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Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.

Johnson CW, Lin YJ, Reid D, Parker J, Pavlopoulos S, Dischinger P, Graveel C, Aguirre AJ, Steensma M, Haigis KM, Mattos C.

Cell Rep. 2019 Aug 6;28(6):1538-1550.e7. doi: 10.1016/j.celrep.2019.07.026.


Enabling microbial syringol conversion through structure-guided protein engineering.

Machovina MM, Mallinson SJB, Knott BC, Meyers AW, Garcia-Borràs M, Bu L, Gado JE, Oliver A, Schmidt GP, Hinchen DJ, Crowley MF, Johnson CW, Neidle EL, Payne CM, Houk KN, Beckham GT, McGeehan JE, DuBois JL.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13970-13976. doi: 10.1073/pnas.1820001116. Epub 2019 Jun 24.


Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.


Sensor-Enabled Alleviation of Product Inhibition in Chorismate Pyruvate-Lyase.

Jha RK, Narayanan N, Pandey N, Bingen JM, Kern TL, Johnson CW, Strauss CEM, Beckham GT, Hennelly SP, Dale T.

ACS Synth Biol. 2019 Apr 19;8(4):775-786. doi: 10.1021/acssynbio.8b00465. Epub 2019 Mar 25.


Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism.

Padilla SL, Perez JG, Ben-Hamo M, Johnson CW, Sanchez REA, Bussi IL, Palmiter RD, de la Iglesia HO.

Curr Biol. 2019 Feb 18;29(4):592-604.e4. doi: 10.1016/j.cub.2019.01.022. Epub 2019 Feb 7.


Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory.

Chan LC, Rossetti M, Miller LS, Filler SG, Johnson CW, Lee HK, Wang H, Gjertson D, Fowler VG Jr, Reed EF, Yeaman MR; MRSA Systems Immunobiology Group.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11111-E11119. doi: 10.1073/pnas.1808353115. Epub 2018 Oct 8.


A Neural Circuit Underlying the Generation of Hot Flushes.

Padilla SL, Johnson CW, Barker FD, Patterson MA, Palmiter RD.

Cell Rep. 2018 Jul 10;24(2):271-277. doi: 10.1016/j.celrep.2018.06.037.


A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion.

Mallinson SJB, Machovina MM, Silveira RL, Garcia-Borràs M, Gallup N, Johnson CW, Allen MD, Skaf MS, Crowley MF, Neidle EL, Houk KN, Beckham GT, DuBois JL, McGeehan JE.

Nat Commun. 2018 Jun 27;9(1):2487. doi: 10.1038/s41467-018-04878-2.


Accelerating pathway evolution by increasing the gene dosage of chromosomal segments.

Tumen-Velasquez M, Johnson CW, Ahmed A, Dominick G, Fulk EM, Khanna P, Lee SA, Schmidt AL, Linger JG, Eiteman MA, Beckham GT, Neidle EL.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7105-7110. doi: 10.1073/pnas.1803745115. Epub 2018 Jun 18.


A protocatechuate biosensor for Pseudomonas putida KT2440 via promoter and protein evolution.

Jha RK, Bingen JM, Johnson CW, Kern TL, Khanna P, Trettel DS, Strauss CEM, Beckham GT, Dale T.

Metab Eng Commun. 2018 Mar 7;6:33-38. doi: 10.1016/j.meteno.2018.03.001. eCollection 2018 Jun.


Characterization and engineering of a plastic-degrading aromatic polyesterase.

Austin HP, Allen MD, Donohoe BS, Rorrer NA, Kearns FL, Silveira RL, Pollard BC, Dominick G, Duman R, El Omari K, Mykhaylyk V, Wagner A, Michener WE, Amore A, Skaf MS, Crowley MF, Thorne AW, Johnson CW, Woodcock HL, McGeehan JE, Beckham GT.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4350-E4357. doi: 10.1073/pnas.1718804115. Epub 2018 Apr 17.


Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation With a 2-Coil Device in Treatment-Resistant Major Depressive Disorder.

