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Items: 1 to 50 of 155

1.

Precision Retargeting: A Selective Covalent Inhibitor Illuminates CDK7 Biology.

Jones LH.

Cell Chem Biol. 2019 Jun 20;26(6):779-780. doi: 10.1016/j.chembiol.2019.05.012.

PMID:
31226310
2.

Expanding chemogenomic space using chemoproteomics.

Jones LH.

Bioorg Med Chem. 2019 Aug 1;27(15):3451-3453. doi: 10.1016/j.bmc.2019.06.022. Epub 2019 Jun 13. Review.

PMID:
31221609
3.

Quantifying drug-target engagement in live cells using sulfonyl fluoride chemical probes.

Jones LH, Xu H, Fadeyi OO.

Methods Enzymol. 2019;622:201-220. doi: 10.1016/bs.mie.2019.02.010. Epub 2019 Mar 9.

PMID:
31155053
4.

Emerging Utility of Fluorosulfate Chemical Probes.

Jones LH.

ACS Med Chem Lett. 2018 Jun 27;9(7):584-586. doi: 10.1021/acsmedchemlett.8b00276. eCollection 2018 Jul 12.

5.

Reactive Chemical Probes: Beyond the Kinase Cysteinome.

Jones LH.

Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9220-9223. doi: 10.1002/anie.201802693. Epub 2018 Jun 12. Review.

PMID:
29644769
6.

Small-Molecule Kinase Downregulators.

Jones LH.

Cell Chem Biol. 2018 Jan 18;25(1):30-35. doi: 10.1016/j.chembiol.2017.10.011. Epub 2017 Nov 22. Review.

7.

Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary Cells.

Li J, Wang B, Juba BM, Vazquez M, Kortum SW, Pierce BS, Pacheco M, Roberts L, Strohbach JW, Jones LH, Hett E, Thorarensen A, Telliez JB, Sharei A, Bunnage M, Gilbert JB.

ACS Chem Biol. 2017 Dec 15;12(12):2970-2974. doi: 10.1021/acschembio.7b00683. Epub 2017 Nov 13.

PMID:
29088528
8.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. doi: 10.1016/j.bmcl.2017.09.056. Epub 2017 Sep 28.

PMID:
29029933
9.

In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.

Cherry JJ, DiDonato CJ, Androphy EJ, Calo A, Potter K, Custer SK, Du S, Foley TL, Gopalsamy A, Reedich EJ, Gordo SM, Gordon W, Hosea N, Jones LH, Krizay DK, LaRosa G, Li H, Mathur S, Menard CA, Patel P, Ramos-Zayas R, Rietz A, Rong H, Zhang B, Tones MA.

PLoS One. 2017 Sep 25;12(9):e0185079. doi: 10.1371/journal.pone.0185079. eCollection 2017.

10.

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.

Fadeyi OO, Hoth LR, Choi C, Feng X, Gopalsamy A, Hett EC, Kyne RE Jr, Robinson RP, Jones LH.

ACS Chem Biol. 2017 Aug 18;12(8):2015-2020. doi: 10.1021/acschembio.7b00403. Epub 2017 Jul 20.

PMID:
28718624
11.

A flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I.

Zhang F, Bodycombe NE, Haskell KM, Sun YL, Wang ET, Morris CA, Jones LH, Wood LD, Pletcher MT.

Hum Mol Genet. 2017 Aug 15;26(16):3056-3068. doi: 10.1093/hmg/ddx190.

12.

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW.

Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.

13.

Clinical chemoproteomics-Opportunities and obstacles.

Jones LH, Neubert H.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaaf7951. doi: 10.1126/scitranslmed.aaf7951. Review.

PMID:
28424333
14.

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.

Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock I, Sahasrabudhe P, Bonin P, Hay DA, Brennan PE, Pletcher M, Jones LH, Chekler ELP.

J Med Chem. 2017 Jul 13;60(13):5349-5363. doi: 10.1021/acs.jmedchem.6b01839. Epub 2017 May 12.

PMID:
28375629
15.

Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor.

Field SD, Arkin J, Li J, Jones LH.

ACS Chem Biol. 2017 May 19;12(5):1183-1187. doi: 10.1021/acschembio.7b00116. Epub 2017 Mar 22.

PMID:
28318222
16.

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Gopalsamy A, Narayanan A, Liu S, Parikh MD, Kyne RE Jr, Fadeyi O, Tones MA, Cherry JJ, Nabhan JF, LaRosa G, Petersen DN, Menard C, Foley TL, Noell S, Ren Y, Loria PM, Maglich-Goodwin J, Rong H, Jones LH.

J Med Chem. 2017 Apr 13;60(7):3094-3108. doi: 10.1021/acs.jmedchem.7b00124. Epub 2017 Mar 16.

PMID:
28257199
17.

Applications of chemogenomic library screening in drug discovery.

Jones LH, Bunnage ME.

