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Items: 1 to 50 of 877

1.

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.

Noel M, O'Reilly EM, Wolpin BM, Ryan DP, Bullock AJ, Britten CD, Linehan DC, Belt BA, Gamelin EC, Ganguly B, Yin D, Joh T, Jacobs IA, Taylor CT, Lowery MA.

Invest New Drugs. 2019 Jul 12. doi: 10.1007/s10637-019-00830-3. [Epub ahead of print]

PMID:
31297636
2.

Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.

Maekawa M, Hiyoshi H, Nakayama J, Kido K, Sawasaki T, Semba K, Kubota E, Joh T, Higashiyama S.

Biochem Biophys Res Commun. 2019 Sep 3;516(4):1116-1122. doi: 10.1016/j.bbrc.2019.07.010. Epub 2019 Jul 5.

3.

Correction to: Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study.

Isshi K, Matsuhashi N, Joh T, Higuchi K, Iwakiri K, Kamiya T, Manabe N, Ogawa M, Arihiro S, Haruma K, Nakada K.

J Gastroenterol. 2019 May;54(5):480-483. doi: 10.1007/s00535-019-01557-x.

PMID:
30859319
4.

Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study.

Isshi K, Matsuhashi N, Joh T, Higuchi K, Iwakiri K, Kamiya T, Manabe N, Ogawa M, Arihiro S, Haruma K, Nakada K.

J Gastroenterol. 2019 Jun;54(6):492-500. doi: 10.1007/s00535-019-01546-0. Epub 2019 Jan 23. Erratum in: J Gastroenterol. 2019 May;54(5):480-483.

PMID:
30673836
5.

Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial.

Gumbiner B, Esteves B, Dell V, Joh T, Garzone PD, Forgie A, Udata C.

Endocrine. 2018 Nov;62(2):371-380. doi: 10.1007/s12020-018-1597-1. Epub 2018 Sep 10.

PMID:
30203123
6.

Endoscopic submucosal resection with an endoscopic variceal ligation device for the treatment of rectal neuroendocrine tumors.

Ebi M, Nakagawa S, Yamaguchi Y, Tamura Y, Izawa S, Hijikata Y, Shimura T, Funaki Y, Ogasawara N, Sasaki M, Joh T, Kasugai K.

Int J Colorectal Dis. 2018 Dec;33(12):1703-1708. doi: 10.1007/s00384-018-3152-1. Epub 2018 Aug 30.

PMID:
30167779
7.

A Case of Euthyroid Graves' Ophthalmopathy in a Patient Sero-Negative for TSH Receptor Autoantibody.

Hotta A, Tanaka T, Kato H, Kakoi S, Shimizu Y, Hasegawa C, Hayakawa A, Yasuda S, Ogawa K, Ito S, Ohguchi H, Yagi T, Koyama H, Kawamura M, Sugitani K, Ogura Y, Joh T, Imaeda K.

Case Rep Endocrinol. 2018 Jun 13;2018:1707959. doi: 10.1155/2018/1707959. eCollection 2018.

8.

Long-term Outcomes of One Stage Surgery Using Transanal Colorectal Tube for Acute Colorectal Obstruction of Stage II/III Distal Colon Cancer.

Okuda Y, Yamada T, Hirata Y, Shimura T, Yamaguchi R, Sakamoto E, Sobue S, Nakazawa T, Kataoka H, Joh T.

Cancer Res Treat. 2019 Apr;51(2):474-482. doi: 10.4143/crt.2018.059. Epub 2018 Jun 6.

9.

Combination Therapy With Intensive Granulocyte and Monocyte Adsorptive Apheresis Plus Ustekinumab in Patients With Refractory Crohn's Disease.

Tanida S, Mizoshita T, Ozeki K, Katano T, Tanaka M, Nishie H, Shimura T, Okamoto Y, Kubota E, Kataoka H, Joh T.

Ther Apher Dial. 2018 Jun;22(3):295-300. doi: 10.1111/1744-9987.12697. Epub 2018 May 23.

PMID:
29790276
10.

The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib.

Mori Y, Kinoshita S, Kanamori T, Kataoka H, Joh T, Iida S, Takemoto M, Kondo M, Kuroda J, Komatsu H.

