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Borrelia burgdorferi hijacks cellular metabolism of immune cells: Consequences for host defense.

Kerstholt M, Netea MG, Joosten LAB.

Ticks Tick Borne Dis. 2020 Feb 3:101386. doi: 10.1016/j.ttbdis.2020.101386. [Epub ahead of print] Review.


Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.

Dos Santos JC, Leite Quixabeira VB, Teodoro Silva MV, Damen MSMA, Schraa K, Jaeger M, Oosting M, Keating ST, Dorta ML, Alves Pinto S, Bugalho Duarte F, de Araújo Pereira LI, Netea MG, Ribeiro-Dias F, Joosten LAB.

PLoS Negl Trop Dis. 2020 Feb 5;14(2):e0008029. doi: 10.1371/journal.pntd.0008029. [Epub ahead of print]


Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.

Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB.

Inflammation. 2020 Jan 30. doi: 10.1007/s10753-020-01190-4. [Epub ahead of print]


Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locus.

Zaidi F, Narang RK, Phipps-Green A, Gamble GG, Tausche AK, So A, Riches P, Andres M, Perez-Ruiz F, Doherty M, Janssen M, Joosten LAB, Jansen TL, Kurreeman F, Torres RJ, McCarthy GM, Miner JN, Stamp LK, Merriman TR, Dalbeth N.

Rheumatology (Oxford). 2020 Jan 30. pii: kez685. doi: 10.1093/rheumatology/kez685. [Epub ahead of print]


Advances in understanding molecular regulation of innate immune memory.

Domínguez-Andrés J, Fanucchi S, Joosten LAB, Mhlanga MM, Netea MG.

Curr Opin Cell Biol. 2020 Jan 25;63:68-75. doi: 10.1016/ [Epub ahead of print] Review.


A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.

Brouwer MAE, van de Schoor FR, Vrijmoeth HD, Netea MG, Joosten LAB.

Immunol Rev. 2020 Jan 13. doi: 10.1111/imr.12837. [Epub ahead of print] Review.


Training the trainable cells of the immune system and beyond.

Kar UK, Joosten LAB.

Nat Immunol. 2020 Feb;21(2):115-119. doi: 10.1038/s41590-019-0583-y. No abstract available.


Arterial wall inflammation and increased hematopoietic activity in patients with primary aldosteronism.

van der Heijden CDCC, Smeets EMM, Aarntzen EHJG, Noz MP, Monajemi H, Kersten S, Kaffa C, Hoischen A, Deinum J, Joosten LAB, Netea MG, Riksen NP.

J Clin Endocrinol Metab. 2019 Dec 25. pii: dgz306. doi: 10.1210/clinem/dgz306. [Epub ahead of print]


Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia.

Cabău G, Crișan TO, Klück V, Popp RA, Joosten LAB.

Immunol Rev. 2019 Dec 19. doi: 10.1111/imr.12833. [Epub ahead of print] Review.


Asymptomatic hyperuricaemia: a silent activator of the innate immune system.

Joosten LAB, Crişan TO, Bjornstad P, Johnson RJ.

Nat Rev Rheumatol. 2020 Feb;16(2):75-86. doi: 10.1038/s41584-019-0334-3. Epub 2019 Dec 10. Review.


Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-α, in Endothelial Cells.

Le KTT, Chu X, Jaeger M, Plantinga JA, Matzaraki V, Withoff S, Joosten LAB, Netea MG, Wijmenga C, Li Y, Moser J, Kumar V.

Front Immunol. 2019 Oct 25;10:2508. doi: 10.3389/fimmu.2019.02508. eCollection 2019.


The role of Toll-like receptor 10 in modulation of trained immunity.

Mourits VP, Arts RJW, Novakovic B, Matzaraki V, de Bree LCJ, Koeken VACM, Moorlag SJCFM, van Puffelen JH, Groh L, van der Heijden CDCC, Keating ST, Netea MG, Oosting M, Joosten LAB.

Immunology. 2020 Mar;159(3):289-297. doi: 10.1111/imm.13145. Epub 2019 Nov 26.


Sixteen-Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State.

Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP.

J Am Heart Assoc. 2019 Nov 5;8(21):e013764. doi: 10.1161/JAHA.119.013764. Epub 2019 Oct 18.



Dalbeth N, Choi HK, Joosten LAB, Khanna PP, Matsuo H, Perez-Ruiz F, Stamp LK.

