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Items: 1 to 50 of 534

1.

High-intensity interval training for reducing blood pressure: a randomized trial vs. moderate-intensity continuous training in males with overweight or obesity.

Clark T, Morey R, Jones MD, Marcos L, Ristov M, Ram A, Hakansson S, Franklin A, McCarthy C, De Carli L, Ward R, Keech A.

Hypertens Res. 2020 Jan 14. doi: 10.1038/s41440-019-0392-6. [Epub ahead of print]

PMID:
31937915
2.

A Novel Single Domain Antibody Targeting FliC Flagellin of Salmonella enterica for Effective Inhibition of Host Cell Invasion.

Huen J, Yan Z, Iwashkiw J, Dubey S, Gimenez MC, Ortiz ME, Patel SV, Jones MD, Riazi A, Terebiznik M, Babaei S, Shahinas D.

Front Microbiol. 2019 Nov 26;10:2665. doi: 10.3389/fmicb.2019.02665. eCollection 2019.

3.

Zinc Complexes for PLA Formation and Chemical Recycling: Towards a Circular Economy.

McKeown P, Román-Ramírez LA, Bates S, Wood J, Jones MD.

ChemSusChem. 2019 Nov 12. doi: 10.1002/cssc.201902755. [Epub ahead of print]

PMID:
31714680
4.

The synthesis, characterisation and application of iron(iii)-acetate complexes for cyclic carbonate formation and the polymerisation of lactide.

Driscoll OJ, Hafford-Tear CH, McKeown P, Stewart JA, Kociok-Köhn G, Mahon MF, Jones MD.

Dalton Trans. 2019 Oct 14;48(40):15049-15058. doi: 10.1039/c9dt03327k.

PMID:
31515544
5.

Dual-mycorrhizal plants: their ecology and relevance.

Teste FP, Jones MD, Dickie IA.

New Phytol. 2019 Sep 12. doi: 10.1111/nph.16190. [Epub ahead of print] Review.

PMID:
31514244
6.

A systematic review examining the effectiveness of medicines information services for patients and the general public.

Williams M, Jordan A, Scott J, Jones MD.

Int J Pharm Pract. 2020 Feb;28(1):26-40. doi: 10.1111/ijpp.12571. Epub 2019 Sep 12. Review.

PMID:
31512292
7.

Letters of Recommendation.

Bourque SL, Lee CJ, Jones MD Jr, Sullivan GM.

J Grad Med Educ. 2019 Aug;11(4):479-480. doi: 10.4300/JGME-D-19-00344.1. No abstract available.

PMID:
31440346
8.

The health literacy of hospitalized trauma patients: We should be screening for deficiencies.

Weinberg JA, Shehada MZ, Chapple KM, Israr S, Jones MD, Jacobs JV, Bogert JN.

J Trauma Acute Care Surg. 2019 Nov;87(5):1214-1219. doi: 10.1097/TA.0000000000002465.

PMID:
31389918
9.

An in-vitro animal bone model study to predict spiral fracture strength of long bones in the young infant.

Malik SS, Malik S, Shenoy R, Jones MD, Theobald PS.

J Clin Orthop Trauma. 2019 Jul-Aug;10(4):744-749. doi: 10.1016/j.jcot.2018.10.001. Epub 2018 Oct 13.

PMID:
31316248
10.

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.

Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK.

Nat Chem Biol. 2019 Jul;15(7):747-755. doi: 10.1038/s41589-019-0304-8. Epub 2019 Jun 17.

11.

Aluminium-catalysed isocyanate trimerization, enhanced by exploiting a dynamic coordination sphere.

Bahili MA, Stokes EC, Amesbury RC, Ould DMC, Christo B, Horne RJ, Kariuki BM, Stewart JA, Taylor RL, Williams PA, Jones MD, Harris KDM, Ward BD.

Chem Commun (Camb). 2019 Jul 7;55(53):7679-7682. doi: 10.1039/c9cc03339d. Epub 2019 Jun 17.

PMID:
31204737
12.

Can real-time feedback improve the simulated infant cardiopulmonary resuscitation performance of basic life support and lay rescuers?

Kandasamy J, Theobald PS, Maconochie IK, Jones MD.