Intern Med. 2018 Sep 15;57(18):2753-2757. doi: 10.2169/internalmedicine.9879-17. Epub 2018 May 18.

11.

The utility and efficacy of self-expandable metal stents for treating malignant gastric outlet obstructions in patients under best supportive care.

Hori Y, Naitoh I, Hayashi K, Miyabe K, Yoshida M, Fujita Y, Natsume M, Jinno N, Kato A, Nakazawa T, Shimizu S, Hirano A, Okumura F, Ando T, Sano H, Takada H, Togawa S, Joh T.

Support Care Cancer. 2018 Oct;26(10):3587-3592. doi: 10.1007/s00520-018-4221-2. Epub 2018 May 3.

PMID:
29725801
12.

An Autopsy Case of Pulmonary Tumor Thrombotic Microangiopathy Due to Rapidly Progressing Colon Cancer in a Patient with Type 2 Diabetes.

Ohguchi H, Imaeda K, Hotta A, Kakoi S, Yasuda S, Shimizu Y, Hayakawa A, Mishina H, Hasegawa C, Ito S, Ogawa K, Yagi T, Koyama H, Tanaka T, Kato H, Takahashi S, Joh T.

Intern Med. 2018 Sep 1;57(17):2533-2539. doi: 10.2169/internalmedicine.0204-17. Epub 2018 Mar 30.

13.

Case of pancreatic metastasis from colon cancer in which cell block using the Trefle® endoscopic scraper enables differential diagnosis from pancreatic cancer.

Kato A, Naitoh I, Kato H, Hayashi K, Miyabe K, Yoshida M, Hori Y, Natsume M, Jinno N, Yanagita T, Takiguchi S, Takahashi S, Joh T.

World J Gastrointest Oncol. 2018 Mar 15;10(3):91-95. doi: 10.4251/wjgo.v10.i3.91.

14.

Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways.

Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T.

Oncotarget. 2018 Jan 31;9(12):10650-10664. doi: 10.18632/oncotarget.24367. eCollection 2018 Feb 13.

15.

Differential diagnosis of cholangiocarcinoma and IgG4-related sclerosing cholangitis by fluorescence in situ hybridization using transpapillary forceps biopsy specimens.

Kato A, Naitoh I, Miyabe K, Hayashi K, Kondo H, Yoshida M, Kato H, Kuno T, Takahashi S, Joh T.

J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):188-194. doi: 10.1002/jhbp.536.

PMID:
29532638
16.

Refractory gastric antral ulcers without Helicobacter pylori infection and non-steroidal anti-inflammatory drugs.

Nishie H, Kataoka H, Kato H, Suzuki T, Ichikawa H, Nojiri Y, Kitagawa M, Inagaki Y, Iwasaki H, Tanaka M, Katano T, Okamoto Y, Ozeki K, Mizoshita T, Shimura T, Kubota E, Tanida S, Joh T.

Clin J Gastroenterol. 2018 Jun;11(3):251-256. doi: 10.1007/s12328-018-0835-7. Epub 2018 Feb 16.

PMID:
29453508
17.

Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e6.

Nishie H, Kataoka H, Yano S, Yamaguchi H, Nomoto A, Tanaka M, Kato A, Shimura T, Mizoshita T, Kubota E, Tanida S, Joh T.

Biochem Biophys Res Commun. 2018 Feb 19;496(4):1204-1209. doi: 10.1016/j.bbrc.2018.01.171. Epub 2018 Jan 31.

PMID:
29408755
18.

Questionnaire-Based Survey on Gastrointestinal Bleeding and Management of Antithrombotic Agents during Endoscopy Among Asian Countries.

Tsuruoka N, Iwakiri R, Sakata Y, Fujimoto K, Kamiya T, Joh T, Tokunaga K, Takahashi S, Kinoshita Y, Uchiyama K, Naito Y, Nagahara A, Watanabe T, Chan FKL, Hahm KB, Kachintorn U, Fock KM, Syam AF, Rani AA, Sollano JD, Zhu Q.

Digestion. 2018;97(1):97-106. doi: 10.1159/000484228. Epub 2018 Feb 2.

19.

Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells.

