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A quality improvement approach to reducing hospital readmissions in patients with cancer and heart failure.

Fadol A, Estrella J, Shelton V, Zaghian M, Vanbenschop D, Counts V, Mendoza TR, Rubio D, Johnston PA.

Cardiooncology. 2019 Jun 10;5:5. doi: 10.1186/s40959-019-0041-x. eCollection 2019.


Maximizing the Value of Cancer Drug Screening in Multicellular Tumor Spheroid Cultures: A Case Study in Five Head and Neck Squamous Cell Carcinoma Cell Lines.

Kochanek SJ, Close DA, Camarco DP, Johnston PA.

SLAS Discov. 2020 Apr;25(4):329-349. doi: 10.1177/2472555219896999. Epub 2020 Jan 25.


Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck.

Dorman HR, Close D, Wingert BM, Camacho CJ, Johnston PA, Smithgall TE.

Front Chem. 2019 Nov 28;7:822. doi: 10.3389/fchem.2019.00822. eCollection 2019.


Orthologous receptor kinases quantitatively affect the host status of barley to leaf rust fungi.

Wang Y, Subedi S, de Vries H, Doornenbal P, Vels A, Hensel G, Kumlehn J, Johnston PA, Qi X, Blilou I, Niks RE, Krattinger SG.

Nat Plants. 2019 Nov;5(11):1129-1135. doi: 10.1038/s41477-019-0545-2. Epub 2019 Nov 11.


Professional Organization Membership: The Benefits of Increasing Nursing Participation.

Cline D, Curtin K, Johnston PA.

Clin J Oncol Nurs. 2019 Oct 1;23(5):543-546. doi: 10.1188/19.CJON.543-546.


Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor.

Fancher AT, Hua Y, Strock CJ, Johnston PA.

Assay Drug Dev Technol. 2019 Nov/Dec;17(8):364-386. doi: 10.1089/adt.2019.940. Epub 2019 Sep 6.


Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy.

Kochanek SJ, Close DA, Wang AX, Shun T, Empey PE, Eiseman JL, Johnston PA.

SLAS Discov. 2019 Jul;24(6):653-668. doi: 10.1177/2472555219844566. Epub 2019 Apr 30.


Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database.

Close DA, Wang AX, Kochanek SJ, Shun T, Eiseman JL, Johnston PA.

SLAS Discov. 2019 Mar;24(3):242-263. doi: 10.1177/2472555218812429. Epub 2018 Nov 30.


Genetic mapping of a barley leaf rust resistance gene Rph26 introgressed from Hordeum bulbosum.

Yu X, Kong HY, Meiyalaghan V, Casonato S, Chng S, Jones EE, Butler RC, Pickering R, Johnston PA.

Theor Appl Genet. 2018 Dec;131(12):2567-2580. doi: 10.1007/s00122-018-3173-8. Epub 2018 Sep 3.


High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer.

Fancher AT, Hua Y, Camarco DP, Close DA, Strock CJ, Johnston PA.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):297-319. doi: 10.1089/adt.2018.858. Epub 2018 Aug 15.


Erratum to: High Content Screening.

Johnston PA, Trask OJ.

Methods Mol Biol. 2018;1683:E1. doi: 10.1007/978-1-4939-7357-6_23. No abstract available.


High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer.

Shan F, Close DA, Camarco DP, Johnston PA.

Assay Drug Dev Technol. 2018 Jan;16(1):27-50. doi: 10.1089/adt.2017.812. Epub 2017 Dec 7.


The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.

Close DA, Camarco DP, Shan F, Kochanek SJ, Johnston PA.

Methods Mol Biol. 2018;1683:355-369. doi: 10.1007/978-1-4939-7357-6_20. Erratum in: Methods Mol Biol. 2018;1683:E1.


High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines.

Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Grandis JR.

Methods Mol Biol. 2018;1683:229-244. doi: 10.1007/978-1-4939-7357-6_14. Erratum in: Methods Mol Biol. 2018;1683:E1.


Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone.

Masoodi KZ, Eisermann K, Yang Z, Dar JA, Pascal LE, Nguyen M, O'Malley K, Parrinello E, Feturi FG, Kenefake AN, Nelson JB, Johnston PA, Wipf P, Wang Z.

Endocrinology. 2017 Oct 1;158(10):3152-3161. doi: 10.1210/en.2017-00408.


Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR.

