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Items: 14


Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning.

Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee KW.

Front Pharmacol. 2019 May 24;10:560. doi: 10.3389/fphar.2019.00560. eCollection 2019.


Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acidA receptor subtypes for the treatment of chronic pain.

Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW.

Pain. 2019 Jan;160(1):198-209. doi: 10.1097/j.pain.0000000000001392.


Role of β2/3-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis.

Reddy DS, Yoshimura RF, Ramanathan G, Carver C, Johnstone TB, Hogenkamp DJ, Gee KW.

Epilepsy Behav. 2018 May;82:57-63. doi: 10.1016/j.yebeh.2018.02.020. Epub 2018 Mar 26.


PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA Jr, Ostrom RS.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):530-541. doi: 10.1165/rcmb.2017-0294OC.


cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes.

Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS.

Mol Pharmacol. 2018 Apr;93(4):270-276. doi: 10.1124/mol.117.110825. Epub 2017 Dec 7. Review.


Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.

Hogenkamp DJ, Tran MB, Yoshimura RF, Johnstone TB, Kanner R, Gee KW.

Psychopharmacology (Berl). 2014 Sep;231(17):3517-24. doi: 10.1007/s00213-014-3494-5. Epub 2014 Feb 28.


Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator.

Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW.

J Psychopharmacol. 2014 May;28(5):472-8. doi: 10.1177/0269881113507643. Epub 2013 Oct 9.


Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.

Hogenkamp DJ, Ford-Hutchinson TA, Li WY, Whittemore ER, Yoshimura RF, Tran MB, Johnstone TB, Bascom GD, Rollins H, Lu L, Gee KW.

J Med Chem. 2013 Nov 14;56(21):8352-65. doi: 10.1021/jm400704g. Epub 2013 Oct 30.


Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition.

Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, Huang JC, Tran MB, Belluzzi JD, Yakel JL, Gee KW.

J Pharmacol Exp Ther. 2011 Mar;336(3):908-15. doi: 10.1124/jpet.110.176255. Epub 2010 Dec 15.


Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.

Gee KW, Tran MB, Hogenkamp DJ, Johnstone TB, Bagnera RE, Yoshimura RF, Huang JC, Belluzzi JD, Whittemore ER.

J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53. doi: 10.1124/jpet.109.161885. Epub 2009 Nov 25.


Enaminone amides as novel orally active GABAA receptor modulators.

Hogenkamp DJ, Johnstone TB, Huang JC, Li WY, Tran M, Whittemore ER, Bagnera RE, Gee KW.

J Med Chem. 2007 Jul 12;50(14):3369-79. Epub 2007 Jun 16.


Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.

Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee KW.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.


Reversible lipidization for the oral delivery of leu-enkephalin.

Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee KW.

J Drug Target. 2006 Apr;14(3):127-36.


Modifying quinolone antibiotics yields new anxiolytics.

Johnstone TB, Hogenkamp DJ, Coyne L, Su J, Halliwell RF, Tran MB, Yoshimura RF, Li WY, Wang J, Gee KW.

Nat Med. 2004 Jan;10(1):31-2. Epub 2003 Nov 30.


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