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Items: 1 to 50 of 83

1.

Dichotomous Role of TGF-β Controls Inducible Treg Cell Fate in Allergic Airway Disease Through Smad3 and TAK1.

Joetham A, Schedel M, Ning F, Wang M, Takeda K, Gelfand EW.

J Allergy Clin Immunol. 2019 Oct 15. pii: S0091-6749(19)31321-1. doi: 10.1016/j.jaci.2019.09.032. [Epub ahead of print]

PMID:
31626843
2.

Hypoxia enhances CD8+ TC2 cell-dependent airway hyperresponsiveness and inflammation through hypoxia-inducible factor 1α.

Ning F, Takeda K, Schedel M, Domenico J, Joetham A, Gelfand EW.

J Allergy Clin Immunol. 2019 Jun;143(6):2026-2037.e7. doi: 10.1016/j.jaci.2018.11.049. Epub 2019 Jan 17.

PMID:
30660639
3.

Spectrum of T-lymphocyte activities regulating allergic lung inflammation.

Gelfand EW, Joetham A, Wang M, Takeda K, Schedel M.

Immunol Rev. 2017 Jul;278(1):63-86. doi: 10.1111/imr.12561. Review.

4.

Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy.

Wang M, Yang IV, Davidson EJ, Joetham A, Takeda K, O'Connor BP, Gelfand EW.

J Allergy Clin Immunol. 2018 Feb;141(2):659-670.e2. doi: 10.1016/j.jaci.2017.04.020. Epub 2017 May 4.

5.

Dysregulation of metabolic pathways in a mouse model of allergic asthma.

Quinn KD, Schedel M, Nkrumah-Elie Y, Joetham A, Armstrong M, Cruickshank-Quinn C, Reisdorph R, Gelfand EW, Reisdorph N.

Allergy. 2017 Sep;72(9):1327-1337. doi: 10.1111/all.13144. Epub 2017 Mar 29.

PMID:
28213886
6.

Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.

Joetham A, Schedel M, O'Connor BP, Kim S, Takeda K, Abbott J, Gelfand EW.

J Allergy Clin Immunol. 2017 Apr;139(4):1331-1342. doi: 10.1016/j.jaci.2016.06.051. Epub 2016 Aug 16.

7.

1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.

Schedel M, Jia Y, Michel S, Takeda K, Domenico J, Joetham A, Ning F, Strand M, Han J, Wang M, Lucas JJ, Vogelberg C, Kabesch M, O'Connor BP, Gelfand EW.

Nat Commun. 2016 Jan 11;7:10213. doi: 10.1038/ncomms10213.

8.

JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.

Joetham A, Schedel M, Takeda K, Jia Y, Ashino S, Dakhama A, Lluis A, Okamoto M, Gelfand EW.

J Immunol. 2014 Sep 1;193(5):2238-47. doi: 10.4049/jimmunol.1400604. Epub 2014 Jul 28.

9.

Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.

Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine PR, Gelfand EW.

J Allergy Clin Immunol. 2014 Apr;133(4):1162-74. doi: 10.1016/j.jaci.2013.10.036. Epub 2013 Dec 22.

10.

Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation.

Jia Y, Takeda K, Han J, Joetham A, Marcus RA, Lucas JJ, O'Connor BP, Gelfand EW.

J Immunol. 2013 Apr 15;190(8):4056-65. doi: 10.4049/jimmunol.1202640. Epub 2013 Mar 18.

11.

Sequential engagement of FcεRI on Mast Cells and Basophil Histamine H(4) Receptor and FcεRI in Allergic Rhinitis.

Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, Gelfand EW.

J Immunol. 2013 Jan 15;190(2):539-48. doi: 10.4049/jimmunol.1202049. Epub 2012 Dec 14.

12.

Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.

Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, Gelfand EW.

J Biol Chem. 2012 May 18;287(21):17100-8. doi: 10.1074/jbc.M111.316943. Epub 2012 Mar 29.

13.

Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells.

Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW.

Int Arch Allergy Immunol. 2012;157(1):65-72. doi: 10.1159/000324836. Epub 2011 Sep 6.

14.

SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.

Peterson LK, Shaw LA, Joetham A, Sakaguchi S, Gelfand EW, Dragone LL.

J Immunol. 2011 Feb 15;186(4):2273-81. doi: 10.4049/jimmunol.1003601. Epub 2011 Jan 19.

15.

CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.

Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, Dakhama A, Gelfand EW.