Arch Dis Child. 2019 Aug;104(8):793-801. doi: 10.1136/archdischild-2018-316576. Epub 2019 Jun 4.

PMID:
31164375
13.

A coupled physical-computational methodology for the investigation of short fall related infant head impact injury.

Khalid GA, Prabhu RK, Arthurs O, Jones MD.

Forensic Sci Int. 2019 Jul;300:170-186. doi: 10.1016/j.forsciint.2019.04.034. Epub 2019 May 7.

PMID:
31125762
14.

In-depth interviews to assess the relevancy and fit of a peer-mentored intervention for transition-age youth with chronic medical conditions.

Wiemann CM, Graham SC, Garland BH, Raphael JL, Jones MD, Sanchez-Fournier BE, Hergenroeder AC, Benavides JM.

J Pediatr Nurs. 2019 May 13. pii: S0882-5963(18)30608-0. doi: 10.1016/j.pedn.2019.04.028. [Epub ahead of print]

PMID:
31097229
15.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER 3rd, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, Aguet F, Weir BA, Rothberg MV, Paolella BR, Lawrence MS, Akbani R, Lu Y, Tiv HL, Gokhale PC, de Weck A, Mansour AA, Oh C, Shih J, Hadi K, Rosen Y, Bistline J, Venkatesan K, Reddy A, Sonkin D, Liu M, Lehar J, Korn JM, Porter DA, Jones MD, Golji J, Caponigro G, Taylor JE, Dunning CM, Creech AL, Warren AC, McFarland JM, Zamanighomi M, Kauffmann A, Stransky N, Imielinski M, Maruvka YE, Cherniack AD, Tsherniak A, Vazquez F, Jaffe JD, Lane AA, Weinstock DM, Johannessen CM, Morrissey MP, Stegmeier F, Schlegel R, Hahn WC, Getz G, Mills GB, Boehm JS, Golub TR, Garraway LA, Sellers WR.

Nature. 2019 May;569(7757):503-508. doi: 10.1038/s41586-019-1186-3. Epub 2019 May 8.

16.

Establishing Cohorts to Generate the Evidence Base to Reduce the Burden of Breast Cancer in Sub-Saharan Africa: Results From a Feasibility Study in Kenya.

Subramanian S, Gakunga R, Jones MD, Kinyanjui A, Ochieng' E, Gikaara N, Maluni F, Wata D, Korir A, Mutebi M, Ali Z.

J Glob Oncol. 2019 Mar;5:1-10. doi: 10.1200/JGO.18.00225.

17.

First Spectroscopy of the Near Drip-line Nucleus ^{40}Mg.

Crawford HL, Fallon P, Macchiavelli AO, Doornenbal P, Aoi N, Browne F, Campbell CM, Chen S, Clark RM, Cortés ML, Cromaz M, Ideguchi E, Jones MD, Kanungo R, MacCormick M, Momiyama S, Murray I, Niikura M, Paschalis S, Petri M, Sakurai H, Salathe M, Schrock P, Steppenbeck D, Takeuchi S, Tanaka YK, Taniuchi R, Wang H, Wimmer K.

Phys Rev Lett. 2019 Feb 8;122(5):052501. doi: 10.1103/PhysRevLett.122.052501.

18.

Tuning a robust system: N,O zinc guanidine catalysts for the ROP of lactide.

Schäfer PM, McKeown P, Fuchs M, Rittinghaus RD, Hermann A, Henkel J, Seidel S, Roitzheim C, Ksiazkiewicz AN, Hoffmann A, Pich A, Jones MD, Herres-Pawlis S.

Dalton Trans. 2019 May 7;48(18):6071-6082. doi: 10.1039/c8dt04938f.

PMID:
30758389
19.

Aerobic Exercise Reduces Pressure More Than Heat Pain Sensitivity in Healthy Adults.

Jones MD, Nuzzo JL, Taylor JL, Barry BK.

Pain Med. 2019 Jan 10. doi: 10.1093/pm/pny289. [Epub ahead of print]

PMID:
30649457
20.

Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer.

