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Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure.

Anthis AHC, Tsolaki E, Didierlaurent L, Staubli S, Zboray R, Neels A, Dietrich D, Manser P, Desbiolles LM, Leschka S, Wildermuth S, Lehner S, Chavatte-Palmer P, Jochum W, Wick P, Dommann A, Bürki-Turnherr T, Fischer T, Hornung R, Bertazzo S, Herrmann IK.

Analyst. 2019 Nov 18;144(23):6850-6857. doi: 10.1039/c9an01312a.


Ki-67 assessment in early breast cancer: SAKK28/12 validation study on the IBCSG VIII and IBCSG IX cohort.

Varga Z, Li Q, Jochum W, Perriard U, Rau T, Tille JC, Hawle H, Klingbiel D, Thuerlimann B, Ruhstaller T.

Sci Rep. 2019 Sep 19;9(1):13534. doi: 10.1038/s41598-019-49638-4.


High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification.

Zhu Y, Weiss T, Zhang Q, Sun R, Wang B, Yi X, Wu Z, Gao H, Cai X, Ruan G, Zhu T, Xu C, Lou S, Yu X, Gillet L, Blattmann P, Saba K, Fankhauser CD, Schmid MB, Rutishauser D, Ljubicic J, Christiansen A, Fritz C, Rupp NJ, Poyet C, Rushing E, Weller M, Roth P, Haralambieva E, Hofer S, Chen C, Jochum W, Gao X, Teng X, Chen L, Zhong Q, Wild PJ, Aebersold R, Guo T.

Mol Oncol. 2019 Nov;13(11):2305-2328. doi: 10.1002/1878-0261.12570. Epub 2019 Sep 18.


BP180-specific IgG is associated with skin adverse events, therapy response, and overall survival in non-small cell lung cancer patients treated with checkpoint inhibitors.

Hasan Ali O, Bomze D, Ring SS, Berner F, Fässler M, Diem S, Abdou MT, Hammers C, Emtenani S, Braun A, Cozzio A, Mani B, Jochum W, Schmidt E, Zillikens D, Sadik CD, Flatz L.

J Am Acad Dermatol. 2020 Apr;82(4):854-861. doi: 10.1016/j.jaad.2019.08.045. Epub 2019 Aug 23.


PD-L1 testing of non-small cell lung cancer using different antibodies and platforms: a Swiss cross-validation study.

Savic S, Berezowska S, Eppenberger-Castori S, Cathomas G, Diebold J, Fleischmann A, Jochum W, Komminoth P, McKee T, Letovanec I, Jasarevic Z, Rössle M, Singer G, von Gunten M, Zettl A, Zweifel R, Soltermann A, Bubendorf L.

Virchows Arch. 2019 Jul;475(1):67-76. doi: 10.1007/s00428-019-02582-0. Epub 2019 May 24.


Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience.

Baumeler S, Jochum W, Neuweiler J, Bergamin I, Semela D.

Swiss Med Wkly. 2019 Apr 26;149:w20077. doi: 10.4414/smw.2019.20077. eCollection 2019 Apr 22.


Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer.

Berner F, Bomze D, Diem S, Ali OH, Fässler M, Ring S, Niederer R, Ackermann CJ, Baumgaertner P, Pikor N, Cruz CG, van de Veen W, Akdis M, Nikolaev S, Läubli H, Zippelius A, Hartmann F, Cheng HW, Hönger G, Recher M, Goldman J, Cozzio A, Früh M, Neefjes J, Driessen C, Ludewig B, Hegazy AN, Jochum W, Speiser DE, Flatz L.

JAMA Oncol. 2019 Jul 1;5(7):1043-1047. doi: 10.1001/jamaoncol.2019.0402. Erratum in: JAMA Oncol. 2019 Jul 1;5(7):1070.


Patterns of progression on osimertinib in EGFR T790M positive NSCLC: A Swiss cohort study.

Schmid S, Klingbiel D, Aeppli S, Britschgi C, Gautschi O, Pless M, Rothschild S, Wannesson L, Janthur W, Foerbs D, Demmer I, Jochum W, Früh M.

Lung Cancer. 2019 Apr;130:149-155. doi: 10.1016/j.lungcan.2019.02.020. Epub 2019 Feb 19.


Cost-Efficient and Easy to Perform PCR-Based Assay to Identify Met Exon 14 Skipping in Formalin-Fixed Paraffin-Embedded (FFPE) Non-Small Cell Lung Cancer (NSCLC) Samples.

