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Items: 1 to 50 of 151

1.

Melatonin receptor structures shed new light on melatonin research.

Cecon E, Liu L, Jockers R.

J Pineal Res. 2019 Aug 23:e12606. doi: 10.1111/jpi.12606. [Epub ahead of print]

PMID:
31442321
2.

[In-depth analysis of the relationship between the MT2 receptor of melatonin and type 2 diabetes].

Hegron A, Jockers R.

Med Sci (Paris). 2019 May;35(5):412-416. doi: 10.1051/medsci/2019088. Epub 2019 May 22. French. No abstract available.

PMID:
31115323
3.

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor.

Cecon E, Dam J, Luka M, Gautier C, Chollet AM, Delagrange P, Danober L, Jockers R.

Br J Pharmacol. 2019 Sep;176(18):3475-3488. doi: 10.1111/bph.14688. Epub 2019 May 20.

PMID:
30981214
4.

A novel leptin receptor antagonist uncouples leptin's metabolic and immune functions.

Zabeau L, Wauman J, Dam J, Van Lint S, Burg E, De Geest J, Rogge E, Silva A, Jockers R, Tavernier J.

Cell Mol Life Sci. 2019 Mar;76(6):1201-1214. doi: 10.1007/s00018-019-03004-9. Epub 2019 Jan 18.

PMID:
30659329
5.

O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors.

Karamitri A, Sadek MS, Journé AS, Gbahou F, Gerbier R, Osman MB, Habib SAM, Jockers R, Zlotos DP.

Bioorg Chem. 2019 Apr;85:349-356. doi: 10.1016/j.bioorg.2019.01.004. Epub 2019 Jan 4.

PMID:
30658234
6.

Melatonin in type 2 diabetes mellitus and obesity.

Karamitri A, Jockers R.

Nat Rev Endocrinol. 2019 Feb;15(2):105-125. doi: 10.1038/s41574-018-0130-1. Review.

PMID:
30531911
7.

Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain.

Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P, Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R.

J Pineal Res. 2019 Mar;66(2):e12540. doi: 10.1111/jpi.12540. Epub 2019 Jan 17.

PMID:
30475390
8.

[Mitochondrial signaling of G protein-coupled receptors].

Lahuna O, Jockers R.

Biol Aujourdhui. 2018;212(1-2):21-26. doi: 10.1051/jbio/2018024. Epub 2018 Oct 26. Review. French.

PMID:
30362452
9.

Endospanin 1 Determines the Balance of Leptin-Regulated Hypothalamic Functions.

Roujeau C, Jockers R, Dam J.

Neuroendocrinology. 2019;108(2):132-141. doi: 10.1159/000494557. Epub 2018 Oct 16. Review.

10.

Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay.

Auriau J, Roujeau C, Belaid Choucair Z, Oishi A, Derviaux C, Roux T, Trinquet E, Hermine O, Jockers R, Dam J.

Biochem Pharmacol. 2018 Dec;158:45-59. doi: 10.1016/j.bcp.2018.09.014. Epub 2018 Sep 17.

PMID:
30236477
11.

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling.

Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, Bouvier M, Jockers R.

Sci Signal. 2018 Aug 28;11(545). pii: eaan6622. doi: 10.1126/scisignal.aan6622.

PMID:
30154102
12.

Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.

Benleulmi-Chaachoua A, Hegron A, Le Boulch M, Karamitri A, Wierzbicka M, Wong V, Stagljar I, Delagrange P, Ahmad R, Jockers R.

Cell Mol Life Sci. 2018 Dec;75(23):4357-4370. doi: 10.1007/s00018-018-2876-y. Epub 2018 Jul 24.

PMID:
30043140
13.

GPR50 in TGFβ signaling and breast cancer.

Ahmad R, Wojciech S, Jockers R.

Oncoscience. 2018 Jun 27;5(5-6):157-158. doi: 10.18632/oncoscience.433. eCollection 2018 May. No abstract available.

14.

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor.

Igonet S, Raingeval C, Cecon E, Pučić-Baković M, Lauc G, Cala O, Baranowski M, Perez J, Jockers R, Krimm I, Jawhari A.

Sci Rep. 2018 May 25;8(1):8142. doi: 10.1038/s41598-018-26113-0.

15.

Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function.

Oishi A, Cecon E, Jockers R.

Int Rev Cell Mol Biol. 2018;338:59-77. doi: 10.1016/bs.ircmb.2018.02.002. Epub 2018 Apr 5. Review.

PMID:
29699692
16.

