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Items: 1 to 50 of 77

1.

Emergent Properties of the HNF4α-PPARγ Network May Drive Consequent Phenotypic Plasticity in NAFLD.

Sahoo S, Singh D, Chakraborty P, Jolly MK.

J Clin Med. 2020 Mar 22;9(3). pii: E870. doi: 10.3390/jcm9030870.

2.

Decoding molecular interplay between RUNX1 and FOXO3a underlying the pulsatile IGF1R expression during acquirement of chemoresistance.

Dhadve AC, Hari K, Rekhi B, Jolly MK, De A, Ray P.

Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165754. doi: 10.1016/j.bbadis.2020.165754. Epub 2020 Mar 3.

PMID:
32142859
3.

A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells.

Tripathi S, Chakraborty P, Levine H, Jolly MK.

PLoS Comput Biol. 2020 Feb 10;16(2):e1007619. doi: 10.1371/journal.pcbi.1007619. eCollection 2020 Feb.

4.

The Physics of Cellular Decision Making During Epithelial-Mesenchymal Transition.

Tripathi S, Levine H, Jolly MK.

Annu Rev Biophys. 2020 Jan 8. doi: 10.1146/annurev-biophys-121219-081557. [Epub ahead of print]

PMID:
31913665
5.

Anticipating critical transitions in epithelial-hybrid-mesenchymal cell-fate determination.

Sarkar S, Sinha SK, Levine H, Jolly MK, Dutta PS.

Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 201913773. doi: 10.1073/pnas.1913773116. [Epub ahead of print]

PMID:
31843939
6.

Differential Contributions of Pre- and Post-EMT Tumor Cells in Breast Cancer Metastasis.

Lourenco AR, Ban Y, Crowley MJ, Lee SB, Ramchandani D, Du W, Elemento O, George JT, Jolly MK, Levine H, Sheng J, Wong ST, Altorki NK, Gao D.

Cancer Res. 2020 Jan 15;80(2):163-169. doi: 10.1158/0008-5472.CAN-19-1427. Epub 2019 Nov 8.

7.

Pericytes enable effective angiogenesis in the presence of proinflammatory signals.

Kang TY, Bocci F, Jolly MK, Levine H, Onuchic JN, Levchenko A.

Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23551-23561. doi: 10.1073/pnas.1913373116. Epub 2019 Nov 4.

PMID:
31685607
8.

A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer.

Thangavel H, De Angelis C, Vasaikar S, Bhat R, Jolly MK, Nagi C, Creighton CJ, Chen F, Dobrolecki LE, George JT, Kumar T, Abdulkareem NM, Mao S, Nardone A, Rimawi M, Osborne CK, Lewis MT, Levine H, Zhang B, Schiff R, Giuliano M, Trivedi MV.

J Clin Med. 2019 Oct 24;8(11). pii: E1772. doi: 10.3390/jcm8111772.

9.

Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS.

Kalvala A, Wallet P, Yang L, Wang C, Li H, Nam A, Nathan A, Mambetsariev I, Poroyko V, Gao H, Chu P, Sattler M, Bild A, Manuel ER, Lee PP, Jolly MK, Kulkarni P, Salgia R.

J Clin Med. 2019 Oct 18;8(10). pii: E1726. doi: 10.3390/jcm8101726.

10.

Computational Modeling of Collective Cell Migration: Mechanical and Biochemical Aspects.

Yang Y, Jolly MK, Levine H.

Adv Exp Med Biol. 2019;1146:1-11. doi: 10.1007/978-3-030-17593-1_1. Review.

PMID:
31612450
11.

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis.

Celià-Terrassa T, Jolly MK.

Cold Spring Harb Perspect Med. 2019 Sep 30. pii: a036905. doi: 10.1101/cshperspect.a036905. [Epub ahead of print]

PMID:
31570380
12.

Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression

Jolly MK, Celià-Terrassa T.

J Clin Med. 2019 Sep 25;8(10). pii: E1542. doi: 10.3390/jcm8101542. Review.

13.

