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Items: 1 to 50 of 240

1.

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

Atkinson BN, Steadman D, Zhao Y, Sipthorp J, Vecchia L, Ruza RR, Jeganathan F, Lines G, Frew S, Monaghan A, Kjær S, Bictash M, Jones EY, Fish PV.

Medchemcomm. 2019 Apr 29;10(8):1361-1369. doi: 10.1039/c9md00096h. eCollection 2019 Aug 1.

2.

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.

Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY.

Nat Commun. 2019 Aug 15;10(1):3691. doi: 10.1038/s41467-019-11683-y.

3.

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

Chen S, Wu J, Zhong S, Li Y, Zhang P, Ma J, Ren J, Tan Y, Wang Y, Au KF, Siebold C, Bond GL, Chen Z, Lu M, Jones EY, Lu X.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17470-17479. doi: 10.1073/pnas.1909393116. Epub 2019 Aug 8.

4.

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.

van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS.

Cell. 2019 Feb 7;176(4):729-742.e18. doi: 10.1016/j.cell.2018.12.009. Epub 2019 Jan 17.

5.

Designer protein delivers signal of choice.

Jones EY.

Nature. 2019 Jan;565(7738):165-166. doi: 10.1038/d41586-018-07883-z. No abstract available.

PMID:
30626947
6.

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR.

Nat Protoc. 2018 Dec;13(12):2991-3017. doi: 10.1038/s41596-018-0075-9.

7.

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Nov 13;9(1):4833. doi: 10.1038/s41467-018-07304-9.

8.

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Aug 7;9(1):3137. doi: 10.1038/s41467-018-05459-z. Erratum in: Nat Commun. 2018 Nov 13;9(1):4833.

9.

Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.

Zhao Y, Ren J, Lu W, Harlos K, Jones EY.

FEBS Lett. 2018 Sep;592(18):3152-3162. doi: 10.1002/1873-3468.13212. Epub 2018 Aug 24.

10.

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.

Gorvin CM, Frost M, Malinauskas T, Cranston T, Boon H, Siebold C, Jones EY, Hannan FM, Thakker RV.

Hum Mol Genet. 2018 Nov 1;27(21):3720-3733. doi: 10.1093/hmg/ddy263.

11.

Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function.

Chavent M, Karia D, Kalli AC, Domański J, Duncan AL, Hedger G, Stansfeld PJ, Seiradake E, Jones EY, Sansom MSP.

Structure. 2018 Jul 3;26(7):1025-1034.e2. doi: 10.1016/j.str.2018.05.003. Epub 2018 Jun 7.

12.

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

Gorvin CM, Babinsky VN, Malinauskas T, Nissen PH, Schou AJ, Hanyaloglu AC, Siebold C, Jones EY, Hannan FM, Thakker RV.

Sci Signal. 2018 Feb 20;11(518). pii: eaan3714. doi: 10.1126/scisignal.aan3714.

13.

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

Schwerd T, Twigg SRF, Aschenbrenner D, Manrique S, Miller KA, Taylor IB, Capitani M, McGowan SJ, Sweeney E, Weber A, Chen L, Bowness P, Riordan A, Cant A, Freeman AF, Milner JD, Holland SM, Frede N, Müller M, Schmidt-Arras D, Grimbacher B, Wall SA, Jones EY, Wilkie AOM, Uhlig HH.

J Exp Med. 2017 Sep 4;214(9):2547-2562. doi: 10.1084/jem.20161810. Epub 2017 Jul 26.

14.

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.

Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X.

Cancer Cell. 2016 Nov 14;30(5):822-823. doi: 10.1016/j.ccell.2016.09.019. No abstract available.

15.

Structural Perspectives on Axon Guidance.

Seiradake E, Jones EY, Klein R.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:577-608. Epub 2016 Aug 24. Review.

PMID:
27576119
16.

Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.

Zebisch M, Jackson VA, Zhao Y, Jones EY.

Structure. 2016 Sep 6;24(9):1599-605. doi: 10.1016/j.str.2016.06.020. Epub 2016 Aug 11.

17.

Structural Basis for Plexin Activation and Regulation.

Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY.

Neuron. 2016 Aug 3;91(3):548-60. doi: 10.1016/j.neuron.2016.06.018. Epub 2016 Jul 7.

18.

Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ.

Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21.

19.

Corrigendum: Correlative in-resin super-resolution and electron microscopy using standard fluorescent proteins.

Johnson E, Seiradake E, Jones EY, Davis I, Grünewald K, Kaufmann R.

