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Items: 1 to 50 of 65

1.

Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice.

van de Peppel IP, Bertolini A, van Dijk TH, Groen AK, Jonker JW, Verkade HJ.

J Lipid Res. 2019 Jul 19. pii: jlr.M094607. doi: 10.1194/jlr.M094607. [Epub ahead of print]

2.

Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.

Zwarts I, van Zutphen T, Kruit JK, Liu W, Oosterveer MH, Verkade HJ, Uhlenhaut NH, Jonker JW.

Sci Rep. 2019 Jun 26;9(1):9299. doi: 10.1038/s41598-019-45803-x.

3.

Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease.

van Zutphen T, Bertolini A, de Vries HD, Bloks VW, de Boer JF, Jonker JW, Kuipers F.

Handb Exp Pharmacol. 2019 Jun 25. doi: 10.1007/164_2019_233. [Epub ahead of print]

PMID:
31236687
4.

Senescent cells in the development of cardiometabolic disease.

Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK.

Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602.

5.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.

Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, Mulder M.

Sci Rep. 2019 Mar 20;9(1):4908. doi: 10.1038/s41598-019-41399-4.

6.

Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application.

Struik D, Dommerholt MB, Jonker JW.

Curr Opin Lipidol. 2019 Jun;30(3):235-243. doi: 10.1097/MOL.0000000000000599.

7.

LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats.

van der Schoor LWE, Hulzebos CV, van Faassen MH, Kema IP, de Bruin A, Havinga R, Koster M, Youssef SA, Bongiovanni L, Jonker JW, Verkade HJ.

Pediatr Res. 2019 Jun;85(7):1041-1047. doi: 10.1038/s41390-019-0367-y. Epub 2019 Mar 9.

PMID:
30851724
8.

Defective FXR-FGF15 signaling and bile acid homeostasis in cystic fibrosis mice can be restored by the laxative polyethylene glycol.

Bertolini A, van de Peppel IP, Doktorova-Demmin M, Bodewes FAJA, de Jonge H, Bijvelds M, Verkade HJ, Jonker JW.

Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G404-G411. doi: 10.1152/ajpgi.00188.2018. Epub 2019 Jan 17.

PMID:
30653340
9.

IVACAFTOR restores FGF19 regulated bile acid homeostasis in cystic fibrosis patients with an S1251N or a G551D gating mutation.

van de Peppel IP, Doktorova M, Berkers G, de Jonge HR, Houwen RHJ, Verkade HJ, Jonker JW, Bodewes FAJA.

J Cyst Fibros. 2019 Mar;18(2):286-293. doi: 10.1016/j.jcf.2018.09.001. Epub 2018 Sep 29.

PMID:
30279125
10.

Bile acid homeostasis in gastrointestinal and metabolic complications of cystic fibrosis.

van de Peppel IP, Bodewes FAJA, Verkade HJ, Jonker JW.

J Cyst Fibros. 2019 May;18(3):313-320. doi: 10.1016/j.jcf.2018.08.009. Epub 2018 Sep 7. Review.

PMID:
30201330
11.

GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.

Qin J, Sikkema AH, van der Bij K, de Jonge JC, Klappe K, Nies V, Jonker JW, Kok JW, Hoekstra D, Baron W.

J Neurosci. 2017 Oct 11;37(41):9925-9938. doi: 10.1523/JNEUROSCI.0103-17.2017. Epub 2017 Sep 12.

12.

TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.

Nies VJM, Struik D, Wolfs MGM, Rensen SS, Szalowska E, Unmehopa UA, Fluiter K, van der Meer TP, Hajmousa G, Buurman WA, Greve JW, Rezaee F, Shiri-Sverdlov R, Vonk RJ, Swaab DF, Wolffenbuttel BHR, Jonker JW, van Vliet-Ostaptchouk JV.

Int J Obes (Lond). 2018 Mar;42(3):376-383. doi: 10.1038/ijo.2017.214. Epub 2017 Aug 30.

PMID:
28852204
13.

Diagnosis, follow-up and treatment of cystic fibrosis-related liver disease.

van de Peppel IP, Bertolini A, Jonker JW, Bodewes FAJA, Verkade HJ.

Curr Opin Pulm Med. 2017 Nov;23(6):562-569. doi: 10.1097/MCP.0000000000000428. Review.

PMID:
28837442
14.

Cystic Fibrosis-related Liver Disease: Research Challenges and Future Perspectives.