O'Brien O, Wright MC, O'Brien C, Geoghegan O, Leonard N, Nicholson S, Cuffe S, Fabre A, Jochum W, Joerger M, Gray SG, Finn SP.

Diagnostics (Basel). 2019 Jan 18;9(1). pii: E13. doi: 10.3390/diagnostics9010013.


[Treatment of Advanced Prostate Carcinoma - an Interdisciplinary Recommendation].

Omlin A, Spahn M, Beyer J, Eberli D, Gillessen S, Jochum W, Kueng M, Nitzsche E, Rentsch CA, Roggero E, Schmid HP, Stenner F, Templeton AJ, Wild D, Wyler S, Zwahlen D, Cathomas R.

Praxis (Bern 1994). 2018 Sep;107(19):1043-1051. doi: 10.1024/1661-8157/a003054. Review. German. No abstract available.


Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma.

Plath M, Broglie MA, Förbs D, Stoeckli SJ, Jochum W.

J Otolaryngol Head Neck Surg. 2018 Sep 6;47(1):53. doi: 10.1186/s40463-018-0298-3.


Endoscopic Treatment of Early Barrett's Adenocarcinoma and Dysplasia: Focus on Submucosal Cancer.

Frei N, Frei R, Semadeni GM, Jochum W, Brand S, Borovicka J.

Digestion. 2019;99(4):293-300. doi: 10.1159/000492217. Epub 2018 Sep 3.


Organ-specific response to nivolumab in patients with non-small cell lung cancer (NSCLC).

Schmid S, Diem S, Li Q, Krapf M, Flatz L, Leschka S, Desbiolles L, Klingbiel D, Jochum W, Früh M.

Cancer Immunol Immunother. 2018 Dec;67(12):1825-1832. doi: 10.1007/s00262-018-2239-4. Epub 2018 Aug 31.


Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers.

Guo T, Li L, Zhong Q, Rupp NJ, Charmpi K, Wong CE, Wagner U, Rueschoff JH, Jochum W, Fankhauser CD, Saba K, Poyet C, Wild PJ, Aebersold R, Beyer A.

Life Sci Alliance. 2018 May 29;1(2). pii: e201800042. doi: 10.26508/lsa.201800042.


The prognostic value of signet ring cell histology in stage I/II colon cancer-a population-based, propensity score-matched analysis.

Ackermann CJ, Guller U, Jochum W, Schmied BM, Warschkow R.

Int J Colorectal Dis. 2018 Sep;33(9):1183-1193. doi: 10.1007/s00384-018-3096-5. Epub 2018 Jun 7.


Multi-laboratory proficiency testing of clinical cancer genomic profiling by next-generation sequencing.

Zhong Q, Wagner U, Kurt H, Molinari F, Cathomas G, Komminoth P, Barman-Aksözen J, Schneider-Yin X, Rey JP, Vassella E, Rogel U, Diebold J, McKee T, Jochum W, Kashofer K, Hofman P, Zischka M, Moch H, Rechsteiner M, Wild PJ.

Pathol Res Pract. 2018 Jul;214(7):957-963. doi: 10.1016/j.prp.2018.05.020. Epub 2018 May 22.


Anti-PD-1 Therapy Leads to Near-Complete Remission in a Patient with Metastatic Basal Cell Carcinoma.

Fischer S, Hasan Ali O, Jochum W, Kluckert T, Flatz L, Siano M.

Oncol Res Treat. 2018;41(6):391-394. doi: 10.1159/000487084. Epub 2018 May 3.


Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness.

Boesch M, Onder L, Cheng HW, Novkovic M, Mörbe U, Sopper S, Gastl G, Jochum W, Ruhstaller T, Knauer M, Ludewig B.

Oncoimmunology. 2018 Jan 3;7(4):e1414129. doi: 10.1080/2162402X.2017.1414129. eCollection 2018.


CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses.

Cheng HW, Onder L, Cupovic J, Boesch M, Novkovic M, Pikor N, Tarantino I, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B.

J Allergy Clin Immunol. 2018 Oct;142(4):1257-1271.e4. doi: 10.1016/j.jaci.2017.12.998. Epub 2018 Jan 31.


Reappraisal of Morphologic Differences Between Renal Medullary Carcinoma, Collecting Duct Carcinoma, and Fumarate Hydratase-deficient Renal Cell Carcinoma.

