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Genetic Mosaicism in Calmodulinopathy.

Wren LM, Jiménez-Jáimez J, Al-Ghamdi S, Al-Aama JY, Bdeir A, Al-Hassnan ZN, Kuan JL, Foo RY, Potet F, Johnson CN, Aziz MC, Carvill GL, Kaski JP, Crotti L, Perin F, Monserrat L, Burridge PW, Schwartz PJ, Chazin WJ, Bhuiyan ZA, George AL Jr.

Circ Genom Precis Med. 2019 Sep;12(9):375-385. doi: 10.1161/CIRCGEN.119.002581. Epub 2019 Aug 27.


Administration of a Postbiotic Causes Immunomodulatory Responses in Broiler Gut and Reduces Disease Pathogenesis Following Challenge.

Johnson CN, Kogut MH, Genovese K, He H, Kazemi S, Arsenault RJ.

Microorganisms. 2019 Aug 17;7(8). pii: E268. doi: 10.3390/microorganisms7080268.


The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.

Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC.

Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul 30.


Decision-making in Orthopaedic Oncology: Does Cognitive Bias Affect a Virtual Patient's Choice Between Limb Salvage and Amputation?

Gurich RW Jr, Cizik AM, Punt SE, Namekata M, Johnson CN, Symons RG, Brewer EG, Thompson MJ.

Clin Orthop Relat Res. 2019 Apr 30. doi: 10.1097/CORR.0000000000000674. [Epub ahead of print]


Novel combinations of experimental and computational analysis tested on the binding of metalloprotoporphyrins to albumin.

Hu J, Hernandez Soraiz E, Johnson CN, Demeler B, Brancaleon L.

Int J Biol Macromol. 2019 Aug 1;134:445-457. doi: 10.1016/j.ijbiomac.2019.05.060. Epub 2019 May 10.


Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci.

Chatterjee A, Johnson CN, Luong P, Hullahalli K, McBride SW, Schubert AM, Palmer KL, Carlson PE Jr, Duerkop BA.

Infect Immun. 2019 May 21;87(6). pii: e00085-19. doi: 10.1128/IAI.00085-19. Print 2019 Jun.


Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.

Grainger R, Heightman TD, Ley SV, Lima F, Johnson CN.

Chem Sci. 2018 Dec 21;10(8):2264-2271. doi: 10.1039/c8sc04789h. eCollection 2019 Feb 28.


Ecosystem engineering by digging mammals: effects on soil fertility and condition in Tasmanian temperate woodland.

Davies GTO, Kirkpatrick JB, Cameron EZ, Carver S, Johnson CN.

R Soc Open Sci. 2019 Jan 16;6(1):180621. doi: 10.1098/rsos.180621. eCollection 2019 Jan.


Calcium modulation of cardiac sodium channels.

Johnson CN.

J Physiol. 2019 Feb 1. doi: 10.1113/JP277553. [Epub ahead of print]


Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JTM, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2018 Nov 30;38(6). pii: BSR-20150194_COR. doi: 10.1042/BSR-20150194_COR. Print 2018 Dec 21. No abstract available.


Top carnivore decline has cascading effects on scavengers and carrion persistence.

Cunningham CX, Johnson CN, Barmuta LA, Hollings T, Woehler EJ, Jones ME.

Proc Biol Sci. 2018 Nov 28;285(1892). pii: 20181582. doi: 10.1098/rspb.2018.1582.


Fragment-to-Lead Medicinal Chemistry Publications in 2017.

Mortenson PN, Erlanson DA, de Esch IJP, Jahnke W, Johnson CN.

J Med Chem. 2019 Apr 25;62(8):3857-3872. doi: 10.1021/acs.jmedchem.8b01472. Epub 2018 Nov 21.


Contemporary Management of Appendicular Skeletal Metastasis by Primary Tumor Type.

Johnson CN, Gurich RW Jr, Pavey GJ, Thompson MJ.

J Am Acad Orthop Surg. 2019 May 15;27(10):345-355. doi: 10.5435/JAAOS-D-17-00749.


Hope and caution: rewilding to mitigate the impacts of biological invasions.

Derham TT, Duncan RP, Johnson CN, Jones ME.

Philos Trans R Soc Lond B Biol Sci. 2018 Oct 22;373(1761). pii: 20180127. doi: 10.1098/rstb.2018.0127. Review.


Can trophic rewilding reduce the impact of fire in a more flammable world?

Johnson CN, Prior LD, Archibald S, Poulos HM, Barton AM, Williamson GJ, Bowman DMJS.

Philos Trans R Soc Lond B Biol Sci. 2018 Oct 22;373(1761). pii: 20170443. doi: 10.1098/rstb.2017.0443. Review.


Zoonotic Helminth Diseases in Dogs and Dingoes Utilising Shared Resources in an Australian Aboriginal Community.

Smout FA, Skerratt LF, Johnson CN, Butler JRA, Congdon BC.

Trop Med Infect Dis. 2018 Oct 8;3(4). pii: E110. doi: 10.3390/tropicalmed3040110.


Cardiac Arrhythmias as Manifestations of Nanopathies: An Emerging View.