Debray D, Narkewicz MR, Bodewes FAJA, Colombo C, Housset C, de Jonge HR, Jonker JW, Kelly DA, Ling SC, Poynard T, Sogni P, Trauner M, Witters P, Baumann U, Wilschanski M, Verkade HJ.

J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):443-448. doi: 10.1097/MPG.0000000000001676.

PMID:
28753176
15.

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1785-1798. doi: 10.1016/j.bbamcr.2017.07.005. Epub 2017 Jul 16.

16.

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia.

Doktorova M, Zwarts I, Zutphen TV, Dijk THV, Bloks VW, Harkema L, Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW.

Sci Rep. 2017 Apr 12;7(1):846. doi: 10.1038/s41598-017-00889-z.

17.

Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology.

Bijsmans IT, Milona A, Ijssennagger N, Willemsen EC, Ramos Pittol JM, Jonker JW, Lange K, Hooiveld GJ, van Mil SW.

Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):687-700. doi: 10.1016/j.bbadis.2016.12.004. Epub 2016 Dec 10.

18.

Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction.

van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, de Moraes RA, Zhang L, Wolters JC, Bischoff R, Wanders RJ, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH.

J Hepatol. 2016 Dec;65(6):1198-1208. doi: 10.1016/j.jhep.2016.05.046. Epub 2016 Jun 14.

19.

Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease.

Liu W, Struik D, Nies VJ, Jurdzinski A, Harkema L, de Bruin A, Verkade HJ, Downes M, Evans RM, van Zutphen T, Jonker JW.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2288-93. doi: 10.1073/pnas.1525093113. Epub 2016 Feb 8.

20.

Fibroblast Growth Factor Signaling in Metabolic Regulation.

Nies VJ, Sancar G, Liu W, van Zutphen T, Struik D, Yu RT, Atkins AR, Evans RM, Jonker JW, Downes MR.

Front Endocrinol (Lausanne). 2016 Jan 19;6:193. doi: 10.3389/fendo.2015.00193. eCollection 2015. Review.

21.

Reply to: "Impaired expression of multidrug resistance-associated protein 2 and liver damage in erythropoietic protoporphyria".

Bloks VW, Plösch T, Jonker JW, Kuipers F.

Hepatology. 2016 May;63(5):1743-4. doi: 10.1002/hep.27993. Epub 2015 Aug 21. No abstract available.

PMID:
26173575
22.

Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM.

Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14304. Epub 2015 Mar 4. No abstract available.

PMID:
25739500
23.

Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation.

den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM.

Diabetes. 2015 Jul;64(7):2398-408. doi: 10.2337/db14-1213. Epub 2015 Feb 18.

24.

Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice.

Boesjes M, Bloks VW, Hageman J, Bos T, van Dijk TH, Havinga R, Wolters H, Jonker JW, Kuipers F, Groen AK.

PLoS One. 2014 Dec 15;9(12):e115028. doi: 10.1371/journal.pone.0115028. eCollection 2014.

25.

New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition.

van der Schoor LW, Verkade HJ, Kuipers F, Jonker JW.

Expert Opin Drug Metab Toxicol. 2015 Feb;11(2):273-93. doi: 10.1517/17425255.2015.981152. Epub 2014 Nov 7. Review.

PMID:
25380746
26.

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM.

Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16. Erratum in: Nature. 2015 Apr 16;520(7547):388.

27.

Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.

Thedieck K, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid SN, Kremmer E, Nitschke R, Kuehn EW, Jonker JW, Groen AK, Reth M, Hall MN, Baumeister R.

Cell. 2013 Aug 15;154(4):859-74. doi: 10.1016/j.cell.2013.07.031. Erratum in: Cell. 2013 Nov 7;155(4):964-6.

28.

Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease.

Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8555-60. doi: 10.1073/pnas.1306182110. Epub 2013 May 7.

29.

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.

Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, He M, Juguilon H, Yin YQ, Phillips CT, Yu RT, Olefsky JM, Henry RR, Downes M, Evans RM.

Nature. 2012 May 17;485(7398):391-4. doi: 10.1038/nature10998.

30.

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

Lamia KA, Papp SJ, Yu RT, Barish GD, Uhlenhaut NH, Jonker JW, Downes M, Evans RM.

Nature. 2011 Dec 14;480(7378):552-6. doi: 10.1038/nature10700.

31.

FXR and PXR: potential therapeutic targets in cholestasis.

Jonker JW, Liddle C, Downes M.

J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):147-58. doi: 10.1016/j.jsbmb.2011.06.012. Epub 2011 Jul 20. Review.

32.

Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ.