Ohe C, Smith SC, Sirohi D, Divatia M, de Peralta-Venturina M, Paner GP, Agaimy A, Amin MB, Argani P, Chen YB, Cheng L, Colecchia M, Compérat E, Werneck da Cunha I, Epstein JI, Gill AJ, Hes O, Hirsch MS, Jochum W, Kunju LP, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Nesi G, Osunkoya AO, Picken MM, Rao P, Reuter VE, de Oliveira Salles PG, Schultz L, Tickoo SK, Tomlins SA, Trpkov K, Amin MB.

Am J Surg Pathol. 2018 Mar;42(3):279-292. doi: 10.1097/PAS.0000000000001000.


Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score - a multicenter study.

Diebold M, Soltermann A, Hottinger S, Haile SR, Bubendorf L, Komminoth P, Jochum W, Grobholz R, Theegarten D, Berezowska S, Darwiche K, Oezkan F, Kohler M, Franzen DP.

Respir Res. 2017 Dec 16;18(1):210. doi: 10.1186/s12931-017-0693-8.


Individualized treatment approaches for Langerhans cell histiocytosis.

Roider E, Signer C, Fehrenbacher B, Metzler G, Schaller M, Kamarachev J, Kerl K, Balabanov S, Jochum W, Hoetzenecker W, Cozzio A, French LE, Dummer R, Guenova E.

Br J Dermatol. 2018 Jun;178(6):1423-1424. doi: 10.1111/bjd.16171. Epub 2018 Mar 23. No abstract available.


Tumor infiltrating lymphocytes in lymph node metastases of stage III melanoma correspond to response and survival in nine patients treated with ipilimumab at the time of stage IV disease.

Diem S, Hasan Ali O, Ackermann CJ, Bomze D, Koelzer VH, Jochum W, Speiser DE, Mertz KD, Flatz L.

Cancer Immunol Immunother. 2018 Jan;67(1):39-45. doi: 10.1007/s00262-017-2061-4. Epub 2017 Sep 11.


Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab.

Diem S, Schmid S, Krapf M, Flatz L, Born D, Jochum W, Templeton AJ, Früh M.

Lung Cancer. 2017 Sep;111:176-181. doi: 10.1016/j.lungcan.2017.07.024. Epub 2017 Jul 24.


Recurrent Dystrophic Calcification of the Prostatic Resection Cavity After Transurethral Resection of the Prostate: Clinical Presentation and Endoscopic Management.

Zumstein V, Betschart P, Müllhaupt G, Jochum W, Schmid HP, Abt D.

J Endourol Case Rep. 2017 Jun 1;3(1):81-83. doi: 10.1089/cren.2017.0058. eCollection 2017.


Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery.

Broglie MA, Stoeckli SJ, Sauter R, Pasche P, Reinhard A, de Leval L, Huber GF, Pezier TF, Soltermann A, Giger R, Arnold A, Dettmer M, Arnoux A, Müller M, Spreitzer S, Lang F, Lutchmaya M, Stauffer E, Espeli V, Martucci F, Bongiovanni M, Foerbs D, Jochum W.

Head Neck. 2017 Oct;39(10):2004-2015. doi: 10.1002/hed.24865. Epub 2017 Jul 10.


Evaluation of type-specific antibodies to high risk-human papillomavirus (HPV) proteins in patients with oropharyngeal cancer.

Broglie MA, Jochum W, Michel A, Waterboer T, Foerbs D, Schoenegg R, Stoeckli SJ, Pawlita M, Holzinger D.

Oral Oncol. 2017 Jul;70:43-50. doi: 10.1016/j.oraloncology.2017.05.010. Epub 2017 May 25.


Epidermal growth factor receptor and anaplastic lymphoma kinase testing and mutation prevalence in patients with advanced non-small cell lung cancer in Switzerland: A comprehensive evaluation of real world practices.

Ess SM, Herrmann C, Frick H, Krapf M, Cerny T, Jochum W, Früh M.

Eur J Cancer Care (Engl). 2017 Nov;26(6). doi: 10.1111/ecc.12721. Epub 2017 May 30.


Impact of particle size and surface modification on gold nanoparticle penetration into human placental microtissues.

Muoth C, Großgarten M, Karst U, Ruiz J, Astruc D, Moya S, Diener L, Grieder K, Wichser A, Jochum W, Wick P, Buerki-Thurnherr T.

