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Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin in Aspergillus fumigatus: a new direction in natural product functionality.

Saleh AA, Jones GW, Tinley FC, Delaney SF, Alabbadi SH, Fenlon K, Doyle S, Owens RA.

Metallomics. 2018 Jun 20;10(6):854-866. doi: 10.1039/c8mt00052b.


Radiotherapy utilization in developing countries: An IAEA study.

Rosenblatt E, Fidarova E, Zubizarreta EH, Barton MB, Jones GW, Mackillop WJ, Cordero L, Yarney J, Lim G, Gan JV, Cernea V, Stojanovic-Rundic S, Strojan P, Kochbati L, Quarneti A.

Radiother Oncol. 2018 May 30. pii: S0167-8140(18)30273-1. doi: 10.1016/j.radonc.2018.05.014. [Epub ahead of print]


Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus.

Doyle S, Jones GW, Dolan SK.

Fungal Biol. 2018 Apr;122(4):214-221. doi: 10.1016/j.funbio.2017.12.007. Epub 2017 Dec 18.


IL-27: a double agent in the IL-6 family.

Jones GW, Hill DG, Cardus A, Jones SA.

Clin Exp Immunol. 2018 Jul;193(1):37-46. doi: 10.1111/cei.13116. Epub 2018 Mar 9. Review.


Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.

Hill DG, Yu L, Gao H, Balic JJ, West A, Oshima H, McLeod L, Oshima M, Gallimore A, D'Costa K, Bhathal PS, Sievert W, Ferrero RL, Jenkins BJ, Jones GW.

Int J Cancer. 2018 Jul 1;143(1):167-178. doi: 10.1002/ijc.31298. Epub 2018 Feb 19.


In Vivo Models for Inflammatory Arthritis.

Jones GW, Hill DG, Sime K, Williams AS.

Methods Mol Biol. 2018;1725:101-118. doi: 10.1007/978-1-4939-7568-6_9.


Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Colbeck EJ, Ager A, Gallimore A, Jones GW.

Front Immunol. 2017 Dec 19;8:1830. doi: 10.3389/fimmu.2017.01830. eCollection 2017. Review.


The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation.

Xu L, Gong W, Cusack SA, Wu H, Loovers HM, Zhang H, Perrett S, Jones GW.

Cell Mol Life Sci. 2018 Apr;75(8):1445-1459. doi: 10.1007/s00018-017-2698-3. Epub 2017 Nov 9.


The prostate cancer screening clinic in the Bahamas: a model for low- and middle-income countries.

Roberts R, Mitchell C, Tancawan AL, Pedican M, Jones GW.

Cancer Causes Control. 2017 Nov;28(11):1187-1193. doi: 10.1007/s10552-017-0972-1. Epub 2017 Nov 8.


Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain.

Xue YL, Zhou L, Sun Y, Li H, Jones GW, Song Y.

J Mol Model. 2017 Oct 23;23(11):320. doi: 10.1007/s00894-017-3453-2.


Management of failed spinal anaesthesia for caesarean section.

Jones GW, Samuel RA, Biccard BM.

S Afr Med J. 2017 Jun 30;107(7):611-614. doi: 10.7196/SAMJ.2017.v107i7.12056.


Outcomes of treatment in men with prostate cancer at the cancer centre Bahamas.

Jones GW, Kellini O, Roberts R, Girgis N, Brown C, Nottage K, McGowan T, Quee-Brown CS, Brown C.

Cancer Causes Control. 2017 Nov;28(11):1285-1293. doi: 10.1007/s10552-017-0940-9. Epub 2017 Sep 1.


Quantized Transport, Strain-Induced Perfectly Conducting Modes, and Valley Filtering on Shape-Optimized Graphene Corbino Devices.

Jones GW, Bahamon DA, Castro Neto AH, Pereira VM.

Nano Lett. 2017 Sep 13;17(9):5304-5313. doi: 10.1021/acs.nanolett.7b01663. Epub 2017 Aug 9.


Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].

Xue YL, Wang H, Riedy M, Roberts BL, Sun Y, Song YB, Jones GW, Masison DC, Song Y.

J Biomol Struct Dyn. 2018 May;36(7):1764-1775. doi: 10.1080/07391102.2017.1334594. Epub 2017 Aug 2.


The influence of extra-curricular physical activities in the development of coordination in pre-school children.

Silva Batista MA, Almeida Honório SA, Jones GW, Matos Serrano JJ, Duarte Petrica JM.

Minerva Pediatr. 2017 May 31. doi: 10.23736/S0026-4946.17.04981-7. [Epub ahead of print]


The double life of the ribosome: When its protein folding activity supports prion propagation.

Voisset C, Blondel M, Jones GW, Friocourt G, Stahl G, Chédin S, Béringue V, Gillet R.

Prion. 2017 Mar 4;11(2):89-97. doi: 10.1080/19336896.2017.1303587. Review.


Insights into the mechanism of how Morin suppresses amyloid fibrillation of hen egg white lysozyme.