Deciphering Hydrodynamic and Drug-Resistant Behaviors of Metastatic EMT Breast Cancer Cells Moving in a Constricted Microcapillary.

Nath B, Bidkar AP, Kumar V, Dalal A, Jolly MK, Ghosh SS, Biswas G.

J Clin Med. 2019 Aug 9;8(8). pii: E1194. doi: 10.3390/jcm8081194.

14.

Phenotypic heterogeneity in circulating tumor cells and its prognostic value in metastasis and overall survival.

Saxena K, Subbalakshmi AR, Jolly MK.

EBioMedicine. 2019 Aug;46:4-5. doi: 10.1016/j.ebiom.2019.07.074. Epub 2019 Aug 6. No abstract available.

15.

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression.

Saxena K, Jolly MK.

Biomolecules. 2019 Aug 3;9(8). pii: E339. doi: 10.3390/biom9080339. Review.

16.

A possible role for epigenetic feedback regulation in the dynamics of the epithelial-mesenchymal transition (EMT).

Jia W, Deshmukh A, Mani SA, Jolly MK, Levine H.

Phys Biol. 2019 Sep 6;16(6):066004. doi: 10.1088/1478-3975/ab34df.

17.

NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype.

Bocci F, Tripathi SC, Vilchez Mercedes SA, George JT, Casabar JP, Wong PK, Hanash SM, Levine H, Onuchic JN, Jolly MK.

Integr Biol (Camb). 2019 Jun 1;11(6):251-263. doi: 10.1093/intbio/zyz021.

18.

Small Cell Lung Cancer Therapeutic Responses Through Fractal Measurements: From Radiology to Mitochondrial Biology.

Mambetsariev I, Mirzapoiazova T, Lennon F, Jolly MK, Li H, Nasser MW, Vora L, Kulkarni P, Batra SK, Salgia R.

J Clin Med. 2019 Jul 16;8(7). pii: E1038. doi: 10.3390/jcm8071038.

19.

Functional balance between Tcf21-Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines.

Varankar SS, More M, Abraham A, Pansare K, Kumar B, Narayanan NJ, Jolly MK, Mali AM, Bapat SA.

Carcinogenesis. 2019 Jun 25. pii: bgz119. doi: 10.1093/carcin/bgz119. [Epub ahead of print]

PMID:
31241128
20.

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response.

Jia D, Li X, Bocci F, Tripathi S, Deng Y, Jolly MK, Onuchic JN, Levine H.

J Clin Med. 2019 May 22;8(5). pii: E725. doi: 10.3390/jcm8050725. Review.

21.

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer.

Jolly MK, Preca BT, Tripathi SC, Jia D, George JT, Hanash SM, Brabletz T, Stemmler MP, Maurer J, Levine H.

APL Bioeng. 2018 Aug 22;2(3):031908. doi: 10.1063/1.5024874. eCollection 2018 Sep.

22.

E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.

Jolly MK, Ware KE, Xu S, Gilja S, Shetler S, Yang Y, Wang X, Austin RG, Runyambo D, Hish AJ, Bartholf DeWitt S, George JT, Kreulen RT, Boss MK, Lazarides AL, Kerr DL, Gerber DG, Sivaraj D, Armstrong AJ, Dewhirst MW, Eward WC, Levine H, Somarelli JA.

Mol Cancer Res. 2019 Jun;17(6):1391-1402. doi: 10.1158/1541-7786.MCR-18-0763. Epub 2019 Mar 12.

23.

Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level.

Lin X, Kulkarni P, Bocci F, Schafer NP, Roy S, Tsai MY, He Y, Chen Y, Rajagopalan K, Mooney SM, Zeng Y, Weninger K, Grishaev A, Onuchic JN, Levine H, Wolynes PG, Salgia R, Rangarajan G, Uversky V, Orban J, Jolly MK.

Biomolecules. 2019 Feb 22;9(2). pii: E77. doi: 10.3390/biom9020077.

24.

An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance.

Xu S, Ware KE, Ding Y, Kim SY, Sheth MU, Rao S, Chan W, Armstrong AJ, Eward WC, Jolly MK, Somarelli JA.

