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Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

Low A, Mak E, Malpetti M, Chouliaras L, Nicastro N, Su L, Holland N, Rittman T, Rodríguez PV, Passamonti L, Bevan-Jones WR, Jones PS, Rowe JB, O'Brien JT.

Alzheimers Dement (Amst). 2019 Oct 1;11:690-699. doi: 10.1016/j.dadm.2019.08.001. eCollection 2019 Dec.


Epicardial adipocyte size does not correlate with body mass index.

Aitken-Buck HM, Babakr AA, Coffey S, Jones PP, Tse RD, Lamberts RR.

Cardiovasc Pathol. 2019 Aug 1;43:107144. doi: 10.1016/j.carpath.2019.07.003. [Epub ahead of print]


Dyadic Plasticity in Cardiomyocytes.

Jones PP, MacQuaide N, Louch WE.

Front Physiol. 2018 Dec 11;9:1773. doi: 10.3389/fphys.2018.01773. eCollection 2018. Review.


Activation of RyR2 by class I kinase inhibitors.

Chakraborty AD, Gonano LA, Munro ML, Smith LJ, Thekkedam C, Staudacher V, Gamble AB, Macquaide N, Dulhunty AF, Jones PP.

Br J Pharmacol. 2019 Mar;176(6):773-786. doi: 10.1111/bph.14562. Epub 2019 Jan 30.


Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy.

Gardner RJM, Crozier IG, Binfield AL, Love DR, Lehnert K, Gibson K, Lintott CJ, Snell RG, Jacobsen JC, Jones PP, Waddell-Smith KE, Kennedy MA, Skinner JR.

Mol Genet Genomic Med. 2019 Jan;7(1):e00476. doi: 10.1002/mgg3.476. Epub 2018 Oct 21.


Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.

Daniels LJ, Wallace RS, Nicholson OM, Wilson GA, McDonald FJ, Jones PP, Baldi JC, Lamberts RR, Erickson JR.

Cardiovasc Diabetol. 2018 Jun 14;17(1):89. doi: 10.1186/s12933-018-0732-x.


Ghrelin Preserves Ischemia-Induced Vasodilation of Male Rat Coronary Vessels Following β-Adrenergic Receptor Blockade.

Pearson JT, Collie N, Lamberts RR, Inagaki T, Yoshimoto M, Umetani K, Davis P, Wilkins G, Jones PP, Shirai M, Schwenke DO.

Endocrinology. 2018 Apr 1;159(4):1763-1773. doi: 10.1210/en.2017-03070.


Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2.

Jones PP, Guo W, Chen SRW.

J Gen Physiol. 2017 Sep 4;149(9):867-875. doi: 10.1085/jgp.201711805. Epub 2017 Aug 10. Review. No abstract available.


FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.

Gonano LA, Jones PP.

Channels (Austin). 2017 Sep 3;11(5):415-425. doi: 10.1080/19336950.2017.1344799. Epub 2017 Jun 21. Review.


Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias.

Xiao Z, Guo W, Sun B, Hunt DJ, Wei J, Liu Y, Wang Y, Wang R, Jones PP, Back TG, Chen SR.

J Biol Chem. 2016 Nov 18;291(47):24528-24537. Epub 2016 Oct 12.


Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release.

Waddell HMM, Zhang JZ, Hoeksema KJ, McLachlan JJ, McLay JC, Jones PP.

Biophys J. 2016 Jun 7;110(11):2386-2396. doi: 10.1016/j.bpj.2016.04.036.


FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2.

Zhang JZ, Waddell HM, Wu E, Dholakia J, Okolo CA, McLay JC, Jones PP.

Biochem J. 2016 Jul 15;473(14):2049-60. doi: 10.1042/BCJ20160389. Epub 2016 May 6.


Sympathetic hyper-excitation in obesity and pulmonary hypertension: physiological relevance to the 'obesity paradox'.

Diong C, Jones PP, Tsuchimochi H, Gray EA, Hughes G, Inagaki T, Bussey CT, Fujii Y, Umetani K, Shirai M, Schwenke DO.

Int J Obes (Lond). 2016 Jun;40(6):938-46. doi: 10.1038/ijo.2016.33. Epub 2016 Feb 23.


Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction.

Bussey CT, Hughes G, Saxena P, Galvin IF, Bunton RW, Noye MK, Coffey S, Williams MJ, Baldi JC, Jones PP, Lamberts RR.

