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Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.

Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C, Nadjar A, Layé S.

Brain Behav Immun. 2018 Jun 4. pii: S0889-1591(18)30220-4. doi: 10.1016/j.bbi.2018.06.004. [Epub ahead of print]


Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AAD, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2018 Apr 27;9(32):22870. doi: 10.18632/oncotarget.25335. eCollection 2018 Apr 27.


Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring.

Rey C, Nadjar A, Joffre F, Amadieu C, Aubert A, Vaysse C, Pallet V, Layé S, Joffre C.

Prostaglandins Leukot Essent Fatty Acids. 2018 Jun;133:1-7. doi: 10.1016/j.plefa.2018.04.003. Epub 2018 Apr 25.


Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology.

Layé S, Nadjar A, Joffre C, Bazinet RP.

Pharmacol Rev. 2018 Jan;70(1):12-38. doi: 10.1124/pr.117.014092. Review.


Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia.

Heydt Q, Larrue C, Saland E, Bertoli S, Sarry JE, Besson A, Manenti S, Joffre C, Mansat-De Mas V.

Oncogene. 2018 Feb 8;37(6):787-797. doi: 10.1038/onc.2017.376. Epub 2017 Oct 23.


Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats.

Rincel M, Lépinay AL, Janthakhin Y, Soudain G, Yvon S, Da Silva S, Joffre C, Aubert A, Séré A, Layé S, Theodorou V, Ferreira G, Darnaudéry M.

Brain Struct Funct. 2018 Mar;223(2):883-895. doi: 10.1007/s00429-017-1526-8. Epub 2017 Oct 11.


Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro.

Fourrier C, Remus-Borel J, Greenhalgh AD, Guichardant M, Bernoud-Hubac N, Lagarde M, Joffre C, Layé S.

J Neuroinflammation. 2017 Aug 24;14(1):170. doi: 10.1186/s12974-017-0939-x.


Amplification of mGlu5-Endocannabinoid Signaling Rescues Behavioral and Synaptic Deficits in a Mouse Model of Adolescent and Adult Dietary Polyunsaturated Fatty Acid Imbalance.

Manduca A, Bara A, Larrieu T, Lassalle O, Joffre C, Layé S, Manzoni OJ.

J Neurosci. 2017 Jul 19;37(29):6851-6868. doi: 10.1523/JNEUROSCI.3516-16.2017. Epub 2017 Jun 19.


[The yin and the yang of autophagy in cancer cells].

Joffre C, Djavaheri-Mergny M, Pattingre S, Giuriato S.

Med Sci (Paris). 2017 Mar;33(3):328-334. doi: 10.1051/medsci/20173303021. Epub 2017 Apr 3. Review. French.


Modulation of brain PUFA content in different experimental models of mice.

Joffre C, Grégoire S, De Smedt V, Acar N, Bretillon L, Nadjar A, Layé S.

Prostaglandins Leukot Essent Fatty Acids. 2016 Nov;114:1-10. doi: 10.1016/j.plefa.2016.09.003. Epub 2016 Sep 30.


Impact of Lactobacillus fermentum and dairy lipids in the maternal diet on the fatty acid composition of pups' brain and peripheral tissues.

Joffre C, Dinel AL, Aubert A, Fressange-Mazda C, Le Ruyet P, Layé S.

Prostaglandins Leukot Essent Fatty Acids. 2016 Dec;115:24-34. doi: 10.1016/j.plefa.2016.10.002. Epub 2016 Oct 11.


Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota.

Madore C, Leyrolle Q, Lacabanne C, Benmamar-Badel A, Joffre C, Nadjar A, Layé S.

Neural Plast. 2016;2016:3597209. Epub 2016 Oct 20. Review.


Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood.

Dinel AL, Rey C, Baudry C, Fressange-Mazda C, Le Ruyet P, Nadjar A, Pallet P, Joffre C, Layé S.

Prostaglandins Leukot Essent Fatty Acids. 2016 Oct;113:9-18. doi: 10.1016/j.plefa.2016.08.013. Epub 2016 Aug 24.


Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robbez-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S.

Nat Commun. 2016 Jul 22;7:12392. doi: 10.1038/ncomms12392. No abstract available.


Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology.

Nadjar A, Leyrolle Q, Joffre C, Laye S.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt A):19-26. doi: 10.1016/j.pnpbp.2016.07.004. Epub 2016 Jul 5. Review.


Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robert-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S.

Nat Commun. 2016 Jun 23;7:11942. doi: 10.1038/ncomms11942.


Children with Down syndrome: Clinical course and mortality-associated factors in a French medical paediatric intensive care unit.

Joffre C, Lesage F, Bustarret O, Hubert P, Oualha M.

J Paediatr Child Health. 2016 Jun;52(6):595-9. doi: 10.1111/jpc.13214.


Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.

Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AA, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A.

Oncotarget. 2016 Jul 12;7(28):44142-44160. doi: 10.18632/oncotarget.9875. Erratum in: Oncotarget. 2018 Apr 27;9(32):22870.


Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice.

Dinel AL, Rey C, Bonhomme C, Le Ruyet P, Joffre C, Layé S.

Prostaglandins Leukot Essent Fatty Acids. 2016 Jun;109:29-38. doi: 10.1016/j.plefa.2016.03.013. Epub 2016 Apr 20.


STK38 at the crossroad between autophagy and apoptosis.

Joffre C, Codogno P, Fanto M, Hergovich A, Camonis J.

Autophagy. 2016;12(3):594-5. doi: 10.1080/15548627.2015.1135283. Epub 2016 Feb 18.


Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro.

Rey C, Nadjar A, Buaud B, Vaysse C, Aubert A, Pallet V, Layé S, Joffre C.

Brain Behav Immun. 2016 Jul;55:249-259. doi: 10.1016/j.bbi.2015.12.013. Epub 2015 Dec 21.


The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.

Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C, Cascone I, Codogno P, Fanto M, Hergovich A, Camonis J.

Curr Biol. 2015 Oct 5;25(19):2479-92. doi: 10.1016/j.cub.2015.08.031. Epub 2015 Sep 17.


Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.

Larrue C, Saland E, Boutzen H, Vergez F, David M, Joffre C, Hospital MA, Tamburini J, Delabesse E, Manenti S, Sarry JE, Récher C.

Blood. 2016 Feb 18;127(7):882-92. doi: 10.1182/blood-2015-05-646497. Epub 2015 Aug 18.


Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment.

Delpech JC, Thomazeau A, Madore C, Bosch-Bouju C, Larrieu T, Lacabanne C, Remus-Borel J, Aubert A, Joffre C, Nadjar A, Layé S.

Neuropsychopharmacology. 2015 Nov;40(12):2774-87. doi: 10.1038/npp.2015.127. Epub 2015 May 7.


Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding.

Lépinay AL, Larrieu T, Joffre C, Acar N, Gárate I, Castanon N, Ferreira G, Langelier B, Guesnet P, Brétillon L, Parnet P, Layé S, Darnaudéry M.

Psychoneuroendocrinology. 2015 Mar;53:82-93. doi: 10.1016/j.psyneuen.2014.12.008. Epub 2014 Dec 15.


Microglia in neuronal plasticity: Influence of stress.

Delpech JC, Madore C, Nadjar A, Joffre C, Wohleb ES, Layé S.

Neuropharmacology. 2015 Sep;96(Pt A):19-28. doi: 10.1016/j.neuropharm.2014.12.034. Epub 2015 Jan 9. Review.


Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers.

Lefort S, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F.

Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788.


Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation.

Delpech JC, Madore C, Joffre C, Aubert A, Kang JX, Nadjar A, Layé S.

Neuropsychopharmacology. 2015 Feb;40(3):525-36. doi: 10.1038/npp.2014.196. Epub 2014 Aug 5.


Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood.

Dinel AL, Joffre C, Trifilieff P, Aubert A, Foury A, Le Ruyet P, Layé S.

J Neuroinflammation. 2014 Sep 17;11:155. doi: 10.1186/s12974-014-0155-x.


Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice.

Pietropaolo S, Goubran MG, Joffre C, Aubert A, Lemaire-Mayo V, Crusio WE, Layé S.

Psychoneuroendocrinology. 2014 Nov;49:119-29. doi: 10.1016/j.psyneuen.2014.07.002. Epub 2014 Jul 9.


n-3 LCPUFA improves cognition: the young, the old and the sick.

Joffre C, Nadjar A, Lebbadi M, Calon F, Laye S.

Prostaglandins Leukot Essent Fatty Acids. 2014 Jul-Aug;91(1-2):1-20. doi: 10.1016/j.plefa.2014.05.001. Epub 2014 May 14. Review.


Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes.

Madore C, Nadjar A, Delpech JC, Sere A, Aubert A, Portal C, Joffre C, Layé S.

Brain Behav Immun. 2014 Oct;41:22-31. doi: 10.1016/j.bbi.2014.03.021. Epub 2014 Apr 13.


Measuring the role for Met endosomal signaling in tumorigenesis.

Barrow R, Joffre C, Ménard L, Kermorgant S.

Methods Enzymol. 2014;535:121-40. doi: 10.1016/B978-0-12-397925-4.00008-0.


Medical education in Ecuador.

Joffre CP, Delgado B, Kosik RO, Huang L, Zhao X, Su TP, Wang SJ, Chen Q, Fan AP.

Med Teach. 2013 Dec;35(12):979-84. doi: 10.3109/0142159X.2013.826789. Epub 2013 Sep 4.


Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide.

Madore C, Joffre C, Delpech JC, De Smedt-Peyrusse V, Aubert A, Coste L, Layé S, Nadjar A.

Brain Behav Immun. 2013 Nov;34:151-8. doi: 10.1016/j.bbi.2013.08.008. Epub 2013 Aug 29.


Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice.

Larrieu T, Madore C, Joffre C, Layé S.

J Physiol Biochem. 2012 Dec;68(4):671-81. doi: 10.1007/s13105-012-0179-6. Epub 2012 Jun 16.


Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.

Labrousse VF, Nadjar A, Joffre C, Costes L, Aubert A, Grégoire S, Bretillon L, Layé S.

PLoS One. 2012;7(5):e36861. doi: 10.1371/journal.pone.0036861. Epub 2012 May 25.


Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice.

Moranis A, Delpech JC, De Smedt-Peyrusse V, Aubert A, Guesnet P, Lavialle M, Joffre C, Layé S.

Brain Behav Immun. 2012 Jul;26(5):721-31. doi: 10.1016/j.bbi.2011.11.001. Epub 2011 Nov 9.


Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells.

Viau S, Leclère L, Buteau B, Grégoire S, Acar N, Bron A, Creuzot-Garcher CP, Bretillon L, Joffre C.

Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):211-22. doi: 10.1007/s00417-011-1801-y. Epub 2011 Sep 6.


A direct role for Met endocytosis in tumorigenesis.

Joffre C, Barrow R, Ménard L, Calleja V, Hart IR, Kermorgant S.

Nat Cell Biol. 2011 Jun 5;13(7):827-37. doi: 10.1038/ncb2257.


Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid.

Milanovic M, Radtke S, Peel N, Howell M, Carrière V, Joffre C, Kermorgant S, Parker PJ.

Int J Cancer. 2012 Mar 1;130(5):1060-70. doi: 10.1002/ijc.26066. Epub 2011 May 9.


No consequences of dietary n-3 polyunsaturated fatty acid deficiency on the severity of scopolamine-induced dry eye.

Viau S, Pasquis B, Maire MA, Fourgeux C, Grégoire S, Acar N, Bretillon L, Creuzot-Garcher CP, Joffre C.

Graefes Arch Clin Exp Ophthalmol. 2011 Apr;249(4):547-57. doi: 10.1007/s00417-010-1576-6. Epub 2010 Dec 16.


Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.


Differential effect of maternal diet supplementation with alpha-Linolenic adcid or n-3 long-chain polyunsaturated fatty acids on glial cell phosphatidylethanolamine and phosphatidylserine fatty acid profile in neonate rat brains.

Destaillats F, Joffre C, Acar N, Joffre F, Bezelgues JB, Pasquis B, Cruz-Hernandez C, Rezzi S, Montoliu I, Dionisi F, Bretillon L.

Nutr Metab (Lond). 2010 Jan 14;7:2. doi: 10.1186/1743-7075-7-2.


Red blood cell plasmalogens and docosahexaenoic acid are independently reduced in primary open-angle glaucoma.

Acar N, Berdeaux O, Juaneda P, Grégoire S, Cabaret S, Joffre C, Creuzot-Garcher CP, Bretillon L, Bron AM.

Exp Eye Res. 2009 Dec;89(6):840-53. doi: 10.1016/j.exer.2009.07.008. Epub 2009 Jul 21.


Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.

Fourgeux C, Martine L, Björkhem I, Diczfalusy U, Joffre C, Acar N, Creuzot-Garcher C, Bron A, Bretillon L.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5712-7. doi: 10.1167/iovs.09-3655. Epub 2009 Jun 24.


Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells.

Joffre C, Souchier M, Leclere L, Buteau B, Grégoire S, Lizard G, Montange T, Acar N, Bron A, Creuzot-Garcher C, Diebold Y, Bretillon L.

Br J Ophthalmol. 2009 Oct;93(10):1391-5. doi: 10.1136/bjo.2008.156356. Epub 2009 Jun 10.


Adipose-derived cardiomyogenic cells: in vitro expansion and functional improvement in a mouse model of myocardial infarction.

Léobon B, Roncalli J, Joffre C, Mazo M, Boisson M, Barreau C, Calise D, Arnaud E, André M, Pucéat M, Pénicaud L, Prosper F, Planat-Bénard V, Casteilla L.

Cardiovasc Res. 2009 Sep 1;83(4):757-67. doi: 10.1093/cvr/cvp167. Epub 2009 Jun 8.


Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation.

Schnebelen C, Viau S, Grégoire S, Joffre C, Creuzot-Garcher CP, Bron AM, Bretillon L, Acar N.

Ophthalmic Res. 2009;41(4):216-24. doi: 10.1159/000217726. Epub 2009 May 15.


A dietary combination of omega-3 and omega-6 polyunsaturated fatty acids is more efficient than single supplementations in the prevention of retinal damage induced by elevation of intraocular pressure in rats.

Schnebelen C, Pasquis B, Salinas-Navarro M, Joffre C, Creuzot-Garcher CP, Vidal-Sanz M, Bron AM, Bretillon L, Acar N.

Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1191-203. doi: 10.1007/s00417-009-1094-6. Epub 2009 May 13.


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