Nat Rev Drug Discov. 2017 Apr;16(4):285-296. doi: 10.1038/nrd.2016.244. Epub 2017 Jan 20. Review.

PMID:
28104905
18.

Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans-cyclooctene largazole thiol probe.

Xu H, Roberts LR, Chou S, Pierce B, Narayanan A, Jones LH.

Medchemcomm. 2017 Jan 9;8(4):767-770. doi: 10.1039/c6md00633g. eCollection 2017 Apr 1.

19.

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.

Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J.

J Am Chem Soc. 2017 Jan 18;139(2):680-685. doi: 10.1021/jacs.6b08536. Epub 2017 Jan 4.

20.

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.

Fadeyi O, Parikh MD, Chen MZ, Kyne RE Jr, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP.

Chembiochem. 2016 Oct 17;17(20):1925-1930. doi: 10.1002/cbic.201600427. Epub 2016 Aug 30.

PMID:
27504718
21.

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.

Liu S, Dakin LA, Xing L, Withka JM, Sahasrabudhe PV, Li W, Banker ME, Balbo P, Shanker S, Chrunyk BA, Guo Z, Chen JM, Young JA, Bai G, Starr JT, Wright SW, Bussenius J, Tan S, Gopalsamy A, Lefker BA, Vincent F, Jones LH, Xu H, Hoth LR, Geoghegan KF, Qiu X, Bunnage ME, Thorarensen A.

Sci Rep. 2016 Aug 16;6:30859. doi: 10.1038/srep30859.

22.

Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium.

Porter JD, Watson J, Roberts LR, Gill SK, Groves H, Dhariwal J, Almond MH, Wong E, Walton RP, Jones LH, Tregoning J, Kilty I, Johnston SL, Edwards MR.

J Antimicrob Chemother. 2016 Oct;71(10):2767-81. doi: 10.1093/jac/dkw222. Epub 2016 Jul 25.

23.

Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques.

Hett EC, Kyne RE Jr, Gopalsamy A, Tones MA, Xu H, Thio GL, Nolan E, Jones LH.

ACS Comb Sci. 2016 Oct 10;18(10):611-615. Epub 2016 Aug 17.

PMID:
27494431
24.

Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.

Rana P, Will Y, Nadanaciva S, Jones LH.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):4003-6. doi: 10.1016/j.bmcl.2016.06.088. Epub 2016 Jun 30.

PMID:
27397500
25.

Modern advances in heterocyclic chemistry in drug discovery.

Taylor AP, Robinson RP, Fobian YM, Blakemore DC, Jones LH, Fadeyi O.

Org Biomol Chem. 2016 Jul 12;14(28):6611-37. doi: 10.1039/c6ob00936k. Review.

PMID:
27282396
26.

Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells.

Xu H, Gopalsamy A, Hett EC, Salter S, Aulabaugh A, Kyne RE, Pierce B, Jones LH.

Org Biomol Chem. 2016 Jul 14;14(26):6179-83. doi: 10.1039/c6ob01078d. Epub 2016 May 24.

PMID:
27216142
27.

Protein labelling.

Jones LH, Weerapana E.

Mol Biosyst. 2016 May 24;12(6):1725-7. doi: 10.1039/c6mb90019d. No abstract available.

PMID:
27215194
28.

The human placental proteome is affected by maternal smoking.

Huuskonen P, Amezaga MR, Bellingham M, Jones LH, Storvik M, Häkkinen M, Keski-Nisula L, Heinonen S, O'Shaughnessy PJ, Fowler PA, Pasanen M.

Reprod Toxicol. 2016 Aug;63:22-31. doi: 10.1016/j.reprotox.2016.05.009. Epub 2016 May 14.

29.

An industry perspective on drug target validation.

Jones LH.

Expert Opin Drug Discov. 2016 Jul;11(7):623-5. doi: 10.1080/17460441.2016.1182484. Epub 2016 May 9. No abstract available.

PMID:
27111834
30.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI.

Mol Biosyst. 2016 May 24;12(6):1781-9. doi: 10.1039/c6mb00109b.

PMID:
27021930
31.

Understanding the chemically-reactive proteome.

Jones LH.

Mol Biosyst. 2016 May 24;12(6):1728-30. doi: 10.1039/c5mb00760g.

PMID:
26726011
32.

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.

Chekler EL, Pellegrino JA, Lanz TA, Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Lee K, Pletcher MT, Jones LH.

Chem Biol. 2015 Dec 17;22(12):1588-96. doi: 10.1016/j.chembiol.2015.10.013. Epub 2015 Dec 3.

33.

Recent advances in the molecular design of synthetic vaccines.

Jones LH.

Nat Chem. 2015 Dec;7(12):952-60. doi: 10.1038/nchem.2396. Review.

PMID:
26587710
34.

Cell permeable affinity- and activity-based probes.

Jones LH.

