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Distinct evolutionary origins of common multi-drug resistance phenotypes in Salmonella typhimurium DT104: a convergent process for adaptation under stress.

Tang L, Zhu SL, Fang X, Li YG, Poppe C, Johnston RN, Liu GR, Liu SL.

Mol Genet Genomics. 2019 Jun;294(3):597-605. doi: 10.1007/s00438-019-01531-5. Epub 2019 Feb 1.


Going (Reo)Viral: Factors Promoting Successful Reoviral Oncolytic Infection.

Bourhill T, Mori Y, Rancourt DE, Shmulevitz M, Johnston RN.

Viruses. 2018 Aug 11;10(8). pii: E421. doi: 10.3390/v10080421. Review.


Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells.

Inagaki Y, Kubota E, Mori Y, Aoyama M, Kataoka H, Johnston RN, Joh T.

Oncotarget. 2017 Dec 18;8(70):115632-115646. doi: 10.18632/oncotarget.23361. eCollection 2017 Dec 29.


Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9.

Liu H, Zeng Z, Wang S, Li T, Mastriani E, Li QH, Bao HX, Zhou YJ, Wang X, Liu Y, Liu W, Hu S, Gao S, Yu M, Qi Y, Shen Z, Wang H, Gao T, Dong L, Johnston RN, Liu SL.

Cancer Biol Ther. 2017 Dec 2;18(12):990-999. doi: 10.1080/15384047.2017.1394542. Epub 2017 Nov 27.


Differential degeneration of the ACTAGT sequence among Salmonella: a reflection of distinct nucleotide amelioration patterns during bacterial divergence.

Tang L, Mastriani E, Zhou YJ, Zhu S, Fang X, Liu YP, Liu WQ, Li YG, Johnston RN, Guo Z, Liu GR, Liu SL.

Sci Rep. 2017 Sep 8;7(1):10985. doi: 10.1038/s41598-017-11226-9.


Increased EGFR expression induced by a novel oncogene, CUG2, confers resistance to doxorubicin through Stat1-HDAC4 signaling.

Kaowinn S, Jun SW, Kim CS, Shin DM, Hwang YH, Kim K, Shin B, Kaewpiboon C, Jeong HH, Koh SS, Krämer OH, Johnston RN, Chung YH.

Cell Oncol (Dordr). 2017 Dec;40(6):549-561. doi: 10.1007/s13402-017-0343-7. Epub 2017 Aug 3.


Enterolactone has stronger effects than enterodiol on ovarian cancer.

Liu H, Liu J, Wang S, Zeng Z, Li T, Liu Y, Mastriani E, Li QH, Bao HX, Zhou YJ, Wang X, Hu S, Gao S, Qi Y, Shen Z, Wang H, Yu M, Gao T, Johnston RN, Liu SL.

J Ovarian Res. 2017 Jul 24;10(1):49. doi: 10.1186/s13048-017-0346-z.


Enzastaurin: A lesson in drug development.

Bourhill T, Narendran A, Johnston RN.

Crit Rev Oncol Hematol. 2017 Apr;112:72-79. doi: 10.1016/j.critrevonc.2017.02.003. Epub 2017 Feb 11. Review.


African Swine Fever Virus NP868R Capping Enzyme Promotes Reovirus Rescue during Reverse Genetics by Promoting Reovirus Protein Expression, Virion Assembly, and RNA Incorporation into Infectious Virions.

Eaton HE, Kobayashi T, Dermody TS, Johnston RN, Jais PH, Shmulevitz M.

J Virol. 2017 May 12;91(11). pii: e02416-16. doi: 10.1128/JVI.02416-16. Print 2017 Jun 1.


Conserved intergenic sequences revealed by CTAG-profiling in Salmonella: thermodynamic modeling for function prediction.

Tang L, Zhu S, Mastriani E, Fang X, Zhou YJ, Li YG, Johnston RN, Guo Z, Liu GR, Liu SL.

Sci Rep. 2017 Mar 6;7:43565. doi: 10.1038/srep43565.


Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants.

Mohamed A, Johnston RN, Shmulevitz M.

Viruses. 2015 Dec 1;7(12):6251-78. doi: 10.3390/v7122936. Review.


Biobanking in the Twenty-First Century: Driving Population Metrics into Biobanking Quality.

