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Items: 1 to 50 of 61


Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data.

Johnston IG, Hoffmann T, Greenbury SF, Cominetti O, Jallow M, Kwiatkowski D, Barahona M, Jones NS, Casals-Pascual C.

NPJ Digit Med. 2019 Jul 10;2:63. doi: 10.1038/s41746-019-0140-y. eCollection 2019.


Model selection and parameter estimation for root architecture models using likelihood-free inference.

Ziegler C, Dyson RJ, Johnston IG.

J R Soc Interface. 2019 Jul 26;16(156):20190293. doi: 10.1098/rsif.2019.0293. Epub 2019 Jul 10.


Mitochondrial Network State Scales mDNA Genetic Dynamics.

Aryaman J, Bowles C, Jones NS, Johnston IG.

Genetics. 2019 Aug;212(4):1429-1443. doi: 10.1534/genetics.119.302423. Epub 2019 Jun 28.


Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations.

Hoitzing H, Gammage PA, Haute LV, Minczuk M, Johnston IG, Jones NS.

PLoS Comput Biol. 2019 Jun 26;15(6):e1007023. doi: 10.1371/journal.pcbi.1007023. eCollection 2019 Jun.


Mitochondrial Heterogeneity.

Aryaman J, Johnston IG, Jones NS.

Front Genet. 2019 Jan 25;9:718. doi: 10.3389/fgene.2018.00718. eCollection 2018. Review.


Global Topological Order Emerges through Local Mechanical Control of Cell Divisions in the Arabidopsis Shoot Apical Meristem.

Jackson MDB, Duran-Nebreda S, Kierzkowski D, Strauss S, Xu H, Landrein B, Hamant O, Smith RS, Johnston IG, Bassel GW.

Cell Syst. 2019 Jan 23;8(1):53-65.e3. doi: 10.1016/j.cels.2018.12.009. Epub 2019 Jan 16.


Tension and Resolution: Dynamic, Evolving Populations of Organelle Genomes within Plant Cells.

Johnston IG.

Mol Plant. 2019 Jun 3;12(6):764-783. doi: 10.1016/j.molp.2018.11.002. Epub 2018 Nov 13. Review.


Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.

Burgstaller JP, Kolbe T, Havlicek V, Hembach S, Poulton J, Piálek J, Steinborn R, Rülicke T, Brem G, Jones NS, Johnston IG.

Nat Commun. 2018 Jun 27;9(1):2488. doi: 10.1038/s41467-018-04797-2.


Identification of a bet-hedging network motif generating noise in hormone concentrations and germination propensity in Arabidopsis.

Johnston IG, Bassel GW.

J R Soc Interface. 2018 Apr;15(141). pii: 20180042. doi: 10.1098/rsif.2018.0042.


The Essential Genome of Escherichia coli K-12.

Goodall ECA, Robinson A, Johnston IG, Jabbari S, Turner KA, Cunningham AF, Lund PA, Cole JA, Henderson IR.

MBio. 2018 Feb 20;9(1). pii: e02096-17. doi: 10.1128/mBio.02096-17.


Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease.

Aryaman J, Johnston IG, Jones NS.

Biochem J. 2017 Nov 24;474(23):4019-4034. doi: 10.1042/BCJ20170651.


Mitochondrial heterogeneity, metabolic scaling and cell death.

Aryaman J, Hoitzing H, Burgstaller JP, Johnston IG, Jones NS.

Bioessays. 2017 Jul;39(7). doi: 10.1002/bies.201700001. Epub 2017 Jun 8. Review.


Temperature variability is integrated by a spatially embedded decision-making center to break dormancy in Arabidopsis seeds.

Topham AT, Taylor RE, Yan D, Nambara E, Johnston IG, Bassel GW.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6629-6634. doi: 10.1073/pnas.1704745114. Epub 2017 Jun 5.


Toward Precision Healthcare: Context and Mathematical Challenges.

Colijn C, Jones N, Johnston IG, Yaliraki S, Barahona M.

Front Physiol. 2017 Mar 21;8:136. doi: 10.3389/fphys.2017.00136. eCollection 2017.


Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations.

Johnston IG, Jones NS.