Inagaki Y, Kubota E, Mori Y, Aoyama M, Kataoka H, Johnston RN, Joh T.

Oncotarget. 2017 Dec 18;8(70):115632-115646. doi: 10.18632/oncotarget.23361. eCollection 2017 Dec 29.

20.

The absence of class III β-tubulin is predictive of a favorable response to nab-paclitaxel and gemcitabine in patients with unresectable pancreatic ductal adenocarcinoma.

Kato A, Naiki-Ito A, Naitoh I, Hayashi K, Nakazawa T, Shimizu S, Nishi Y, Okumura F, Inoue T, Takada H, Kondo H, Yoshida M, Takahashi S, Joh T.

Hum Pathol. 2018 Apr;74:92-98. doi: 10.1016/j.humpath.2018.01.009. Epub 2018 Jan 12.

PMID:
29339176
21.

Corrigendum: The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.

Sakaue T, Sakakibara I, Uesugi T, Fujisaki A, Nakashiro KI, Hamakawa H, Kubota E, Joh T, Imai Y, Izutani H, Higashiyama S.

Sci Rep. 2017 Dec 22;7:46915. doi: 10.1038/srep46915.

22.

Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature.

Yoshida M, Marumo Y, Naitoh I, Hayashi K, Miyabe K, Nishi Y, Fujita Y, Jinno N, Hori Y, Natsume M, Kato A, Iida S, Joh T.

Intern Med. 2018 Jun 15;57(12):1725-1732. doi: 10.2169/internalmedicine.9818-17. Epub 2017 Dec 21.

23.

Percutaneous Transhepatic Self-expanding Metallic Stent Placement for the Treatment of Malignant Afferent Loop Obstruction.

Jinno N, Naitoh I, Nagura Y, Fujioka K, Mizuno Y, Momose J, Ooyama M, Hayashi K, Miyaki T, Nakamura M, Joh T.

Intern Med. 2018 Feb 1;57(3):333-337. doi: 10.2169/internalmedicine.9382-17. Epub 2017 Nov 1.

24.

The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.

Gumbiner B, Joh T, Liang H, Wan H, Levisetti M, Vana AM, Shelton DL, Forgues P, Billotte S, Pons J, Baum CM, Garzone PD.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12309. Epub 2017 Nov 23.

PMID:
29078037
25.

Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin.

Fazio S, Robertson DG, Joh T, Wan H, Riel T, Forgues P, Baum CM, Garzone PD, Gumbiner B.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12308. Epub 2017 Nov 25.

PMID:
29057618
26.

Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells.

Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S.

Biol Open. 2017 Nov 15;6(11):1707-1719. doi: 10.1242/bio.029579.

27.

Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition with Bococizumab on Lipoprotein Particles in Hypercholesterolemic Subjects.

Wan H, Gumbiner B, Joh T, Riel T, Udata C, Forgues P, Garzone PD.

Clin Ther. 2017 Nov;39(11):2243-2259.e5. doi: 10.1016/j.clinthera.2017.09.009. Epub 2017 Oct 14.

PMID:
29037448
28.

Transglucosidase improves the bowel movements in type 2 diabetes mellitus patients: A preliminary randomized double-blind, placebo-controlled study.

Shimozato A, Sasaki M, Ogasawara N, Funaki Y, Ebi M, Goto C, Koikeda S, Joh T, Kasugai K.

United European Gastroenterol J. 2017 Oct;5(6):898-907. doi: 10.1177/2050640617692268. Epub 2017 Jan 31.

29.

Covered duodenal self-expandable metal stents prolong biliary stent patency in double stenting: The largest series of bilioduodenal obstruction.

Hori Y, Naitoh I, Hayashi K, Kondo H, Yoshida M, Shimizu S, Hirano A, Okumura F, Ando T, Jinno N, Takada H, Togawa S, Joh T.

J Gastroenterol Hepatol. 2018 Mar;33(3):696-703. doi: 10.1111/jgh.13977.

PMID:
28902972
30.

Development and validation of a simple and multifaceted instrument, GERD-TEST, for the clinical evaluation of gastroesophageal reflux and dyspeptic symptoms.

Nakada K, Matsuhashi N, Iwakiri K, Oshio A, Joh T, Higuchi K, Haruma K.

