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Items: 1 to 50 of 199

1.

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM.

Nature. 2019 Aug;572(7769):E18. doi: 10.1038/s41586-019-1459-x.

PMID:
31363232
2.

Pancreatitis Incidence in the Exenatide BID, Exenatide QW, and Exenatide QW Suspension Development Programs: Pooled Analysis of 35 Clinical Trials.

Vetter ML, Johnsson K, Hardy E, Wang H, Iqbal N.

Diabetes Ther. 2019 Aug;10(4):1249-1270. doi: 10.1007/s13300-019-0627-1. Epub 2019 May 10.

3.

A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons.

Sundukova M, Prifti E, Bucci A, Kirillova K, Serrao J, Reymond L, Umebayashi M, Hovius R, Riezman H, Johnsson K, Heppenstall PA.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2341-2344. doi: 10.1002/anie.201812967. Epub 2019 Jan 25.

4.

Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold.

Day AL, Greisen P, Doyle L, Schena A, Stella N, Johnsson K, Baker D, Stoddard B.

Protein Eng Des Sel. 2018 Oct 1;31(10):375-387. doi: 10.1093/protein/gzy031.

PMID:
30566669
5.

Small-Molecule Fluorescent Probes for Live-Cell Super-Resolution Microscopy.

Wang L, Frei MS, Salim A, Johnsson K.

J Am Chem Soc. 2019 Feb 20;141(7):2770-2781. doi: 10.1021/jacs.8b11134. Epub 2019 Jan 29.

PMID:
30550714
6.

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM.

Nature. 2018 Nov;563(7732):564-568. doi: 10.1038/s41586-018-0701-2. Epub 2018 Nov 7. Erratum in: Nature. 2019 Aug;572(7769):E18.

7.

Semisynthetic sensor proteins enable metabolic assays at the point of care.

Yu Q, Xue L, Hiblot J, Griss R, Fabritz S, Roux C, Binz PA, Haas D, Okun JG, Johnsson K.

Science. 2018 Sep 14;361(6407):1122-1126. doi: 10.1126/science.aat7992.

PMID:
30213915
8.

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand.

Farrants H, Gutzeit VA, Acosta-Ruiz A, Trauner D, Johnsson K, Levitz J, Broichhagen J.

ACS Chem Biol. 2018 Sep 21;13(9):2682-2688. doi: 10.1021/acschembio.8b00628. Epub 2018 Sep 7.

9.

A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1.

Karch S, Broichhagen J, Schneider J, Böning D, Hartmann S, Schmid B, Tripal P, Palmisano R, Alzheimer C, Johnsson K, Huth T.

J Med Chem. 2018 Jul 26;61(14):6121-6139. doi: 10.1021/acs.jmedchem.8b00387. Epub 2018 Jul 10.

PMID:
29939737
10.

Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides.

Sallin O, Reymond L, Gondrand C, Raith F, Koch B, Johnsson K.

Elife. 2018 May 29;7. pii: e32638. doi: 10.7554/eLife.32638.

11.

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons.

Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA.

Nat Commun. 2018 Apr 24;9(1):1640. doi: 10.1038/s41467-018-04049-3.

12.

Glucose Control and Weight Change Associated with Treatment with Exenatide Compared with Basal Insulin: A Retrospective Study.

Morgan CL, Qiao Q, Grandy S, Johnsson K, Jenkins-Jones S, Holden S, Currie CJ.

Diabetes Ther. 2018 Feb;9(1):269-283. doi: 10.1007/s13300-017-0359-z. Epub 2018 Jan 9.

13.

Sampling and energy evaluation challenges in ligand binding protein design.

Dou J, Doyle L, Jr Greisen P, Schena A, Park H, Johnsson K, Stoddard BL, Baker D.

Protein Sci. 2017 Dec;26(12):2426-2437. doi: 10.1002/pro.3317. Epub 2017 Oct 30.

14.

Luciferases with Tunable Emission Wavelengths.