Roberts JN, Karvonen C, Graham K, Weinfeld M, Joy AA, Koebel M, Morris D, Robson PJ, Johnston RN, Brockton NT.

Adv Exp Med Biol. 2015;864:95-114. doi: 10.1007/978-3-319-20579-3_8. Review.


Complete genome sequence of Salmonella enterica subspecies arizonae str. RKS2983.

Wang CX, Zhu SL, Wang XY, Feng Y, Li B, Li YG, Johnston RN, Liu GR, Zhou J, Liu SL.

Stand Genomic Sci. 2015 Jun 3;10:30. doi: 10.1186/s40793-015-0015-z. eCollection 2015.


Biobank bootstrapping: is biobank sustainability possible through cost recovery?

Albert M, Bartlett J, Johnston RN, Schacter B, Watson P.

Biopreserv Biobank. 2014 Dec;12(6):374-80. doi: 10.1089/bio.2014.0051.


Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells.

Hamano S, Mori Y, Aoyama M, Kataoka H, Tanaka M, Ebi M, Kubota E, Mizoshita T, Tanida S, Johnston RN, Asai K, Joh T.

Cancer Lett. 2015 Jan 28;356(2 Pt B):846-54. doi: 10.1016/j.canlet.2014.10.046. Epub 2014 Nov 17.


Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells.

Kaewpiboon C, Srisuttee R, Malilas W, Moon J, Oh S, Jeong HG, Johnston RN, Assavalapsakul W, Chung YH.

Mol Med Rep. 2015 Mar;11(3):2315-21. doi: 10.3892/mmr.2014.2949. Epub 2014 Nov 14.


CTAG-containing cleavage site profiling to delineate Salmonella into natural clusters.

Tang L, Liu WQ, Fang X, Sun Q, Zhu SL, Wang CX, Wang XY, Li YG, Zhu DL, Sanderson KE, Johnston RN, Liu GR, Liu SL.

PLoS One. 2014 Aug 19;9(8):e103388. doi: 10.1371/journal.pone.0103388. eCollection 2014.


Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation.

Bao HX, Tang L, Yu L, Wang XY, Li Y, Deng X, Li YG, Li A, Zhu DL, Johnston RN, Liu GR, Feng Y, Liu SL.

BMC Microbiol. 2014 Jun 14;14:157. doi: 10.1186/1471-2180-14-157.


A framework for biobank sustainability.

Watson PH, Nussbeck SY, Carter C, O'Donoghue S, Cheah S, Matzke LA, Barnes RO, Bartlett J, Carpenter J, Grizzle WE, Johnston RN, Mes-Masson AM, Murphy L, Sexton K, Shepherd L, Simeon-Dubach D, Zeps N, Schacter B.

Biopreserv Biobank. 2014 Feb;12(1):60-8. doi: 10.1089/bio.2013.0064.


Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.

Kaewpiboon C, Surapinit S, Malilas W, Moon J, Phuwapraisirisan P, Tip-Pyang S, Johnston RN, Koh SS, Assavalapsakul W, Chung YH.

Int J Oncol. 2014 Apr;44(4):1233-42. doi: 10.3892/ijo.2014.2297. Epub 2014 Feb 11.


Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis.

Malilas W, Koh SS, Lee S, Srisuttee R, Cho IR, Moon J, Kaowinn S, Johnston RN, Chung YH.

Int J Oncol. 2014 Apr;44(4):1177-84. doi: 10.3892/ijo.2014.2264. Epub 2014 Jan 21.


Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-κB.

Kaewpiboon C, Srisuttee R, Malilas W, Moon J, Kaowinn S, Cho IR, Johnston RN, Assavalapsakul W, Chung YH.

Oncol Rep. 2014 Jan;31(1):161-8. doi: 10.3892/or.2013.2844. Epub 2013 Nov 12.


Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains.

Zhao EY, Bao HX, Tang L, Zou QH, Liu WQ, Zhu DL, Chin J, Dong YY, Li YG, Cao FL, Poppe C, Sanderson KE, Johnston RN, Zhou D, Liu GR, Liu SL.

Mol Genet Genomics. 2013 Nov;288(11):549-57. doi: 10.1007/s00438-013-0762-8. Epub 2013 Aug 11.


Genetic boundaries to delineate the typhoid agent and other Salmonella serotypes into distinct natural lineages.

Tang L, Wang CX, Zhu SL, Li Y, Deng X, Johnston RN, Liu GR, Liu SL.