Sci Rep. 2016 Mar 8;6:22681. doi: 10.1038/srep22681. No abstract available.

20.

Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.

Chavent M, Seiradake E, Jones EY, Sansom MS.

Structure. 2016 Feb 2;24(2):337-47. doi: 10.1016/j.str.2015.11.008. Epub 2015 Dec 24.

21.

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.

Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY.

Elife. 2015 Jul 9;4. doi: 10.7554/eLife.06554.

22.

Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.

Zebisch M, Jones EY.

J Struct Biol. 2015 Aug;191(2):149-55. doi: 10.1016/j.jsb.2015.05.008. Epub 2015 Jun 26.

23.

ZNRF3/RNF43--A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling.

Zebisch M, Jones EY.

Prog Biophys Mol Biol. 2015 Sep;118(3):112-8. doi: 10.1016/j.pbiomolbio.2015.04.006. Epub 2015 May 1. Review.

24.

Correlative in-resin super-resolution and electron microscopy using standard fluorescent proteins.

Johnson E, Seiradake E, Jones EY, Davis I, Grünewald K, Kaufmann R.

Sci Rep. 2015 Mar 31;5:9583. doi: 10.1038/srep09583. Erratum in: Sci Rep. 2016;6:22681.

25.

Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.

Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, He X.

Dev Cell. 2015 Mar 23;32(6):719-30. doi: 10.1016/j.devcel.2015.02.014. Epub 2015 Mar 12.

26.

Notum deacylates Wnt proteins to suppress signalling activity.

Kakugawa S, Langton PF, Zebisch M, Howell S, Chang TH, Liu Y, Feizi T, Bineva G, O'Reilly N, Snijders AP, Jones EY, Vincent JP.

Nature. 2015 Mar 12;519(7542):187-192. doi: 10.1038/nature14259. Epub 2015 Feb 25.

27.

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.

Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T, Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A, Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ, Vinuesa CG.

Nat Commun. 2015 Feb 20;6:6253. doi: 10.1038/ncomms7253.

28.

Understanding cell signalling systems: paving the way for new therapies.

Jones EY.

Philos Trans A Math Phys Eng Sci. 2015 Mar 6;373(2036). pii: 20130155. doi: 10.1098/rsta.2013.0155. Review.

29.

Production of cell surface and secreted glycoproteins in mammalian cells.

Seiradake E, Zhao Y, Lu W, Aricescu AR, Jones EY.

Methods Mol Biol. 2015;1261:115-27. doi: 10.1007/978-1-4939-2230-7_6.

PMID:
25502196
30.

Extracellular modulators of Wnt signalling.

Malinauskas T, Jones EY.

Curr Opin Struct Biol. 2014 Dec;29:77-84. doi: 10.1016/j.sbi.2014.10.003. Epub 2014 Oct 20. Review.

31.

Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.

Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR.

Nat Commun. 2014 Nov 11;5:5209. doi: 10.1038/ncomms6209.

32.

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.

Seiradake E, del Toro D, Nagel D, Cop F, Härtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R.

Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014 Oct 22.

33.

Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.

Coles CH, Jones EY, Aricescu AR.

Semin Cell Dev Biol. 2015 Jan;37:98-107. doi: 10.1016/j.semcdb.2014.09.007. Epub 2014 Sep 16. Review.

34.

Super-resolution microscopy using standard fluorescent proteins in intact cells under cryo-conditions.

Kaufmann R, Schellenberger P, Seiradake E, Dobbie IM, Jones EY, Davis I, Hagen C, Grünewald K.

Nano Lett. 2014 Jul 9;14(7):4171-5. doi: 10.1021/nl501870p. Epub 2014 Jun 4.

35.

Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1.

Zhao Y, Malinauskas T, Harlos K, Jones EY.

Structure. 2014 Apr 8;22(4):612-20. doi: 10.1016/j.str.2014.01.009. Epub 2014 Feb 27.

36.

Biology of CD1- and MR1-restricted T cells.

Salio M, Silk JD, Jones EY, Cerundolo V.

Annu Rev Immunol. 2014;32:323-66. doi: 10.1146/annurev-immunol-032713-120243. Epub 2014 Jan 31. Review.

PMID:
24499274
37.

Efficacy of a Plasmodium vivax malaria vaccine using ChAd63 and modified vaccinia Ankara expressing thrombospondin-related anonymous protein as assessed with transgenic Plasmodium berghei parasites.

Bauza K, Malinauskas T, Pfander C, Anar B, Jones EY, Billker O, Hill AV, Reyes-Sandoval A.