Narkar VA, Fan W, Downes M, Yu RT, Jonker JW, Alaynick WA, Banayo E, Karunasiri MS, Lorca S, Evans RM.

Cell Metab. 2011 Mar 2;13(3):283-93. doi: 10.1016/j.cmet.2011.01.019.

33.

ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.

Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN.

Mol Endocrinol. 2010 Feb;24(2):299-309. doi: 10.1210/me.2009-0114. Epub 2009 Dec 4.

34.

ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis.

Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Yi-Chang C, McDonnell DP, Evans RM, Billin AN.

Endocr Rev. 2009 Dec 1;30(7):931. doi: 10.1210/edrv.30.7.9988. No abstract available.

PMID:
28199598
35.

Hepatobiliary ABC transporters: physiology, regulation and implications for disease.

Jonker JW, Stedman CA, Liddle C, Downes M.

Front Biosci (Landmark Ed). 2009 Jun 1;14:4904-20. Review.

PMID:
19482594
36.

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis.

Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20021-6. doi: 10.1073/pnas.0811012105. Epub 2008 Dec 9.

37.

ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.

Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguère V, Evans RM.

Cell Metab. 2007 Jul;6(1):13-24.

38.

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.

Jonker JW, Musters S, Vlaming ML, Plösch T, Gooijert KE, Hillebrand MJ, Rosing H, Beijnen JH, Verkade HJ, Schinkel AH.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2204-12. Epub 2007 Feb 21.

39.

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.

van Herwaarden AE, Wagenaar E, Merino G, Jonker JW, Rosing H, Beijnen JH, Schinkel AH.

Mol Cell Biol. 2007 Feb;27(4):1247-53. Epub 2006 Dec 4.

40.

Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism.

Ogasawara M, Yamauchi K, Satoh Y, Yamaji R, Inui K, Jonker JW, Schinkel AH, Maeyama K.

J Pharmacol Sci. 2006 May;101(1):24-30. Epub 2006 Apr 28. Review.

41.

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice.

Jonker JW, Freeman J, Bolscher E, Musters S, Alvi AJ, Titley I, Schinkel AH, Dale TC.

Stem Cells. 2005 Sep;23(8):1059-65. Epub 2005 Jul 7.

42.

Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.

van Herwaarden AE, Wagenaar E, Karnekamp B, Merino G, Jonker JW, Schinkel AH.

Carcinogenesis. 2006 Jan;27(1):123-30. Epub 2005 Jul 6.

PMID:
16000399
43.

Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).

Kondo C, Onuki R, Kusuhara H, Suzuki H, Suzuki M, Okudaira N, Kojima M, Ishiwata K, Jonker JW, Sugiyama Y.

Pharm Res. 2005 Apr;22(4):613-8. Epub 2005 Apr 7.

PMID:
15846469
44.

Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver.

Merino G, van Herwaarden AE, Wagenaar E, Jonker JW, Schinkel AH.

Mol Pharmacol. 2005 May;67(5):1765-71. Epub 2005 Feb 18.

PMID:
15722455
45.

The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

Merino G, Jonker JW, Wagenaar E, van Herwaarden AE, Schinkel AH.

Mol Pharmacol. 2005 May;67(5):1758-64. Epub 2005 Feb 11.

PMID:
15709111
46.

Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).

Merino G, Jonker JW, Wagenaar E, Pulido MM, Molina AJ, Alvarez AI, Schinkel AH.

Drug Metab Dispos. 2005 May;33(5):614-8. Epub 2005 Feb 9.

PMID:
15703302
47.

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

Jonker JW, Merino G, Musters S, van Herwaarden AE, Bolscher E, Wagenaar E, Mesman E, Dale TC, Schinkel AH.

Nat Med. 2005 Feb;11(2):127-9. Epub 2005 Jan 30.

48.

Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein.

Lee YJ, Kusuhara H, Jonker JW, Schinkel AH, Sugiyama Y.

J Pharmacol Exp Ther. 2005 Jan;312(1):44-52. Epub 2004 Sep 24.

PMID:
15448171
49.

Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

Pavek P, Merino G, Wagenaar E, Bolscher E, Novotna M, Jonker JW, Schinkel AH.

J Pharmacol Exp Ther. 2005 Jan;312(1):144-52. Epub 2004 Sep 13.

PMID:
15365089
50.

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

Mizuno N, Suzuki M, Kusuhara H, Suzuki H, Takeuchi K, Niwa T, Jonker JW, Sugiyama Y.

Drug Metab Dispos. 2004 Sep;32(9):898-901.

PMID:
15319327

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