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Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria.

Villaverde C, Namazzi R, Shabani E, Park GS, Datta D, Hanisch B, Opoka RO, John CC.

J Pediatric Infect Dis Soc. 2019 Dec 6. pii: piz082. doi: 10.1093/jpids/piz082. [Epub ahead of print]


Hydroxyurea to lower TCD velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort.

Opoka RO, Hume HA, Latham TS, Lane A, Williams O, Tymon J, Nakafeero M, Kasirye P, Ndugwa CM, John CC, Ware RE.

Haematologica. 2019 Oct 24. pii: haematol.2019.231407. doi: 10.3324/haematol.2019.231407. [Epub ahead of print]


Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria.

Rivera-Correa J, Conroy AL, Opoka RO, Batte A, Namazzi R, Ouma B, Bangirana P, Idro R, Schwaderer AL, John CC, Rodriguez A.

Sci Rep. 2019 Oct 17;9(1):14940. doi: 10.1038/s41598-019-51426-z.


HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya.

Odhiambo EO, Datta D, Guyah B, Ayodo G, Ondigo BN, Abong'o BO, John CC, Frosch AEP.

Malar J. 2019 Aug 30;18(1):297. doi: 10.1186/s12936-019-2915-7.


Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia.

Datta D, Namazzi R, Conroy AL, Cusick SE, Hume HA, Tagoola A, Ware RE, Opoka RO, John CC.

Trials. 2019 Jul 26;20(1):460. doi: 10.1186/s13063-019-3569-z.


Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study.

Opoka RO, Waiswa A, Harriet N, John CC, Tumwine JK, Karamagi C.

Clin Infect Dis. 2019 Jul 12. pii: ciz648. doi: 10.1093/cid/ciz648. [Epub ahead of print]


Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia.

Carman AS, Sautter C, Anyanwu JN, Ssemata AS, Opoka RO, Ware RE, Rujumba J, John CC.

Pediatr Blood Cancer. 2019 May 28:e27830. doi: 10.1002/pbc.27830. [Epub ahead of print]


Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria.

Conroy AL, Opoka RO, Bangirana P, Idro R, Ssenkusu JM, Datta D, Hodges JS, Morgan C, John CC.

BMC Med. 2019 May 21;17(1):98. doi: 10.1186/s12916-019-1332-7.


Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria.

Datta D, Conroy AL, Castelluccio PF, Ssenkusu JM, Park GS, Opoka RO, Bangirana P, Idro R, Saykin AJ, John CC.

Clin Infect Dis. 2019 May 2. pii: ciz325. doi: 10.1093/cid/ciz325. [Epub ahead of print]


Blood use in sub-Saharan Africa: a systematic review of current data.

Dhabangi A, Dzik WH, Idro R, John CC, Butler EK, Spijker R, van Hensbroek MB.

Transfusion. 2019 Jul;59(7):2446-2454. doi: 10.1111/trf.15280. Epub 2019 Mar 28. Review. No abstract available.


What causes severe malaria and its complications in children? Lessons learned over the past 15 years.

Conroy AL, Datta D, John CC.

BMC Med. 2019 Mar 7;17(1):52. doi: 10.1186/s12916-019-1291-z.


Caregivers and community perceptions of blood transfusion for children with severe anaemia in Uganda.

Dhabangi A, Idro R, John CC, Dzik WH, Opoka R, Siu GE, Ayebare F, van Hensbroek MB.

Transfus Med. 2019 Feb;29(1):61-67. doi: 10.1111/tme.12581. Epub 2019 Feb 10.


Patterns of traumatic brain injury and six-month neuropsychological outcomes in Uganda.

Bangirana P, Giordani B, Kobusingye O, Murungyi L, Mock C, John CC, Idro R.

BMC Neurol. 2019 Feb 4;19(1):18. doi: 10.1186/s12883-019-1246-1.


Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals.

Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Karamagi C, Tumwine JK.

PLoS One. 2019 Jan 25;14(1):e0210982. doi: 10.1371/journal.pone.0210982. eCollection 2019.


Risk factors for recurrent severe anemia among previously transfused children in Uganda: an age-matched case-control study.

Dhabangi A, Idro R, John CC, Dzik WH, Opoka R, Ssenyonga R, van Hensbroek MB.

BMC Pediatr. 2019 Jan 18;19(1):27. doi: 10.1186/s12887-019-1398-6.


Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins.