J Clin Med. 2019 Feb 7;8(2). pii: E205. doi: 10.3390/jcm8020205.

25.

Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer.

Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK.

Cancer Res. 2019 Apr 15;79(8):1831-1843. doi: 10.1158/0008-5472.CAN-18-2636. Epub 2019 Feb 7.

PMID:
30733195
26.

Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment.

Li X, Jolly MK, George JT, Pienta KJ, Levine H.

Front Oncol. 2019 Jan 23;9:10. doi: 10.3389/fonc.2019.00010. eCollection 2019.

27.

Quantitative Characteristic of ncRNA Regulation in Gene Regulatory Networks.

Bocci F, Jolly MK, Levine H, Onuchic JN.

Methods Mol Biol. 2019;1912:341-366. doi: 10.1007/978-1-4939-8982-9_14.

PMID:
30635901
28.

The DNA walk and its demonstration of deterministic chaos-relevance to genomic alterations in lung cancer.

Hewelt B, Li H, Jolly MK, Kulkarni P, Mambetsariev I, Salgia R.

Bioinformatics. 2019 Aug 15;35(16):2738-2748. doi: 10.1093/bioinformatics/bty1021.

29.

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment.

Bocci F, Gearhart-Serna L, Boareto M, Ribeiro M, Ben-Jacob E, Devi GR, Levine H, Onuchic JN, Jolly MK.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):148-157. doi: 10.1073/pnas.1815345116. Epub 2018 Dec 26.

30.

Testing the gene expression classification of the EMT spectrum.

Jia D, George JT, Tripathi SC, Kundnani DL, Lu M, Hanash SM, Onuchic JN, Jolly MK, Levine H.

Phys Biol. 2019 Jan 18;16(2):025002. doi: 10.1088/1478-3975/aaf8d4.

PMID:
30557866
31.

Stability and mean residence times for hybrid epithelial/mesenchymal phenotype.

Biswas K, Jolly MK, Ghosh A.

Phys Biol. 2019 Jan 29;16(2):025003. doi: 10.1088/1478-3975/aaf7b7.

PMID:
30537698
32.

Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities.

Eapen MS, Hansbro PM, Larsson-Callerfelt AK, Jolly MK, Myers S, Sharma P, Jones B, Rahman MA, Markos J, Chia C, Larby J, Haug G, Hardikar A, Weber HC, Mabeza G, Cavalheri V, Khor YH, McDonald CF, Sohal SS.

Drugs. 2018 Nov;78(16):1717-1740. doi: 10.1007/s40265-018-1001-8. Review.

PMID:
30392114
33.

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas.

Jolly MK, Somarelli JA, Sheth M, Biddle A, Tripathi SC, Armstrong AJ, Hanash SM, Bapat SA, Rangarajan A, Levine H.

Pharmacol Ther. 2019 Feb;194:161-184. doi: 10.1016/j.pharmthera.2018.09.007. Epub 2018 Sep 28. Review.

PMID:
30268772
34.

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling.

Bocci F, Jolly MK, George JT, Levine H, Onuchic JN.

Oncotarget. 2018 Jul 6;9(52):29906-29920. doi: 10.18632/oncotarget.25692. eCollection 2018 Jul 6.

35.
36.

Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis?

Jolly MK, Mani SA, Levine H.

Biochim Biophys Acta Rev Cancer. 2018 Dec;1870(2):151-157. doi: 10.1016/j.bbcan.2018.07.001. Epub 2018 Jul 8. Review.

PMID:
29997040
37.

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target.

Salgia R, Jolly MK, Dorff T, Lau C, Weninger K, Orban J, Kulkarni P.

J Clin Med. 2018 Jun 17;7(6). pii: E156. doi: 10.3390/jcm7060156. Review.

38.

PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.

Lin X, Roy S, Jolly MK, Bocci F, Schafer NP, Tsai MY, Chen Y, He Y, Grishaev A, Weninger K, Orban J, Kulkarni P, Rangarajan G, Levine H, Onuchic JN.

