Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 49

1.

Feasibility of Human Neural Stem Cell Transplantation for the Treatment of Acute Subdural Hematoma in a Rat Model: A Pilot Study.

Yokobori S, Sasaki K, Kanaya T, Igarashi Y, Nakae R, Onda H, Masuno T, Suda S, Sowa K, Nakajima M, Spurlock MS, Onn Chieng L, Hazel TG, Johe K, Gajavelli S, Fuse A, Bullock MR, Yokota H.

Front Neurol. 2019 Feb 12;10:82. doi: 10.3389/fneur.2019.00082. eCollection 2019.

2.

A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder.

Papakostas GI, Johe K, Hand H, Drouillard A, Russo P, Kay G, Kashambwa R, Hoeppner B, Flynn M, Yeung A, Martinson MA, Fava M.

Mol Psychiatry. 2019 Jan 9. doi: 10.1038/s41380-018-0334-8. [Epub ahead of print]

PMID:
30626911
3.

Targeted intraspinal injections to assess therapies in rodent models of neurological disorders.

Chen KS, McGinley LM, Kashlan ON, Hayes JM, Bruno ES, Chang JS, Mendelson FE, Tabbey MA, Johe K, Sakowski SA, Feldman EL.

Nat Protoc. 2019 Feb;14(2):331-349. doi: 10.1038/s41596-018-0095-5.

PMID:
30610242
4.

Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189.

Liu Y, Johe K, Sun J, Hao X, Wang Y, Bi X, Baudry M.

Neuropharmacology. 2019 Jan;144:337-344. doi: 10.1016/j.neuropharm.2018.10.038. Epub 2018 Nov 5.

PMID:
30408487
5.

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease.

McGinley LM, Kashlan ON, Bruno ES, Chen KS, Hayes JM, Kashlan SR, Raykin J, Johe K, Murphy GG, Feldman EL.

Sci Rep. 2018 Oct 3;8(1):14776. doi: 10.1038/s41598-018-33017-6.

6.

Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS.

Goutman SA, Brown MB, Glass JD, Boulis NM, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges L, Patil PG, Sakowski SA, Feldman EL.

Ann Clin Transl Neurol. 2018 May 2;5(6):730-740. doi: 10.1002/acn3.567. eCollection 2018 Jun.

7.

Remediation of Radiation-Induced Cognitive Dysfunction through Oral Administration of the Neuroprotective Compound NSI-189.

Allen BD, Acharya MM, Lu C, Giedzinski E, Chmielewski NN, Quach D, Hefferan M, Johe KK, Limoli CL.

Radiat Res. 2018 Apr;189(4):345-353. doi: 10.1667/RR14879.1. Epub 2018 Jan 19.

8.

Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice.

McGinley LM, Kashlan ON, Chen KS, Bruno ES, Hayes JM, Backus C, Feldman S, Kashlan BN, Johe K, Feldman EL.

Ann Clin Transl Neurol. 2017 Aug 18;4(10):749-755. doi: 10.1002/acn3.443. eCollection 2017 Oct.

9.

The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects.

McIntyre RS, Johe K, Rong C, Lee Y.

Expert Opin Investig Drugs. 2017 Jun;26(6):767-770. doi: 10.1080/13543784.2017.1324847. Epub 2017 May 8. Review.

PMID:
28460574
10.

Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells.

Spurlock MS, Ahmed AI, Rivera KN, Yokobori S, Lee SW, Sam PN, Shear DA, Hefferan MP, Hazel TG, Johe KK, Gajavelli S, Tortella FC, Bullock RM.

J Neurotrauma. 2017 Jun 1;34(11):1981-1995. doi: 10.1089/neu.2016.4602. Epub 2017 Mar 23.

PMID:
28249550
11.

NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats.

Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV.

J Cell Physiol. 2017 Oct;232(10):2731-2740. doi: 10.1002/jcp.25847. Epub 2017 Apr 25.

12.

Feasibility of Three-Dimensional Placement of Human Therapeutic Stem Cells Using the Intracerebral Microinjection Instrument.

Glud AN, Bjarkam CR, Azimi N, Johe K, Sorensen JC, Cunningham M.

Neuromodulation. 2016 Oct;19(7):708-716. doi: 10.1111/ner.12484. Epub 2016 Sep 4. Erratum in: Neuromodulation. 2016 Dec;19(8):904.

PMID:
27593216
13.

A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients.

Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP.

Mol Psychiatry. 2016 Oct;21(10):1483-4. doi: 10.1038/mp.2016.140. Epub 2016 Aug 16. No abstract available.

14.

Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials.

Glass JD, Hertzberg VS, Boulis NM, Riley J, Federici T, Polak M, Bordeau J, Fournier C, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges LF, Rutkove SB, Duell J, Patil PG, Goutman SA, Feldman EL.

