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Items: 48


Home-cage hypoactivity in mouse genetic models of autism spectrum disorder.

Angelakos CC, Tudor JC, Ferri SL, Jongens TA, Abel T.

Neurobiol Learn Mem. 2019 Feb 20:107000. doi: 10.1016/j.nlm.2019.02.010. [Epub ahead of print]


Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function.

Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA.

Hum Mol Genet. 2018 Jan 1;27(1):95-106. doi: 10.1093/hmg/ddx387.


Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.

Choi CH, Schoenfeld BP, Bell AJ, Hinchey J, Rosenfelt C, Gertner MJ, Campbell SR, Emerson D, Hinchey P, Kollaros M, Ferrick NJ, Chambers DB, Langer S, Sust S, Malik A, Terlizzi AM, Liebelt DA, Ferreiro D, Sharma A, Koenigsberg E, Choi RJ, Louneva N, Arnold SE, Featherstone RE, Siegel SJ, Zukin RS, McDonald TV, Bolduc FV, Jongens TA, McBride SM.

Front Behav Neurosci. 2016 Jun 30;10:136. doi: 10.3389/fnbeh.2016.00136. eCollection 2016.


Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model.

Monyak RE, Emerson D, Schoenfeld BP, Zheng X, Chambers DB, Rosenfelt C, Langer S, Hinchey P, Choi CH, McDonald TV, Bolduc FV, Sehgal A, McBride SMJ, Jongens TA.

Mol Psychiatry. 2017 Aug;22(8):1140-1148. doi: 10.1038/mp.2016.51. Epub 2016 Apr 19.


Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.

Wu Y, Gause M, Xu D, Misulovin Z, Schaaf CA, Mosarla RC, Mannino E, Shannon M, Jones E, Shi M, Chen WF, Katz OL, Sehgal A, Jongens TA, Krantz ID, Dorsett D.

PLoS Genet. 2015 Nov 6;11(11):e1005655. doi: 10.1371/journal.pgen.1005655. eCollection 2015 Nov.


Deciphering discord: How Drosophila research has enhanced our understanding of the importance of FMRP in different spatial and temporal contexts.

Weisz ED, Monyak RE, Jongens TA.

Exp Neurol. 2015 Dec;274(Pt A):14-24. doi: 10.1016/j.expneurol.2015.05.015. Epub 2015 May 28. Review.


Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.

Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ.

Cell Rep. 2015 May 5;11(5):727-36. doi: 10.1016/j.celrep.2015.03.060. Epub 2015 Apr 23.


PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.

Choi CH, Schoenfeld BP, Weisz ED, Bell AJ, Chambers DB, Hinchey J, Choi RJ, Hinchey P, Kollaros M, Gertner MJ, Ferrick NJ, Terlizzi AM, Yohn N, Koenigsberg E, Liebelt DA, Zukin RS, Woo NH, Tranfaglia MR, Louneva N, Arnold SE, Siegel SJ, Bolduc FV, McDonald TV, Jongens TA, McBride SM.

J Neurosci. 2015 Jan 7;35(1):396-408. doi: 10.1523/JNEUROSCI.1356-12.2015.


Modulation of cAMP and ras signaling pathways improves distinct behavioral deficits in a zebrafish model of neurofibromatosis type 1.

Wolman MA, de Groh ED, McBride SM, Jongens TA, Granato M, Epstein JA.

Cell Rep. 2014 Sep 11;8(5):1265-70. doi: 10.1016/j.celrep.2014.07.054. Epub 2014 Aug 28.


Using Drosophila as a tool to identify pharmacological therapies for fragile X syndrome.

McBride SM, Holloway SL, Jongens TA.

Drug Discov Today Technol. 2013 Spring;10(1):e129-36. doi: 10.1016/j.ddtec.2012.09.005. Review.


Using Drosophila as a tool to identify Pharmacological Therapies for Fragile X Syndrome.

McBride SM, Holloway SL, Jongens TA.

Drug Discov Today Technol. 2012 Sep 24;10(1):e129-e136.


The Drosophila DmGluRA is required for social interaction and memory.

Schoenfeld BP, Choi RJ, Choi CH, Terlizzi AM, Hinchey P, Kollaros M, Ferrick NJ, Koenigsberg E, Ferreiro D, Leibelt DA, Siegel SJ, Bell AJ, McDonald TV, Jongens TA, McBride SM.

Front Pharmacol. 2013 May 23;4:64. doi: 10.3389/fphar.2013.00064. eCollection 2013.


Disruption of CHTF18 causes defective meiotic recombination in male mice.

Berkowitz KM, Sowash AR, Koenig LR, Urcuyo D, Khan F, Yang F, Wang PJ, Jongens TA, Kaestner KH.

PLoS Genet. 2012;8(11):e1002996. doi: 10.1371/journal.pgen.1002996. Epub 2012 Nov 1.


Tandem Affinity Purification in Drosophila Heads and Ovaries.

Pepper A, Bhogal B, Jongens T.

Bio Protoc. 2012 Aug 5;2(15). pii: e245.


Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein.

Bhogal B, Jepson JE, Savva YA, Pepper AS, Reenan RA, Jongens TA.

Nat Neurosci. 2011 Oct 30;14(12):1517-24. doi: 10.1038/nn.2950.


Behavior in a Drosophila model of fragile X.

McBride SM, Bell AJ, Jongens TA.

Results Probl Cell Differ. 2012;54:83-117. doi: 10.1007/978-3-642-21649-7_6. Review.


A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms.

Beerman RW, Jongens TA.