J Immunol. 2011 Jan 1;186(1):113-20. doi: 10.4049/jimmunol.1001663. Epub 2010 Nov 29.

16.

Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway.

Wang M, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Joetham A, Gelfand EW.

J Allergy Clin Immunol. 2010 Aug;126(2):306-16, 316.e1-12. doi: 10.1016/j.jaci.2010.05.017. Epub 2010 Jul 10.

17.

Effects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammation.

Takeda K, Shiraishi Y, Matsubara S, Miyahara N, Matsuda H, Okamoto M, Joetham A, Gelfand EW.

Br J Pharmacol. 2010 Jul;160(6):1399-407. doi: 10.1111/j.1476-5381.2010.00797.x.

18.

Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.

Okamoto M, Matsuda H, Joetham A, Lucas JJ, Domenico J, Yasutomo K, Takeda K, Gelfand EW.

J Immunol. 2009 Sep 1;183(5):2995-3003. doi: 10.4049/jimmunol.0900692. Epub 2009 Aug 10.

19.

Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells.

Joetham A, Takeda K, Okamoto M, Taube C, Matsuda H, Dakhama A, Gelfand EW.

J Immunol. 2009 Aug 1;183(3):1821-7. doi: 10.4049/jimmunol.0900303. Epub 2009 Jul 10.

20.

Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation.

Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW.

J Immunol. 2009 Jul 1;183(1):181-90. doi: 10.4049/jimmunol.0803967.

21.

Leukotriene B4 release from mast cells in IgE-mediated airway hyperresponsiveness and inflammation.

Miyahara N, Ohnishi H, Miyahara S, Takeda K, Matsubara S, Matsuda H, Okamoto M, Loader JE, Joetham A, Tanimoto M, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2009 Jun;40(6):672-82. doi: 10.1165/rcmb.2008-0095OC. Epub 2008 Nov 21.

22.

Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness.

Matsubara S, Takeda K, Jin N, Okamoto M, Matsuda H, Shiraishi Y, Park JW, McConville G, Joetham A, O'Brien RL, Dakhama A, Born WK, Gelfand EW.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):454-63. doi: 10.1165/rcmb.2008-0346OC. Epub 2008 Oct 16.

23.

Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses.

Joetham A, Matsubara S, Okamoto M, Takeda K, Miyahara N, Dakhama A, Gelfand EW.

J Immunol. 2008 Jun 1;180(11):7117-24.

24.

Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.

Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Swanson BJ, Yasutomo K, Dakhama A, Gelfand EW.

J Exp Med. 2008 May 12;205(5):1087-97. doi: 10.1084/jem.20072200. Epub 2008 Apr 21.

25.

Contribution of allergen-specific and nonspecific nasal responses to early-phase and late-phase nasal responses.

Miyahara S, Miyahara N, Lucas JJ, Joetham A, Matsubara S, Ohnishi H, Dakhama A, Gelfand EW.

J Allergy Clin Immunol. 2008 Mar;121(3):718-24. Epub 2007 Dec 21.

PMID:
18155286
26.

Estrogen determines sex differences in airway responsiveness after allergen exposure.

Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K, Gelfand EW.

Am J Respir Cell Mol Biol. 2008 May;38(5):501-8. Epub 2007 Dec 6.

27.

IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus.

Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A.

Am J Respir Crit Care Med. 2008 Jan 15;177(2):208-18. Epub 2007 Oct 25.

28.

Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.

Joetham A, Takeda K, Miyahara N, Matsubara S, Ohnishi H, Koya T, Dakhama A, Gelfand EW.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15057-62. Epub 2007 Sep 12.

29.

Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta.

Joetham A, Takeda K, Taube C, Miyahara N, Matsubara S, Koya T, Rha YH, Dakhama A, Gelfand EW.

J Immunol. 2007 Feb 1;178(3):1433-42. Erratum in: J Immunol. 2007 Apr 15;178(8):5400. Takada, Katsuyuki [corrected to Takeda, Katsuyuki]; Matsubara, Satoko [corrected to Matsubara, Shigeki].

30.

IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-gamma, and natural killer cells.

Matsubara S, Takeda K, Kodama T, Joetham A, Miyahara N, Koya T, Swasey CH, Okamoto M, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):324-32. Epub 2006 Oct 12.

31.

Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.

Taube C, Thurman JM, Takeda K, Joetham A, Miyahara N, Carroll MC, Dakhama A, Giclas PC, Holers VM, Gelfand EW.