Am J Hum Genet. 2016 Nov 3;99(5):1150-1162. doi: 10.1016/j.ajhg.2016.09.016. Epub 2016 Oct 27.


mtDNA diversity in human populations highlights the merit of haplotype matching in gene therapies.

Røyrvik EC, Burgstaller JP, Johnston IG.

Mol Hum Reprod. 2016 Nov;22(11):809-817. Epub 2016 Sep 8.


Variability in seeds: biological, ecological, and agricultural implications.

Mitchell J, Johnston IG, Bassel GW.

J Exp Bot. 2017 Feb 1;68(4):809-817. doi: 10.1093/jxb/erw397. Review.


The State of Vaccine Confidence 2016: Global Insights Through a 67-Country Survey.

Larson HJ, de Figueiredo A, Xiahong Z, Schulz WS, Verger P, Johnston IG, Cook AR, Jones NS.

EBioMedicine. 2016 Oct;12:295-301. doi: 10.1016/j.ebiom.2016.08.042. Epub 2016 Sep 13.


Continuous electroencephalograph monitoring in the intensive care unit.

Johnston IG.

Anaesth Intensive Care. 2016 Sep;44(5):639-40. No abstract available.


Forecasted trends in vaccination coverage and correlations with socioeconomic factors: a global time-series analysis over 30 years.

de Figueiredo A, Johnston IG, Smith DM, Agarwal S, Larson HJ, Jones NS.

Lancet Glob Health. 2016 Oct;4(10):e726-35. doi: 10.1016/S2214-109X(16)30167-X. Epub 2016 Aug 25.


Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children.

Diot A, Dombi E, Lodge T, Liao C, Morten K, Carver J, Wells D, Child T, Johnston IG, Williams S, Poulton J.

Biochem Soc Trans. 2016 Aug 15;44(4):1091-100. doi: 10.1042/BST20160095.


Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention.

Johnston IG, Williams BP.

Cell Syst. 2016 Feb 24;2(2):101-11. doi: 10.1016/j.cels.2016.01.013. Epub 2016 Feb 18.


Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring.

Potter M, Badder L, Hoade Y, Johnston IG, Morten KJ.

Adv Exp Med Biol. 2016;876:257-263. doi: 10.1007/978-1-4939-3023-4_32.


Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.

Johnston IG, Burgstaller JP, Havlicek V, Kolbe T, Rülicke T, Brem G, Poulton J, Jones NS.

Elife. 2015 Jun 2;4:e07464. doi: 10.7554/eLife.07464.


Multiple hypothesis correction is vital and undermines reported mtDNA links to diseases including AIDS, cancer, and Huntingdon's.

Johnston IG.

Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Sep;27(5):3423-7. doi: 10.3109/19401736.2015.1022732. Epub 2015 Apr 17.


What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research.

Hoitzing H, Johnston IG, Jones NS.

Bioessays. 2015 Jun;37(6):687-700. doi: 10.1002/bies.201400188. Epub 2015 Apr 3. Review.


Explicit tracking of uncertainty increases the power of quantitative rule-of-thumb reasoning in cell biology.

Johnston IG, Rickett BC, Jones NS.

Biophys J. 2014 Dec 2;107(11):2612-7. doi: 10.1016/j.bpj.2014.08.040. Epub 2014 Dec 2.


Mitochondrial DNA disease and developmental implications for reproductive strategies.

Burgstaller JP, Johnston IG, Poulton J.

Mol Hum Reprod. 2015 Jan;21(1):11-22. doi: 10.1093/molehr/gau090. Epub 2014 Nov 24. Review.


The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.


FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis.

El Zawily AM, Schwarzländer M, Finkemeier I, Johnston IG, Benamar A, Cao Y, Gissot C, Meyer AJ, Wilson K, Datla R, Macherel D, Jones NS, Logan DC.

Plant Physiol. 2014 Oct;166(2):808-28. doi: 10.1104/pp.114.243824. Epub 2014 Aug 27.


MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage.

Burgstaller JP, Johnston IG, Jones NS, Albrechtová J, Kolbe T, Vogl C, Futschik A, Mayrhofer C, Klein D, Sabitzer S, Blattner M, Gülly C, Poulton J, Rülicke T, Piálek J, Steinborn R, Brem G.