Nanomedicine (Lond). 2017 May;12(10):1119-1133. doi: 10.2217/nnm-2017-0428. Epub 2017 Apr 27.


Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes.

Burmeister K, Quagliata L, Andreozzi M, Eppenberger-Castori S, Matter MS, Perrina V, Grobholz R, Jochum W, Horber D, Moosmann P, Lehmann F, Köberle D, Ng CK, Piscuoglio S, Tornillo L, Terracciano LM.

PLoS One. 2017 Apr 12;12(4):e0175563. doi: 10.1371/journal.pone.0175563. eCollection 2017.


Low tissue levels of miR-125b predict malignancy in solitary fibrous tumors of the pleura.

Brock M, Hottinger S, Diebold M, Soltermann A, Jochum W, Kohler M, Huber LC, Franzen DP.

Respir Res. 2017 Mar 2;18(1):43. doi: 10.1186/s12931-017-0528-7.


Clinical Outcome of ALK-Positive Non-Small Cell Lung Cancer (NSCLC) Patients with De Novo EGFR or KRAS Co-Mutations Receiving Tyrosine Kinase Inhibitors (TKIs).

Schmid S, Gautschi O, Rothschild S, Mark M, Froesch P, Klingbiel D, Reichegger H, Jochum W, Diebold J, Früh M.

J Thorac Oncol. 2017 Apr;12(4):681-688. doi: 10.1016/j.jtho.2016.12.003. Epub 2016 Dec 19.


Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer.

Hasan Ali O, Diem S, Markert E, Jochum W, Kerl K, French LE, Speiser DE, Früh M, Flatz L.

Oncoimmunology. 2016 Sep 19;5(11):e1231292. doi: 10.1080/2162402X.2016.1231292. eCollection 2016.


Correction: Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart.

Sibilia M, Wagner B, Hoebertz A, Elliott C, Marino S, Jochum W, Wagner EF.

Development. 2016 Dec 15;143(24):4755. No abstract available.


Tubulocystic Carcinoma of the Kidney With Poorly Differentiated Foci: A Frequent Morphologic Pattern of Fumarate Hydratase-deficient Renal Cell Carcinoma.

Smith SC, Trpkov K, Chen YB, Mehra R, Sirohi D, Ohe C, Cani AK, Hovelson DH, Omata K, McHugh JB, Jochum W, Colecchia M, Amin M, Divatia MK, Hes O, Menon S, Werneck da Cunha I, Tripodi S, Brimo F, Gill AJ, Osunkoya AO, Magi-Galluzzi C, Sibony M, Williamson SR, Nesi G, Picken MM, Maclean F, Agaimy A, Cheng L, Epstein JI, Reuter VE, Tickoo SK, Tomlins SA, Amin MB.

Am J Surg Pathol. 2016 Nov;40(11):1457-1472.


A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment.

Muoth C, Wichser A, Monopoli M, Correia M, Ehrlich N, Loeschner K, Gallud A, Kucki M, Diener L, Manser P, Jochum W, Wick P, Buerki-Thurnherr T.

Nanoscale. 2016 Oct 6;8(39):17322-17332.


Rapid Intracranial Response to Osimertinib in a Patient with Epidermal Growth Factor Receptor T790M-Positive Adenocarcinoma of the Lung.

Reichegger H, Jochum W, Förbs D, Hader C, Früh M.

Oncol Res Treat. 2016;39(7-8):461-3. doi: 10.1159/000446759. Epub 2016 Jun 15.


Reproducible Tissue Homogenization and Protein Extraction for Quantitative Proteomics Using MicroPestle-Assisted Pressure-Cycling Technology.

Shao S, Guo T, Gross V, Lazarev A, Koh CC, Gillessen S, Joerger M, Jochum W, Aebersold R.

J Proteome Res. 2016 Jun 3;15(6):1821-9. doi: 10.1021/acs.jproteome.5b01136. Epub 2016 May 10.


Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity.

Zhong Q, Rüschoff JH, Guo T, Gabrani M, Schüffler PJ, Rechsteiner M, Liu Y, Fuchs TJ, Rupp NJ, Fankhauser C, Buhmann JM, Perner S, Poyet C, Blattner M, Soldini D, Moch H, Rubin MA, Noske A, Rüschoff J, Haffner MC, Jochum W, Wild PJ.

Sci Rep. 2016 Apr 7;6:24146. doi: 10.1038/srep24146.


NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial.