Conroy AL, Bangirana P, Muhindo MK, Kakuru A, Jagannathan P, Opoka RO, Liechty EA, Nakalembe M, Kamya MR, Dorsey G, John CC.

Am J Trop Med Hyg. 2019 Mar;100(3):552-555. doi: 10.4269/ajtmh.18-0659.


Malaria: How Are We Doing and How Can We Do Better?

Rosenthal PJ, John CC, Rabinovich NR.

Am J Trop Med Hyg. 2019 Feb;100(2):239-241. doi: 10.4269/ajtmh.18-0997. No abstract available.


Comparison of non-magnetic and magnetic beads multiplex assay for assessment of Plasmodium falciparum antibodies.

Ondigo BN, Park GS, Ayieko C, Nyangahu DD, Wasswa R, John CC.

PeerJ. 2019 Jan 3;7:e6120. doi: 10.7717/peerj.6120. eCollection 2019.


Community perceptions of paediatric severe anaemia in Uganda.

Dhabangi A, Idro R, John CC, Dzik WH, Siu GE, Opoka RO, Ayebare F, van Hensbroek MB.

PLoS One. 2019 Jan 3;14(1):e0209476. doi: 10.1371/journal.pone.0209476. eCollection 2019.


Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial.

Kwambai TK, Dhabangi A, Idro R, Opoka R, Kariuki S, Samuels AM, Desai M, van Hensbroek MB, John CC, Robberstad B, Wang D, Phiri K, Ter Kuile FO.

Trials. 2018 Nov 6;19(1):610. doi: 10.1186/s13063-018-2972-1.


"I feel so bad but have nothing to do." Exploring Ugandan caregivers' experiences of parenting a child with severe malaria and subsequent repeated uncomplicated malaria.

Nakitende AJ, Bangirana P, Nakasujja N, Semrud-Clikeman M, Ssemata AS, John CC, Idro R.

Malar J. 2018 Oct 12;17(1):360. doi: 10.1186/s12936-018-2514-z.


Whole-Blood Transcriptional Signatures Composed of Erythropoietic and NRF2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia.

Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM.

J Infect Dis. 2019 Jan 1;219(1):154-164. doi: 10.1093/infdis/jiy468.


High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals.

Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Tumwine JK, Karamagi C.

BMC Health Serv Res. 2018 Jul 18;18(1):566. doi: 10.1186/s12913-018-3382-5.


The Art of Constructive Worrying.

John CC.

JAMA. 2018 Jun 12;319(22):2273-2274. doi: 10.1001/jama.2018.6670. No abstract available.


The Collaborative Role of North American Departments of Pediatrics in Global Child Health.

Gladding SP, McGann PT, Summer A, Russ CM, Uwemedimo OT, Matamoros Aguilar M, Chakraborty R, Moore M, Lieh-Lai M, Opoka R, Howard C, John CC; Global Health Task Force of the American Board of Pediatrics.

Pediatrics. 2018 Jul;142(1). pii: e20172966. doi: 10.1542/peds.2017-2966. Epub 2018 Jun 12. Review.


Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes.

Postels DG, Wu X, Li C, Kaplan PW, Seydel KB, Taylor TE, Kousa YA, Idro R, Opoka R, John CC, Birbeck GL.

Malar J. 2018 May 22;17(1):208. doi: 10.1186/s12936-018-2355-9.


Use of pre-hospital medication in children presenting with malaria to the emergency unit of Mulago Hospital, Uganda: A descriptive study.

Tumukunde VS, Kiboneka E, John CC, Opoka RO, Idro R.

Malariaworld J. 2017 Jul;8. pii: 8. Epub 2017 Jul 28.


Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria.

Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC.

Malar J. 2018 Feb 15;17(1):82. doi: 10.1186/s12936-018-2225-5.


Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC.

PLoS One. 2018 Jan 25;13(1):e0191550. doi: 10.1371/journal.pone.0191550. eCollection 2018.


Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia.

Opoka RO, Ndugwa CM, Latham TS, Lane A, Hume HA, Kasirye P, Hodges JS, Ware RE, John CC.

Blood. 2017 Dec 14;130(24):2585-2593. doi: 10.1182/blood-2017-06-788935. Epub 2017 Oct 19.


Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria.

Shabani E, Hanisch B, Opoka RO, Lavstsen T, John CC.

BMC Med. 2017 Oct 13;15(1):183. doi: 10.1186/s12916-017-0945-y.