Cell Rep. 2014 Jun 26;7(6):2031-2041. doi: 10.1016/j.celrep.2014.05.020. Epub 2014 Jun 6.


Efficient parametric inference for stochastic biological systems with measured variability.

Johnston IG.

Stat Appl Genet Mol Biol. 2014 Jun;13(3):379-90. doi: 10.1515/sagmb-2013-0061.


A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.

Greenbury SF, Johnston IG, Louis AA, Ahnert SE.

J R Soc Interface. 2014 Apr 9;11(95):20140249. doi: 10.1098/rsif.2014.0249. Print 2014 Jun 6.


Phenotypic landscape inference reveals multiple evolutionary paths to C4 photosynthesis.

Williams BP, Johnston IG, Covshoff S, Hibberd JM.

Elife. 2013 Sep 28;2:e00961. doi: 10.7554/eLife.00961.


The use of enhanced recovery after surgery (ERAS) principles in Scottish orthopaedic units--an implementation and follow-up at 1 year, 2010-2011: a report from the Musculoskeletal Audit, Scotland.

Scott NB, McDonald D, Campbell J, Smith RD, Carey AK, Johnston IG, James KR, Breusch SJ.

Arch Orthop Trauma Surg. 2013 Jan;133(1):117-24. doi: 10.1007/s00402-012-1619-z. Epub 2012 Oct 16.


Mitochondrial variability as a source of extrinsic cellular noise.

Johnston IG, Gaal B, Neves RP, Enver T, Iborra FJ, Jones NS.

PLoS Comput Biol. 2012;8(3):e1002416. doi: 10.1371/journal.pcbi.1002416. Epub 2012 Mar 8.


Pulsing of membrane potential in individual mitochondria: a stress-induced mechanism to regulate respiratory bioenergetics in Arabidopsis.

Schwarzländer M, Logan DC, Johnston IG, Jones NS, Meyer AJ, Fricker MD, Sweetlove LJ.

Plant Cell. 2012 Mar;24(3):1188-201. doi: 10.1105/tpc.112.096438. Epub 2012 Mar 6.


Epistasis can lead to fragmented neutral spaces and contingency in evolution.

Schaper S, Johnston IG, Louis AA.

Proc Biol Sci. 2012 May 7;279(1734):1777-83. doi: 10.1098/rspb.2011.2183. Epub 2011 Dec 7.


Evolutionary dynamics in a simple model of self-assembly.

Johnston IG, Ahnert SE, Doye JP, Louis AA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Jun;83(6 Pt 2):066105. Epub 2011 Jun 13.


Modelling the self-assembly of virus capsids.

Johnston IG, Louis AA, Doye JP.

J Phys Condens Matter. 2010 Mar 17;22(10):104101. doi: 10.1088/0953-8984/22/10/104101. Epub 2010 Feb 23.


Self-assembly, modularity, and physical complexity.

Ahnert SE, Johnston IG, Fink TM, Doye JP, Louis AA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Aug;82(2 Pt 2):026117. Epub 2010 Aug 27.


The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks.

Greenbury SF, Johnston IG, Smith MA, Doye JP, Louis AA.

J Theor Biol. 2010 Nov 7;267(1):48-61. doi: 10.1016/j.jtbi.2010.08.006. Epub 2010 Aug 7.


The self-assembly of DNA Holliday junctions studied with a minimal model.

Ouldridge TE, Johnston IG, Louis AA, Doye JP.

J Chem Phys. 2009 Feb 14;130(6):065101. doi: 10.1063/1.3055595.


Survey of intensive care nurses' knowledge relating to the pulmonary artery catheter.

Johnston IG, Jane R, Fraser JF, Kruger P, Hickling K.

Anaesth Intensive Care. 2004 Aug;32(4):564-8.


Pre-emptive epidural information: anaesthetic shortfall.

Johnston IG.

Int J Obstet Anesth. 1998 Apr;7(2):141. No abstract available.


Which women want food during labour?: results of an audit in a Scottish DGH.

Armstrong TS, Johnston IG.

Health Bull (Edinb). 2000 Mar;58(2):141-4.


Undergraduate teaching; a missed opportunity?

Johnston IG.

Anaesthesia. 2001 Jun;56(6):587. No abstract available.

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