Dreyer SB, Pinese M, Jamieson NB, Scarlett CJ, Colvin EK, Pajic M, Johns AL, Humphris JL, Wu J, Cowley MJ, Chou A, Nagrial AM, Chantrill L, Chin VT, Jones MD, Moran-Jones K, Carter CR, Dickson EJ, Samra JS, Merrett ND, Gill AJ, Kench JG, Duthie F, Miller DK, Cooke S, Aust D, Knösel T, Rümmele P, Grützmann R, Pilarsky C, Nguyen NQ, Musgrove EA, Bailey PJ, McKay CJ, Biankin AV, Chang DK; Australian Pancreatic Cancer Genome Initiative; Glasgow Precision Oncology Laboratory.

Ann Surg. 2018 Nov 30. doi: 10.1097/SLA.0000000000003143. [Epub ahead of print]

PMID:
30570546
21.

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.

Liu H, Golji J, Brodeur LK, Chung FS, Chen JT, deBeaumont RS, Bullock CP, Jones MD, Kerr G, Li L, Rakiec DP, Schlabach MR, Sovath S, Growney JD, Pagliarini RA, Ruddy DA, MacIsaac KD, Korn JM, McDonald ER 3rd.

Nat Med. 2019 Jan;25(1):95-102. doi: 10.1038/s41591-018-0302-5. Epub 2018 Dec 17.

PMID:
30559422
22.

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA.

Nature. 2019 Jan;565(7738):E5-E6. doi: 10.1038/s41586-018-0722-x. No abstract available.

PMID:
30559381
23.

Operating a patient medicines helpline: a survey study exploring current practice in England using the RE-AIM evaluation framework.

Williams M, Jordan A, Scott J, Jones MD.

BMC Health Serv Res. 2018 Nov 20;18(1):868. doi: 10.1186/s12913-018-3690-9.

24.

Pneumomediastinum in blunt trauma: If aerodigestive injury is not seen on CT, invasive workup is not indicated.

Matthees NG, Mankin JA, Trahan AM, Israr S, Jones MD, Dameworth JL, Petersen SR, Weinberg JA.

Am J Surg. 2019 Jun;217(6):1047-1050. doi: 10.1016/j.amjsurg.2018.11.002. Epub 2018 Nov 9.

PMID:
30446160
25.

Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan.

Saha M, Reddy HM, Salih MA, Estrella E, Jones MD, Mitsuhashi S, Cho KA, Suzuki-Hatano S, Rizzo SA, Hamad MH, Mukhtar MM, Hamed AA, Elseed MA, Lek M, Valkanas E, MacArthur DG, Kunkel LM, Pacak CA, Draper I, Kang PB.

Physiol Genomics. 2018 Nov 1;50(11):929-939. doi: 10.1152/physiolgenomics.00036.2018. Epub 2018 Aug 31.

26.

Acid-responsive activity of the Helicobacter pylori metalloregulator NikR.

Jones MD, Li Y, Zamble DB.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8966-8971. doi: 10.1073/pnas.1808393115. Epub 2018 Aug 20.

27.

Biomechanical properties and microstructure of neonatal porcine ventricles.

Ahmad F, Prabhu RJ, Liao J, Soe S, Jones MD, Miller J, Berthelson P, Enge D, Copeland KM, Shaabeth S, Johnston R, Maconochie I, Theobald PS.

J Mech Behav Biomed Mater. 2018 Dec;88:18-28. doi: 10.1016/j.jmbbm.2018.07.038. Epub 2018 Jul 29.

28.

AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome.

Suzuki-Hatano S, Saha M, Rizzo SA, Witko RL, Gosiker BJ, Ramanathan M, Soustek MS, Jones MD, Kang PB, Byrne BJ, Cade WT, Pacak CA.

Hum Gene Ther. 2019 Feb;30(2):139-154. doi: 10.1089/hum.2018.020. Epub 2018 Oct 3.

PMID:
30070157
29.

Correction of copy number induced false positives in CRISPR screens.

de Weck A, Golji J, Jones MD, Korn JM, Billy E, McDonald ER 3rd, Schmelzle T, Bitter H, Kauffmann A.

PLoS Comput Biol. 2018 Jul 19;14(7):e1006279. doi: 10.1371/journal.pcbi.1006279. eCollection 2018 Jul.

30.

Intensity-dependent effects of aerobic training on pressure pain threshold in overweight men: A randomized trial.

Hakansson S, Jones MD, Ristov M, Marcos L, Clark T, Ram A, Morey R, Franklin A, McCarthy C, Carli LD, Ward R, Keech A.