J Mol Biol. 2018 Aug 3;430(16):2422-2438. doi: 10.1016/j.jmb.2018.05.011. Epub 2018 Jun 5.

39.

Phenotypic Plasticity, Bet-Hedging, and Androgen Independence in Prostate Cancer: Role of Non-Genetic Heterogeneity.

Jolly MK, Kulkarni P, Weninger K, Orban J, Levine H.

Front Oncol. 2018 Mar 6;8:50. doi: 10.3389/fonc.2018.00050. eCollection 2018. Review.

40.

XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.

Evans MK, Brown MC, Geradts J, Bao X, Robinson TJ, Jolly MK, Vermeulen PB, Palmer GM, Gromeier M, Levine H, Morse MA, Van Laere SJ, Devi GR.

Cancer Res. 2018 Apr 1;78(7):1726-1738. doi: 10.1158/0008-5472.CAN-17-1667. Epub 2018 Jan 19.

41.

Numb prevents a complete epithelial-mesenchymal transition by modulating Notch signalling.

Bocci F, Jolly MK, Tripathi SC, Aguilar M, Hanash SM, Levine H, Onuchic JN.

J R Soc Interface. 2017 Nov;14(136). pii: 20170512. doi: 10.1098/rsif.2017.0512.

42.

Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.

George JT, Jolly MK, Xu S, Somarelli JA, Levine H.

Cancer Res. 2017 Nov 15;77(22):6415-6428. doi: 10.1158/0008-5472.CAN-16-3521. Epub 2017 Sep 25.

43.

Inflammatory breast cancer: a model for investigating cluster-based dissemination.

Jolly MK, Boareto M, Debeb BG, Aceto N, Farach-Carson MC, Woodward WA, Levine H.

NPJ Breast Cancer. 2017 Jun 6;3:21. doi: 10.1038/s41523-017-0023-9. eCollection 2017.

44.

Epithelial-mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease.

Jolly MK, Ward C, Eapen MS, Myers S, Hallgren O, Levine H, Sohal SS.

Dev Dyn. 2018 Mar;247(3):346-358. doi: 10.1002/dvdy.24541. Epub 2017 Jul 21. Review.

45.

MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway.

Tripathi SC, Fahrmann JF, Celiktas M, Aguilar M, Marini KD, Jolly MK, Katayama H, Wang H, Murage EN, Dennison JB, Watkins DN, Levine H, Ostrin EJ, Taguchi A, Hanash SM.

Cancer Res. 2017 Aug 15;77(16):4414-4425. doi: 10.1158/0008-5472.CAN-16-2874. Epub 2017 Jun 23.

46.

Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory.

Jia D, Jolly MK, Kulkarni P, Levine H.

Cancers (Basel). 2017 Jun 22;9(7). pii: E70. doi: 10.3390/cancers9070070. Review.

47.

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

Jolly MK, Tripathi SC, Somarelli JA, Hanash SM, Levine H.

Mol Oncol. 2017 Jul;11(7):739-754. doi: 10.1002/1878-0261.12084. Epub 2017 Jun 19. Review.

48.

EMT and MET: necessary or permissive for metastasis?

Jolly MK, Ware KE, Gilja S, Somarelli JA, Levine H.

Mol Oncol. 2017 Jul;11(7):755-769. doi: 10.1002/1878-0261.12083. Epub 2017 Jun 12. Review.

49.

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.

Ware KE, Gilja S, Xu S, Shetler S, Jolly MK, Wang X, Bartholf Dewitt S, Hish AJ, Jordan S, Eward W, Levine H, Armstrong AJ, Somarelli JA.

J Vis Exp. 2017 Apr 7;(122). doi: 10.3791/55520.

50.

Operating principles of tristable circuits regulating cellular differentiation.

Jia D, Jolly MK, Harrison W, Boareto M, Ben-Jacob E, Levine H.

Phys Biol. 2017 May 23;14(3):035007. doi: 10.1088/1478-3975/aa6f90.

PMID:
28443829

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