Radwański PB, Johnson CN, Györke S, Veeraraghavan R.

Front Physiol. 2018 Sep 4;9:1228. doi: 10.3389/fphys.2018.01228. eCollection 2018. Review.


Lipomatous Soft-tissue Tumors.

Johnson CN, Ha AS, Chen E, Davidson D.

J Am Acad Orthop Surg. 2018 Nov 15;26(22):779-788. doi: 10.5435/JAAOS-D-17-00045. Review.


The gut microbiome as a driver of individual variation in cognition and functional behaviour.

Davidson GL, Cooke AC, Johnson CN, Quinn JL.

Philos Trans R Soc Lond B Biol Sci. 2018 Sep 26;373(1756). pii: 20170286. doi: 10.1098/rstb.2017.0286. Review.


A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).

Johnson CN, Ahn JS, Buck IM, Chiarparin E, Day JEH, Hopkins A, Howard S, Lewis EJ, Martins V, Millemaggi A, Munck JM, Page LW, Peakman T, Reader M, Rich SJ, Saxty G, Smyth T, Thompson NT, Ward GA, Williams PA, Wilsher NE, Chessari G.

J Med Chem. 2018 Aug 23;61(16):7314-7329. doi: 10.1021/acs.jmedchem.8b00900. Epub 2018 Aug 9.


Modeling underwater noise propagation from marine hydrokinetic power devices through a time-domain, velocity-pressure solution.

Hafla E, Johnson E, Johnson CN, Preston L, Aldridge D, Roberts JD.

J Acoust Soc Am. 2018 Jun;143(6):3242. doi: 10.1121/1.5039839.


Liposomal bupivacaine reduces opioid consumption and length of stay in patients undergoing primary total hip arthroplasty.

VanWagner MJ, Krebs NM, Corser W, Johnson CN.

Hip Int. 2019 May;29(3):276-281. doi: 10.1177/1120700018778240. Epub 2018 May 29.


Charles Darwin, Richard Owen, and Natural Selection: A Question of Priority.

Johnson CN.

J Hist Biol. 2019 Mar;52(1):45-85. doi: 10.1007/s10739-018-9514-2.


ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.

Ward GA, Lewis EJ, Ahn JS, Johnson CN, Lyons JF, Martins V, Munck JM, Rich SJ, Smyth T, Thompson NT, Williams PA, Wilsher NE, Wallis NG, Chessari G.

Mol Cancer Ther. 2018 Jul;17(7):1381-1391. doi: 10.1158/1535-7163.MCT-17-0848. Epub 2018 Apr 25.


Multi-wavelength analytical ultracentrifugation of human serum albumin complexed with porphyrin.

Johnson CN, Gorbet GE, Ramsower H, Urquidi J, Brancaleon L, Demeler B.

Eur Biophys J. 2018 Oct;47(7):789-797. doi: 10.1007/s00249-018-1301-7. Epub 2018 Apr 19.


A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL Jr, Chazin WJ.

Structure. 2018 May 1;26(5):683-694.e3. doi: 10.1016/j.str.2018.03.005. Epub 2018 Apr 5.


MRI Identification of the Osseous Extent of Pediatric Bone Sarcomas.

Thompson MJ, Shapton JC, Punt SE, Johnson CN, Conrad EU 3rd.

Clin Orthop Relat Res. 2018 Mar;476(3):559-564. doi: 10.1007/s11999.0000000000000068.


Characterization of Pathogenic Vibrio parahaemolyticus from the Chesapeake Bay, Maryland.

Chen AJ, Hasan NA, Haley BJ, Taviani E, Tarnowski M, Brohawn K, Johnson CN, Colwell RR, Huq A.

Front Microbiol. 2017 Dec 15;8:2460. doi: 10.3389/fmicb.2017.02460. eCollection 2017.


Exopolysaccharide production in Caulobacter crescentus: A resource allocation trade-off between protection and proliferation.

Herr KL, Carey AM, Heckman TI, Chávez JL, Johnson CN, Harvey E, Gamroth WA, Wulfing BS, Van Kessel RA, Marks ME.

PLoS One. 2018 Jan 2;13(1):e0190371. doi: 10.1371/journal.pone.0190371. eCollection 2018.


Dietary partitioning of Australia's two marsupial hypercarnivores, the Tasmanian devil and the spotted-tailed quoll, across their shared distributional range.

Andersen GE, Johnson CN, Barmuta LA, Jones ME.

PLoS One. 2017 Nov 27;12(11):e0188529. doi: 10.1371/journal.pone.0188529. eCollection 2017.


Prey use by dingoes in a contested landscape: Ecosystem service provider or biodiversity threat?

Morrant DS, Wurster CM, Johnson CN, Butler JRA, Congdon BC.

Ecol Evol. 2017 Sep 21;7(21):8927-8935. doi: 10.1002/ece3.3345. eCollection 2017 Nov.


Fragment-to-Lead Medicinal Chemistry Publications in 2016.

Johnson CN, Erlanson DA, Jahnke W, Mortenson PN, Rees DC.

J Med Chem. 2018 Mar 8;61(5):1774-1784. doi: 10.1021/acs.jmedchem.7b01298. Epub 2017 Oct 31. Review.