Kavanaugh BC, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Schneider MB, Carpenter LL.

J ECT. 2018 Dec;34(4):258-265. doi: 10.1097/YCT.0000000000000494.


Conversion and assimilation of furfural and 5-(hydroxymethyl)furfural by Pseudomonas putida KT2440.

Guarnieri MT, Ann Franden M, Johnson CW, Beckham GT.

Metab Eng Commun. 2017 Feb 8;4:22-28. doi: 10.1016/j.meteno.2017.02.001. eCollection 2017 Jun.


Identifying Possible Pheromones of Cerambycid Beetles by Field Testing Known Pheromone Components in Four Widely Separated Regions of the United States.

Millar JG, Mitchell RF, Mongold-Diers JA, Zou Y, Bográn CE, Fierke MK, Ginzel MD, Johnson CW, Meeker JR, Poland TM, Ragenovich I, Hanks LM.

J Econ Entomol. 2018 Feb 9;111(1):252-259. doi: 10.1093/jee/tox312.


Eliminating a global regulator of carbon catabolite repression enhances the conversion of aromatic lignin monomers to muconate in Pseudomonas putida KT2440.

Johnson CW, Abraham PE, Linger JG, Khanna P, Hettich RL, Beckham GT.

Metab Eng Commun. 2017 May 31;5:19-25. doi: 10.1016/j.meteno.2017.05.002. eCollection 2017 Dec.


rTMS with a two-coil array: Safety and efficacy for treatment resistant major depressive disorder.

Carpenter LL, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Stannard EL, Schneider MB.

Brain Stimul. 2017 Sep - Oct;10(5):926-933. doi: 10.1016/j.brs.2017.06.003. Epub 2017 Jun 9.


The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

Johnson CW, Reid D, Parker JA, Salter S, Knihtila R, Kuzmic P, Mattos C.

J Biol Chem. 2017 Aug 4;292(31):12981-12993. doi: 10.1074/jbc.M117.778886. Epub 2017 Jun 19.


Seasonal water storage, stress modulation, and California seismicity.

Johnson CW, Fu Y, Bürgmann R.

Science. 2017 Jun 16;356(6343):1161-1164. doi: 10.1126/science.aak9547.


Metformin inhibits the proliferation of benign prostatic epithelial cells.

Wang Z, Xiao X, Ge R, Li J, Johnson CW, Rassoulian C, Olumi AF.

PLoS One. 2017 Mar 2;12(3):e0173335. doi: 10.1371/journal.pone.0173335. eCollection 2017.


Distribution of RANK and RANK Ligand in Normal Human Tissues as Determined by an Optimized Immunohistochemical Method.

Taylor CR, Branstetter D, Manna E, Dougall WC, Bussiere J, Johnson CW.

Appl Immunohistochem Mol Morphol. 2017 May/Jun;25(5):299-307. doi: 10.1097/PAI.0000000000000503.


Innate Immune Memory Contributes to Host Defense against Recurrent Skin and Skin Structure Infections Caused by Methicillin-Resistant Staphylococcus aureus.

Chan LC, Chaili S, Filler SG, Miller LS, Solis NV, Wang H, Johnson CW, Lee HK, Diaz LF, Yeaman MR.

Infect Immun. 2017 Jan 26;85(2). pii: e00876-16. doi: 10.1128/IAI.00876-16. Print 2017 Feb.


Corrigendum to "Extended-release naltrexone opioid treatment at jail reentry (XOR)" [Contemp. Clin. Trials 49 (2016) 57-64].

McDonald RD, Tofighi B, Laska E, Goldfeld K, Bonilla W, Flannery M, Santana-Correa N, Johnson CW, Leibowitz N, Rotrosen J, Gourevitch MN, Lee JD.

Contemp Clin Trials. 2016 Nov;51:96. doi: 10.1016/j.cct.2016.09.009. Epub 2016 Oct 13. No abstract available.


Extended-release naltrexone opioid treatment at jail reentry (XOR).