Proc Natl Acad Sci U S A. 2006 May 23;103(21):8084-9. Epub 2006 May 15.

32.

RANTES (CCL5) regulates airway responsiveness after repeated allergen challenge.

Koya T, Takeda K, Kodama T, Miyahara N, Matsubara S, Balhorn A, Joetham A, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2006 Aug;35(2):147-54. Epub 2006 Mar 9.

33.

Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation.

Matsubara S, Koya T, Takeda K, Joetham A, Miyahara N, Pine P, Masuda ES, Swasey CH, Gelfand EW.

Am J Respir Cell Mol Biol. 2006 Apr;34(4):426-33. Epub 2005 Dec 9.

34.

Physiologic assessment of allergic rhinitis in mice: role of the high-affinity IgE receptor (FcepsilonRI).

Miyahara S, Miyahara N, Takeda K, Joetham A, Gelfand EW.

J Allergy Clin Immunol. 2005 Nov;116(5):1020-7.

PMID:
16275370
35.

Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure.

Koya T, Kodama T, Takeda K, Miyahara N, Yang ES, Taube C, Joetham A, Park JW, Dakhama A, Gelfand EW.

Am J Respir Crit Care Med. 2006 Jan 1;173(1):42-55. Epub 2005 Sep 28.

36.
37.

Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness.

Miyahara N, Takeda K, Miyahara S, Matsubara S, Koya T, Joetham A, Krishnan E, Dakhama A, Haribabu B, Gelfand EW.

Am J Respir Crit Care Med. 2005 Jul 15;172(2):161-7. Epub 2005 Apr 22.

38.

Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challenge.

Joetham A, Takeda K, Taube C, Miyahara N, Kanehiro A, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):89-96. Epub 2005 Apr 21.

39.

Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness.

Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, Matsubara S, Dakhama A, Tager AM, Luster AD, Gelfand EW.

J Immunol. 2005 Apr 15;174(8):4979-84.

40.

Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection.

Dakhama A, Park JW, Taube C, El Gazzar M, Kodama T, Miyahara N, Takeda K, Kanehiro A, Balhorn A, Joetham A, Loader JE, Larsen GL, Gelfand EW.

Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L761-70. Epub 2004 Dec 17.

41.

The role of virus-specific immunoglobulin E in airway hyperresponsiveness.

Dakhama A, Park JW, Taube C, Chayama K, Balhorn A, Joetham A, Wei XD, Fan RH, Swasey C, Miyahara N, Kodama T, Alvarez A, Takeda K, Gelfand EW.

Am J Respir Crit Care Med. 2004 Nov 1;170(9):952-9. Epub 2004 Aug 11.

PMID:
15306536
42.

Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization.

Gelfand EW, Joetham A, Cui ZH, Balhorn A, Takeda K, Taube C, Dakhama A.

J Immunol. 2004 Jul 15;173(2):1298-306.

43.

Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant.

Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, Shultz LD, Donaldson DD, Hamelmann EH, Dakhama A, Gelfand EW.

J Immunol. 2004 May 15;172(10):6398-406.

44.

Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13.

Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park JW, Miyahara S, Balhorn A, Dakhama A, Gelfand EW.

J Immunol. 2004 Feb 15;172(4):2549-58.

45.

Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone.

Park JW, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim SH, Dinarello CA, Gelfand EW.

Am J Respir Cell Mol Biol. 2004 Jun;30(6):830-6. Epub 2004 Jan 30.

PMID:
14754758
46.

Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness.

Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha YH, Park JW, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW.

Am J Respir Cell Mol Biol. 2004 Jun;30(6):837-43. Epub 2004 Jan 23.

PMID:
14742296
47.

Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.

Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW.

Am J Respir Crit Care Med. 2004 Mar 15;169(6):726-32. Epub 2003 Dec 30.

PMID:
14701711
48.

Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen.

Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW.

J Allergy Clin Immunol. 2003 Dec;112(6):1078-87.

PMID:
14657862
49.

Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on gammadelta T cells.

Cui ZH, Joetham A, Aydintug MK, Hahn YS, Born WK, Gelfand EW.

Am J Respir Crit Care Med. 2003 Dec 1;168(11):1324-32.

PMID:
14644924
50.

Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness.

Mäkelä MJ, Tripp R, Dakhama A, Park JW, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW.

J Allergy Clin Immunol. 2003 Nov;112(5):861-9.

PMID:
14610471

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