Nat Rev Dis Primers. 2019 Sep 26;5(1):69. doi: 10.1038/s41572-019-0115-y. Review.


β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32.

Dos Santos JC, Barroso de Figueiredo AM, Teodoro Silva MV, Cirovic B, de Bree LCJ, Damen MSMA, Moorlag SJCFM, Gomes RS, Helsen MM, Oosting M, Keating ST, Schlitzer A, Netea MG, Ribeiro-Dias F, Joosten LAB.

Cell Rep. 2019 Sep 3;28(10):2659-2672.e6. doi: 10.1016/j.celrep.2019.08.004.


Validation of cellular tests for Lyme borreliosis (VICTORY) study.

van de Schoor FR, Baarsma ME, Gauw SA, Joosten LAB, Kullberg BJ, van den Wijngaard CC, Hovius JW.

BMC Infect Dis. 2019 Aug 20;19(1):732. doi: 10.1186/s12879-019-4323-6.


Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes.

Damen MSMA, Ballak D, Sapinsley Z, Bai X, Chan ED, Seals DR, Popa CD, Joosten LAB.

Cytokine. 2020 Jan;125:154793. doi: 10.1016/j.cyto.2019.154793. Epub 2019 Aug 6.


IL-32 and its splice variants are associated with protection against Mycobacterium tuberculosis infection and skewing of Th1/Th17 cytokines.

Koeken VACM, Verrall AJ, Ardiansyah E, Apriani L, Dos Santos JC, Kumar V, Alisjahbana B, Hill PC, Joosten LAB, van Crevel R, van Laarhoven A.

J Leukoc Biol. 2020 Jan;107(1):113-118. doi: 10.1002/JLB.4AB0219-071R. Epub 2019 Aug 4.


Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients.

Raijmakers RP, Stenos J, Keijmel SP, Ter Horst R, Novakovic B, Nguyen C, Van Der Meer JW, Netea MG, Bleeker-Rovers CP, Joosten LA, Graves SR.

Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz296. doi: 10.1093/ofid/ofz296.


Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells.

Bossel Ben-Moshe N, Hen-Avivi S, Levitin N, Yehezkel D, Oosting M, Joosten LAB, Netea MG, Avraham R.

Nat Commun. 2019 Jul 22;10(1):3266. doi: 10.1038/s41467-019-11257-y.


A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.

Jaeger M, Matzaraki V, Aguirre-Gamboa R, Gresnigt MS, Chu X, Johnson MD, Oosting M, Smeekens SP, Withoff S, Jonkers I, Perfect JR, van de Veerdonk FL, Kullberg BJ, Joosten LAB, Li Y, Wijmenga C, Netea MG, Kumar V.

J Infect Dis. 2019 Jul 31;220(5):862-872. doi: 10.1093/infdis/jiz206.


Non-specific effects of BCG in protozoal infections: tegumentary leishmaniasis and malaria.

Dos Santos JC, Vilela Teodoro Silva M, Ribeiro-Dias F, Joosten LAB.

Clin Microbiol Infect. 2019 Dec;25(12):1479-1483. doi: 10.1016/j.cmi.2019.06.002. Epub 2019 Jun 15. Review.


Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Bekkering S, Stiekema LCA, Bernelot Moens S, Verweij SL, Novakovic B, Prange K, Versloot M, Roeters van Lennep JE, Stunnenberg H, de Winther M, Stroes ESG, Joosten LAB, Netea MG, Riksen NP.

Cell Metab. 2019 Jul 2;30(1):1-2. doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.


Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration.

Sloot YJE, Rabold K, Ulas T, De Graaf DM, Heinhuis B, Händler K, Schultze JL, Netea MG, Smit JWA, Joosten LAB, Netea-Maier RT.

Cell Oncol (Dordr). 2019 Oct;42(5):691-703. doi: 10.1007/s13402-019-00457-9. Epub 2019 Jun 14.


A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis.

Jaeger M, Pinelli M, Borghi M, Constantini C, Dindo M, van Emst L, Puccetti M, Pariano M, Ricaño-Ponce I, Büll C, Gresnigt MS, Wang X, Gutierrez Achury J, Jacobs CWM, Xu N, Oosting M, Arts P, Joosten LAB, van de Veerdonk FL, Veltman JA, Ten Oever J, Kullberg BJ, Feng M, Adema GJ, Wijmenga C, Kumar V, Sobel J, Gilissen C, Romani L, Netea MG.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaar3558. doi: 10.1126/scitranslmed.aar3558.