Plasmodium falciparum Histidine-Rich Protein-2 Plasma Concentrations Are Higher in Retinopathy-Negative Cerebral Malaria Than in Severe Malarial Anemia.

Park GS, Opoka RO, Shabani E, Wypyszynski A, Hanisch B, John CC.

Open Forum Infect Dis. 2017 Jul 22;4(3):ofx151. doi: 10.1093/ofid/ofx151. eCollection 2017 Summer.


Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency.

Jaramillo EG, Mupere E, Opoka RO, Hodges JS, Lund TC, Georgieff MK, John CC, Cusick SE.

PLoS One. 2017 Aug 30;12(8):e0183977. doi: 10.1371/journal.pone.0183977. eCollection 2017.


Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia.

Opoka RO, Bangirana P, Idro R, Shabani E, Namazzi R, John CC.

Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26745. Epub 2017 Aug 17.


Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria.

Holmberg D, Franzén-Röhl E, Idro R, Opoka RO, Bangirana P, Sellgren CM, Wickström R, Färnert A, Schwieler L, Engberg G, John CC.

Malar J. 2017 Jul 28;16(1):303. doi: 10.1186/s12936-017-1954-1.


The Benjamin H. Kean Travel Fellowship in Tropical Medicine: Assessment of Impact at 15 Years.

Carman AS, John CC.

Am J Trop Med Hyg. 2017 Sep;97(3):958-963. doi: 10.4269/ajtmh.17-0120. Epub 2017 Jul 19.


Supporting Global Health at the Pediatric Department Level: Why and How.

Pitt MB, Moore MA, John CC, Batra M, Butteris SM, Airewele GE, Suchdev PS, Steinhoff MC; American Board of Pediatrics Global Health Task Force.

Pediatrics. 2017 Jun;139(6). pii: e20163939. doi: 10.1542/peds.2016-3939. Epub 2017 May 3. No abstract available.


Neurodevelopment: The Impact of Nutrition and Inflammation During Early to Middle Childhood in Low-Resource Settings.

John CC, Black MM, Nelson CA 3rd.

Pediatrics. 2017 Apr;139(Suppl 1):S59-S71. doi: 10.1542/peds.2016-2828H. Review.


Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum-Specific Atypical Memory B Cells.

Frosch AE, Odumade OA, Taylor JJ, Ireland K, Ayodo G, Ondigo B, Narum DL, Vulule J, John CC.

J Immunol. 2017 Jun 15;198(12):4629-4638. doi: 10.4049/jimmunol.1600773. Epub 2017 May 19.


Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.

Shabani E, Ouma BJ, Idro R, Bangirana P, Opoka RO, Park GS, Conroy AL, John CC.

Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12438. Epub 2017 May 28.


Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria.

Villaverde C, Namazzi R, Shabani E, Opoka RO, John CC.

Am J Trop Med Hyg. 2017 May;96(5):1176-1184. doi: 10.4269/ajtmh.16-0315. Epub 2017 Jan 30.


Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission.

Ayieko C, Ogola BS, Ochola L, Ngwena GAM, Ayodo G, Hodges JS, Noland GS, John CC.

PeerJ. 2017 Jan 10;5:e2855. doi: 10.7717/peerj.2855. eCollection 2017.


Long-term Behavioral Problems in Children With Severe Malaria.

Ssenkusu JM, Hodges JS, Opoka RO, Idro R, Shapiro E, John CC, Bangirana P.

Pediatrics. 2016 Nov;138(5). pii: e20161965. Epub 2016 Oct 5. Erratum in: Pediatrics. 2017 Nov;140(5):null.


Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.

Tiberti N, Latham SL, Bush S, Cohen A, Opoka RO, John CC, Juillard A, Grau GE, Combes V.

Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.


Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC.

BMC Pediatr. 2016 Nov 4;16(1):177.


Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw134. eCollection 2016 Sep.


Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality.

Brand NR, Opoka RO, Hamre KE, John CC.

PLoS One. 2016 Sep 29;11(9):e0163728. doi: 10.1371/journal.pone.0163728. eCollection 2016.


[Formula: see text]Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries.

Semrud-Clikeman M, Romero RAA, Prado EL, Shapiro EG, Bangirana P, John CC.

Child Neuropsychol. 2017 Oct;23(7):761-802. doi: 10.1080/09297049.2016.1216536. Epub 2016 Sep 9.


Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria.

Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC.

J Infect Dis. 2016 Oct 15;214(8):1268-75. doi: 10.1093/infdis/jiw357. Epub 2016 Aug 11.

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