Eur J Pain. 2018 Nov;22(10):1813-1823. doi: 10.1002/ejp.1277. Epub 2018 Jul 11.

PMID:
29956398
31.

Bipyrrolidine salan alkoxide complexes of lanthanides: synthesis, characterisation, activity in the polymerisation of lactide and mechanistic investigation by DOSY NMR.

Beament J, Kociok-Köhn G, Jones MD, Buchard A.

Dalton Trans. 2018 Jul 10;47(27):9164-9172. doi: 10.1039/c8dt02108b.

PMID:
29946604
32.

Proceed With Caution: Implementing Competency-Based Graduate Medical Education.

Jones MD Jr, Lockspeiser TM.

J Grad Med Educ. 2018 Jun;10(3):276-278. doi: 10.4300/JGME-D-18-00311.1. No abstract available.

33.

Regional versus local drivers of water quality in the Windermere catchment, Lake District, United Kingdom: The dominant influence of wastewater pollution over the past 200 years.

Moorhouse HL, McGowan S, Taranu ZE, Gregory-Eaves I, Leavitt PR, Jones MD, Barker P, Brayshaw SA.

Glob Chang Biol. 2018 Sep;24(9):4009-4022. doi: 10.1111/gcb.14299. Epub 2018 Jun 7.

PMID:
29749028
34.

Changes in frictional coefficient with increased tendon surface tear-An experimental animal model.

Thangaraj R, Jones MD, Theobald P.

J Clin Orthop Trauma. 2018 Mar;9(Suppl 1):S19-S25. doi: 10.1016/j.jcot.2017.08.003. Epub 2017 Aug 31.

35.

Group-specific environmental sequencing reveals high levels of ecological heterogeneity across the microsporidian radiation.

Williams BAP, Hamilton KM, Jones MD, Bass D.

Environ Microbiol Rep. 2018 Jun;10(3):328-336. doi: 10.1111/1758-2229.12642.

36.

Positive predictive value of medical student specialty choices.

Jones MD Jr, Yamashita T, Ross RG, Gong J.

BMC Med Educ. 2018 Mar 9;18(1):33. doi: 10.1186/s12909-018-1138-x.

37.

Physical ability of people with rheumatoid arthritis and age-sex matched controls to use four commonly prescribed inhaler devices.

Kafaei Shirmanesh Y, Jones MD.

Respir Med. 2018 Feb;135:12-14. doi: 10.1016/j.rmed.2017.12.014. Epub 2018 Jan 3.

PMID:
29414447
38.

Sustainable Synthesis of Oxalic and Succinic Acid through Aerobic Oxidation of C6 Polyols Under Mild Conditions.

Ventura M, Williamson D, Lobefaro F, Jones MD, Mattia D, Nocito F, Aresta M, Dibenedetto A.

ChemSusChem. 2018 Mar 22;11(6):1073-1081. doi: 10.1002/cssc.201702347. Epub 2018 Feb 23.

PMID:
29336527
39.

The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time.

Brown TA, Avery JC, Jones MD, Anderson LK, Wierenga CE, Kaye WH.

Eur Eat Disord Rev. 2018 Mar;26(2):150-155. doi: 10.1002/erv.2574. Epub 2017 Dec 21.

PMID:
29266572
40.

Corrigendum: Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide.

Schäfer PM, Fuchs M, Ohligschläger A, Rittinghaus R, McKeown P, Akin E, Schmidt M, Hoffmann A, Liauw MA, Jones MD, Herres-Pawlis S.

ChemSusChem. 2017 Dec 8;10(23):4799. doi: 10.1002/cssc.201702066. Epub 2017 Nov 14. No abstract available.

PMID:
29218842
41.

Early death following revision total hip arthroplasty.

Jones MD, Parry M, Whitehouse MR, Blom AW.

Hip Int. 2018 Jul;28(4):400-406. doi: 10.5301/hipint.5000593. Epub 2017 Apr 12.

PMID:
29218686
42.

Rapid, portable detection of endocrine disrupting chemicals through ligand-nuclear hormone receptor interactions.

Hunt JP, Schinn SM, Jones MD, Bundy BC.