J Chem Biol. 2017 May 11;10(3):129-141. doi: 10.1007/s12154-017-0169-9. eCollection 2017 Jul.


Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules.

Masoodi KZ, Xu Y, Dar JA, Eisermann K, Pascal LE, Parrinello E, Ai J, Johnston PA, Nelson JB, Wipf P, Wang Z.

Mol Cancer Ther. 2017 Oct;16(10):2120-2129. doi: 10.1158/1535-7163.MCT-17-0176. Epub 2017 Jun 27.


The production of 3D tumor spheroids for cancer drug discovery.

Sant S, Johnston PA.

Drug Discov Today Technol. 2017 Mar;23:27-36. doi: 10.1016/j.ddtec.2017.03.002. Epub 2017 Apr 14. Review.


Immunotherapy Toxicities: 
A New Electronic Documentation Template to Improve Patient Care.

Reimschissel E, Dela Cruz B, Gonzalez M, Buitrago J, Goodman C, Johnston PA.

Clin J Oncol Nurs. 2017 Apr 1;21(2 Suppl):41-44. doi: 10.1188/17.CJON.S2.41-44.


Symptom word documentation: A novel approach to identifying and managing hospital-acquired infections.

Carry-Littles K, Nguyen K, Rowe T, Johnston PA, Brassil K.

Am J Infect Control. 2016 Nov 1;44(11):1424-1426. doi: 10.1016/j.ajic.2016.03.004. Epub 2016 Apr 22.


Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.

Kiesel BF, Parise RA, Guo J, Huryn DM, Johnston PA, Colombo R, Sen M, Grandis JR, Beumer JH, Eiseman JL.

Cancer Chemother Pharmacol. 2016 Dec;78(6):1225-1235. doi: 10.1007/s00280-016-3181-9. Epub 2016 Oct 24.


Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.

Fancher AT, Hua Y, Camarco DP, Close DA, Strock CJ, Johnston PA.

Assay Drug Dev Technol. 2016 Oct;14(8):453-477. Epub 2016 Sep 8.


Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer.

Johnson JK, Skoda EM, Zhou J, Parrinello E, Wang D, O'Malley K, Eyer BR, Kazancioglu M, Eisermann K, Johnston PA, Nelson JB, Wang Z, Wipf P.

ACS Med Chem Lett. 2016 May 27;7(8):785-90. doi: 10.1021/acsmedchemlett.6b00186. eCollection 2016 Aug 11.


Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.

LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3581-5. doi: 10.1016/j.bmcl.2016.06.017. Epub 2016 Jun 9.


Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.

Johnston PA, Nguyen MM, Dar JA, Ai J, Wang Y, Masoodi KZ, Shun T, Shinde S, Camarco DP, Hua Y, Huryn DM, Wilson GM, Lazo JS, Nelson JB, Wipf P, Wang Z.

Assay Drug Dev Technol. 2016 May;14(4):226-39. doi: 10.1089/adt.2016.716.


HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines.

Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR.

Assay Drug Dev Technol. 2015 Sep;13(7):356-76. doi: 10.1089/adt.2015.663.


Standardization of high content imaging and informatics.

Trask OJ Jr, Johnston PA.

Assay Drug Dev Technol. 2015 Sep;13(7):341-6. doi: 10.1089/adt.2015.29022.ojt. No abstract available.


Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation.

Singh M, Close DA, Mukundan S, Johnston PA, Sant S.

Assay Drug Dev Technol. 2015 Nov;13(9):570-83. doi: 10.1089/adt.2015.662. Epub 2015 Aug 14.


Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

Van Allen EM, Lui VW, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR.

JAMA Oncol. 2015 May;1(2):238-44. doi: 10.1001/jamaoncol.2015.34.


Design and activity of AP endonuclease-1 inhibitors.

Feng Z, Kochanek S, Close D, Wang L, Srinivasan A, Almehizia AA, Iyer P, Xie XQ, Johnston PA, Gold B.

J Chem Biol. 2015 Apr 19;8(3):79-93. doi: 10.1007/s12154-015-0131-7. eCollection 2015 Jul.


High content screening biosensor assay to identify disruptors of p53-hDM2 protein-protein interactions.

Hua Y, Strock CJ, Johnston PA.

Methods Mol Biol. 2015;1278:555-65. doi: 10.1007/978-1-4939-2425-7_37.


Accuracy of harm scores entered into an event reporting system.

Abbasi T, Adornetto-Garcia D, Johnston PA, Segovia JH, Summers B.