McDonald RD, Tofighi B, Laska E, Goldfeld K, Bonilla W, Flannery M, Santana-Correa N, Johnson CW, Leibowitz N, Rotrosen J, Gourevitch MN, Lee JD.

Contemp Clin Trials. 2016 Jul;49:57-64. doi: 10.1016/j.cct.2016.05.002. Epub 2016 May 10. Erratum in: Contemp Clin Trials. 2016 Nov;51:96.


Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity.

Johnson CW, Salvachúa D, Khanna P, Smith H, Peterson DJ, Beckham GT.

Metab Eng Commun. 2016 Apr 22;3:111-119. doi: 10.1016/j.meteno.2016.04.002. eCollection 2016 Dec.


Opportunities and challenges in biological lignin valorization.

Beckham GT, Johnson CW, Karp EM, Salvachúa D, Vardon DR.

Curr Opin Biotechnol. 2016 Dec;42:40-53. doi: 10.1016/j.copbio.2016.02.030. Epub 2016 Mar 11. Review.


Racial and Ethnic Differences in Self-Reported Periodontal Disease in the Multi-Ethnic Study of Atherosclerosis (MESA).

Weatherspoon DJ, Borrell LN, Johnson CW, Mujahid MS, Neighbors HW, Adar SD.

Oral Health Prev Dent. 2016;14(3):249-57. doi: 10.3290/j.ohpd.a35614.


Expression, purification, crystallization and X-ray data collection for RAS and its mutants.

Johnson CW, Buhrman G, Ting PY, Colicelli J, Mattos C.

Data Brief. 2015 Dec 17;6:423-7. doi: 10.1016/j.dib.2015.12.007. eCollection 2016 Mar.


Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

Ting PY, Johnson CW, Fang C, Cao X, Graeber TG, Mattos C, Colicelli J.

FASEB J. 2015 Sep;29(9):3750-61. doi: 10.1096/fj.15-271510. Epub 2015 May 21.


Aromatic catabolic pathway selection for optimal production of pyruvate and lactate from lignin.

Johnson CW, Beckham GT.

Metab Eng. 2015 Mar;28:240-247. doi: 10.1016/j.ymben.2015.01.005. Epub 2015 Jan 21.


miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family.

Hogan EM, Casserly AP, Scofield MD, Mou Z, Zhao-Shea R, Johnson CW, Tapper AR, Gardner PD.

RNA. 2014 Dec;20(12):1890-9. doi: 10.1261/rna.034066.112. Epub 2014 Oct 24.


Lignin valorization through integrated biological funneling and chemical catalysis.

Linger JG, Vardon DR, Guarnieri MT, Karp EM, Hunsinger GB, Franden MA, Johnson CW, Chupka G, Strathmann TJ, Pienkos PT, Beckham GT.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12013-8. doi: 10.1073/pnas.1410657111. Epub 2014 Aug 4.


Assessing the benefit of a personalized EHR-generated informed consent in a dental school setting.

Valenza JA, Taylor D, Walji MF, Johnson CW.

J Dent Educ. 2014 Aug;78(8):1182-93.


Mobile phone-based clinical guidance for rural health providers in India.

Gautham M, Iyengar MS, Johnson CW.

Health Informatics J. 2015 Dec;21(4):253-66. doi: 10.1177/1460458214523153. Epub 2014 Mar 12.


Optimized dual threshold entity resolution for electronic health record databases--training set size and active learning.

Joffe E, Byrne MJ, Reeder P, Herskovic JR, Johnson CW, McCoy AB, Bernstam EV.

AMIA Annu Symp Proc. 2013 Nov 16;2013:721-30. eCollection 2013.


"It's complicated": collective memories of transgender, queer, and questioning youth in high school.

Johnson CW, Singh AA, Gonzalez M.

J Homosex. 2014;61(3):419-34. doi: 10.1080/00918369.2013.842436.


A phase 2 randomized trial of paclitaxel and carboplatin with or without panitumumab for first-line treatment of advanced non-small-cell lung cancer.

Crawford J, Swanson P, Schwarzenberger P, Sandler A, Prager D, Zhang K, Freeman DJ, Johnson CW, Krishnan K, Johnson D.