Hiblot J, Yu Q, Sabbadini MDB, Reymond L, Xue L, Schena A, Sallin O, Hill N, Griss R, Johnsson K.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14556-14560. doi: 10.1002/anie.201708277. Epub 2017 Oct 9.

PMID:
28941028
15.

Computational design of environmental sensors for the potent opioid fentanyl.

Bick MJ, Greisen PJ, Morey KJ, Antunes MS, La D, Sankaran B, Reymond L, Johnsson K, Medford JI, Baker D.

Elife. 2017 Sep 19;6. pii: e28909. doi: 10.7554/eLife.28909.

16.

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.

Lee RFS, Riedel T, Escrig S, Maclachlan C, Knott GW, Davey CA, Johnsson K, Meibom A, Dyson PJ.

Metallomics. 2017 Oct 18;9(10):1413-1420. doi: 10.1039/c7mt00153c.

PMID:
28913538
17.

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins.

Scarabelli S, Tan KT, Griss R, Hovius R, D'Alessandro PL, Vorherr T, Johnsson K.

ACS Sens. 2017 Aug 25;2(8):1191-1197. doi: 10.1021/acssensors.7b00331. Epub 2017 Aug 2.

PMID:
28766337
18.

What is a "unimodal" cell population? Using statistical tests as criteria for unimodality in automated gating and quality control.

Johnsson K, Linderoth M, Fontes M.

Cytometry A. 2017 Sep;91(9):908-916. doi: 10.1002/cyto.a.23173. Epub 2017 Jul 31.

19.

Bioluminescent Antibodies for Point-of-Care Diagnostics.

Xue L, Yu Q, Griss R, Schena A, Johnsson K.

Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7112-7116. doi: 10.1002/anie.201702403. Epub 2017 May 16.

20.

Expression proteomics study to determine metallodrug targets and optimal drug combinations.

Lee RFS, Chernobrovkin A, Rutishauser D, Allardyce CS, Hacker D, Johnsson K, Zubarev RA, Dyson PJ.

Sci Rep. 2017 May 8;7(1):1590. doi: 10.1038/s41598-017-01643-1.

21.

Assessment of Saxagliptin Efficacy: Meta-Analysis of 14 Phase 2 and 3 Clinical Trials.

Sjöstrand M, Wei C, Cook W, Johnsson K, Pollack PS, Stahre C, Hirshberg B.

Diabetes Ther. 2017 Jun;8(3):587-599. doi: 10.1007/s13300-017-0261-8. Epub 2017 Apr 21.

22.

Highly Modular Bioluminescent Sensors for Small Molecules and Proteins.

Yu Q, Griss R, Schena A, Johnsson K.

Methods Enzymol. 2017;589:365-382. doi: 10.1016/bs.mie.2017.01.005. Epub 2017 Feb 28. Review.

PMID:
28336070
23.

Rational Design and Applications of Semisynthetic Modular Biosensors: SNIFITs and LUCIDs.

Farrants H, Hiblot J, Griss R, Johnsson K.

Methods Mol Biol. 2017;1596:101-117. doi: 10.1007/978-1-4939-6940-1_7.

PMID:
28293883
24.

Multivariate Prediction Equations for HbA1c Lowering, Weight Change, and Hypoglycemic Events Associated with Insulin Rescue Medication in Type 2 Diabetes Mellitus: Informing Economic Modeling.

Willis M, Asseburg C, Nilsson A, Johnsson K, Kartman B.

Value Health. 2017 Mar;20(3):357-371. doi: 10.1016/j.jval.2016.10.004. Epub 2016 Dec 1.

25.

Acetylated tubulin is essential for touch sensation in mice.

Morley SJ, Qi Y, Iovino L, Andolfi L, Guo D, Kalebic N, Castaldi L, Tischer C, Portulano C, Bolasco G, Shirlekar K, Fusco CM, Asaro A, Fermani F, Sundukova M, Matti U, Reymond L, De Ninno A, Businaro L, Johnsson K, Lazzarino M, Ries J, Schwab Y, Hu J, Heppenstall PA.