World J Gastroenterol. 2017 Jul 28;23(28):5216-5228. doi: 10.3748/wjg.v23.i28.5216.

31.

Prospective comparison of preference and efficacy of adalimumab and infliximab for treating ulcerative colitis naive to antitumor necrosis factor therapy.

Mizoshita T, Katano T, Tanida S, Hirano A, Miyaki T, Ozeki K, Suzuki Y, Sugimura N, Kataoka H, Joh T.

Medicine (Baltimore). 2017 Aug;96(32):e7800. doi: 10.1097/MD.0000000000007800.

32.

Stable Isotope Analysis of Hydrogen and Oxygen in a Traditional Japanese Alcoholic Beverage, Sake, from Niigata Prefecture in Japan and Other Countries.

Kuribayashi T, Sugawara M, Sato K, Nabekura Y, Aoki T, Kano N, Joh T, Kaneoke M.

Anal Sci. 2017;33(8):979-982. doi: 10.2116/analsci.33.979.

33.

Expression and subcellular localization of AT motif binding factor 1 in colon tumours.

Kataoka H, Miura Y, Kawaguchi M, Suzuki S, Okamoto Y, Ozeki K, Shimura T, Mizoshita T, Kubota E, Tanida S, Takahashi S, Asai K, Joh T.

Mol Med Rep. 2017 Sep;16(3):3095-3102. doi: 10.3892/mmr.2017.7016. Epub 2017 Jul 15.

34.

Mechanisms of PTHrP-induced inhibition of smooth muscle contractility in the guinea pig gastric antrum.

Ohguchi H, Mitsui R, Imaeda K, Joh T, Hashitani H.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13142. Epub 2017 Jun 28.

PMID:
28656682
35.

Novel non-canonical genetic rearrangements termed "complex structural variations" in HBV genome.

Fujiwara K, Matsunami K, Iio E, Nojiri S, Joh T.

Virus Res. 2017 Jun 15;238:84-93. doi: 10.1016/j.virusres.2017.06.009. Epub 2017 Jun 13.

PMID:
28627394
36.

New photodynamic therapy with next-generation photosensitizers.

Kataoka H, Nishie H, Hayashi N, Tanaka M, Nomoto A, Yano S, Joh T.

Ann Transl Med. 2017 Apr;5(8):183. doi: 10.21037/atm.2017.03.59. Review.

37.

Urinary kallikrein 10 predicts the incurability of gastric cancer.

Shimura T, Ebi M, Yamada T, Yamada T, Katano T, Nojiri Y, Iwasaki H, Nomura S, Hayashi N, Mori Y, Kataoka H, Moses MA, Joh T.

Oncotarget. 2017 Apr 25;8(17):29247-29257. doi: 10.18632/oncotarget.16453.

38.

A multicenter randomized trial comparing rabeprazole and itopride in patients with functional dyspepsia in Japan: the NAGOYA study.

Kamiya T, Shikano M, Kubota E, Mizoshita T, Wada T, Tanida S, Kataoka H, Adachi H, Hirako M, Okuda N, Joh T.

J Clin Biochem Nutr. 2017 Mar;60(2):130-135. doi: 10.3164/jcbn.16-106. Epub 2017 Feb 24.

39.

Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer.

Kato A, Kataoka H, Yano S, Hayashi K, Hayashi N, Tanaka M, Naitoh I, Ban T, Miyabe K, Kondo H, Yoshida M, Fujita Y, Hori Y, Natsume M, Murakami T, Narumi A, Nomoto A, Naiki-Ito A, Takahashi S, Joh T.

Mol Cancer Ther. 2017 Jun;16(6):1124-1132. doi: 10.1158/1535-7163.MCT-16-0670. Epub 2017 Mar 14.

40.

Predictors of stent dysfunction after self-expandable metal stent placement for malignant gastric outlet obstruction: tumor ingrowth in uncovered stents and migration of covered stents.

Hori Y, Naitoh I, Hayashi K, Ban T, Natsume M, Okumura F, Nakazawa T, Takada H, Hirano A, Jinno N, Togawa S, Ando T, Kataoka H, Joh T.