Aldosterone induces trained immunity: the role of fatty acid synthesis.

van der Heijden CDCC, Keating ST, Groh L, Joosten LAB, Netea MG, Riksen NP.

Cardiovasc Res. 2020 Feb 1;116(2):317-328. doi: 10.1093/cvr/cvz137.


A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, Ter Horst R, Roerink ME, Novakovic B, Joosten LAB, van der Meer JWM, Netea MG, Bleeker-Rovers CP.

J Transl Med. 2019 May 14;17(1):157. doi: 10.1186/s12967-019-1906-3.


High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Ascone G, Di Ceglie I, van den Bosch MHJ, Kruisbergen NNL, Walgreen B, Sloetjes AW, Lindhout E, Joosten LAB, van de Loo FAJ, Koenders MI, van der Kraan PM, Blom AB, van Lent PLEM.

Clin Exp Rheumatol. 2019 Nov-Dec;37(6):983-993. Epub 2019 May 7.


Immunometabolism orchestrates training of innate immunity in atherosclerosis.

van Tuijl J, Joosten LAB, Netea MG, Bekkering S, Riksen NP.

Cardiovasc Res. 2019 Jul 1;115(9):1416-1424. doi: 10.1093/cvr/cvz107.


Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.

Mirea AM, Toonen EJM, van den Munckhof I, Munsterman ID, Tjwa ETTL, Jaeger M, Oosting M, Schraa K, Rutten JHW, van der Graaf M, Riksen NP, de Graaf J, Netea MG, Tack CJ, Chavakis T, Joosten LAB.

Mol Med. 2019 May 2;25(1):16. doi: 10.1186/s10020-019-0084-3.


Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides.

Neidhart M, Pajak A, Laskari K, Riksen NP, Joosten LAB, Netea MG, Lutgens E, Stroes ESG, Ciurea A, Distler O, Grigorian M, Karouzakis E.

Front Immunol. 2019 Apr 15;10:791. doi: 10.3389/fimmu.2019.00791. eCollection 2019.


A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome.

Raijmakers RPH, Jansen AFM, Keijmel SP, van der Meer JWM, Joosten LAB, Netea MG, Bleeker-Rovers CP.

Eur J Immunol. 2019 Jul;49(7):1015-1022. doi: 10.1002/eji.201848012. Epub 2019 May 9.


Prevalence and determinants of persistent symptoms after treatment for Lyme borreliosis: study protocol for an observational, prospective cohort study (LymeProspect).

Vrijmoeth HD, Ursinus J, Harms MG, Zomer TP, Gauw SA, Tulen AD, Kremer K, Sprong H, Knoop H, Vermeeren YM, van Kooten B, Joosten LAB, Kullberg BJ, Hovius JWR, van den Wijngaard CC.

BMC Infect Dis. 2019 Apr 15;19(1):324. doi: 10.1186/s12879-019-3949-8.


Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk.

Kurilshikov A, van den Munckhof ICL, Chen L, Bonder MJ, Schraa K, Rutten JHW, Riksen NP, de Graaf J, Oosting M, Sanna S, Joosten LAB, van der Graaf M, Brand T, Koonen DPY, van Faassen M; LifeLines DEEP Cohort Study, BBMRI Metabolomics Consortium, Slagboom PE, Xavier RJ, Kuipers F, Hofker MH, Wijmenga C, Netea MG, Zhernakova A, Fu J.

Circ Res. 2019 Jun 7;124(12):1808-1820. doi: 10.1161/CIRCRESAHA.118.314642. Epub 2019 Apr 11.


Therapeutic targeting of trained immunity.

Mulder WJM, Ochando J, Joosten LAB, Fayad ZA, Netea MG.

Nat Rev Drug Discov. 2019 Jul;18(7):553-566. doi: 10.1038/s41573-019-0025-4. Review.


Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guérin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial.

Blok BA, de Bree LCJ, Diavatopoulos DA, Langereis JD, Joosten LAB, Aaby P, van Crevel R, Benn CS, Netea MG.

Clin Infect Dis. 2020 Jan 16;70(3):455-463. doi: 10.1093/cid/ciz246.


Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity.