Genomics. 2013 Oct;102(4):331-7. doi: 10.1016/j.ygeno.2013.07.014. Epub 2013 Aug 6.


Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.

Malilas W, Koh SS, Kim S, Srisuttee R, Cho IR, Moon J, Yoo HS, Oh S, Johnston RN, Chung YH.

Int J Oncol. 2013 Oct;43(4):1111-6. doi: 10.3892/ijo.2013.2049. Epub 2013 Aug 5.


Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability.

Pillon MC, Dubinsky M, Johnston RN, Liu SL, Guarné A.

DNA Repair (Amst). 2013 Oct;12(10):864-9. doi: 10.1016/j.dnarep.2013.07.003. Epub 2013 Aug 2.


Defining natural species of bacteria: clear-cut genomic boundaries revealed by a turning point in nucleotide sequence divergence.

Tang L, Li Y, Deng X, Johnston RN, Liu GR, Liu SL.

BMC Genomics. 2013 Jul 18;14:489. doi: 10.1186/1471-2164-14-489.


Double-deleted vaccinia virus in virotherapy for refractory and metastatic pediatric solid tumors.

Lun X, Ruan Y, Jayanthan A, Liu DJ, Singh A, Trippett T, Bell J, Forsyth P, Johnston RN, Narendran A.

Mol Oncol. 2013 Oct;7(5):944-54. doi: 10.1016/j.molonc.2013.05.004. Epub 2013 Jun 14.


Genomic compartmentalization of gene families encoding core components of metazoan signaling systems.

Wong H, Soh J, Gordon PM, Yu T, Sensen CW, Parr E, Johnston RN.

Genome. 2013 Apr;56(4):215-25. doi: 10.1139/gen-2013-0021. Epub 2013 Apr 1.


Genomic comparison between Salmonella Gallinarum and Pullorum: differential pseudogene formation under common host restriction.

Feng Y, Johnston RN, Liu GR, Liu SL.

PLoS One. 2013;8(3):e59427. doi: 10.1371/journal.pone.0059427. Epub 2013 Mar 15.


Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling.

Malilas W, Koh SS, Srisuttee R, Boonying W, Cho IR, Jeong CS, Johnston RN, Chung YH.

Cancer Gene Ther. 2013 Feb;20(2):125-32. doi: 10.1038/cgt.2012.96. Epub 2013 Jan 11.


The type VI secretion system gene cluster of Salmonella typhimurium: required for full virulence in mice.

Liu J, Guo JT, Li YG, Johnston RN, Liu GR, Liu SL.

J Basic Microbiol. 2013 Jul;53(7):600-7. doi: 10.1002/jobm.201200047. Epub 2012 Sep 7.


Inheritance of the Salmonella virulence plasmids: mostly vertical and rarely horizontal.

Feng Y, Liu J, Li YG, Cao FL, Johnston RN, Zhou J, Liu GR, Liu SL.

Infect Genet Evol. 2012 Jul;12(5):1058-63. doi: 10.1016/j.meegid.2012.03.004. Epub 2012 Mar 23.


Complete genome sequence of Salmonella enterica serovar pullorum RKS5078.

Feng Y, Xu HF, Li QH, Zhang SY, Wang CX, Zhu DL, Cao FL, Li YG, Johnston RN, Zhou J, Liu GR, Liu SL.

J Bacteriol. 2012 Feb;194(3):744. doi: 10.1128/JB.06507-11.


Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death.

Srisuttee R, Koh SS, Park EH, Cho IR, Min HJ, Jhun BH, Yu DY, Park S, Park DY, Lee MO, Castrillon DH, Johnston RN, Chung YH.

Int J Mol Med. 2011 Aug;28(2):255-60. doi: 10.3892/ijmm.2011.699. Epub 2011 May 11.


Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of β-catenin, leading to a rapid proliferation of pancreatic cells.

Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston RN, Chung YH.

Exp Mol Med. 2011 Feb 28;43(2):82-90.


SPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C.

Zou QH, Li QH, Zhu HY, Feng Y, Li YG, Johnston RN, Liu GR, Liu SL.

BMC Genomics. 2010 Dec 30;11:729. doi: 10.1186/1471-2164-11-729.


Attenuated reovirus displays oncolysis with reduced host toxicity.

Kim M, Garant KA, zur Nieden NI, Alain T, Loken SD, Urbanski SJ, Forsyth PA, Rancourt DE, Lee PW, Johnston RN.