[Hypothalamic endospanin 1 dissociates obesity from type 2 diabetes].

Roujeau C, Jockers R, Dam J.

Med Sci (Paris). 2018 Apr;34(4):288-291. doi: 10.1051/medsci/20183404003. Epub 2018 Apr 16. French. No abstract available.

17.

The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.

Wojciech S, Ahmad R, Belaid-Choucair Z, Journé AS, Gallet S, Dam J, Daulat A, Ndiaye-Lobry D, Lahuna O, Karamitri A, Guillaume JL, Do Cruzeiro M, Guillonneau F, Saade A, Clément N, Courivaud T, Kaabi N, Tadagaki K, Delagrange P, Prévot V, Hermine O, Prunier C, Jockers R.

Nat Commun. 2018 Mar 23;9(1):1216. doi: 10.1038/s41467-018-03609-x.

18.

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.

Owino S, Sánchez-Bretaño A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G.

J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12462. Epub 2018 Jan 9.

19.

Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.

Clement N, Renault N, Guillaume JL, Cecon E, Journé AS, Laurent X, Tadagaki K, Cogé F, Gohier A, Delagrange P, Chavatte P, Jockers R.

Br J Pharmacol. 2018 Aug;175(16):3281-3297. doi: 10.1111/bph.14029. Epub 2017 Oct 27.

20.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5.

21.

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R.

Sci Rep. 2017 Aug 21;7(1):8990. doi: 10.1038/s41598-017-08996-7.

22.

Melatonin receptors: molecular pharmacology and signalling in the context of system bias.

Cecon E, Oishi A, Jockers R.

Br J Pharmacol. 2018 Aug;175(16):3263-3280. doi: 10.1111/bph.13950. Epub 2017 Aug 17. Review.

23.

Design and validation of the first cell-impermeant melatonin receptor agonist.

Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R.

Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11.

24.

Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells.

Belacel-Ouari M, Zhang L, Hubert F, Assaly R, Gerbier R, Jockers R, Dauphin F, Lechêne P, Fischmeister R, Manoury B, Leblais V.

Cell Signal. 2017 Jul;35:118-128. doi: 10.1016/j.cellsig.2017.03.025. Epub 2017 Apr 4.

PMID:
28389413
25.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I.

Mol Syst Biol. 2017 Mar 15;13(3):918. doi: 10.15252/msb.20167430.

26.

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling.

Vauthier V, Roujeau C, Chen P, Sarkis C, Migrenne S, Hosoi T, Ozawa K, Rouillé Y, Foretz M, Mallet J, Launay JM, Magnan C, Jockers R, Dam J.

Mol Metab. 2016 Nov 3;6(1):159-172. doi: 10.1016/j.molmet.2016.10.009. eCollection 2017 Jan.

27.

The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm.

Bonnefond A, Karamitri A, Jockers R, Froguel P.

Cell Metab. 2016 Sep 13;24(3):345-347. doi: 10.1016/j.cmet.2016.08.015. No abstract available.

28.

Update on melatonin receptors: IUPHAR Review 20.

Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP.

Br J Pharmacol. 2016 Sep;173(18):2702-25. doi: 10.1111/bph.13536. Epub 2016 Aug 8. Review.

29.

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

Chandra V, Karamitri A, Richards P, Cormier F, Ramond C, Jockers R, Armanet M, Albagli-Curiel O, Scharfmann R.

Sci Rep. 2016 May 11;6:25765. doi: 10.1038/srep25765.

30.

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R.

J Pineal Res. 2016 Jan;60(1):95-108. doi: 10.1111/jpi.12294. Epub 2015 Nov 30.

PMID:
26514267
31.

Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers.

Kamal M, Gbahou F, Guillaume JL, Daulat AM, Benleulmi-Chaachoua A, Luka M, Chen P, Kalbasi Anaraki D, Baroncini M, Mannoury la Cour C, Millan MJ, Prevot V, Delagrange P, Jockers R.

J Biol Chem. 2015 May 1;290(18):11537-46. doi: 10.1074/jbc.M114.559542. Epub 2015 Mar 13.

32.

Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway.

Cecon E, Chen M, Marçola M, Fernandes PA, Jockers R, Markus RP.

FASEB J. 2015 Jun;29(6):2566-82. doi: 10.1096/fj.14-265678. Epub 2015 Mar 10.

PMID:
25757565
33.

New pharmacological perspectives for the leptin receptor in the treatment of obesity.

Roujeau C, Jockers R, Dam J.