Surg Endosc. 2017 Oct;31(10):4165-4173. doi: 10.1007/s00464-017-5471-7. Epub 2017 Mar 9.

PMID:
28281116
41.

Adalimumab therapy in a patient with Crohn's disease with a giant pelvic paraganglioma after chemotherapy.

Mizoshita T, Ando M, Sagawa H, Mori Y, Katano T, Ozeki K, Tanida S, Okamoto Y, Shimura T, Kubota E, Kataoka H, Kamiya T, Joh T.

Clin J Gastroenterol. 2017 Jun;10(3):250-254. doi: 10.1007/s12328-017-0726-3. Epub 2017 Mar 7.

PMID:
28271435
42.

The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.

Sakaue T, Sakakibara I, Uesugi T, Fujisaki A, Nakashiro KI, Hamakawa H, Kubota E, Joh T, Imai Y, Izutani H, Higashiyama S.

Sci Rep. 2017 Feb 20;7:42845. doi: 10.1038/srep42845. Erratum in: Sci Rep. 2017 Dec 22;7:46915.

43.

A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development.

Udata C, Garzone PD, Gumbiner B, Joh T, Liang H, Liao KH, Williams JH, Meng X.

J Clin Pharmacol. 2017 Jul;57(7):855-864. doi: 10.1002/jcph.867. Epub 2017 Feb 9.

PMID:
28181260
44.

Bovine lactoferrin and Crohn's disease: a case study.

Alexander DB, Iigo M, Abdelgied M, Ozeki K, Tanida S, Joh T, Takahashi S, Tsuda H.

Biochem Cell Biol. 2017 Feb;95(1):133-141. doi: 10.1139/bcb-2016-0107. Epub 2016 Nov 30.

PMID:
28165294
45.

Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study.

Sakaguchi M, Manabe N, Ueki N, Miwa J, Inaba T, Yoshida N, Sakurai K, Nakagawa M, Yamada H, Saito M, Nakada K, Iwakiri K, Joh T, Haruma K.

World J Gastroenterol. 2017 Jan 14;23(2):318-327. doi: 10.3748/wjg.v23.i2.318.

46.

Asian Perspectives on Diagnostic and Therapeutic Strategies in Inflammatory Bowel Disease: Report and Analysis of a Survey with Questionnaires.

Yoshida A, Ueno F, Morizane T, Joh T, Kamiya T, Takahashi S, Tokunaga K, Iwakiri R, Kinoshita Y, Suzuki H, Naito Y, Uchiyama K, Fukodo S, Chan FK, Halm KB, Kachintorn U, Fock KM, Rani AA, Syam AF, Sollano JD, Zhu Q; International Gastroenterology Consensus Symposium Study Group.

Digestion. 2017;95(1):79-88. doi: 10.1159/000453007. Epub 2017 Jan 5.

PMID:
28052284
47.

Novel characteristics of traction force in biliary self-expandable metallic stents.

Hori Y, Hayashi K, Yoshida M, Naitoh I, Ban T, Miyabe K, Kondo H, Nishi Y, Umemura S, Fujita Y, Natsume M, Kato A, Ohara H, Joh T.

Dig Endosc. 2017 May;29(3):347-352. doi: 10.1111/den.12796. Epub 2017 Apr 10.

PMID:
28032654
48.

Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.

Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.

Cancer Sci. 2017 Feb;108(2):208-215. doi: 10.1111/cas.13133.

49.

Effects of branched-chain amino acid supplementation after radiofrequency ablation for hepatocellular carcinoma: A randomized trial.

Nojiri S, Fujiwara K, Shinkai N, Iio E, Joh T.

Nutrition. 2017 Jan;33:20-27. doi: 10.1016/j.nut.2016.07.013. Epub 2016 Aug 8.

PMID:
27908546
50.

A Phase I Randomized Study of a Specifically Engineered, pH-Sensitive PCSK9 Inhibitor RN317 (PF-05335810) in Hypercholesterolemic Subjects on Statin Therapy.

Levisetti M, Joh T, Wan H, Liang H, Forgues P, Gumbiner B, Garzone PD.

Clin Transl Sci. 2017 Jan;10(1):3-11. doi: 10.1111/cts.12430. Epub 2016 Nov 17.

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