Elife. 2016 Dec 13;5. pii: e20813. doi: 10.7554/eLife.20813.

26.

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number.

Graciotti M, Fang Z, Johnsson K, Gönczy P.

Chembiochem. 2016 Nov 3;17(21):2063-2074. doi: 10.1002/cbic.201600327. Epub 2016 Sep 23.

PMID:
27558802
27.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

28.

Hypersensitivity Events, Including Potentially Hypersensitivity-Related Skin Events, with Dapagliflozin in Patients with Type 2 Diabetes Mellitus: A Pooled Analysis.

Mellander A, Billger M, Johnsson E, Träff AK, Yoshida S, Johnsson K.

Clin Drug Investig. 2016 Nov;36(11):925-933.

PMID:
27461213
29.

Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis.

Yang W, Ji L, Zhou Z, Cain VA, Johnsson KM, Sjöström CD.

J Diabetes. 2017 Aug;9(8):787-799. doi: 10.1111/1753-0407.12484. Epub 2016 Nov 14.

PMID:
27625142
30.

Treatment Outcomes and Tolerability Following Initiation of GLP-1 Receptor Agonists Among Type 2 Diabetes Patients in Primary Care Practices in Germany.

Qiao Q, Johnsson K, Grandy S, Kostev K.

J Diabetes Sci Technol. 2017 Mar;11(2):272-277. doi: 10.1177/1932296816661349. Epub 2016 Jul 28.

31.

Fluorogenic Probes for Multicolor Imaging in Living Cells.

Lukinavičius G, Reymond L, Umezawa K, Sallin O, D'Este E, Göttfert F, Ta H, Hell SW, Urano Y, Johnsson K.

J Am Chem Soc. 2016 Aug 3;138(30):9365-8. doi: 10.1021/jacs.6b04782. Epub 2016 Jul 21.

PMID:
27420907
32.

Adherence to GLP-1 receptor agonist therapy administered by once-daily or once-weekly injection in patients with type 2 diabetes in Germany.

Qiao Q, Ouwens MJ, Grandy S, Johnsson K, Kostev K.

Diabetes Metab Syndr Obes. 2016 Jun 28;9:201-5. doi: 10.2147/DMSO.S99732. eCollection 2016.

33.

A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range.

Xue L, Prifti E, Johnsson K.

J Am Chem Soc. 2016 Apr 27;138(16):5258-61. doi: 10.1021/jacs.6b03034. Epub 2016 Apr 15.

PMID:
27071001
34.

Erratum to: BayesFlow: latent modeling of flow cytometry cell populations.

Johnsson K, Wallin J, Fontes M.

BMC Bioinformatics. 2016 Mar 31;17:149. doi: 10.1186/s12859-016-0973-1. No abstract available.

35.

The effect of dapagliflozin on renal function in patients with type 2 diabetes.

Kohan DE, Fioretto P, Johnsson K, Parikh S, Ptaszynska A, Ying L.

J Nephrol. 2016 Jun;29(3):391-400. doi: 10.1007/s40620-016-0261-1. Epub 2016 Feb 19.

PMID:
26894924
36.

A Network Meta-analysis Comparing Exenatide Once Weekly with Other GLP-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus.

Kayaniyil S, Lozano-Ortega G, Bennett HA, Johnsson K, Shaunik A, Grandy S, Kartman B.

Diabetes Ther. 2016 Mar;7(1):27-43. doi: 10.1007/s13300-016-0155-1. Epub 2016 Feb 17. Review.

37.

Osmotic diuresis with SGLT2 inhibition: analysis of events related to volume reduction in dapagliflozin clinical trials.

Johnsson K, Johnsson E, Mansfield TA, Yavin Y, Ptaszynska A, Parikh SJ.

Postgrad Med. 2016 May;128(4):346-55. doi: 10.1080/00325481.2016.1153941. Epub 2016 Mar 2.

PMID:
26878357
38.