Br J Cancer. 2011 Jan 18;104(2):290-9. doi: 10.1038/sj.bjc.6606053. Epub 2010 Dec 21.


mutL as a genetic switch of bacterial mutability: turned on or off through repeat copy number changes.

Chen F, Liu WQ, Liu ZH, Zou QH, Wang Y, Li YG, Zhou J, Eisenstark A, Johnston RN, Liu GR, Yang BF, Liu SL.

FEMS Microbiol Lett. 2010 Nov;312(2):126-32. doi: 10.1111/j.1574-6968.2010.02107.x. Epub 2010 Sep 27.


Multiple genetic switches spontaneously modulating bacterial mutability.

Chen F, Liu WQ, Eisenstark A, Johnston RN, Liu GR, Liu SL.

BMC Evol Biol. 2010 Sep 13;10:277. doi: 10.1186/1471-2148-10-277.


Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo.

Kim M, Hansen KK, Davis L, van Marle G, Gill MJ, Fox JD, Hollenberg MD, Rancourt DE, Lee PW, Yun CO, Johnston RN.

Antivir Ther. 2010;15(6):897-905. doi: 10.3851/IMP1646.


The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status.

Kim M, Williamson CT, Prudhomme J, Bebb DG, Riabowol K, Lee PW, Lees-Miller SP, Mori Y, Rahman MM, McFadden G, Johnston RN.

Oncogene. 2010 Jul 8;29(27):3990-6. doi: 10.1038/onc.2010.137. Epub 2010 May 17.


Oncolytic viral therapy for prostate cancer: efficacy of reovirus as a biological therapeutic.

Thirukkumaran CM, Nodwell MJ, Hirasawa K, Shi ZQ, Diaz R, Luider J, Johnston RN, Forsyth PA, Magliocco AM, Lee P, Nishikawa S, Donnelly B, Coffey M, Trpkov K, Fonseca K, Spurrell J, Morris DG.

Cancer Res. 2010 Mar 15;70(6):2435-44. doi: 10.1158/0008-5472.CAN-09-2408. Epub 2010 Mar 9.


Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation.

Cho IR, Koh SS, Min HJ, Park EH, Srisuttee R, Jhun BH, Kang CD, Kim M, Johnston RN, Chung YH.

Int J Oncol. 2010 Apr;36(4):1023-30.


Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53.

Cho IR, Koh SS, Min HJ, Park EH, Ratakorn S, Jhun BH, Jeong SH, Yoo YH, Youn HD, Johnston RN, Chung YH.

Cancer Gene Ther. 2010 May;17(5):365-72. doi: 10.1038/cgt.2009.84. Epub 2010 Jan 15.


CUG2, a novel oncogene confers reoviral replication through Ras and p38 signaling pathway.

Park EH, Park EH, Cho IR, Srisuttee R, Min HJ, Oh MJ, Jeong YJ, Jhun BH, Johnston RN, Lee S, Koh SS, Chung YH.

Cancer Gene Ther. 2010 May;17(5):307-14. doi: 10.1038/cgt.2009.83. Epub 2010 Jan 15.


Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells.

Min HJ, Koh SS, Cho IR, Srisuttee R, Park EH, Jhun BH, Kim YG, Oh S, Kwak JE, Johnston RN, Chung YH.

Int J Oncol. 2009 Sep;35(3):617-24.


A genome map of Salmonella enterica serovar Agona: numerous insertions and deletions reflecting the evolutionary history of a human pathogen.

Chen F, Poppe C, Liu GR, Li YG, Peng YH, Sanderson KE, Johnston RN, Liu SL.

FEMS Microbiol Lett. 2009 Apr;293(2):188-95.


Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi.

Liu WQ, Feng Y, Wang Y, Zou QH, Chen F, Guo JT, Peng YH, Jin Y, Li YG, Hu SN, Johnston RN, Liu GR, Liu SL.

PLoS One. 2009;4(2):e4510. doi: 10.1371/journal.pone.0004510. Epub 2009 Feb 20.


Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma in the South Indian population.

Pai R, Pai S, Lalitha R, Kumaraswamy S, Lalitha N, Johnston R, Bhargava M.

Ecancermedicalscience. 2009;3:128. doi: 10.3332/ecancer.2008.128. Epub 2009 Feb 23.

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