Endris V, Stenzinger A, Pfarr N, Penzel R, Möbs M, Lenze D, Darb-Esfahani S, Hummel M, Sabine-Merkelbach-Bruse, Jung A, Lehmann U, Kreipe H, Kirchner T, Büttner R, Jochum W, Höfler G, Dietel M, Weichert W, Schirmacher P.

Virchows Arch. 2016 Jun;468(6):697-705. doi: 10.1007/s00428-016-1919-8. Epub 2016 Mar 22.


Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2).

Feilchenfeldt J, Varga Z, Siano M, Grabsch HI, Held U, Schuknecht B, Trip A, Hamaguchi T, Gut P, Balague O, Khanfir K, Diebold J, Jochum W, Shoji H, Kushima R, Wagner D, Shimada Y, Cats A, Knuth A, Moch H, Aebi S, Hofer S.

Br J Cancer. 2015 Dec 22;113(12):1747. doi: 10.1038/bjc.2015.458. No abstract available.


Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy.

Schmid P, Bregenzer A, Huber M, Rauch A, Jochum W, Müllhaupt B, Vernazza P, Opravil M, Weber R; Swiss HIV Cohort Study.

PLoS One. 2015 Sep 29;10(9):e0138838. doi: 10.1371/journal.pone.0138838. eCollection 2015.


Brush cytology for the detection of high-risk HPV infection in oropharyngeal squamous cell carcinoma.

Broglie MA, Jochum W, Förbs D, Schönegg R, Stoeckli SJ.

Cancer Cytopathol. 2015 Dec;123(12):732-8. doi: 10.1002/cncy.21606. Epub 2015 Sep 8.


Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2).

Feilchenfeldt J, Varga Z, Siano M, Grabsch HI, Held U, Schuknecht B, Trip A, Hamaguchi T, Gut P, Balague O, Khanfir K, Diebold J, Jochum W, Shoji H, Kushima R, Wagner D, Shimada Y, Cats A, Knuth A, Moch H, Aebi S, Hofer S.

Br J Cancer. 2015 Sep 1;113(5):716-21. doi: 10.1038/bjc.2015.279. Epub 2015 Aug 27. Erratum in: Br J Cancer. 2015 Dec 22;113(12):1747.


Minimal sample requirement for highly multiplexed protein quantification in cell lines and tissues by PCT-SWATH mass spectrometry.

Shao S, Guo T, Koh CC, Gillessen S, Joerger M, Jochum W, Aebersold R.

Proteomics. 2015 Nov;15(21):3711-21. doi: 10.1002/pmic.201500161. Epub 2015 Sep 10.


Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts.

Grafmueller S, Manser P, Diener L, Maurizi L, Diener PA, Hofmann H, Jochum W, Krug HF, Buerki-Thurnherr T, von Mandach U, Wick P.

Sci Technol Adv Mater. 2015 Jul 16;16(4):044602. eCollection 2015 Aug.


[How is agonizing leg pain associated with an intrauterine device?].

Jäckel K, Braschler T, Jochum W, Hülder T, Knechtle B.

Praxis (Bern 1994). 2015 May 6;104(10):517-22. doi: 10.1024/1661-8157/a002002. German. Erratum in: Praxis (Bern 1994). 2015 May 20;104(11):542.


Screening for ALK in non-small cell lung carcinomas: 5A4 and D5F3 antibodies perform equally well, but combined use with FISH is recommended.

Savic S, Diebold J, Zimmermann AK, Jochum W, Baschiera B, Grieshaber S, Tornillo L, Bisig B, Kerr K, Bubendorf L.

Lung Cancer. 2015 Aug;89(2):104-9. doi: 10.1016/j.lungcan.2015.05.012. Epub 2015 May 21.


Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model.

Grafmueller S, Manser P, Diener L, Diener PA, Maeder-Althaus X, Maurizi L, Jochum W, Krug HF, Buerki-Thurnherr T, von Mandach U, Wick P.

Environ Health Perspect. 2015 Dec;123(12):1280-6. doi: 10.1289/ehp.1409271. Epub 2015 May 8.


Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps.

Guo T, Kouvonen P, Koh CC, Gillet LC, Wolski WE, Röst HL, Rosenberger G, Collins BC, Blum LC, Gillessen S, Joerger M, Jochum W, Aebersold R.

Nat Med. 2015 Apr;21(4):407-13. doi: 10.1038/nm.3807. Epub 2015 Mar 2.

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