J Nurs Adm. 2015 Apr;45(4):218-25. doi: 10.1097/NNA.0000000000000188.


Marker assisted separation of resistance genes Rph22 and Rym16 (Hb) from an associated yield penalty in a barley: Hordeum bulbosum introgression line.

Johnston PA, Meiyalaghan V, Forbes ME, Habekuß A, Butler RC, Pickering R.

Theor Appl Genet. 2015 Jun;128(6):1137-49. doi: 10.1007/s00122-015-2495-z. Epub 2015 Mar 24.


Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS, Wipf P.

Bioorg Med Chem. 2015 Jun 15;23(12):2810-8. doi: 10.1016/j.bmc.2015.01.043. Epub 2015 Jan 31.


Implementing a standardized home chemotherapy spill kit: a nurse-led interprofessional approach to best practice.

Dike SN, Johnston PA, Ogunmakin TD, Pokluda MD, Shank LA, Yates JL, Payne L.

Clin J Oncol Nurs. 2014 Dec;18(6):650-3. doi: 10.1188/14.CJON.650-653. Review.


Comparison of in-situ and ex-situ catalytic pyrolysis in a micro-reactor system.

Wang K, Johnston PA, Brown RC.

Bioresour Technol. 2014 Dec;173:124-131. doi: 10.1016/j.biortech.2014.09.097. Epub 2014 Sep 28.


2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.

LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5081-5. doi: 10.1016/j.bmcl.2014.09.001. Epub 2014 Sep 15.


Introduction and welcome to the Society of Biomolecular Imaging and Informatics (SBI²).

Trask OJ, Johnston PA.

Assay Drug Dev Technol. 2014 Sep;12(7):369-74. doi: 10.1089/adt.2014.1506. No abstract available.


Quantitation of sugar content in pyrolysis liquids after acid hydrolysis using high-performance liquid chromatography without neutralization.

Johnston PA, Brown RC.

J Agric Food Chem. 2014 Aug 13;62(32):8129-33. doi: 10.1021/jf502250n. Epub 2014 Aug 5.


Production of clean pyrolytic sugars for fermentation.

Rover MR, Johnston PA, Jin T, Smith RG, Brown RC, Jarboe L.

ChemSusChem. 2014 Jun;7(6):1662-8. doi: 10.1002/cssc.201301259. Epub 2014 Apr 6.


Use of an electronic alert to identify patients with acute kidney injury.

Wallace K, Mallard AS, Stratton JD, Johnston PA, Dickinson S, Parry RG.

Clin Med (Lond). 2014 Feb;14(1):22-6. doi: 10.7861/clinmedicine.14-1-22.


High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.

Johnston PA, Sen M, Hua Y, Camarco D, Shun TY, Lazo JS, Grandis JR.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):55-79. doi: 10.1089/adt.2013.524. Epub 2013 Oct 15.


Rph22: mapping of a novel leaf rust resistance gene introgressed from the non-host Hordeum bulbosum L. into cultivated barley (Hordeum vulgare L.).

Johnston PA, Niks RE, Meiyalaghan V, Blanchet E, Pickering R.

Theor Appl Genet. 2013 Jun;126(6):1613-25. doi: 10.1007/s00122-013-2078-9. Epub 2013 Mar 7.


Analysis of trace contaminants in hot gas streams using time-weighted average solid-phase microextraction: proof of concept.

Woolcock PJ, Koziel JA, Cai L, Johnston PA, Brown RC.

J Chromatogr A. 2013 Mar 15;1281:1-8. doi: 10.1016/j.chroma.2013.01.036. Epub 2013 Jan 16.


Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.

Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE.

Chem Biol. 2013 Jan 24;20(1):82-91. doi: 10.1016/j.chembiol.2012.11.005.


FLIPR™ Assays for GPCR and Ion Channel Targets.

Arkin MR, Connor PR, Emkey R, Garbison KE, Heinz BA, Wiernicki TR, Johnston PA, Kandasamy RA, Rankl NB, Sittampalam S.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin CP, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Saradjian P, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2012 Oct 1].


Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic dynein-mediated transport of glucocorticoid receptor to the nucleus.

Johnston PA, Shinde SN, Hua Y, Shun TY, Lazo JS, Day BW.

Assay Drug Dev Technol. 2012 Oct;10(5):432-56. doi: 10.1089/adt.2012.456. Epub 2012 Jul 25.

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