25;9:2471. doi: 10.3389/fimmu.2018.02471. eCollection 2018.


The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.


Induction of Trained Innate Immunity in Human Monocytes by Bovine Milk and Milk-Derived Immunoglobulin G.

van Splunter M, van Osch TLJ, Brugman S, Savelkoul HFJ, Joosten LAB, Netea MG, van Neerven RJJ.

Nutrients. 2018 Sep 27;10(10). pii: E1378. doi: 10.3390/nu10101378.


Induction of innate immune memory: the role of cellular metabolism.

Domínguez-Andrés J, Joosten LA, Netea MG.

Curr Opin Immunol. 2019 Feb;56:10-16. doi: 10.1016/j.coi.2018.09.001. Epub 2018 Sep 19. Review.


Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients.

Damen MSMA, Schraa K, Tweehuysen L, den Broeder AA, Netea MG, Popa CD, Joosten LAB.

Sci Rep. 2018 Sep 19;8(1):14050. doi: 10.1038/s41598-018-32485-0.


Pitfalls in cytokine measurements - Plasma TGF-β1 in chronic fatigue syndrome.

Roerink ME, van der Schaaf ME, Hawinkels LJAC, Raijmakers RPH, Knoop H, Joosten LAB, van der Meer JWM.

Neth J Med. 2018 Sep;76(7):310-313.


The impact of sex hormones on BCG-induced trained immunity.

de Bree LCJ, Janssen R, Aaby P, van Crevel R, Joosten LAB, Benn CS, Netea MG.

J Leukoc Biol. 2018 Sep;104(3):573-578. doi: 10.1002/JLB.5MA0118-027R.


Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies.

van den Munckhof ICL, Kurilshikov A, Ter Horst R, Riksen NP, Joosten LAB, Zhernakova A, Fu J, Keating ST, Netea MG, de Graaf J, Rutten JHW.

Obes Rev. 2018 Dec;19(12):1719-1734. doi: 10.1111/obr.12750. Epub 2018 Aug 24.


NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.

Marchetti C, Swartzwelter B, Koenders MI, Azam T, Tengesdal IW, Powers N, de Graaf DM, Dinarello CA, Joosten LAB.

Arthritis Res Ther. 2018 Aug 3;20(1):169. doi: 10.1186/s13075-018-1664-2.


HDAC inhibitors modulate innate immune responses to micro-organisms relevant to chronic mucocutaneous candidiasis.

Rösler B, Wang X, Keating ST, Joosten LAB, Netea MG, van de Veerdonk FL.

Clin Exp Immunol. 2018 Nov;194(2):205-219. doi: 10.1111/cei.13192. Epub 2018 Oct 1.


Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella burnetii.

Jansen AFM, Dinkla A, Roest HJ, Bleeker-Rovers CP, Schoffelen T, Joosten LAB, Wever PC, van Deuren M, Koets AP.

Infect Immun. 2018 Sep 21;86(10). pii: e00333-18. doi: 10.1128/IAI.00333-18. Print 2018 Oct.


Non-specific effects of vaccines: Current evidence and potential implications.

de Bree LCJ, Koeken VACM, Joosten LAB, Aaby P, Benn CS, van Crevel R, Netea MG.

Semin Immunol. 2018 Oct;39:35-43. doi: 10.1016/j.smim.2018.06.002. Epub 2018 Jul 11. Review.


The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis.

Fischer A, Abdollahi-Roodsaz S, Böhm C, Niederreiter B, Meyer B, Yau ACY, Lönnblom E, Joosten LAB, Koenders M, Lehmann CHK, Dudziak D, Krönke G, Holmdahl R, Steiner G.

J Cell Mol Med. 2018 Sep;22(9):4399-4409. doi: 10.1111/jcmm.13735. Epub 2018 Jul 11.


Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.


Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, Schoffelen T, Scholzen A, van der Meer JWM, Joosten LAB, Netea MG, van Deuren M, Bleeker-Rovers CP.

Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1385-1391. doi: 10.1007/s10096-018-3265-z. Epub 2018 May 26.


Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.

Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, Li Y.

Nat Immunol. 2018 Jul;19(7):776-786. doi: 10.1038/s41590-018-0121-3. Epub 2018 May 21.


Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice.

de Bree LCJ, Marijnissen RJ, Kel JM, Rosendahl Huber SK, Aaby P, Benn CS, Wijnands MVW, Diavatopoulos DA, van Crevel R, Joosten LAB, Netea MG, Dulos J.

Front Immunol. 2018 Apr 30;9:869. doi: 10.3389/fimmu.2018.00869. eCollection 2018. Erratum in: Front Immunol. 2018 Oct 25;9:2471.


Insights into the role of IL-32 in cancer.

Sloot YJE, Smit JW, Joosten LAB, Netea-Maier RT.

Semin Immunol. 2018 Aug;38:24-32. doi: 10.1016/j.smim.2018.03.004. Epub 2018 May 8. Review.


Trained immunity as a novel therapeutic strategy.

Mourits VP, Wijkmans JC, Joosten LA, Netea MG.

Curr Opin Pharmacol. 2018 Aug;41:52-58. doi: 10.1016/j.coph.2018.04.007. Epub 2018 Apr 24. Review.


A role for TLR10 in obesity and adipose tissue morphology.

Boutens L, Mirea AM, van den Munckhof I, Doppenberg-Oosting M, Jaeger M, Hijmans A, Netea MG, Joosten LAB, Stienstra R.

Cytokine. 2018 Aug;108:205-212. doi: 10.1016/j.cyto.2018.03.021. Epub 2018 Apr 23.


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