Neurology. 2016 Jul 26;87(4):392-400. doi: 10.1212/WNL.0000000000002889. Epub 2016 Jun 29. Erratum in: Neurology. 2017 Aug 1;89(5):521.

15.

Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease.

McGinley LM, Sims E, Lunn JS, Kashlan ON, Chen KS, Bruno ES, Pacut CM, Hazel T, Johe K, Sakowski SA, Feldman EL.

Stem Cells Transl Med. 2016 Mar;5(3):379-91. doi: 10.5966/sctm.2015-0103. Epub 2016 Jan 7.

16.

A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients.

Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP.

Mol Psychiatry. 2016 Oct;21(10):1372-80. doi: 10.1038/mp.2015.178. Epub 2015 Dec 8. Erratum in: Mol Psychiatry. 2016 Oct;21(10):1483-4.

17.

Analysis of graft survival in a trial of stem cell transplant in ALS.

Tadesse T, Gearing M, Senitzer D, Saxe D, Brat DJ, Bray R, Gebel H, Hill C, Boulis N, Riley J, Feldman E, Johe K, Hazel T, Polak M, Bordeau J, Federici T, Glass JD.

Ann Clin Transl Neurol. 2014 Nov;1(11):900-8. doi: 10.1002/acn3.134. Epub 2014 Oct 22.

18.

Autocrine production of IGF-I increases stem cell-mediated neuroprotection.

Lunn JS, Sakowski SA, McGinley LM, Pacut C, Hazel TG, Johe K, Feldman EL.

Stem Cells. 2015 May;33(5):1480-9. doi: 10.1002/stem.1933.

19.

Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines.

Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV.

PLoS One. 2014 Mar 10;9(3):e91408. doi: 10.1371/journal.pone.0091408. eCollection 2014.

20.

Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies.

Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M.

J Comp Neurol. 2014 Aug 15;522(12):2784-801. doi: 10.1002/cne.23575. Epub 2014 Apr 12. Review.

PMID:
24610493
21.

Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes.

Feldman EL, Boulis NM, Hur J, Johe K, Rutkove SB, Federici T, Polak M, Bordeau J, Sakowski SA, Glass JD.

Ann Neurol. 2014 Mar;75(3):363-73. doi: 10.1002/ana.24113. Epub 2014 Mar 7.

22.

Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I trial, cervical microinjection, and final surgical safety outcomes.

Riley J, Glass J, Feldman EL, Polak M, Bordeau J, Federici T, Johe K, Boulis NM.

Neurosurgery. 2014 Jan;74(1):77-87. doi: 10.1227/NEU.0000000000000156.

PMID:
24018694
23.

Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation.

Acharya MM, Christie LA, Hazel TG, Johe KK, Limoli CL.

Cell Transplant. 2014;23(10):1255-66. doi: 10.3727/096368913X670200. Epub 2013 Jul 17.

24.

Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival.

Sevc J, Goldberg D, van Gorp S, Leerink M, Juhas S, Juhasova J, Marsala S, Hruska-Plochan M, Hefferan MP, Motlik J, Rypacek F, Machova L, Kakinohana O, Santucci C, Johe K, Lukacova N, Yamada K, Bui JD, Marsala M.

Exp Neurol. 2013 Oct;248:85-99. doi: 10.1016/j.expneurol.2013.05.017. Epub 2013 Jun 5.

PMID:
23748136
25.

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation.

van Gorp S, Leerink M, Kakinohana O, Platoshyn O, Santucci C, Galik J, Joosten EA, Hruska-Plochan M, Goldberg D, Marsala S, Johe K, Ciacci JD, Marsala M.

Stem Cell Res Ther. 2013 May 28;4(3):57. doi: 10.1186/scrt209.

26.

Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation.

Hefferan MP, Galik J, Kakinohana O, Sekerkova G, Santucci C, Marsala S, Navarro R, Hruska-Plochan M, Johe K, Feldman E, Cleveland DW, Marsala M.

PLoS One. 2012;7(8):e42614. doi: 10.1371/journal.pone.0042614. Epub 2012 Aug 20.

27.

Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients.

Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman EL.

Stem Cells. 2012 Jun;30(6):1144-51. doi: 10.1002/stem.1079.

28.

Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study.

Navarro R, Juhas S, Keshavarzi S, Juhasova J, Motlik J, Johe K, Marsala S, Scadeng M, Lazar P, Tomori Z, Schulteis G, Beattie M, Ciacci JD, Marsala M.

J Neurotrauma. 2012 Feb 10;29(3):499-513. doi: 10.1089/neu.2011.2076. Epub 2012 Jan 13.

29.

Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS.

Hefferan MP, Johe K, Hazel T, Feldman EL, Lunn JS, Marsala M.