Infect Immun. 2014 Mar;82(3):1277-86. doi: 10.1128/IAI.01187-13. Epub 2013 Dec 30.

38.

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.

Zebisch M, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY.

Nat Commun. 2013;4:2787. doi: 10.1038/ncomms3787.

39.

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Seiradake E, Schaupp A, del Toro Ruiz D, Kaufmann R, Mitakidis N, Harlos K, Aricescu AR, Klein R, Jones EY.

Nat Struct Mol Biol. 2013 Aug;20(8):958-64. doi: 10.1038/nsmb.2617. Epub 2013 Jun 30.

40.

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.

Rat Genome Sequencing and Mapping Consortium, Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, Jagodic M, Tuncel J, Norin U, Beattie E, Huynh N, Miller WH, Koller DL, Alam I, Falak S, Osborne-Pellegrin M, Martinez-Membrives E, Canete T, Blazquez G, Vicens-Costa E, Mont-Cardona C, Diaz-Moran S, Tobena A, Hummel O, Zelenika D, Saar K, Patone G, Bauerfeind A, Bihoreau MT, Heinig M, Lee YA, Rintisch C, Schulz H, Wheeler DA, Worley KC, Muzny DM, Gibbs RA, Lathrop M, Lansu N, Toonen P, Ruzius FP, de Bruijn E, Hauser H, Adams DJ, Keane T, Atanur SS, Aitman TJ, Flicek P, Malinauskas T, Jones EY, Ekman D, Lopez-Aumatell R, Dominiczak AF, Johannesson M, Holmdahl R, Olsson T, Gauguier D, Hubner N, Fernandez-Teruel A, Cuppen E, Mott R, Flint J.

Nat Genet. 2013 Jul;45(7):767-75. doi: 10.1038/ng.2644. Epub 2013 May 26.

41.

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.

Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X.

Cancer Cell. 2013 May 13;23(5):618-33. doi: 10.1016/j.ccr.2013.03.013. Epub 2013 Apr 25. Erratum in: Cancer Cell. 2016 Nov 14;30(5):822-823.

42.

Structural insights into semaphorins and their receptors.

Siebold C, Jones EY.

Semin Cell Dev Biol. 2013 Mar;24(3):139-45. doi: 10.1016/j.semcdb.2012.11.003. Epub 2012 Dec 17. Review.

PMID:
23253452
43.

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB.

Science. 2012 Nov 30;338(6111):1209-13. doi: 10.1126/science.1228633.

44.

Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms.

Stewart-Jones GB, Simpson P, van der Merwe PA, Easterbrook P, McMichael AJ, Rowland-Jones SL, Jones EY, Gillespie GM.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3483-92. doi: 10.1073/pnas.1207896109. Epub 2012 Nov 16.

45.

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Janssen BJ, Malinauskas T, Weir GA, Cader MZ, Siebold C, Jones EY.

Nat Struct Mol Biol. 2012 Dec;19(12):1293-9. doi: 10.1038/nsmb.2416. Epub 2012 Oct 28.

46.

Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis.

Bowden TA, Baruah K, Coles CH, Harvey DJ, Yu X, Song BD, Stuart DI, Aricescu AR, Scanlan CN, Jones EY, Crispin M.

J Am Chem Soc. 2012 Oct 24;134(42):17554-63. doi: 10.1021/ja306068g. Epub 2012 Oct 15.

47.

Structural basis of fibrillar collagen trimerization and related genetic disorders.

Bourhis JM, Mariano N, Zhao Y, Harlos K, Exposito JY, Jones EY, Moali C, Aghajari N, Hulmes DJ.

Nat Struct Mol Biol. 2012 Oct;19(10):1031-6. doi: 10.1038/nsmb.2389. Epub 2012 Sep 23.

48.

Structure and function in complex macromolecular assemblies: some evolutionary themes.

Jones EY, Yeates TO.

Curr Opin Struct Biol. 2012 Apr;22(2):197-9. doi: 10.1016/j.sbi.2012.03.003. Epub 2012 Mar 21. No abstract available.

PMID:
22444564
49.

Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY.

Dev Cell. 2011 Nov 15;21(5):848-61. doi: 10.1016/j.devcel.2011.09.007. Epub 2011 Oct 13.

50.

Structural basis for cell surface patterning through NetrinG-NGL interactions.

Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY.

EMBO J. 2011 Sep 23;30(21):4479-88. doi: 10.1038/emboj.2011.346.

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