J Thorac Oncol. 2013 Dec;8(12):1510-8. doi: 10.1097/JTO.0b013e3182a7d1da.


Errors in after-hours phone consultations: a simulation study.

Joffe E, Turley JP, Hwang KO, Johnson TR, Johnson CW, Bernstam EV.

BMJ Qual Saf. 2014 May;23(5):398-405. doi: 10.1136/bmjqs-2013-002243. Epub 2013 Dec 13.


Evaluation of a problem-specific SBAR tool to improve after-hours nurse-physician phone communication: a randomized trial.

Joffe E, Turley JP, Hwang KO, Johnson TR, Johnson CW, Bernstam EV.

Jt Comm J Qual Patient Saf. 2013 Nov;39(11):495-501.


DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site.

Kearney BM, Johnson CW, Roberts DM, Swartz P, Mattos C.

J Mol Biol. 2014 Feb 6;426(3):611-29. doi: 10.1016/j.jmb.2013.10.036. Epub 2013 Nov 2.


Anti-social networking: crowdsourcing and the cyber defence of national critical infrastructures.

Johnson CW.

Ergonomics. 2014;57(3):419-33. doi: 10.1080/00140139.2013.812749. Epub 2013 Jul 5.


A benchmark comparison of deterministic and probabilistic methods for defining manual review datasets in duplicate records reconciliation.

Joffe E, Byrne MJ, Reeder P, Herskovic JR, Johnson CW, McCoy AB, Sittig DF, Bernstam EV.

J Am Med Inform Assoc. 2014 Jan-Feb;21(1):97-104. doi: 10.1136/amiajnl-2013-001744. Epub 2013 May 23.


Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model.

Bell RC, Rogith D, Johnson CW, Badea CT, Athreya KK, Espinosa G, Clark D, Ghafoori AP, Li Y, Kirsch DG, Annapragada A, Ghaghada K.

AMIA Annu Symp Proc. 2012;2012:27-35. Epub 2012 Nov 3.


The allosteric switch and conformational states in Ras GTPase affected by small molecules.

Johnson CW, Mattos C.

Enzymes. 2013;33 Pt A:41-67. doi: 10.1016/B978-0-12-416749-0.00003-8. Epub 2013 Aug 8. Review.


Modulating macroautophagy: a neuronal perspective.

Johnson CW, Melia TJ, Yamamoto A.

Future Med Chem. 2012 Sep;4(13):1715-31. doi: 10.4155/fmc.12.112. Review.


Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma.

Improgo MR, Johnson CW, Tapper AR, Gardner PD.

PLoS One. 2011;6(9):e24132. doi: 10.1371/journal.pone.0024132. Epub 2011 Sep 8.


Effect of aerosol surface lubricants on the abundance and richness of selected forest insects captured in multiple-funnel and panel traps.

Allison JD, Johnson CW, Meeker JR, Strom BL, Butler SM.

J Econ Entomol. 2011 Aug;104(4):1258-64.


The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L.

Development. 2011 Aug;138(15):3213-24. doi: 10.1242/dev.058693.


Vgll2a is required for neural crest cell survival during zebrafish craniofacial development.

Johnson CW, Hernandez-Lagunas L, Feng W, Melvin VS, Williams T, Artinger KB.

Dev Biol. 2011 Sep 1;357(1):269-81. doi: 10.1016/j.ydbio.2011.06.034. Epub 2011 Jun 30. Erratum in: Dev Biol. 2012 Mar 1;363(1):332.


Use of tissue cross-reactivity studies in the development of antibody-based biopharmaceuticals: history, experience, methodology, and future directions.

Leach MW, Halpern WG, Johnson CW, Rojko JL, MacLachlan TK, Chan CM, Galbreath EJ, Ndifor AM, Blanset DL, Polack E, Cavagnaro JA.

Toxicol Pathol. 2010 Dec;38(7):1138-66. doi: 10.1177/0192623310382559. Epub 2010 Oct 6.


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