Cell Transplant. 2011;20(8):1153-61. doi: 10.3727/096368910X564553. Epub 2011 Jun 9.

PMID:
21669047
30.

Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats.

Xu L, Shen P, Hazel T, Johe K, Koliatsos VE.

Neurosci Lett. 2011 May 2;494(3):222-6. doi: 10.1016/j.neulet.2011.03.017. Epub 2011 Mar 21.

31.

Cervical multilevel intraspinal stem cell therapy: assessment of surgical risks in Gottingen minipigs.

Raore B, Federici T, Taub J, Wu MC, Riley J, Franz CK, Kliem MA, Snyder B, Feldman EL, Johe K, Boulis NM.

Spine (Phila Pa 1976). 2011 Feb 1;36(3):E164-71. doi: 10.1097/BRS.0b013e3181d77a47.

PMID:
21099736
32.

Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs.

Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M.

Cell Transplant. 2010;19(9):1103-22. doi: 10.3727/096368910X503406. Epub 2010 Apr 21.

PMID:
20412634
33.

The pleotrophic effects of insulin-like growth factor-I on human spinal cord neural progenitor cells.

Lunn JS, Pacut C, Backus C, Hong Y, Johe K, Hefferan M, Marsala M, Feldman EL.

Stem Cells Dev. 2010 Dec;19(12):1983-93. doi: 10.1089/scd.2010.0003. Epub 2010 Oct 7.

34.

Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons.

Guo X, Johe K, Molnar P, Davis H, Hickman J.

J Tissue Eng Regen Med. 2010 Mar;4(3):181-93. doi: 10.1002/term.223.

35.

Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry.

Xu L, Ryugo DK, Pongstaporn T, Johe K, Koliatsos VE.

J Comp Neurol. 2009 Jun 1;514(4):297-309. doi: 10.1002/cne.22022.

36.

Effects of Sertoli cell-conditioned medium on ventral midbrain neural stem cells: a preliminary report.

Shamekh R, Saporta S, Cameron DF, Willing AE, Sanberg CD, Johe K, Sanberg PR.

Neurotox Res. 2008 May-Jun;13(3-4):241-6.

PMID:
18522903
37.

Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells.

Cizkova D, Kakinohana O, Kucharova K, Marsala S, Johe K, Hazel T, Hefferan MP, Marsala M.

Neuroscience. 2007 Jun 29;147(2):546-60. Epub 2007 May 23.

38.

Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord.

Yan J, Xu L, Welsh AM, Hatfield G, Hazel T, Johe K, Koliatsos VE.

PLoS Med. 2007 Feb;4(2):e39.

39.

ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells.

Biton S, Gropp M, Itsykson P, Pereg Y, Mittelman L, Johe K, Reubinoff B, Shiloh Y.

DNA Repair (Amst). 2007 Jan 4;6(1):128-34. Epub 2006 Dec 18.

PMID:
17178256
40.

Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats.

Xu L, Yan J, Chen D, Welsh AM, Hazel T, Johe K, Hatfield G, Koliatsos VE.

Transplantation. 2006 Oct 15;82(7):865-75.

PMID:
17038899
41.
42.

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

Johe KK, Hazel TG, Muller T, Dugich-Djordjevic MM, McKay RD.

Genes Dev. 1996 Dec 15;10(24):3129-40.

43.

Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons.

Vicario-Abejón C, Johe KK, Hazel TG, Collazo D, McKay RD.

Neuron. 1995 Jul;15(1):105-14.

44.

Biochemistry and molecular biology of MNSs blood group antigens.

Huang CH, Johe KK, Seifter S, Blumenfeld OO.

Baillieres Clin Haematol. 1991 Dec;4(4):821-48. Review.

PMID:
1686414
46.

Amino acid sequence of an alpha-delta-glycophorin hybrid. A structure reciprocal to Sta delta-alpha-glycophorin hybrid.

Johe KK, Smith AJ, Vengelen-Tyler V, Blumenfeld OO.

J Biol Chem. 1989 Oct 15;264(29):17486-93.

47.

Studies on the ionic mechanism for the neuromodulatory actions of adenosine in the brain.

Michaelis ML, Johe KK, Moghadam B, Adams RN.

Brain Res. 1988 Nov 15;473(2):249-60.

PMID:
2466522
48.

Delta glycophorin (glycophorin B) gene deletion in two individuals homozygous for the S--s--U-- blood group phenotype.

Huang CH, Johe K, Moulds JJ, Siebert PD, Fukuda M, Blumenfeld OO.

Blood. 1987 Dec;70(6):1830-5.

49.

Age-dependent alterations in synaptic membrane systems for Ca2+ regulation.

Michaelis ML, Johe K, Kitos TE.

Mech Ageing Dev. 1984 Apr-May;25(1-2):215-25.

PMID:
6144821

Supplemental Content

Support Center