Int J Cardiol. 2015 Aug 15;193:53-5. doi: 10.1016/j.ijcard.2015.05.053. Epub 2015 May 12. No abstract available.


Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats.

Thaung HP, Yao Y, Bussey CT, Hughes G, Jones PP, Bahn A, Sammut IA, Lamberts RR.

Exp Physiol. 2015 Jun;100(6):628-39. doi: 10.1113/EP085021.


Increased Efferent Cardiac Sympathetic Nerve Activity and Defective Intrinsic Heart Rate Regulation in Type 2 Diabetes.

Thaung HP, Baldi JC, Wang HY, Hughes G, Cook RF, Bussey CT, Sheard PW, Bahn A, Jones PP, Schwenke DO, Lamberts RR.

Diabetes. 2015 Aug;64(8):2944-56. doi: 10.2337/db14-0955. Epub 2015 Mar 17.


Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination.

Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Van Petegem F, Chen SR.

J Biol Chem. 2015 Mar 20;290(12):7736-46. doi: 10.1074/jbc.M114.618827. Epub 2015 Jan 27.


Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor.

Mi T, Xiao Z, Guo W, Tang Y, Hiess F, Xiao J, Wang Y, Zhang JZ, Zhang L, Wang R, Jones PP, Chen SR.

Biochem J. 2015 Apr 1;467(1):177-90. doi: 10.1042/BJ20141263.


Regulation of RYR2 by sarcoplasmic reticulum Ca(2+).

Zhang JZ, Waddell HM, Jones PP.

Clin Exp Pharmacol Physiol. 2015 Jun;42(6):720-6. doi: 10.1111/1440-1681.12364. Review.


The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).

Zhang JZ, McLay JC, Jones PP.

J Mol Cell Cardiol. 2014 Sep;74:22-31. doi: 10.1016/j.yjmcc.2014.04.019. Epub 2014 May 5.


The early history of Stanford Immunology.

Jones PP, Herzenberg LA.

Immunol Res. 2014 May;58(2-3):164-78. doi: 10.1007/s12026-014-8518-z. Review.


Introduction to the special issue on Stanford Immunology.

Jones PP, Nadeau KC.

Immunol Res. 2014 May;58(2-3):161-3. doi: 10.1007/s12026-014-8520-5. No abstract available.


Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction.

Lamberts RR, Lingam SJ, Wang HY, Bollen IA, Hughes G, Galvin IF, Bunton RW, Bahn A, Katare R, Baldi JC, Williams MJ, Saxena P, Coffey S, Jones PP.

Cardiovasc Diabetol. 2014 Apr 5;13:72. doi: 10.1186/1475-2840-13-72.


The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.


Nonlinear least-squares method for the inverse droplet coagulation problem.

Jones PP, Ball RC, Connaughton C.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jul;88(1):012138. Epub 2013 Jul 29.


Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.


The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

Liu Y, Kimlicka L, Hiess F, Tian X, Wang R, Zhang L, Jones PP, Van Petegem F, Chen SR.

Biochem J. 2013 Aug 15;454(1):123-31. doi: 10.1042/BJ20130594.


Collective oscillations in irreversible coagulation driven by monomer inputs and large-cluster outputs.

Ball RC, Connaughton C, Jones PP, Rajesh R, Zaboronski O.

Phys Rev Lett. 2012 Oct 19;109(16):168304. Epub 2012 Oct 17.


Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR.

Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.


Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.

Wang R, Zhong X, Meng X, Koop A, Tian X, Jones PP, Fruen BR, Wagenknecht T, Liu Z, Chen SR.

J Biol Chem. 2011 Apr 8;286(14):12202-12. doi: 10.1074/jbc.M110.194316. Epub 2011 Jan 24.


Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves.

Mufti RE, Brett SE, Tran CH, Abd El-Rahman R, Anfinogenova Y, El-Yazbi A, Cole WC, Jones PP, Chen SR, Welsh DG.

J Physiol. 2010 Oct 15;588(Pt 20):3983-4005. doi: 10.1113/jphysiol.2010.193300. Epub 2010 Aug 24.


Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia.

Jiang D, Jones PP, Davis DR, Gow R, Green MS, Birnie DH, Chen SR, Gollob MH.

Channels (Austin). 2010 Jul-Aug;4(4):302-10. Epub 2010 Jul 14.


Store operated Ca2+ entry (SOCE): from structure to function.

Jones PP, Braun AP.

Channels (Austin). 2009 Jan-Feb;3(1):1-2. Epub 2009 Jan 23. No abstract available.


Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor.

Kong H, Jones PP, Koop A, Zhang L, Duff HJ, Chen SR.

Biochem J. 2008 Sep 15;414(3):441-52. doi: 10.1042/BJ20080489.


Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.

Jiang D, Chen W, Xiao J, Wang R, Kong H, Jones PP, Zhang L, Fruen B, Chen SR.

J Biol Chem. 2008 Jul 25;283(30):20813-20. doi: 10.1074/jbc.M801944200. Epub 2008 May 27.


Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor.

Jones PP, Meng X, Xiao B, Cai S, Bolstad J, Wagenknecht T, Liu Z, Chen SR.

Biochem J. 2008 Mar 1;410(2):261-70.


Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias.

Xiao J, Tian X, Jones PP, Bolstad J, Kong H, Wang R, Zhang L, Duff HJ, Gillis AM, Fleischer S, Kotlikoff M, Copello JA, Chen SR.

J Biol Chem. 2007 Nov 30;282(48):34828-38. Epub 2007 Oct 5.


Calcineurin negatively regulates TLR-mediated activation pathways.

Kang YJ, Kusler B, Otsuka M, Hughes M, Suzuki N, Suzuki S, Yeh WC, Akira S, Han J, Jones PP.

J Immunol. 2007 Oct 1;179(7):4598-607.


Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.

Xiao B, Tian X, Xie W, Jones PP, Cai S, Wang X, Jiang D, Kong H, Zhang L, Chen K, Walsh MP, Cheng H, Chen SR.

J Biol Chem. 2007 Oct 12;282(41):30256-64. Epub 2007 Aug 10.


K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association.

Hunt DJ, Jones PP, Wang R, Chen W, Bolstad J, Chen K, Shimoni Y, Chen SR.

Biochem J. 2007 Jun 15;404(3):431-8.


Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient.

Jones PP, Bazzazi H, Kargacin GJ, Colyer J.

Biophys J. 2006 Jul 15;91(2):433-43. Epub 2006 Apr 21.


High levels of protein expression using different mammalian CMV promoters in several cell lines.

Xia W, Bringmann P, McClary J, Jones PP, Manzana W, Zhu Y, Wang S, Liu Y, Harvey S, Madlansacay MR, McLean K, Rosser MP, MacRobbie J, Olsen CL, Cobb RR.

Protein Expr Purif. 2006 Jan;45(1):115-24. Epub 2005 Aug 9.


Gender differences and performance in science.

Muller CB, Ride SM, Fouke J, Whitney T, Denton DD, Cantor N, Nelson DJ, Plummer J, Busch-Vishniac I, Meyers C, Rosser SV, Schiebinger L, Roberts E, Burgess D, Beeson C, Metz SS, Sanders L, Watford BA, Ivey ES, Frank Fox M, Wettack S, Klawe M, Wulf WA, Girgus J, Leboy PS, Babco EL, Shanahan B, Didion C, Chubin DE, Frize M, Ganter SL, Nalley EA, Franz J, Abruña HD, Strober MH, Zimmer Daniels J, Carter EA, Rhodes JH, Schrijver I, Zakian VA, Simons B, Martin U, Boaler J, Jolluck KR, Mankekar P, Gray RM, Conkey MW, Stansky P, Xie A, Martin P, Katehi LP, Miller JA, Tess Thornton A, Lapaugh A, Rhode DL, Gelpi BC, Harrold MJ, Spencer CM, Schlatter Ellis C, Lord S, Quinn H, Murnane M, Jones PP, Hellman F, Wight G, O'hara R, Pickering M, Sheppard S, Leith D, Paytan A, Sommer MH, Shafer A, Grusky D, Yennello S, Madan A, Johnson DL, Yanagisako S, Chou-Green JM, Robinson S.

Science. 2005 Feb 18;307(5712):1043. No abstract available.


Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men.

Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D, Seals DR.

Circulation. 2005 Feb 1;111(4):494-8.


Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food.

Jones PP, Van Pelt RE, Johnson DG, Seals DR.

J Clin Endocrinol Metab. 2004 Oct;89(10):5138-44.


High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults.

Bell C, Day DS, Jones PP, Christou DD, Petitt DS, Osterberg K, Melby CL, Seals DR.

J Clin Endocrinol Metab. 2004 Jul;89(7):3573-8.


Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging.

Christou DD, Jones PP, Pimentel AE, Seals DR.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1530-7. Epub 2004 Jun 3.

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