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Items: 14


Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice.

Donaldson TN, Jennings KT, Cherep LA, McNeela AM, Depreux FF, Jodelka FM, Hastings ML, Wallace DG.

Behav Brain Res. 2018 Feb 15;338:76-87. doi: 10.1016/j.bbr.2017.10.012. Epub 2017 Oct 14.


Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment.

Ponnath A, Depreux FF, Jodelka FM, Rigo F, Farris HE, Hastings ML, Lentz JJ.

J Assoc Res Otolaryngol. 2018 Feb;19(1):1-16. doi: 10.1007/s10162-017-0640-x. Epub 2017 Oct 12.


Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide.

Vijayakumar S, Depreux FF, Jodelka FM, Lentz JJ, Rigo F, Jones TA, Hastings ML.

Hum Mol Genet. 2017 Sep 15;26(18):3482-3494. doi: 10.1093/hmg/ddx234.


Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS.

Nat Biotechnol. 2017 Mar;35(3):264-272. doi: 10.1038/nbt.3801. Epub 2017 Feb 6.


Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse.

Depreux FF, Wang L, Jiang H, Jodelka FM, Rosencrans RF, Rigo F, Lentz JJ, Brigande JV, Hastings ML.

Nucleic Acids Res. 2016 Nov 16;44(20):9519-9529. Epub 2016 Sep 28.


Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML.

EMBO Mol Med. 2016 Apr 1;8(4):328-45. doi: 10.15252/emmm.201505846.


Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.

Wee CD, Havens MA, Jodelka FM, Hastings ML.

PLoS One. 2014 Dec 15;9(12):e115205. doi: 10.1371/journal.pone.0115205. eCollection 2014.


SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant.

Dauber A, Golzio C, Guenot C, Jodelka FM, Kibaek M, Kjaergaard S, Leheup B, Martinet D, Nowaczyk MJ, Rosenfeld JA, Zeesman S, Zunich J, Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S, Katsanis N.

Am J Hum Genet. 2013 Nov 7;93(5):798-811. doi: 10.1016/j.ajhg.2013.09.010. Epub 2013 Oct 17. Erratum in: Am J Hum Genet. 2013 Nov 7;93(5):994.


Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness.

Lentz JJ, Jodelka FM, Hinrich AJ, McCaffrey KE, Farris HE, Spalitta MJ, Bazan NG, Duelli DM, Rigo F, Hastings ML.

Nat Med. 2013 Mar;19(3):345-50. doi: 10.1038/nm.3106. Epub 2013 Feb 4.


Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation.

Vorlová S, Rocco G, Lefave CV, Jodelka FM, Hess K, Hastings ML, Henke E, Cartegni L.

Mol Cell. 2011 Sep 16;43(6):927-39. doi: 10.1016/j.molcel.2011.08.009.


A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.

Jodelka FM, Ebert AD, Duelli DM, Hastings ML.

Hum Mol Genet. 2010 Dec 15;19(24):4906-17. doi: 10.1093/hmg/ddq425. Epub 2010 Sep 30.


Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy.

Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR.

Sci Transl Med. 2009 Nov 4;1(5):5ra12. doi: 10.1126/scitranslmed.3000208.


MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9.

Potashkin JA, Kang UJ, Loomis PA, Jodelka FM, Ding Y, Meredith GE.

Brain Res. 2007 Nov 28;1182:1-10. Epub 2007 Sep 14.


BRCA1 promotes induction of ssDNA by ionizing radiation.

Schlegel BP, Jodelka FM, Nunez R.

Cancer Res. 2006 May 15;66(10):5181-9.

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