Analyst. 2017 Dec 4;142(24):4595-4600. doi: 10.1039/c7an01540b. Review.

PMID:
29168846
43.

Comparison of Hallux Rigidus Surgical Treatment Outcomes Between Active Duty and Non-Active Duty Populations A Retrospective Review.

Jones MD, Sweet KJ.

J Am Podiatr Med Assoc. 2018 Jul;108(4):272-279. doi: 10.7547/17-037. Epub 2017 Oct 27.

PMID:
29073775
44.

Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours.

Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, Lawlor RT, Johns AL, Miller DK, Mafficini A, Rusev B, Scardoni M, Antonello D, Barbi S, Sikora KO, Cingarlini S, Vicentini C, McKay S, Quinn MCJ, Bruxner TJC, Christ AN, Harliwong I, Idrisoglu S, McLean S, Nourse C, Nourbakhsh E, Wilson PJ, Anderson MJ, Fink JL, Newell F, Waddell N, Holmes O, Kazakoff SH, Leonard C, Wood S, Xu Q, Hiriyur Nagaraj S, Amato E, Dalai I, Bersani S, Cataldo I, Dei Tos AP, Capelli P, Vittoria Davì M, Landoni L, Malpaga A, Miotto M, Whitehall VLJ, Leggett BA, Harris JL, Harris J, Jones MD, Humphris J, Chantrill LA, Chin V, Nagrial AM, Pajic M, Scarlett CJ, Pinho A, Rooman I, Toon C, Wu J, Pinese M, Cowley M, Barbour A, Mawson A, Humphrey ES, Colvin EK, Chou A, Lovell JA, Jamieson NB, Duthie F, Gingras MC, Fisher WE, Dagg RA, Lau LMS, Lee M, Pickett HA, Reddel RR, Samra JS, Kench JG, Merrett ND, Epari K, Nguyen NQ, Zeps N, Falconi M, Simbolo M, Butturini G, Van Buren G, Partelli S, Fassan M; Australian Pancreatic Cancer Genome Initiative, Khanna KK, Gill AJ, Wheeler DA, Gibbs RA, Musgrove EA, Bassi C, Tortora G, Pederzoli P, Pearson JV, Waddell N, Biankin AV, Grimmond SM.

Nature. 2017 Oct 26;550(7677):548. doi: 10.1038/nature24026. Epub 2017 Sep 27.

PMID:
28953865
45.

Choosing entrustable professional activities for neonatology: a Delphi study.

Parker TA, Guiton G, Jones MD Jr.

J Perinatol. 2017 Dec;37(12):1335-1340. doi: 10.1038/jp.2017.144. Epub 2017 Sep 21.

PMID:
28933775
46.

Zirconium amine tris(phenolate): A more effective initiator for biomedical lactide.

Jones MD, Wu X, Chaudhuri J, Davidson MG, Ellis MJ.

Mater Sci Eng C Mater Biol Appl. 2017 Nov 1;80:69-74. doi: 10.1016/j.msec.2017.03.242. Epub 2017 Mar 29.

PMID:
28866217
47.

Touch Precision Modulates Visual Bias.

Misceo GF, Jones MD.

J Mot Behav. 2018 May-Jun;50(3):307-311. doi: 10.1080/00222895.2017.1341381. Epub 2017 Aug 29.

PMID:
28850323
48.

Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide.

Schäfer PM, Fuchs M, Ohligschläger A, Rittinghaus R, McKeown P, Akin E, Schmidt M, Hoffmann A, Liauw MA, Jones MD, Herres-Pawlis S.

ChemSusChem. 2017 Sep 22;10(18):3547-3556. doi: 10.1002/cssc.201701237. Epub 2017 Sep 19. Erratum in: ChemSusChem. 2017 Dec 8;10 (23 ):4799.

PMID:
28779508
49.

Explicit Education About Exercise-Induced Hypoalgesia Influences Pain Responses to Acute Exercise in Healthy Adults: A Randomized Controlled Trial.

Jones MD, Valenzuela T, Booth J, Taylor JL, Barry BK.

J Pain. 2017 Nov;18(11):1409-1416. doi: 10.1016/j.jpain.2017.07.006. Epub 2017 Aug 1.

PMID:
28778814
50.

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

McDonald ER 3rd, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T, Sellers WR.

Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.

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