Corrigendum: Modulating protein activity using tethered ligands with mutually exclusive binding sites.

Schena A, Griss R, Johnsson K.

Nat Commun. 2016 Feb 15;7:10758. doi: 10.1038/ncomms10758. No abstract available.

39.

Effect of the SGLT2 Inhibitor Dapagliflozin on Potassium Levels in Patients with Type 2 Diabetes Mellitus: A Pooled Analysis.

Yavin Y, Mansfield TA, Ptaszynska A, Johnsson K, Parikh S, Johnsson E.

Diabetes Ther. 2016 Mar;7(1):125-37. doi: 10.1007/s13300-015-0150-y. Epub 2016 Jan 12.

40.

BayesFlow: latent modeling of flow cytometry cell populations.

Johnsson K, Wallin J, Fontes M.

BMC Bioinformatics. 2016 Jan 12;17:25. doi: 10.1186/s12859-015-0862-z. Erratum in: BMC Bioinformatics. 2016;17:149.

41.

Imaging and manipulating proteins in live cells through covalent labeling.

Xue L, Karpenko IA, Hiblot J, Johnsson K.

Nat Chem Biol. 2015 Dec;11(12):917-23. doi: 10.1038/nchembio.1959. Epub 2015 Nov 17.

PMID:
26575238
42.

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

Alanio C, Nicoli F, Sultanik P, Flecken T, Perot B, Duffy D, Bianchi E, Lim A, Clave E, van Buuren MM, Schnuriger A, Johnsson K, Boussier J, Garbarg-Chenon A, Bousquet L, Mottez E, Schumacher TN, Toubert A, Appay V, Heshmati F, Thimme R, Pol S, Mallet V, Albert ML.

Elife. 2015 Nov 14;4. pii: e07916. doi: 10.7554/eLife.07916.

43.

Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid.

Haruki H, Hovius R, Pedersen MG, Johnsson K.

J Biol Chem. 2016 Jan 8;291(2):652-7. doi: 10.1074/jbc.C115.680488. Epub 2015 Nov 12.

44.

Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ.

Chem Commun (Camb). 2015 Nov 28;51(92):16577. doi: 10.1039/c5cc90487k.

PMID:
26507472
45.

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ.

Chem Commun (Camb). 2015 Nov 28;51(92):16486-9. doi: 10.1039/c5cc06983a. Erratum in: Chem Commun (Camb). 2015 Nov 28;51(92):16577.

PMID:
26426486
46.

SiR-Hoechst is a far-red DNA stain for live-cell nanoscopy.

Lukinavičius G, Blaukopf C, Pershagen E, Schena A, Reymond L, Derivery E, Gonzalez-Gaitan M, D'Este E, Hell SW, Wolfram Gerlich D, Johnsson K.

Nat Commun. 2015 Oct 1;6:8497. doi: 10.1038/ncomms9497.

47.

Low Bias Local Intrinsic Dimension Estimation from Expected Simplex Skewness.

Johnsson K, Soneson C, Fontes M.

IEEE Trans Pattern Anal Mach Intell. 2015 Jan;37(1):196-202. doi: 10.1109/TPAMI.2014.2343220.

PMID:
26353219
48.

Assessing Bladder Cancer Risk in Type 2 Diabetes Clinical Trials: the Dapagliflozin Drug Development Program as a 'Case Study'.

Ptaszynska A, Cohen SM, Messing EM, Reilly TP, Johnsson E, Johnsson K.

Diabetes Ther. 2015 Sep;6(3):357-75. doi: 10.1007/s13300-015-0128-9. Epub 2015 Sep 1.

49.

Modulating protein activity using tethered ligands with mutually exclusive binding sites.

Schena A, Griss R, Johnsson K.

Nat Commun. 2015 Jul 22;6:7830. doi: 10.1038/ncomms8830. Erratum in: Nat Commun. 2016;7:10758.

50.

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.

Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ.

Neuron. 2015 Jun 17;86(6):1393-406. doi: 10.1016/j.neuron.2015.05.033.

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