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A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.

Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton DR, Humayun MS.

Sci Transl Med. 2018 Apr 4;10(435). pii: eaao4097. doi: 10.1126/scitranslmed.aao4097.


Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.

Ziauddeen H, Nestor LJ, Subramaniam N, Dodds C, Nathan PJ, Miller SR, Sarai BK, Maltby K, Fernando D, Warren L, Hosking LK, Waterworth D, Korzeniowska A, Win B, Richards DB, Johnson LV, Fletcher PC, Bullmore ET.

Neuropsychopharmacology. 2018 Mar;43(4):927. doi: 10.1038/npp.2017.287.


Complement factor H in AMD: Bridging genetic associations and pathobiology.

Toomey CB, Johnson LV, Bowes Rickman C.

Prog Retin Eye Res. 2018 Jan;62:38-57. doi: 10.1016/j.preteyeres.2017.09.001. Epub 2017 Sep 18. Review.


Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.

Mohan RR, Cabrera AP, Harrison RE, Gorham RD Jr, Johnson LV, Ghosh K, Morikis D.

Mol Vis. 2016 Oct 26;22:1280-1290. eCollection 2016.


The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying.

Hellström PM, Tack J, Johnson LV, Hacquoil K, Barton ME, Richards DB, Alpers DH, Sanger GJ, Dukes GE.

Br J Pharmacol. 2016 Jun;173(11):1768-77. doi: 10.1111/bph.13475. Epub 2016 Apr 13.


Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration.

Radeke MJ, Radeke CM, Shih YH, Hu J, Bok D, Johnson LV, Coffey PJ.

Genome Med. 2015 Jun 19;7(1):58. doi: 10.1186/s13073-015-0183-x. eCollection 2015.


Cellular models and therapies for age-related macular degeneration.

Forest DL, Johnson LV, Clegg DO.

Dis Model Mech. 2015 May;8(5):421-7. doi: 10.1242/dmm.017236. Review.


New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.

Gorham RD Jr, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D.

J Med Chem. 2015 Jan 22;58(2):814-26. doi: 10.1021/jm501345y. Epub 2014 Dec 29.


The Relationship between Personality Type and Acceptable Noise Levels: A Pilot Study.

Franklin C, Johnson LV, White L, Franklin C, Smith-Olinde L.

ISRN Otolaryngol. 2013 Nov 14;2013:902532. doi: 10.1155/2013/902532. eCollection 2013.


Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures.

Gorham RD Jr, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D.

Exp Eye Res. 2013 Nov;116:96-108. doi: 10.1016/j.exer.2013.07.023. Epub 2013 Aug 15.


The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.

Ziauddeen H, Nathan PJ, Dodds C, Maltby K, Miller SR, Waterworth D, Song K, Warren L, Hosking L, Zucchetto M, Bush M, Johnson LV, Sarai B, Mogg K, Bradley BP, Richards DB, Fletcher PC, Bullmore ET.

J Clin Pharmacol. 2013 Oct;53(10):1078-90. doi: 10.1002/jcph.110. Epub 2013 Aug 11.


A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer.

Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton DR, Tai YC, Hikita ST, Johnson LV, Clegg DO, Thomas BB, Humayun MS.

Ophthalmic Res. 2012;48(4):186-91. doi: 10.1159/000338749. Epub 2012 Aug 3.


Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.

Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV, Clegg DO.

J Tissue Eng Regen Med. 2013 Aug;7(8):642-53. doi: 10.1002/term.1458. Epub 2012 Apr 18.


Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks.

Newman AM, Gallo NB, Hancox LS, Miller NJ, Radeke CM, Maloney MA, Cooper JB, Hageman GS, Anderson DH, Johnson LV, Radeke MJ.

Genome Med. 2012 Feb 24;4(2):16. doi: 10.1186/gm315.


Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.

Johnson LV, Forest DL, Banna CD, Radeke CM, Maloney MA, Hu J, Spencer CN, Walker AM, Tsie MS, Bok D, Radeke MJ, Anderson DH.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18277-82. doi: 10.1073/pnas.1109703108. Epub 2011 Oct 3.


Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.

Ding JD, Johnson LV, Herrmann R, Farsiu S, Smith SG, Groelle M, Mace BE, Sullivan P, Jamison JA, Kelly U, Harrabi O, Bollini SS, Dilley J, Kobayashi D, Kuang B, Li W, Pons J, Lin JC, Bowes Rickman C.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):E279-87. doi: 10.1073/pnas.1100901108. Epub 2011 Jun 20.


Age-Related Macular Degeneration (AMD).

Hageman GS, Gehrs K, Johnson LV, Anderson D.

In: Kolb H, Fernandez E, Nelson R, editors. Webvision: The Organization of the Retina and Visual System [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-.
2008 Jan 1.


Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation.

Hu Q, Friedrich AM, Johnson LV, Clegg DO.

Stem Cells. 2010 Nov;28(11):1981-91. doi: 10.1002/stem.531.


Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat.

Carr AJ, Vugler AA, Hikita ST, Lawrence JM, Gias C, Chen LL, Buchholz DE, Ahmado A, Semo M, Smart MJ, Hasan S, da Cruz L, Johnson LV, Clegg DO, Coffey PJ.

PLoS One. 2009 Dec 3;4(12):e8152. doi: 10.1371/journal.pone.0008152.


The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited.

Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV.

Prog Retin Eye Res. 2010 Mar;29(2):95-112. doi: 10.1016/j.preteyeres.2009.11.003. Epub 2009 Dec 2. Review.


Soluble and mature amyloid fibrils in drusen deposits.

Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1304-10. doi: 10.1167/iovs.09-4207. Epub 2009 Nov 5.


Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin.

Rowland TJ, Miller LM, Blaschke AJ, Doss EL, Bonham AJ, Hikita ST, Johnson LV, Clegg DO.

Stem Cells Dev. 2010 Aug;19(8):1231-40. doi: 10.1089/scd.2009.0328.


Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells.

Buchholz DE, Hikita ST, Rowland TJ, Friedrich AM, Hinman CR, Johnson LV, Clegg DO.

Stem Cells. 2009 Oct;27(10):2427-34. doi: 10.1002/stem.189.


Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions.

Kochounian H, Johnson LV, Fong HK.

Exp Eye Res. 2009 Jun;88(6):1129-36. doi: 10.1016/j.exer.2009.01.019. Epub 2009 Feb 11.


Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid.

Radeke MJ, Peterson KE, Johnson LV, Anderson DH.

Exp Eye Res. 2007 Sep;85(3):366-80. Epub 2007 Jun 14.


Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.

Hageman GS, Hancox LS, Taiber AJ, Gehrs KM, Anderson DH, Johnson LV, Radeke MJ, Kavanagh D, Richards A, Atkinson J, Meri S, Bergeron J, Zernant J, Merriam J, Gold B, Allikmets R, Dean M; AMD Clinical Study Group.

Ann Med. 2006;38(8):592-604.


Age-related macular degeneration--emerging pathogenetic and therapeutic concepts.

Gehrs KM, Anderson DH, Johnson LV, Hageman GS.

Ann Med. 2006;38(7):450-71. Review.


Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid.

Johnson PT, Betts KE, Radeke MJ, Hageman GS, Anderson DH, Johnson LV.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17456-61. Epub 2006 Nov 1.


Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: Characterization, ethnic distribution and evolutionary implications.

Hageman GS, Hancox LS, Taiber AJ, Gehrs KM, Anderson DH, Johnson LV, Radeke MJ, Kavanagh D, Richards A, Atkinson J, Meri S, Bergeron J, Zernant J, Merriam J, Gold B, Allikmets R, Dean M.

Ann Med. 2006;38(8):592-604. doi: 10.1080/07853890601097030.


Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen.

Johnson PT, Brown MN, Pulliam BC, Anderson DH, Johnson LV.

Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4788-95.


Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11900-5. Epub 2005 Aug 3.


A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.

Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7227-32. Epub 2005 May 3.


Age-related macular degeneration and the extracellular matrix.

Johnson LV, Anderson DH.

N Engl J Med. 2004 Jul 22;351(4):320-2. No abstract available.


Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling.

Tombran-Tink J, Lara N, Chappa A, Tink AR, Johnson LV, Staples M.

Adv Exp Med Biol. 2003;533:315-26. No abstract available.


Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration.

Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV.

Exp Eye Res. 2004 Feb;78(2):243-56.


Drusen-associated degeneration in the retina.

Johnson PT, Lewis GP, Talaga KC, Brown MN, Kappel PJ, Fisher SK, Anderson DH, Johnson LV.

Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4481-8.


A role for local inflammation in the formation of drusen in the aging eye.

Anderson DH, Mullins RF, Hageman GS, Johnson LV.

Am J Ophthalmol. 2002 Sep;134(3):411-31. Review.


The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.

Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11830-5. Epub 2002 Aug 20.


Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration.

Leu ST, Batni S, Radeke MJ, Johnson LV, Anderson DH, Clegg DO.

Exp Eye Res. 2002 Jan;74(1):141-54.


Complement activation and inflammatory processes in Drusen formation and age related macular degeneration.

Johnson LV, Leitner WP, Staples MK, Anderson DH.

Exp Eye Res. 2001 Dec;73(6):887-96.


An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration.

Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF.

Prog Retin Eye Res. 2001 Nov;20(6):705-32. Review.


Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation.

Anderson DH, Ozaki S, Nealon M, Neitz J, Mullins RF, Hageman GS, Johnson LV.

Am J Ophthalmol. 2001 Jun;131(6):767-81.


A potential role for immune complex pathogenesis in drusen formation.

Johnson LV, Ozaki S, Staples MK, Erickson PA, Anderson DH.

Exp Eye Res. 2000 Apr;70(4):441-9.


Vitronectin gene expression in the adult human retina.

Anderson DH, Hageman GS, Mullins RF, Neitz M, Neitz J, Ozaki S, Preissner KT, Johnson LV.

Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3305-15.


The human retina and retinal pigment epithelium are abundant sources of vitronectin mRNA.

Ozaki S, Johnson LV, Mullins RF, Hageman GS, Anderson DH.

Biochem Biophys Res Commun. 1999 May 19;258(3):524-9.


Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells.

Hageman GS, Mullins RF, Russell SR, Johnson LV, Anderson DH.

FASEB J. 1999 Mar;13(3):477-84.


Characterization of drusen-associated glycoconjugates.

Mullins RF, Johnson LV, Anderson DH, Hageman GS.

Ophthalmology. 1997 Feb;104(2):288-94.


pH-dependent changes in interphotoreceptor matrix domains surrounding cone photoreceptors.

Ishikawa M, Johnson LV, DeWing MD, Koseki T, Tonosaki A, Sakuragi S.

Ophthalmic Res. 1996;28(2):117-24.


Vitronectin receptor expression and distribution at the photoreceptor-retinal pigment epithelial interface.

Anderson DH, Johnson LV, Hageman GS.

J Comp Neurol. 1995 Sep 11;360(1):1-16.


Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity.

Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D.

J Neurosci. 1995 Jul;15(7 Pt 1):4992-5003.

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