Front Endocrinol (Lausanne). 2014 Oct 13;5:167. doi: 10.3389/fendo.2014.00167. eCollection 2014. Review.

34.

Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.

Ahmad R, Wojciech S, Jockers R.

Br J Pharmacol. 2015 Jul;172(13):3212-28. doi: 10.1111/bph.12942. Epub 2014 Dec 15. Review.

35.

Frontiers commentary on tallet et Al. Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer.

Jockers R.

Front Endocrinol (Lausanne). 2014 Jun 18;5:88. doi: 10.3389/fendo.2014.00088. eCollection 2014. No abstract available.

36.

Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease.

Tosini G, Owino S, Guillaume JL, Jockers R.

Bioessays. 2014 Aug;36(8):778-87. doi: 10.1002/bies.201400017. Epub 2014 Jun 5. Review.

37.

Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice.

Vauthier V, Swartz TD, Chen P, Roujeau C, Pagnon M, Mallet J, Sarkis C, Jockers R, Dam J.

Gene Ther. 2014 Jul;21(7):638-44. doi: 10.1038/gt.2014.36. Epub 2014 May 1.

PMID:
24784449
38.

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Ferré S, Casadó V, Devi LA, Filizola M, Jockers R, Lohse MJ, Milligan G, Pin JP, Guitart X.

Pharmacol Rev. 2014 Feb 10;66(2):413-34. doi: 10.1124/pr.113.008052. Print 2014. Review.

39.

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.

Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prévot V.

Cell Metab. 2014 Feb 4;19(2):293-301. doi: 10.1016/j.cmet.2013.12.015.

40.

Comment on "The Use of BRET to Study Receptor-Protein Interactions".

Jockers R.

Front Endocrinol (Lausanne). 2014 Jan 22;5:3. doi: 10.3389/fendo.2014.00003. eCollection 2014. No abstract available.

41.

[G protein-coupled receptors in the spot light].

Benleulmi-Chaachoua A, Wojciech S, Jockers R.

Biol Aujourdhui. 2013;207(3):191-200. doi: 10.1051/jbio/2013014. Epub 2013 Dec 13. Review. French.

PMID:
24330972
42.

Hunting for the functions of short leptin receptor isoforms.

Dam J, Jockers R.

Mol Metab. 2013 Sep 13;2(4):327-8. doi: 10.1016/j.molmet.2013.09.001. eCollection 2013. No abstract available.

43.

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

Zlotos DP, Jockers R, Cecon E, Rivara S, Witt-Enderby PA.

J Med Chem. 2014 Apr 24;57(8):3161-85. doi: 10.1021/jm401343c. Epub 2013 Nov 14.

PMID:
24228714
44.

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.

Baba K, Benleulmi-Chaachoua A, Journé AS, Kamal M, Guillaume JL, Dussaud S, Gbahou F, Yettou K, Liu C, Contreras-Alcantara S, Jockers R, Tosini G.

Sci Signal. 2013 Oct 8;6(296):ra89. doi: 10.1126/scisignal.2004302.

45.

[Involvement of melatonin MT2 receptor mutants in type 2 diabetes development].

Karamitri A, Vincens M, Chen M, Jockers R.

Med Sci (Paris). 2013 Aug-Sep;29(8-9):778-84. doi: 10.1051/medsci/2013298018. Epub 2013 Sep 5. Review. French.

46.

Anti-obesity phenotypic screening looking to increase OBR cell surface expression.

Kim TH, Choi DH, Vauthier V, Dam J, Li X, Nam YJ, Ko Y, Kwon HJ, Shin SH, Cechetto J, Soloveva V, Jockers R.

J Biomol Screen. 2014 Jan;19(1):88-99. doi: 10.1177/1087057113499185. Epub 2013 Aug 19.

PMID:
23958651
48.

Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.

Hill SM, Cheng C, Yuan L, Mao L, Jockers R, Dauchy B, Blask DE.

Curr Aging Sci. 2013 Feb;6(1):125-33. Review.

PMID:
23895529
49.

Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes.

Karamitri A, Renault N, Clement N, Guillaume JL, Jockers R.

Mol Endocrinol. 2013 Aug;27(8):1217-33. doi: 10.1210/me.2013-1101. Epub 2013 Jun 24. Review.

50.

Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression.

Wu YH, Ursinus J, Zhou JN, Scheer FA, Ai-Min B, Jockers R, van Heerikhuize J, Swaab DF.

J Affect Disord. 2013 Jun;148(2-3):357-67. doi: 10.1016/j.jad.2012.12.025. Epub 2013 Jan 26.

PMID:
23357659

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