Huang Z, Wang J, Xu X, Wang H, Qiao Y, Chu WC, Xu S, Chai L, Cottier F, Pavelka N, Oosting M, Joosten LAB, Netea M, Ng CYL, Leong KP, Kundu P, Lam KP, Pettersson S, Wang Y.

Nat Microbiol. 2019 May;4(5):766-773. doi: 10.1038/s41564-019-0381-1. Epub 2019 Mar 4.


Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.

Sanna S, van Zuydam NR, Mahajan A, Kurilshikov A, Vich Vila A, Võsa U, Mujagic Z, Masclee AAM, Jonkers DMAE, Oosting M, Joosten LAB, Netea MG, Franke L, Zhernakova A, Fu J, Wijmenga C, McCarthy MI.

Nat Genet. 2019 Apr;51(4):600-605. doi: 10.1038/s41588-019-0350-x. Epub 2019 Feb 18.


Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Tweehuysen L, den Broeder AA, Schraa K, Netea MG, van den Hoogen FHJ, Joosten LAB.

Clin Exp Rheumatol. 2019 May-Jun;37(3):367-372. Epub 2019 Feb 7.


Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression.

Cleophas MCP, Crişan TO, Klück V, Hoogerbrugge N, Netea-Maier RT, Dinarello CA, Netea MG, Joosten LAB.

Arthritis Res Ther. 2019 Feb 6;21(1):50. doi: 10.1186/s13075-019-1834-x.


Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males.

Cleophas MCP, Ratter JM, Bekkering S, Quintin J, Schraa K, Stroes ES, Netea MG, Joosten LAB.

Sci Rep. 2019 Jan 28;9(1):775. doi: 10.1038/s41598-018-37246-7.


Cytokine profiles in patients with Q fever fatigue syndrome.

Raijmakers RPH, Koeken VACM, Jansen AFM, Keijmel SP, Roerink ME, Joosten LAB, Netea MG, van der Meer JWM, Bleeker-Rovers CP.

J Infect. 2019 May;78(5):349-357. doi: 10.1016/j.jinf.2019.01.006. Epub 2019 Jan 23.


Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens.

Netea MG, Schlitzer A, Placek K, Joosten LAB, Schultze JL.

Cell Host Microbe. 2019 Jan 9;25(1):13-26. doi: 10.1016/j.chom.2018.12.006. Review.


Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q fever.

Jansen AFM, Schoffelen T, Bleeker-Rovers CP, Wever PC, Jaeger M, Oosting M, Adriaans A, Joosten LAB, Netea MG, van Deuren M, van de Vosse E.

Clin Microbiol Infect. 2019 May;25(5):631.e11-631.e15. doi: 10.1016/j.cmi.2018.08.011. Epub 2019 Jan 4.


Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease.

Noz MP, Ter Telgte A, Wiegertjes K, Joosten LAB, Netea MG, de Leeuw FE, Riksen NP.

Stroke. 2018 Dec;49(12):2910-2917. doi: 10.1161/STROKEAHA.118.023192.


Prevalence and associated risk factors for Kaposi's sarcoma among HIV-positive patients in a referral hospital in Northern Tanzania: a retrospective hospital-based study.

Semango GP, Charles RM, Swai CI, Mremi A, Amsi P, Sonda T, Shao ER, Mavura DR, Joosten LAB, Sauli E, Nyindo M.

BMC Cancer. 2018 Dec 17;18(1):1258. doi: 10.1186/s12885-018-5155-2.


Intracellular Alarmins: Hidden dangers signals crucial for cancer, host defense and inflammatory processes.

Joosten LAB, Netea MG.

Semin Immunol. 2018 Aug;38:1-2. doi: 10.1016/j.smim.2018.10.007. Epub 2018 Oct 26. No abstract available.


Role of Glutamine Metabolism in Host Defense Against Mycobacterium tuberculosis Infection.

Koeken VACM, Lachmandas E, Riza A, Matzaraki V, Li Y, Kumar V, Oosting M, Joosten LAB, Netea MG, van Crevel R.

J Infect Dis. 2019 Apr 19;219(10):1662-1670. doi: 10.1093/infdis/jiy709.


Trained Immunity and Local Innate Immune Memory in the Lung.

Netea MG, Joosten LAB.

Cell. 2018 Nov 29;175(6):1463-1465. doi: 10.1016/j.cell.2018.11.007.


DEL-1 promotes macrophage efferocytosis and clearance of inflammation.

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T.

Nat Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.

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