Chong X, Sun L, Sun Y, Chang L, Chang AK, Lu X, Zhou X, Liu J, Zhang B, Jones GW, He J.

Int J Biol Macromol. 2017 Aug;101:321-325. doi: 10.1016/j.ijbiomac.2017.03.107. Epub 2017 Mar 21.


Grasping with a soft glove: intrinsic impedance control in pneumatic actuators.

Paoletti P, Jones GW, Mahadevan L.

J R Soc Interface. 2017 Mar;14(128). pii: 20160867. doi: 10.1098/rsif.2016.0867.


Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.

Dolan SK, Bock T, Hering V, Owens RA, Jones GW, Blankenfeldt W, Doyle S.

Open Biol. 2017 Feb;7(2). pii: 160292. doi: 10.1098/rsob.160292.


Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.

Clement M, Marsden M, Stacey MA, Abdul-Karim J, Gimeno Brias S, Costa Bento D, Scurr MJ, Ghazal P, Weaver CT, Carlesso G, Clare S, Jones SA, Godkin A, Jones GW, Humphreys IR.

PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.


Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease.

Perks WV, Singh RK, Jones GW, Twohig JP, Williams AS, Humphreys IR, Taylor PR, Jones SA, Wang ECY.

Am J Pathol. 2016 Nov;186(11):2813-2823. doi: 10.1016/j.ajpath.2016.07.021. Epub 2016 Sep 21.


Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together.

Jones GW, Hill DG, Jones SA.

Front Immunol. 2016 Oct 3;7:401. eCollection 2016. Review.


Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus.

Sheridan KJ, Lechner BE, Keeffe GO, Keller MA, Werner ER, Lindner H, Jones GW, Haas H, Doyle S.

Sci Rep. 2016 Oct 17;6:35306. doi: 10.1038/srep35306.


Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation.

Blondel M, Soubigou F, Evrard J, Nguyen PH, Hasin N, Chédin S, Gillet R, Contesse MA, Friocourt G, Stahl G, Jones GW, Voisset C.

Sci Rep. 2016 Sep 16;6:32117. doi: 10.1038/srep32117.


The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.

Alves de Castro P, Dos Reis TF, Dolan SK, Oliveira Manfiolli A, Brown NA, Jones GW, Doyle S, Riaño-Pachón DM, Squina FM, Caldana C, Singh A, Del Poeta M, Hagiwara D, Silva-Rocha R, Goldman GH.

Mol Microbiol. 2016 Nov;102(4):642-671. doi: 10.1111/mmi.13484. Epub 2016 Oct 7.


IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.

Patin EC, Jones AV, Thompson A, Clement M, Liao CT, Griffiths JS, Wallace LE, Bryant CE, Lang R, Rosenstiel P, Humphreys IR, Taylor PR, Jones GW, Orr SJ.

J Immunol. 2016 Jul 1;197(1):208-21. doi: 10.4049/jimmunol.1501204. Epub 2016 Jun 3.


Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity.

Smith EB, Dolan SK, Fitzpatrick DA, Doyle S, Jones GW.

Microb Cell. 2016 Feb 19;3(3):120-125. doi: 10.15698/mic2016.03.485.


The biology behind interleukin-6 targeted interventions.

Liu X, Jones GW, Choy EH, Jones SA.

Curr Opin Rheumatol. 2016 Mar;28(2):152-60. doi: 10.1097/BOR.0000000000000255. Review.


Distinct structural changes in wild-type and amyloidogenic chicken cystatin caused by disruption of C95-C115 disulfide bond.

Chong X, Lu X, Wang Y, Chang AK, Xu L, Wang N, Sun Y, Jones GW, Song Y, Song YB, He J.

J Biomol Struct Dyn. 2016 Dec;34(12):2679-2687. Epub 2016 Feb 5.


Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues.

Jones GW, Jones SA.

Immunology. 2016 Feb;147(2):141-51. doi: 10.1111/imm.12554. Epub 2015 Dec 10. Review.


Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger.

Manzanares-Miralles L, Sarikaya-Bayram Ö, Smith EB, Dolan SK, Bayram Ö, Jones GW, Doyle S.

J Proteomics. 2016 Jan 10;131:149-162. doi: 10.1016/j.jprot.2015.10.024. Epub 2015 Oct 21.


Readability of Patient Education Materials From Professional Societies in Radiation Oncology: Are We Meeting the National Standard? In Regard to Byun et al.

Jones GW, Nazroo JY, Larsen T, Menon T.

Int J Radiat Oncol Biol Phys. 2015 Nov 1;93(3):728. doi: 10.1016/j.ijrobp.2015.06.031. No abstract available.


Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.

Jones GW, Bombardieri M, Greenhill CJ, McLeod L, Nerviani A, Rocher-Ros V, Cardus A, Williams AS, Pitzalis C, Jenkins BJ, Jones SA.

J Exp Med. 2015 Oct 19;212(11):1793-802. doi: 10.1084/jem.20132307. Epub 2015 Sep 28.


Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex.