Ecological and evolutionary legacy of megafauna extinctions.

Galetti M, Moleón M, Jordano P, Pires MM, Guimarães PR Jr, Pape T, Nichols E, Hansen D, Olesen JM, Munk M, de Mattos JS, Schweiger AH, Owen-Smith N, Johnson CN, Marquis RJ, Svenning JC.

Biol Rev Camb Philos Soc. 2018 May;93(2):845-862. doi: 10.1111/brv.12374. Epub 2017 Oct 9. Review.


Use of anthropogenic linear features by two medium-sized carnivores in reserved and agricultural landscapes.

Andersen GE, Johnson CN, Barmuta LA, Jones ME.

Sci Rep. 2017 Sep 14;7(1):11624. doi: 10.1038/s41598-017-11454-z.


Results from a clinical trial evaluating the efficacy of real-time body surface visual feedback in reducing patient motion during lung cancer radiotherapy.

Price GJ, Faivre-Finn C, Stratford J, Chauhan S, Bewley M, Clarke L, Johnson CN, Moore CJ.

Acta Oncol. 2018 Feb;57(2):211-218. doi: 10.1080/0284186X.2017.1360511. Epub 2017 Aug 7.


The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages.

Carson WF 4th, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL.

J Immunol. 2017 Sep 1;199(5):1865-1874. doi: 10.4049/jimmunol.1601272. Epub 2017 Jul 21.


Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.


The hookworm Ancylostoma ceylanicum: An emerging public health risk in Australian tropical rainforests and Indigenous communities.

Smout FA, Skerratt LF, Butler JRA, Johnson CN, Congdon BC, Thompson RCA.

One Health. 2017 Apr 26;3:66-69. doi: 10.1016/j.onehlt.2017.04.002. eCollection 2017 Jun.


Top predators constrain mesopredator distributions.

Newsome TM, Greenville AC, Ćirović D, Dickman CR, Johnson CN, Krofel M, Letnic M, Ripple WJ, Ritchie EG, Stoyanov S, Wirsing AJ.

Nat Commun. 2017 May 23;8:15469. doi: 10.1038/ncomms15469.


Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

Tamanini E, Buck IM, Chessari G, Chiarparin E, Day JEH, Frederickson M, Griffiths-Jones CM, Hearn K, Heightman TD, Iqbal A, Johnson CN, Lewis EJ, Martins V, Peakman T, Reader M, Rich SJ, Ward GA, Williams PA, Wilsher NE.

J Med Chem. 2017 Jun 8;60(11):4611-4625. doi: 10.1021/acs.jmedchem.6b01877. Epub 2017 May 24.


Biodiversity losses and conservation responses in the Anthropocene.

Johnson CN, Balmford A, Brook BW, Buettel JC, Galetti M, Guangchun L, Wilmshurst JM.

Science. 2017 Apr 21;356(6335):270-275. doi: 10.1126/science.aam9317. Review.


Communicating Science through a Novel Type of Journal.

Juarez MT, Kenet CM, Johnson CN.

CBE Life Sci Educ. 2017 Summer;16(2). pii: le2. doi: 10.1187/cbe.16-12-0345. No abstract available.


Is God just a big person? Children's conceptions of God across cultures and religious traditions.

Nyhof MA, Johnson CN.

Br J Dev Psychol. 2017 Mar;35(1):60-75. doi: 10.1111/bjdp.12173.


Induction of p53 suppresses chronic myeloid leukemia.

Peterson LF, Lo MC, Liu Y, Giannola D, Mitrikeska E, Donato NJ, Johnson CN, Wang S, Mercer J, Talpaz M.

Leuk Lymphoma. 2017 Sep;58(9):1-14. doi: 10.1080/10428194.2016.1272682. Epub 2017 Jan 13.


Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.

Lebraud H, Wright DJ, Johnson CN, Heightman TD.

ACS Cent Sci. 2016 Dec 28;2(12):927-934. doi: 10.1021/acscentsci.6b00280. Epub 2016 Dec 5.


Livestock guardian dogs as surrogate top predators? How Maremma sheepdogs affect a wildlife community.

van Bommel L, Johnson CN.

Ecol Evol. 2016 Aug 30;6(18):6702-6711. eCollection 2016 Sep.


Fragment-to-Lead Medicinal Chemistry Publications in 2015.

Johnson CN, Erlanson DA, Murray CW, Rees DC.

J Med Chem. 2017 Jan 12;60(1):89-99. doi: 10.1021/acs.jmedchem.6b01123. Epub 2016 Oct 14. Review.


Occupancy of the Invasive Feral Cat Varies with Habitat Complexity.

Hohnen R, Tuft K, McGregor HW, Legge S, Radford IJ, Johnson CN.

PLoS One. 2016 Sep 21;11(9):e0152520. doi: 10.1371/journal.pone.0152520. eCollection 2016.


Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR.

Microarrays (Basel). 2016 May 28;5(2). pii: E13. doi: 10.3390/microarrays5020013.


Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC.

Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e004161. doi: 10.1161/CIRCEP.116.004161.

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