Neuroscience. 2011 May 5;181:48-66. doi: 10.1016/j.neuroscience.2011.02.029. Epub 2011 Feb 17.


Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment.

Choi CH, Schoenfeld BP, Bell AJ, Hinchey P, Kollaros M, Gertner MJ, Woo NH, Tranfaglia MR, Bear MF, Zukin RS, McDonald TV, Jongens TA, McBride SM.

Brain Res. 2011 Mar 22;1380:106-19. doi: 10.1016/j.brainres.2010.11.032. Epub 2010 Nov 12.


Fragile X syndrome and model organisms: identifying potential routes of therapeutic intervention.

Bhogal B, Jongens TA.

Dis Model Mech. 2010 Nov-Dec;3(11-12):693-700. doi: 10.1242/dmm.002006. Epub 2010 Aug 3. Review.


Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function.

McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, Siwicki KK, Nguyen HT, Fortini ME, McDonald TV, Jongens TA.

J Neurosci. 2010 Jul 14;30(28):9510-22. doi: 10.1523/JNEUROSCI.1017-10.2010.


Arginine methylation of vasa protein is conserved across phyla.

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z.

J Biol Chem. 2010 Mar 12;285(11):8148-54. doi: 10.1074/jbc.M109.089821. Epub 2010 Jan 15.


Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue.

Choi CH, McBride SM, Schoenfeld BP, Liebelt DA, Ferreiro D, Ferrick NJ, Hinchey P, Kollaros M, Rudominer RL, Terlizzi AM, Koenigsberg E, Wang Y, Sumida A, Nguyen HT, Bell AJ, McDonald TV, Jongens TA.

Biogerontology. 2010 Jun;11(3):347-62. doi: 10.1007/s10522-009-9259-6. Epub 2009 Dec 29.


Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization.

Kirino Y, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z.

RNA. 2010 Jan;16(1):70-8. doi: 10.1261/rna.1869710. Epub 2009 Nov 19.


Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects.

Pepper AS, Beerman RW, Bhogal B, Jongens TA.

PLoS One. 2009 Oct 27;4(10):e7618. doi: 10.1371/journal.pone.0007618.


Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.

Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z.

Nat Cell Biol. 2009 May;11(5):652-8. doi: 10.1038/ncb1872. Epub 2009 Apr 19.


Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast.

Berkowitz KM, Kaestner KH, Jongens TA.

Mol Hum Reprod. 2008 Mar;14(3):143-50. doi: 10.1093/molehr/gan005. Epub 2008 Feb 4.


Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome.

McBride SM, Choi CH, Wang Y, Liebelt D, Braunstein E, Ferreiro D, Sehgal A, Siwicki KK, Dockendorff TC, Nguyen HT, McDonald TV, Jongens TA.

Neuron. 2005 Mar 3;45(5):753-64.


The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway.

Costa A, Wang Y, Dockendorff TC, Erdjument-Bromage H, Tempst P, Schedl P, Jongens TA.

Dev Cell. 2005 Mar;8(3):331-42.


Fragile X protein functions with lgl and the par complex in flies and mice.

Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST, Moses K.

Dev Cell. 2005 Jan;8(1):43-52.


Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.

Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST.

Nat Neurosci. 2004 Feb;7(2):113-7. Epub 2004 Jan 4.


Transcriptional silencing and translational control: key features of early germline development.

Leatherman JL, Jongens TA.

Bioessays. 2003 Apr;25(4):326-35. Review.


germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage.

Leatherman JL, Levin L, Boero J, Jongens TA.

Curr Biol. 2002 Oct 1;12(19):1681-5.


Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest.

Dockendorff TC, Su HS, McBride SM, Yang Z, Choi CH, Siwicki KK, Sehgal A, Jongens TA.

Neuron. 2002 Jun 13;34(6):973-84.


Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein.

Wan L, Dockendorff TC, Jongens TA, Dreyfuss G.

Mol Cell Biol. 2000 Nov;20(22):8536-47.


Genetic characterization of the 44D-45B region of the Drosophila melanogaster genome based on an F2 lethal screen.

Dockendorff TC, Robertson SE, Faulkner DL, Jongens TA.

Mol Gen Genet. 2000 Feb;263(1):137-43.


Identification of a mouse germ cell-less homologue with conserved activity in Drosophila.

Leatherman JL, Kaestner KH, Jongens TA.

Mech Dev. 2000 Apr;92(2):145-53.


A central role for microtubules in the differentiation of Drosophila oocytes.

Theurkauf WE, Alberts BM, Jan YN, Jongens TA.

Development. 1993 Aug;118(4):1169-80.


A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster.

Mougneau E, von Seggern D, Fowler T, Rosenblatt J, Jongens T, Rogers B, Gietzen D, Beckendorf SK.

Mol Cell Biol. 1993 Jan;13(1):184-95.


Functional redundancy in the tissue-specific enhancer of the Drosophila Sgs-4 gene.

Jongens TA, Fowler T, Shermoen AW, Beckendorf SK.

EMBO J. 1988 Aug;7(8):2559-67.


Mutations affecting a surface glycoprotein, gp80, of Dictyostelium discoideum.

Murray BA, Wheeler S, Jongens T, Loomis WF.

Mol Cell Biol. 1984 Mar;4(3):514-9.


Adhesion-blocking antibodies prepared against gp150 react with gp80 of Dictyostelium.

Loomis WF, Murray BA, Yee L, Jongens T.

Exp Cell Res. 1983 Aug;147(1):231-4.


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