Future Med Chem. 2015;7(16):2131-41. doi: 10.4155/fmc.15.100. Epub 2015 Oct 29. Review.

PMID:
26511518
35.

Molecular hybridization yields triazole bronchodilators for the treatment of COPD.

Jones LH, Burrows J, Feeder N, Glossop P, James K, Jones RM, Kenyon AS, Patel S, Roberts DF, Selby MD, Strang RS, Stuart EF, Trevethick MA, Watson J, Wright KN, Clarke N.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5121-6. doi: 10.1016/j.bmcl.2015.10.008. Epub 2015 Oct 8.

PMID:
26471092
36.

Inflammation-induced formation of fat-associated lymphoid clusters.

Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M, Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie ANJ, Caamaño JH.

Nat Immunol. 2015 Aug;16(8):819-828. doi: 10.1038/ni.3215. Epub 2015 Jun 29.

37.

Know your target, know your molecule.

Bunnage ME, Gilbert AM, Jones LH, Hett EC.

Nat Chem Biol. 2015 Jun;11(6):368-72. doi: 10.1038/nchembio.1813. No abstract available.

PMID:
25978985
38.

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.

Xu H, Hett EC, Gopalsamy A, Parikh MD, Geoghegan KF, Kyne RE Jr, Menard CA, Narayanan A, Robinson RP, Johnson DS, Tones MA, Jones LH.

Mol Biosyst. 2015 Oct;11(10):2709-12. doi: 10.1039/c5mb00288e.

PMID:
25959423
39.

Sulfonyl fluorides as privileged warheads in chemical biology.

Narayanan A, Jones LH.

Chem Sci. 2015 May 1;6(5):2650-2659. doi: 10.1039/c5sc00408j. Epub 2015 Mar 16.

40.

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

Cook PC, Owen H, Deaton AM, Borger JG, Brown SL, Clouaire T, Jones GR, Jones LH, Lundie RJ, Marley AK, Morrison VL, Phythian-Adams AT, Wachter E, Webb LM, Sutherland TE, Thomas GD, Grainger JR, Selfridge J, McKenzie AN, Allen JE, Fagerholm SC, Maizels RM, Ivens AC, Bird A, MacDonald AS.

Nat Commun. 2015 Apr 24;6:6920. doi: 10.1038/ncomms7920.

41.

Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.

Jones LH, Cook PC, Ivens AC, Thomas GD, Phythian-Adams AT, Allen JE, MacDonald AS.

Int Immunol. 2015 Nov;27(11):589-96. doi: 10.1093/intimm/dxv020. Epub 2015 Apr 20.

42.

Click chemistry patents and their impact on drug discovery and chemical biology.

Xu H, Jones LH.

Pharm Pat Anal. 2015;4(2):109-19. doi: 10.4155/ppa.14.59. Review.

PMID:
25853470
43.

TAK1 selective inhibition: state of the art and future opportunities.

Kilty I, Jones LH.

Future Med Chem. 2015;7(1):23-33. doi: 10.4155/fmc.14.138. Review.

PMID:
25582331
44.

Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.

Hett EC, Xu H, Geoghegan KF, Gopalsamy A, Kyne RE Jr, Menard CA, Narayanan A, Parikh MD, Liu S, Roberts L, Robinson RP, Tones MA, Jones LH.

ACS Chem Biol. 2015 Apr 17;10(4):1094-8. doi: 10.1021/cb5009475. Epub 2015 Jan 29.

PMID:
25571984
45.

Chemical biology & drug discovery.

Jones LH, Heinis C.

Eur J Med Chem. 2014 Dec 17;88:1-2. doi: 10.1016/j.ejmech.2014.10.017. Epub 2014 Oct 8. No abstract available.

PMID:
25307206
46.

Rare diseases. Foreword.

Jones LH.

Future Med Chem. 2014 Jun;6(9):969-70. doi: 10.4155/fmc.14.59. No abstract available.

47.

Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds.

Marculescu C, Kossen H, Morgan RE, Mayer P, Fletcher SA, Tolner B, Chester KA, Jones LH, Baker JR.

Chem Commun (Camb). 2014 Jul 11;50(54):7139-42. doi: 10.1039/c4cc02107j.

PMID:
24853662
48.

Understanding and applying tyrosine biochemical diversity.

Jones LH, Narayanan A, Hett EC.

Mol Biosyst. 2014 May;10(5):952-69. doi: 10.1039/c4mb00018h. Review.

PMID:
24623162
49.

Synthetic phosphorylation of p38α recapitulates protein kinase activity.

Chooi KP, Galan SR, Raj R, McCullagh J, Mohammed S, Jones LH, Davis BG.

J Am Chem Soc. 2014 Feb 5;136(5):1698-701. doi: 10.1021/ja4095318. Epub 2014 Jan 27.

50.

Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.

Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R.

J Thromb Haemost. 2013 Dec;11(12):2155-62. doi: 10.1111/jth.12425.

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