Lacroix M, Rousseau F, Guilhot F, Malinge P, Magistrelli G, Herren S, Jones SA, Jones GW, Scheller J, Lissilaa R, Kosco-Vilbois M, Johnson Z, Buatois V, Ferlin W.

J Biol Chem. 2015 Nov 6;290(45):26943-53. doi: 10.1074/jbc.M115.682138. Epub 2015 Sep 11.


Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.

Owens RA, O'Keeffe G, Smith EB, Dolan SK, Hammel S, Sheridan KJ, Fitzpatrick DA, Keane TM, Jones GW, Doyle S.

Eukaryot Cell. 2015 Sep;14(9):941-57. doi: 10.1128/EC.00055-15. Epub 2015 Jul 6.


Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.

Winkelströter LK, Dolan SK, Fernanda Dos Reis T, Bom VL, Alves de Castro P, Hagiwara D, Alowni R, Jones GW, Doyle S, Brown NA, Goldman GH.

G3 (Bethesda). 2015 May 5;5(7):1525-39. doi: 10.1534/g3.115.016766.


Resistance is not futile: gliotoxin biosynthesis, functionality and utility.

Dolan SK, O'Keeffe G, Jones GW, Doyle S.

Trends Microbiol. 2015 Jul;23(7):419-28. doi: 10.1016/j.tim.2015.02.005. Epub 2015 Mar 10. Review.


(-)-epigallocatechin-3-gallate inhibits fibrillogenesis of chicken cystatin.

Wang N, He J, Chang AK, Wang Y, Xu L, Chong X, Lu X, Sun Y, Xia X, Li H, Zhang B, Song Y, Kato A, Jones GW.

J Agric Food Chem. 2015 Feb 11;63(5):1347-51. doi: 10.1021/jf505277e. Epub 2015 Feb 3.


Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis.

Jones GW, McLeod L, Kennedy CL, Bozinovski S, Najdovska M, Jenkins BJ.

Atherosclerosis. 2015 Feb;238(2):321-8. doi: 10.1016/j.atherosclerosis.2014.12.037. Epub 2014 Dec 23.


RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus.

O'Keeffe G, Hammel S, Owens RA, Keane TM, Fitzpatrick DA, Jones GW, Doyle S.

BMC Genomics. 2014 Oct 14;15:894. doi: 10.1186/1471-2164-15-894.


A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus.

Owens RA, Hammel S, Sheridan KJ, Jones GW, Doyle S.

PLoS One. 2014 Sep 8;9(9):e106942. doi: 10.1371/journal.pone.0106942. eCollection 2014.


Myricetin prevents fibrillogenesis of hen egg white lysozyme.

He J, Wang Y, Chang AK, Xu L, Wang N, Chong X, Li H, Zhang B, Jones GW, Song Y.

J Agric Food Chem. 2014 Oct 1;62(39):9442-9. doi: 10.1021/jf5025449. Epub 2014 Sep 18.


Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction.

Greenhill CJ, Jones GW, Nowell MA, Newton Z, Harvey AK, Moideen AN, Collins FL, Bloom AC, Coll RC, Robertson AA, Cooper MA, Rosas M, Taylor PR, O'Neill LA, Humphreys IR, Williams AS, Jones SA.

Arthritis Res Ther. 2014 Aug 30;16(4):419. doi: 10.1186/s13075-014-0419-y.


Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae.

Keane OM, Toft C, Carretero-Paulet L, Jones GW, Fares MA.

Genome Res. 2014 Nov;24(11):1830-41. doi: 10.1101/gr.176792.114. Epub 2014 Aug 22.


Yeast models for amyloid disease.

Panaretou B, Jones GW.

Essays Biochem. 2014;56:85-97. doi: 10.1042/bse0560085.


Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus.

Dolan SK, Owens RA, O'Keeffe G, Hammel S, Fitzpatrick DA, Jones GW, Doyle S.

Chem Biol. 2014 Aug 14;21(8):999-1012. doi: 10.1016/j.chembiol.2014.07.006.


The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine.

Jones GW, Doyle S, Fitzpatrick DA.

Gene. 2014 Oct 1;549(1):161-70. doi: 10.1016/j.gene.2014.07.065. Epub 2014 Jul 26.


Interleukin-6 in renal disease and therapy.

Jones SA, Fraser DJ, Fielding CA, Jones GW.

Nephrol Dial Transplant. 2015 Apr;30(4):564-74. doi: 10.1093/ndt/gfu233. Epub 2014 Jul 10. Review.


Ectopic lymphoid-like structures in infection, cancer and autoimmunity.

Pitzalis C, Jones GW, Bombardieri M, Jones SA.

Nat Rev Immunol. 2014 Jul;14(7):447-62. doi: 10.1038/nri3700. Epub 2014 Jun 20. Review.


Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity.

Hasin N, Cusack SA, Ali SS, Fitzpatrick DA, Jones GW.

BMC Genomics. 2014 Mar 14;15:194. doi: 10.1186/1471-2164-15-194.

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